Vanderbilt University School of Medicine

Wasserman, David H. , Ph.D.
Director, Mouse Metabolic Phenotyping Center
Professor of Molecular Physiology and Biophysics
Annie Mary Lyle Chair

Lab Url: https://labnodes.vanderbilt.edu/community/profile/id/352

Phone Number: 615-343-7336

Email Address:david.wasserman@vanderbilt.edu

Wasserman, David's picture

Office Address   Mailing Address

823 Light Hall

702 Light Hall


Research Keywords
Exercise, Glucose, Amino Acids, Metabolism, Glucagon, Insulin, Catecholamines, Skeletal Muscle, Liver, Diabetes, Endocrinology, Mouse, Physiology, Fat, Long-chain fatty acids,Diabetes,Endocrinology,Kinase,Knockout,Membrane,Mouse,Physiology,Signal transduction

Research Description
We use a variety of animal models, isotopic techniques and analytical methods that allow us to study metabolism from gene to the whole organism. In many of our studies we use physical exercise, insulin-stimulation or diet to perturb metabolic fuel systems. The research we undertake is not only critical to a basic understanding of fuel metabolism but also has important implications to diabetes and heart disease. Possible research projects include studies of:

a. site-specific (extracellular glucose delivery, glucose transport, glucose phosphorylation) regulation of muscle glucose uptake in normal physiology, in insulin resistant states induced by high fat feeding and in insulin sensitive states induced by physical exercise.

b. roles of insulin, glucagon, and glucagon-like peptides in regulation of hepatic glucose metabolism during and after exercise.

c. integrated control of glucose and fat metabolism in health and disease.

d. central role of AMP kinase in control of intra- and interorgan fuel fluxes.

Publications
Hasenour, CM, Ridley, DE, Hughey, CC, James, FD, Donahue, EP, Shearer, J, Viollet, B, Foretz, M, Wasserman, DH. 5-Aminoimidazole-4-carboxamide-1-??-D-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPK in Vivo. J Biol Chem, 289(9), 5950-9, 2014.

Hughey, CC, James, FD, Ma, L, Bracy, DP, Wang, Z, Wasserman, DH, Rottman, JN, Shearer, J. Diminishing impairments in glucose uptake, mitochondrial content, and ADP-stimulated oxygen flux by mesenchymal stem cell therapy in the infarcted heart. Am J Physiol Cell Physiol, 306(1), C19-27, 2014.

Kang, L, Mayes, WH, James, FD, Bracy, DP, Wasserman, DH. Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. Diabetologia, 57(3), 603-13, 2014.

Bonner, JS, Lantier, L, Hasenour, CM, James, FD, Bracy, DP, Wasserman, DH. Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance. Diabetes, 62(2), 572-80, 2013.

Bonner, JS, Lantier, L, Hocking, KM, Kang, L, Owolabi, M, James, FD, Bracy, DP, Brophy, CM, Wasserman, DH. Relaxin treatment reverses insulin resistance in mice fed a high-fat diet. Diabetes, 62(9), 3251-60, 2013.

Fessel, JP, Flynn, CR, Robinson, LJ, Penner, NL, Gladson, S, Kang, CJ, Wasserman, DH, Hemnes, AR, West, JD. Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. Am J Respir Cell Mol Biol, 49(5), 778-87, 2013.

Hasenour, CM, Berglund, ED, Wasserman, DH. Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver. Mol Cell Endocrinol, 366(2), 152-62, 2013.

Hughey, CC, Ma, L, James, FD, Bracy, DP, Wang, Z, Wasserman, DH, Rottman, JN, Hittel, DS, Shearer, J. Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart. Cardiovasc Diabetol, 12, 128, 2013.

Kang, L, Lantier, L, Kennedy, A, Bonner, JS, Mayes, WH, Bracy, DP, Bookbinder, LH, Hasty, AH, Thompson, CB, Wasserman, DH. Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance. Diabetes, 62(6), 1888-96, 2013.

