Vanderbilt University School of Medicine

Crofford, Leslie , M.D.
Professor of Medicine
Professor of Pathology, Microbiology and Immunology

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Phone Number: 615-322-4746


Crofford, Leslie's picture

Office Address   Mailing Address

T-3113 MCN

T-3113 MCN 37232-2681

Clinical Research Keywords
Arthritis, myositis, scleroderma, fibromyalgia, pain, inflammation

Patient Care Specialty
Rheumatology, polymyositis, dermatomyositis, scleroderma, rheumatoid arthritis

Research Specialty
Innate and acquired immunity in inflammatory arthritis

Research Description
Inflammatory arthritis, including rheumatoid arthritis, is a systemic disease causing pain, fatigue, disability, and early mortality. Clinical expression of systemic autoimmune inflammatory arthritis is associated with activation of innate and acquired immune systems. In addition to the local effects of synovitis, systemic effects include skeletal muscle dysfunction likely mediated by pro-inflammatory cytokines.

Our research focuses on the role of prostaglandins and other lipid mediators in mediating innate immune functions and the transition from innate to acquired immunity.

We also are involved with the intersection of inflammation and pain in patients with rheumatic diseases.

Finally, we have focused on the systemic effects of inflammatory arthritis on skeletal muscle function.

Cleary, LC, Crofford, LJ, Long, D, Charnigo, R, Clasey, J, Beaman, F, Jenkins, KA, Fraser, N, Srinivas, A, Dhaon, N, Hanaoka, BY. Does computed tomography-based muscle density predict muscle function and health-related quality of life in patients with idiopathic inflammatory myopathies. Arthritis Care Res (Hoboken), 67(7), 1031-40, 2015.

Crofford, LJ. Psychological aspects of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol, 29(1), 147-55, 2015.

Noehren, B, Dailey, DL, Rakel, BA, Vance, CG, Zimmerman, MB, Crofford, LJ, Sluka, KA. Effect of transcutaneous electrical nerve stimulation on pain, function, and quality of life in fibromyalgia: a double-blind randomized clinical trial. Phys Ther, 95(1), 129-40, 2015.

Salt, E, Rayens, MK, Kerr, AM, Alikhan, M, Crofford, LJ. Examining rheumatoid arthritis patients'' trust in their provider over time: the effects of demographic factors and accessing sources of information. Orthop Nurs, 34(3), 159-65, 2015.

Maseda, D, Bonami, RH, Crofford, LJ. Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis. Expert Rev Clin Immunol, 10(6), 747-62, 2014.

Brogden, NK, Banks, SL, Crofford, LJ, Stinchcomb, AL. Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans. Pharm Res, 30(8), 1947-55, 2013.

Brogden, NK, Ghosh, P, Hardi, L, Crofford, LJ, Stinchcomb, AL. Development of in vivo impedance spectroscopy techniques for measurement of micropore formation following microneedle insertion. J Pharm Sci, 102(6), 1948-56, 2013.

Hung, EW, Mayes, MD, Sharif, R, Assassi, S, Machicao, VI, Hosing, C, St Clair, EW, Furst, DE, Khanna, D, Forman, S, Mineishi, S, Phillips, K, Seibold, JR, Bredeson, C, Csuka, ME, Nash, RA, Wener, MH, Simms, R, Ballen, K, Leclercq, S, Storek, J, Goldmuntz, E, Welch, B, Keyes-Elstein, L, Castina, S, Crofford, LJ, Mcsweeney, P, Sullivan, KM. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. J Rheumatol, 40(4), 455-60, 2013.

Oddis, CV, Reed, AM, Aggarwal, R, Rider, LG, Ascherman, DP, Levesque, MC, Barohn, RJ, Feldman, BM, Harris-Love, MO, Koontz, DC, Fertig, N, Kelley, SS, Pryber, SL, Miller, FW, Rockette, HE, , . Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. Arthritis Rheum, 65(2), 314-24, 2013.

