Shin Yamazaki , Ph.D.

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Phone Number: (615) 322-8054

Email Address:

Yamazaki, Shin's picture

Office Address   Mailing Address

U8231A MRBIII /U8224 (lab)

Box 35-1634 VU Station B 37235-1634

Research Keywords
biological rhythms,Cell cycle,Mouse,Neuroscience

Research Description
I have been an active scientist in the field of circadian rhythms, the study of the daily biological "clock", for over 20 years. I am primarily interested in a basic understanding of circadian phenomena in mammals. Recent progress in the cloning of circadian genes in mammals as well as the discovery of peripheral clocks (circadian clocks outside the central nervous system) has raised the intriguing possibility that altered circadian rhythms are involved in human disease. Therefore my interests have extended further into translational studies which are aimed at understanding circadian mechanisms involved in disease. I am also involved in the development of technology for noninvasive measurement of circadian gene expression rhythms from cultured tissues.

Pendergast, JS, Branecky, KL, Yang, W, Ellacott, KL, Niswender, KD, Yamazaki, S. High-fat diet acutely affects circadian organisation and eating behavior. Eur J Neurosci, , , 2013.

Pendergast, JS, Niswender, KD, Yamazaki, S. Tissue-specific function of period3 in circadian rhythmicity. PLoS One, 7(1), e30254, 2012.

Pendergast, JS, Oda, GA, Niswender, KD, Yamazaki, S. Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s). Proc Natl Acad Sci U S A, , , 2012.

Pendergast, JS, Yamazaki, S. The Mammalian circadian system is resistant to dioxin. J Biol Rhythms, 27(2), 156-63, 2012.

Nakamura, TJ, Nakamura, W, Yamazaki, S, Kudo, T, Cutler, T, Colwell, CS, Block, GD. Age-related decline in circadian output. J Neurosci, 31(28), 10201-5, 2011.

Pendergast, JS, Yamazaki, S. Masking Responses to Light in Period Mutant Mice. Chronobiol Int, , , 2011.

Um, JH, Pendergast, JS, Springer, DA, Foretz, M, Viollet, B, Brown, A, Kim, MK, Yamazaki, S, Chung, JH. AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner. PLoS One, 6(3), e18450, 2011.

Pendergast, JS, Friday, RC, Yamazaki, S. Photic Entrainment of Period Mutant Mice is Predicted from Their Phase Response Curves. J Neurosci, 30(36), 12179-84, 2010.

Pendergast, JS, Friday, RC, Yamazaki, S. Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis. PLoS One, 5(1), e8552, 2010.

Pendergast, JS, Yeom, M, Reyes, BA, Ohmiya, Y, Yamazaki, S. Disconnected circadian and cell cycles in a tumor-driven cell line. Commun Integr Biol, 3(6), 536-539, 2010.

Shi, S, Hida, A, McGuinness, OP, Wasserman, DH, Yamazaki, S, Johnson, CH. Circadian Clock Gene Bmal1 Is Not Essential; Functional Replacement with its Paralog, Bmal2. Curr Biol, , , 2010.

Yeom, M, Pendergast, JS, Ohmiya, Y, Yamazaki, S. Circadian-independent cell mitosis in immortalized fibroblasts. Proc Natl Acad Sci U S A, , , 2010.

Pendergast, JS, Friday, RC, Yamazaki, S. Endogenous Rhythms in Period1 Mutant Suprachiasmatic Nuclei In Vitro Do Not Represent Circadian Behavior. J Neurosci, 29(46), 14681-14686, 2009.

Pendergast, JS, Nakamura, W, Friday, RC, Hatanaka, F, Takumi, T, Yamazaki, S. Robust Food Anticipatory Activity in BMAL1-Deficient Mice. PLoS ONE, 4(3), e4860, 2009.

Yamazaki, S, Yoshikawa, T, Biscoe, EW, Numano, R, Gallaspy, LM, Soulsby, S, Papadimas, E, Pezuk, P, Doyle, SE, Tei, H, Sakaki, Y, Block, GD, Menaker, M. Ontogeny of Circadian Organization in the Rat. J Biol Rhythms, 24(1), 55-63, 2009.

Akashi, M, Hayasaka, N, Yamazaki, S, Node, K. Mitogen-Activated Protein Kinase Is a Functional Component of the Autonomous Circadian System in the Suprachiasmatic Nucleus. J Neurosci, 28(18), 4619-4623, 2008.

Davidson, AJ, Yamazaki, S, Arble, DM, Menaker, M, Block, GD. Resetting of central and peripheral circadian oscillators in aged rats. Neurobiol Aging, 29(3), 471-7, 2008.