Lee-Young, RS, Bonner, JS, Mayes, WH, Iwueke, I, Barrick, BA, Hasenour, CM, Kang, L, Wasserman, DH. AMP-activated protein kinase (AMPK)??2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle. Diabetologia, 56(3), 608-17, 2013.

Morton, GJ, Matsen, ME, Bracy, DP, Meek, TH, Nguyen, HT, Stefanovski, D, Bergman, RN, Wasserman, DH, Schwartz, MW. FGF19 action in the brain induces insulin-independent glucose lowering. J Clin Invest, 123(11), 4799-808, 2013.

Shi, SQ, Ansari, TS, McGuinness, OP, Wasserman, DH, Johnson, CH. Circadian disruption leads to insulin resistance and obesity. Curr Biol, 23(5), 372-81, 2013.

Wang, HY, Ducommun, S, Quan, C, Xie, B, Li, M, Wasserman, DH, Sakamoto, K, Mackintosh, C, Chen, S. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J, 449(2), 479-89, 2013.

von Wilamowitz-Moellendorff, A, Hunter, RW, Garc??a-Rocha, M, Kang, L, L??pez-Soldado, I, Lantier, L, Patel, K, Peggie, MW, Mart??nez-Pons, C, Voss, M, Calb??, J, Cohen, PT, Wasserman, DH, Guinovart, JJ, Sakamoto, K. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes, 62(12), 4070-82, 2013.

Berglund, ED, Li, CY, Ayala, JE, McGuinness, OP, Wasserman, DH. Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice. PLoS One, 7(12), e52355, 2012.

Burmeister, MA, Bracy, DP, James, FD, Holt, RM, Ayala, J, King, EM, Wasserman, DH, Drucker, DJ, Ayala, JE. Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor. J Physiol, 590(Pt 20), 5245-55, 2012.

Drake, KJ, Sidorov, VY, McGuinness, OP, Wasserman, DH, Wikswo, JP. Amino acids as metabolic substrates during cardiac ischemia. Exp Biol Med (Maywood), 237(12), 1369-78, 2012.

Fletcher, SJ, Kalupahana, NS, Soltani-Bejnood, M, Kim, JH, Saxton, AM, Wasserman, DH, De Taeye, B, Voy, BH, Quignard-Boulange, A, Moustaid-Moussa, N. Transgenic mice overexpressing Renin exhibit glucose intolerance and diet-genotype interactions. Front Endocrinol (Lausanne), 3, 166, 2012.

Kang, L, Lustig, ME, Bonner, JS, Lee-Young, RS, Mayes, WH, James, FD, Lin, CT, Perry, CG, Anderson, EJ, Neufer, PD, Wasserman, DH. Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet. J Appl Physiol (1985), 113(8), 1173-83, 2012.

Laughlin, MR, Lloyd, KC, Cline, GW, Wasserman, DH, , . NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping. Mamm Genome, 23(9-10), 623-31, 2012.

Mulligan, KX, Morris, RT, Otero, YF, Wasserman, DH, McGuinness, OP. Disassociation of muscle insulin signaling and insulin-stimulated glucose uptake during endotoxemia. PLoS One, 7(1), e30160, 2012.

Orr, JS, Puglisi, MJ, Ellacott, KL, Lumeng, CN, Wasserman, DH, Hasty, AH. Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes, 61(11), 2718-27, 2012.

Wu, L, Parekh, VV, Gabriel, CL, Bracy, DP, Marks-Shulman, PA, Tamboli, RA, Kim, S, Mendez-Fernandez, YV, Besra, GS, Lomenick, JP, Williams, B, Wasserman, DH, Van Kaer, L. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A, 109(19), E1143-52, 2012.

Ayala, JE, Bracy, DP, Malabanan, C, James, FD, Ansari, T, Fueger, PT, McGuinness, OP, Wasserman, DH. Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice. J Vis Exp, (57), , 2011.