Pagorek, S, Kuperstein, J, Guo, J, Ballert, KN, Crofford, LJ. The Association of Chronic Back Pain and Stress Urinary Incontinence: A Cross-Sectional Study. J Womens Health Phys Therap, 37(1), 11-18, 2013.

Painter, JT, Crofford, LJ. Chronic opioid use in fibromyalgia syndrome: a clinical review. J Clin Rheumatol, 19(2), 72-7, 2013.

Painter, JT, Crofford, LJ, Talbert, J. Geographic variation of chronic opioid use in fibromyalgia. Clin Ther, 35(3), 303-11, 2013.

Salt, E, Crofford, LJ, Studts, JL, Lightfoot, R, Hall, LA. Development of a quality of patient-health care provider communication scale from the perspective of patients with rheumatoid arthritis. Chronic Illn, 9(2), 103-15, 2013.

Srikuea, R, Symons, TB, Long, DE, Lee, JD, Shang, Y, Chomentowski, PJ, Yu, G, Crofford, LJ, Peterson, CA. Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. Arthritis Rheum, 65(2), 519-28, 2013.

Arnold, LM, Stanford, SB, Welge, JA, Crofford, LJ. Development and testing of the fibromyalgia diagnostic screen for primary care. J Womens Health (Larchmt), 21(2), 231-9, 2012.

Aschbacher, K, Adam, EK, Crofford, LJ, Kemeny, ME, Demitrack, MA, Ben-Zvi, A. Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study. Brain Behav Immun, 26(7), 1047-56, 2012.

Brogden, NK, Milewski, M, Ghosh, P, Hardi, L, Crofford, LJ, Stinchcomb, AL. Diclofenac delays micropore closure following microneedle treatment in human subjects. J Control Release, 163(2), 220-9, 2012.

Hanaoka, BY, Peterson, CA, Crofford, LJ. Glucocorticoid effects on skeletal muscle: benefit and risk in patients with autoimmune inflammatory rheumatoid diseases. Expert Rev Clin Immunol, 8(8), 695-7, 2012.

Hanaoka, BY, Peterson, CA, Horbinski, C, Crofford, LJ. Implications of glucocorticoid therapy in idiopathic inflammatory myopathies. Nat Rev Rheumatol, 8(8), 448-57, 2012.

Salt, E, Crofford, L. Rheumatoid arthritis: new treatments, better outcomes. Nurse Pract, 37(11), 16-22; quiz 23, 2012.

Schiopu, E, Phillips, K, MacDonald, PM, Crofford, LJ, Somers, EC. Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. Arthritis Res Ther, 14(1), R22, 2012.

Shang, Y, Gurley, K, Symons, B, Long, D, Srikuea, R, Crofford, LJ, Peterson, CA, Yu, G. Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia. Arthritis Res Ther, 14(6), R236, 2012.

Kojima, F, Matnani, RG, Kawai, S, Ushikubi, F, Crofford, LJ. Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis. Inflamm Regen, 31(2), 157-166, 2011.

Lommel, K, Bandyopadhyay, A, Martin, C, Kapoor, S, Crofford, L. A pilot study of a combined intervention for management of juvenile primary fibromyalgia symptoms in adolescents in an inpatient psychiatric unit. Int J Adolesc Med Health, 23(3), 193-7, 2011.

Sarnes, E, Crofford, L, Watson, M, Dennis, G, Kan, H, Bass, D. Incidence and US costs of corticosteroid-associated adverse events: a systematic literature review. Clin Ther, 33(10), 1413-32, 2011.

Boomershine, CS, Crofford, LJ. A symptom-based approach to pharmacologic management of fibromyalgia. Nat Rev Rheumatol, 5(4), 191-9, 2009.

Dubois, RN, Abramson, SB, Crofford, L, Gupta, RA, Simon, LS, Van De Putte, LB, Lipsky, PE. Cyclooxygenase in biology and disease. FASEB J, 12(12), 1063-73, 1998.

Postdoctoral Position Available

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