Hiler, DJ, Bhattacherjee, A, Yamazaki, S, Tei, H, Geusz, ME. Circadian mPer1 gene expression in mesencephalic trigeminal nucleus cultures. Brain Res, , , 2008.

Kusanagi, H, Hida, A, Satoh, K, Echizenya, M, Shimizu, T, Pendergast, JS, Yamazaki, S, Mishima, K. Expression profiles of 10 circadian clock genes in human peripheral blood mononuclear cells. Neurosci Res, , , 2008.

Mistlberger, RE, Yamazaki, S, Pendergast, JS, Landry, GJ, Takumi, T, Nakamura, W. Comment on "Differential rescue of light- and food-entrainable circadian rhythms". Science, 322(5902), 675; author reply 675, 2008.

Nakamura, W, Yamazaki, S, Nakamura, TJ, Shirakawa, T, Block, GD, Takumi, T. In vivo monitoring of circadian timing in freely moving mice. Curr Biol, 18(5), 381-5, 2008.

Reyes, BA, Pendergast, JS, Yamazaki, S. Mammalian peripheral circadian oscillators are temperature compensated. J Biol Rhythms, 23(1), 95-8, 2008.

Ruan, GX, Allen, GC, Yamazaki, S, McMahon, DG. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol, 6(10), e249, 2008.

Um, JH, Yang, S, Yamazaki, S, Kang, H, Viollet, B, Chung, JH. Activation of AMPK with diabetes drug metformin induces CKIe-dependent degradation of clock protein mPer2. J Biol Chem, , , 2007.

Davidson, AJ, Sellix, MT, Daniel, J, Yamazaki, S, Menaker, M, Block, GD. Chronic jet-lag increases mortality in aged mice. Curr Biol, 16(21), R914-6, 2006.

Numano, R, Yamazaki, S, Umeda, N, Samura, T, Sujino, M, Takahashi, R, Ueda, M, Mori, A, Yamada, K, Sakaki, Y, Inouye, ST, Menaker, M, Tei, H. Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms. Proc Natl Acad Sci U S A, 103(10), 3716-21, 2006.

Ruan, GX, Zhang, DQ, Zhou, T, Yamazaki, S, McMahon, DG. Circadian organization of the mammalian retina. Proc Natl Acad Sci U S A, , , 2006.

Fukuhara, C, Yamazaki, S, Liang, J. Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. J Neurochem, 93(1), 156-62, 2005.

Nakamura, W, Yamazaki, S, Takasu, NN, Mishima, K, Block, GD. Differential response of Period 1 expression within the suprachiasmatic nucleus. J Neurosci, 25(23), 5481-7, 2005.

Ohta, H, Yamazaki, S, McMahon, DG. Constant light desynchronizes mammalian clock neurons. Nat Neurosci, 8(3), 267-9, 2005.

Yamazaki, S, Takahashi, JS. Real-time luminescence reporting of circadian gene expression in mammals. Methods Enzymol, 393, 288-301, 2005.

Yoo, Seung-Hee, Ko, Caroline H, Lowrey, Phillip L, Buhr, Ethan D, Song, Eun-Joo, Chang, Suhwan, Yoo, Ook Joon, Yamazaki, Shin, Lee, Choogon, Takahashi, Joseph S. A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Proc Natl Acad Sci U S A, , , 2005.

Yoshikawa, T, Yamazaki, S, Menaker, M. Effects of preparation time on phase of cultured tissues reveal complexity of circadian organization. J Biol Rhythms, 20(6), 500-12, 2005.

Aton,S.J., Block, G.D., T. H., Yamazaki, S., Herzog, E.D.. Plasticity of circadian behavior and the suprachiasmatic nucleus following exposure to non-24-hour light cycles. J Biol Rhythms, 19(3), 198-207, 2004.

Yoo, S.H., Yamazaki, S., Lowrey, P.L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S.M., Hong, H.K, Oh, W. J., Yoo, O. J., Menaker, M., Takahashi, J.S.. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A, 101(15), 5339-46, 2004.

Davidson, A J, Poole, A S, Yamazaki, S, Menaker, M. Is the food-entrainable circadian oscillator in the digestive system. Genes Brain Behav, 2(1), 32-9, 2003.

Davidson, A. J., Yamazaki, S., Menaker, M.. SCN: ringmaster of the circadian circus or conductor of the circadian orchestra. Novartis Found Symp, 253(), 110-21; discussion 121-5, 281-4, 2003.

Izumo, M., Johnson, C. H., Yamazaki, S.. Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: temperature compensation and damping. Proc Natl Acad Sci U S A, 100(26), 16089-94, 2003.