Berglund, ED, Lustig, DG, Baheza, RA, Hasenour, CM, Lee-Young, RS, Donahue, EP, Lynes, SE, Swift, LL, Charron, MJ, Damon, BM, Wasserman, DH. Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver. Diabetes, 60(11), 2720-9, 2011.

Chen, S, Wasserman, DH, MacKintosh, C, Sakamoto, K. Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab, 13(1), 68-79, 2011.

Kang, L, Ayala, JE, Lee-Young, RS, Zhang, Z, James, FD, Neufer, PD, Pozzi, A, Zutter, MM, Wasserman, DH. Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin {alpha}2{beta}1 in Mice. Diabetes, 60(2), 416-26, 2011.

Luther, JM, Luo, P, Kreger, MT, Brissova, M, Dai, C, Whitfield, TT, Kim, HS, Wasserman, DH, Powers, AC, Brown, NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia, 54(8), 2152-63, 2011.

Wasserman, DH, Kang, L, Ayala, JE, Fueger, PT, Lee-Young, RS. The physiological regulation of glucose flux into muscle in vivo. J Exp Biol, 214(Pt 2), 254-62, 2011.

Wullschleger, S, Wasserman, DH, Gray, A, Sakamoto, K, Alessi, DR. Role of TAPP1 and TAPP2 adaptors binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Biochem J, , , 2011.

Yin, DP, Gao, Q, Ma, LL, Yan, W, Williams, PE, McGuinness, OP, Wasserman, DH, Abumrad, NN. Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice. Ann Surg, 254(1), 73-82, 2011.

Ayala, JE, Bracy, DP, James, FD, Burmeister, MA, Wasserman, DH, Drucker, DJ. Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance. Endocrinology, 151(10), 4678-87, 2010.

Ayala, JE, Samuel, VT, Morton, GJ, Obici, S, Croniger, CM, Shulman, GI, Wasserman, DH, McGuinness, OP, , . Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech, 3(9-10), 525-34, 2010.

Berglund, ED, Kang, L, Lee-Young, RS, Hasenour, CM, Lustig, DG, Lynes, SE, Donahue, EP, Swift, LL, Charron, MJ, Wasserman, DH. Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo. Am J Physiol Endocrinol Metab, 299(4), E607-14, 2010.

Lee-Young, RS, Ayala, JE, Fueger, PT, Mayes, WH, Kang, L, Wasserman, DH. Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKI?2 in the regulation of exercise capacity in vivo. Int J Obes (Lond), , , 2010.

Lee-Young, RS, Ayala, JE, Hunley, CF, James, FD, Bracy, DP, Kang, L, Wasserman, DH. Endothelial Nitric Oxide Synthase is Central to Skeletal Muscle Metabolic Regulation and Enzymatic Signaling during Exercise In Vivo. Am J Physiol Regul Integr Comp Physiol, , , 2010.

Shi, S, Hida, A, McGuinness, OP, Wasserman, DH, Yamazaki, S, Johnson, CH. Circadian Clock Gene Bmal1 Is Not Essential; Functional Replacement with its Paralog, Bmal2. Curr Biol, 20(4), 316-321, 2010.

Anderson, EJ, Lustig, ME, Boyle, KE, Woodlief, TL, Kane, DA, Lin, CT, Price, JW, Kang, L, Rabinovitch, PS, Szeto, HH, Houmard, JA, Cortright, RN, Wasserman, DH, Neufer, PD. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest, , , 2009. PMCID:2648700

Ayala, JE, Bracy, DP, James, FD, Julien, BM, Wasserman, DH, Drucker, DJ. The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action. Endocrinology, 150(3), 1155-64, 2009. PMCID:2654733

Berglund, ED, Lee-Young, RS, Lustig, DG, Lynes, SE, Donahue, EP, Camacho, RC, Meredith, ME, Magnuson, MA, Charron, MJ, Wasserman, DH. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest, 119(8), 2412-22, 2009. PMCID:2719934

Berglund, ED, Li, CY, Bina, HA, Lynes, SE, Michael, MD, Shanafelt, AB, Kharitonenkov, A, Wasserman, DH. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology, 150(9), 4084-93, 2009. PMCID:2719934

Coenen, KR, Gruen, ML, Lee-Young, RS, Puglisi, MJ, Wasserman, DH, Hasty, AH. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia, 52(2), 318-28, 2009. PMCID:2615827

Lee-Young, RS, Griffee, SR, Lynes, SE, Bracy, DP, Ayala, JE, McGuinness, OP, Wasserman, DH. Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo. J Biol Chem, 284(36), 23925-34, 2009. PMCID:2719934

McGuinness, OP, Ayala, JE, Laughlin, MR, Wasserman, DH. NIH Experiment in Centralized Mouse Phenotyping: The Vanderbilt Experience and Recommendations for Evaluating Glucose Homeostasis in the Mouse. Am J Physiol Endocrinol Metab, , , 2009. PMCID:2719934

Wasserman, DH. Four grams of glucose. Am J Physiol Endocrinol Metab, 296(1), E11-21, 2009. PMCID:2636990

Wasserman, DH, Ayala, JE, McGuinness, OP. Lost in translation. Diabetes, 58(9), 1947-50, 2009.

Berglund, ED, Li, CY, Poffenberger, G, Ayala, JE, Fueger, PT, Willis, SE, Jewell, MM, Powers, AC, Wasserman, DH. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes, 57(7), 1790-9, 2008. PMCID:2453626

Han, BG, Hao, CM, Tchekneva, EE, Wang, YY, Lee, CA, Ebrahim, B, Harris, RC, Kern, TS, Wasserman, DH, Breyer, MD, Qi, Z. Markers of Glycemic Control in the Mouse: Comparisons of Six-hour and Overnight Fasted Blood Glucoses to HbA1c. Am J Physiol Endocrinol Metab, , , 2008. PMCID:2575908

Shearer, J, Coenen, KR, Pencek, RR, Swift, LL, Wasserman, DH, Rottman, JN. Long Chain Fatty Acid Uptake In Vivo: Comparison of [(125)I]-BMIPP and [ (3)H]-Bromopalmitate. Lipids, 43(8), 703-11, 2008.

Shearer, J, Duggan, G, Weljie, A, Hittel, DS, Wasserman, DH, Vogel, HJ. Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. Diabetes Obes Metab, 10(10), 950-8, 2008.

Shearer, J, Fueger, PT, Wang, Z, Bracy, DP, Wasserman, DH, Rottman, JN. Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle. Biochim Biophys Acta, 1782(10), 586-92, 2008.

Ayala, JE, Bracy, DP, Hansotia, T, Flock, G, Seino, Y, Wasserman, DH, Drucker, DJ. Insulin Action in the Double Incretin Receptor Knockout Mouse. Diabetes, , , 2007.

Ayala, JE, Bracy, DP, Julien, BM, Rottman, JN, Fueger, PT, Wasserman, DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes, 56(4), 1025-33, 2007.

Fueger, PT, Lee-Young, RS, Shearer, J, Bracy, DP, Heikkinen, S, Laakso, M, Rottman, JN, Wasserman, DH. Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II. Diabetes, 56(10), 2476-84, 2007.

Fueger, PT, Li, CY, Ayala, JE, Shearer, J, Bracy, DP, Charron, MJ, Rottman, JN, Wasserman, DH. Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter. J Physiol, 582(Pt 2), 801-12, 2007. PMCID:2075340

Rao, R, Hao, CM, Redha, R, Wasserman, DH, McGuinness, OP, Breyer, MD. Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice. Diabetologia, 50(2), 452-60, 2007.

Shearer, J, Sellars, EA, Farah, A, Graham, TE, Wasserman, DH. Effects of chronic coffee consumption on glucose kinetics in the conscious rat. Can J Physiol Pharmacol, 85(8), 823-30, 2007.

Ayala, JE, Bracy, DP, McGuinness, OP, Wasserman, DH. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes, 55(2), 390-7, 2006.