Vansteensel, M.J., Yamazaki, S., Albus, H., Deboer, T., Block, G.D., Meijer, J. H. Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle. Curr Biol, 13(17), 1538-42, 2003.

Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., Block, G. D.. Circadian rhythms in isolated brain regions. J Neurosci, 22(1), 350-6, 2002.

Davidson, Alec J, Stokkan, Karl-Arne, Yamazaki, Shin, Menaker, Michael. Food-anticipatory activity and liver per1-luc activity in diabetic transgenic rats. Physiol Behav, 76(1), 21-6, 2002.

Wilsbacher, Lisa D, Yamazaki, Shin, Herzog, Erik D, Song, Eun-Joo, Radcliffe, Laurel A, Abe, Michikazu, Block, Gene, Spitznagel, Edward, Menaker, Michael, Takahashi, Joseph S. Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo. Proc Natl Acad Sci U S A, 99(1), 489-94, 2002.

Yamazaki, S., Alones, V., Menaker, M. Interaction of the retina with suprachiasmatic pacemakers in the control of circadian behavior. J Biol Rhythms, 17(4), 315-29, 2002.

Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., Block, G. D.. Effects of aging on central and peripheral mammalian clocks. Proc Natl Acad Sci U S A, 99(16), 10801-6, 2002.

Stokkan, K A, Yamazaki, S, Tei, H, Sakaki, Y, Menaker, M. Entrainment of the circadian clock in the liver by feeding. Science, 291(5503), 490-3, 2001.

Lowrey, P L, Shimomura, K, Antoch, M P, Yamazaki, S, Zemenides, P D, Ralph, M R, Menaker, M, Takahashi, J S. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science, 288(5465), 483-92, 2000.

Miranda-Anaya, M, Bartell, P A, Yamazaki, S, Menaker, M. Circadian rhythm of ERG in Iguana iguana: role of the pineal. J Biol Rhythms, 15(2), 163-71, 2000.

Yamazaki, S, Numano, R, Abe, M, Hida, A, Takahashi, R, Ueda, M, Block, G D, Sakaki, Y, Menaker, M, Tei, H. Resetting central and peripheral circadian oscillators in transgenic rats. Science, 288(5466), 682-5, 2000.

Yamazaki, S, Goto, M, Menaker, M. No evidence for extraocular photoreceptors in the circadian system of the Syrian hamster. J Biol Rhythms, 14(3), 197-201, 1999.

Shimomura, K, Kornhauser, J M, Wisor, J P, Umezu, T, Yamazaki, S, Ihara, N L, Takahashi, J S, Menaker, M. Circadian behavior and plasticity of light-induced c-fos expression in SCN of tau mutant hamsters. J Biol Rhythms, 13(4), 305-14, 1998.

Yamazaki, S, Kerbeshian, M C, Hocker, C G, Block, G D, Menaker, M. Rhythmic properties of the hamster suprachiasmatic nucleus in vivo. J Neurosci, 18(24), 10709-23, 1998.

Yamazaki, S, Inouye, S T, Kuroda, Y. TTX-resistant Ca2+ oscillation in cultured hypothalamus: similarity to the mammalian circadian pacemaker. Neuroreport, 6(9), 1306-8, 1995.

Yamazaki, S, Ishida, Y, Inouye, S. Circadian rhythms of adenosine triphosphate contents in the suprachiasmatic nucleus, anterior hypothalamic area and caudate putamen of the rat--negative correlation with electrical activity. Brain Res, 664(1-2), 237-40, 1994.

Yamazaki, S, Maruyama, M, Cagampang, F R, Inouye, S T. Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat. Brain Res, 651(1-2), 329-31, 1994.

Cagampang, F R, Yamazaki, S, Otori, Y, Inouye, S I. Serotonin in the raphe nuclei: regulation by light and an endogenous pacemaker. Neuroreport, 5(1), 49-52, 1993.

Otori, Y, Cagampang, F A, Yamazaki, S, Inouye, S T, Mano, T, Tano, Y. Circadian rhythm of neuropeptide Y-like immunoreactivity in the iris-ciliary body of the rat. Curr Eye Res, 12(9), 803-7, 1993.

Otori, Y, Tominaga, K, Fukuhara, C, Yang, J, Yamazaki, S, Cagampang, F R, Okamura, H, Inouye, S T. Substance P-like immunoreactivity in the suprachiasmatic nucleus of the rat. Brain Res, 619(1-2), 271-7, 1993.

Postdoctoral Position Available

Postdoctoral Position Details
NSF funded research associate position is available.

Please see our recent publications and if interested contact me by e-mail

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