Camacho, RC, Donahue, EP, James, FD, Berglund, ED, Wasserman, DH. Energy state of the liver during short-term and exhaustive exercise in C57BL/6J mice. Am J Physiol Endocrinol Metab, 290(3), E405-8, 2006.

Liang, X, Kanjanabuch, T, Mao, SL, Hao, CM, Tang, YW, Declerck, PJ, Hasty, AH, Wasserman, DH, Fogo, AB, Ma, LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am J Physiol Endocrinol Metab, 290(1), E103-E113, 2006.

Nunemaker, CS, Wasserman, DH, McGuinness, OP, Sweet, IR, Teague, JC, Satin, LS. Insulin secretion in the conscious mouse is biphasic and pulsatile. Am J Physiol Endocrinol Metab, 290(3), E523-9, 2006.

Sigal, RJ, Kenny, GP, Wasserman, DH, Castaneda-Sceppa, C, White, RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care, 29(6), 1433-8, 2006.

Wasserman, DH, Fueger, P, Ploug, T, Vinten, J. Point: Counterpoint Glucose Phosphorylation is/ is not a Significant Barrier to Muscle Glucose Uptake By the Working Muscle. J Appl Physiol, , , 2006.

Wasserman, DH, Fueger, PT. Point-Counterpoint: Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle. J Appl Physiol, 101(6), 1803-5, 2006.

Camacho, RC, Galassetti, P, Davis, SN, Wasserman, DH. Glucoregulation during and after exercise in health and insulin-dependent diabetes. Exerc Sport Sci Rev, 33(1), 17-23, 2005.

Camacho, RC, Lacy, DB, James, FD, Donahue, EP, Wasserman, DH. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin. Am J Physiol Endocrinol Metab, 289(6), E1039-43, 2005.

Camacho, RC, Pencek, RR, Lacy, DB, James, FD, Donahue, EP, Wasserman, DH. Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. Diabetes, 54(2), 373-82, 2005.

Fueger, PT, Shearer, J, Bracy, DP, Posey, KA, Pencek, RR, McGuinness, OP, Wasserman, DH. Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice. J Physiol, 562(Pt 3), 925-35, 2005. PMCID:1665542

Fueger, PT, Shearer, J, Krueger, TM, Posey, KA, Bracy, DP, Heikkinen, S, Laakso, M, Rottman, JN, Wasserman, DH. Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. J Physiol, 566(Pt 2), 533-41, 2005. PMCID:1464755

Nunemaker, CS, Zhang, M, Wasserman, DH, McGuinness, OP, Powers, AC, Bertram, R, Sherman, A, Satin, LS. Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo. Diabetes, 54(12), 3517-22, 2005.

Pencek, RR, Fueger, PT, Camacho, RC, Wasserman, DH. Mobilization of glucose from the liver during exercise and replenishment afterward. Can J Appl Physiol, 30(3), 292-303, 2005.

Pencek, RR, Shearer, J, Camacho, RC, James, FD, Lacy, DB, Fueger, PT, Donahue, EP, Snead, W, Wasserman, DH. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. Diabetes, 54(2), 355-60, 2005.

Shearer, J, Fueger, PT, Bracy, DP, Wasserman, DH, Rottman, JN. Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance. Diabetes, 54(11), 3133-9, 2005.

Wasserman, DH, Ayala, JE. Interaction of physiological mechanisms in control of muscle glucose uptake. Clin Exp Pharmacol Physiol, 32(4), 319-23, 2005.

Bederman, IR, Reszko, AE, Kasumov, T, David, F, Wasserman, DH, Kelleher, JK, Brunengraber, H. Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis. J Biol Chem, 279(41), 43207-16, 2004.

Camacho, Raul C, Denny, Joshua C, Pencek, R Richard, Koyama, Yoshiharu, Lacy, D Brooks, James, Freyja D, Wasserman, David H. Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog. Metabolism, 53(10), 1290-5, 2004.

Camacho, Raul C, Lacy, D Brooks, James, Freyja D, Coker, Robert H, Wasserman, David H. Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose. Am J Physiol Endocrinol Metab, 287(2), E269-74, 2004.

Camacho, Raul C, Pencek, R Richard, Lacy, D Brooks, James, Freyja D, Wasserman, David H. Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin. Diabetes, 53(2), 285-93, 2004.

Fueger, PT, Hess, HS, Bracy, DP, Pencek, RR, Posey, KA, Charron, MJ, Wasserman, DH. Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacity. Endocrinology, 145(11), 4912-6, 2004.

Fueger, PT, Hess, HS, Posey, KA, Bracy, DP, Pencek, RR, Charron, MJ, Wasserman, DH. Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse. J Biol Chem, 279(49), 50956-61, 2004.

Fueger, Patrick T, Bracy, Deanna P, Malabanan, Carlo M, Pencek, R Richard, Granner, Daryl K, Wasserman, David H. Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice. Diabetes, 53(2), 306-14, 2004.

Fueger, Patrick T, Bracy, Deanna P, Malabanan, Carlo M, Pencek, R Richard, Wasserman, David H. Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation. Am J Physiol Endocrinol Metab, 286(1), E77-84, 2004.

Galassetti, Pietro, Tate, Donna, Neill, Ray A., Morrey, Sachiko, Wasserman, David H., Davis, Stephen N.. Effect of Gender on the Counterregulatory Responses to Exercise after Antecedent Hypoglycemia in Type-1 Diabetes. Am J Physiol Endocrinol Metab, , , 2004.

Ma, Li-Jun, Mao, Su-Li, Taylor, Kevin L, Kanjanabuch, Talerngsak, Guan, YouFei, Zhang, YaHua, Brown, Nancy J, Swift, Larry L, McGuinness, Owen P, Wasserman, David H, Vaughan, Douglas E, Fogo, Agnes B. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes, 53(2), 336-46, 2004.

Pencek, RR, Battram, D, Shearer, J, James, FD, Lacy, DB, Jabbour, K, Williams, PE, Graham, TE, Wasserman, DH. Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs. J Nutr, 134(11), 3042-6, 2004.

Pencek, RR, James, FD, Lacy, DB, Jabbour, K, Williams, PE, Fueger, PT, Wasserman, DH. Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver. Diabetes, 53(12), 3041-7, 2004.

Shearer, Jane, Fueger, Patrick T, Rottman, Jeffrey N, Bracy, Deanna P, Martin, Paul H, Wasserman, David H. AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo. Am J Physiol Endocrinol Metab, 287(5), E871-7, 2004.

Shearer, Jane, Fueger, Patrick T, Vorndick, Brittney, Bracy, Deanna P, Rottman, Jeffery N, Clanton, Jeffery A, Wasserman, David H. AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide. Diabetes, 53(6), 1429-35, 2004.

Shearer, Jane, Fueger, Patrick T., Rottman, Jeffrey N., Bracy, Deanna P., Binas, Bert, Wasserman, David H.. Heart-Type Fatty Acid Binding Protein Reciprocally Regulates Glucose and Fatty Acid Utilization during Exercise. Am J Physiol Endocrinol Metab, , , 2004.

Sigal, RJ, Kenny, GP, Wasserman, DH, Castaneda-Sceppa, C. Physical activity/exercise and type 2 diabetes. Diabetes Care, 27(10), 2518-39, 2004.

Fueger, Patrick T, Heikkinen, Sami, Bracy, Deanna P, Malabanan, Carlo M, Pencek, R Richard, Laakso, Markku, Wasserman, David H. Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice. Am J Physiol Endocrinol Metab, 285(5), E958-63, 2003.

Galassetti, Pietro, Tate, Donna, Neill, Ray A, Morrey, Sachiko, Wasserman, David H, Davis, Stephen N. Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes. Diabetes, 52(7), 1761-9, 2003.

Moore, Mary Courtney, Cherrington, Alan D, Wasserman, David H. Regulation of hepatic and peripheral glucose disposal. Best Pract Res Clin Endocrinol Metab, 17(3), 343-64, 2003.

Pencek, R Richard, James, Freyja, Lacy, D Brooks, Jabbour, Kareem, Williams, Phillip E, Fueger, Patrick T, Wasserman, David H. Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose load. Diabetes, 52(8), 1897-903, 2003.

Pencek, R Richard, Koyama, Yoshiharu, Lacy, D Brooks, James, Freyja D, Fueger, Patrick T, Jabbour, Kareem, Williams, Phillip E, Wasserman, David H. Prior exercise enhances passive absorption of intraduodenal glucose. J Appl Physiol, 95(3), 1132-8, 2003.

Petersen, Hilary Ann, Fueger, Patrick T, Bracy, Deanna P, Wasserman, David H, Halseth, Amy E. Fiber type-specific determinants of Vmax for insulin-stimulated muscle glucose uptake in vivo. Am J Physiol Endocrinol Metab, 284(3), E541-8, 2003.

Shearer, Jane, Farah, Adriana, de Paulis, Tomas, Bracy, Deanna P, Pencek, R Richard, Graham, Terry E, Wasserman, David H. Quinides of roasted coffee enhance insulin action in conscious rats. J Nutr, 133(11), 3529-32, 2003.

Coker, Robert H, Koyama, Yoshiharu, Denny, Joshua C, Camacho, Raul C, Lacy, D Brooks, Wasserman, David H. Prevention of overt hypoglycemia during exercise: stimulation of endogenous glucose production independent of hepatic catecholamine action and changes in pancreatic hormone concentration. Diabetes, 51(5), 1310-8, 2002.

Koyama, Yoshiharu, Galassetti, Pietro, Coker, Robert H, Pencek, R Richard, Lacy, D Brooks, Davis, Stephen N, Wasserman, David H. Prior exercise and the response to insulin-induced hypoglycemia in the dog. Am J Physiol Endocrinol Metab, 282(5), E1128-38, 2002.

Pencek, R Richard, Koyama, Yoshiharu, Lacy, D Brooks, James, Freyja D, Fueger, Patrick T, Jabbour, Kareem, Williams, Phillip E, Wasserman, David H. Transporter-mediated absorption is the primary route of entry and is required for passive absorption of intestinal glucose into the blood of conscious dogs. J Nutr, 132(7), 1929-34, 2002.

Rottman, Jeffrey N, Bracy, Deanna, Malabanan, Carlo, Yue, Zou, Clanton, Jeff, Wasserman, David H. Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice. Am J Physiol Endocrinol Metab, 283(1), E116-23, 2002.

Coker, RH, Simonsen, L, B??low, J, Wasserman, DH, Kjaer, M. Stimulation of splanchnic glucose production during exercise in humans contains a glucagon-independent component. Am J Physiol Endocrinol Metab, 280(6), E918-27, 2001.

Galassetti, P, Mann, S, Tate, D, Neill, R A, Costa, F, Wasserman, D H, Davis, S N. Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. Am J Physiol Endocrinol Metab, 280(6), E908-17, 2001.

Galassetti, P, Mann, S, Tate, D, Neill, R A, Wasserman, D H, Davis, S N. Effect of morning exercise on counterregulatory responses to subsequent, afternoon exercise. J Appl Physiol, 91(1), 91-9, 2001.

Galassetti, P, Neill, A R, Tate, D, Ertl, A C, Wasserman, D H, Davis, S N. Sexual dimorphism in counterregulatory responses to hypoglycemia after antecedent exercise. J Clin Endocrinol Metab, 86(8), 3516-24, 2001.

Halseth, A E, Bracy, D P, Wasserman, D H. Functional limitations to glucose uptake in muscles comprised of different fiber types. Am J Physiol Endocrinol Metab, 280(6), E994-9, 2001.

Koyama, Y, Coker, R H, Denny, J C, Lacy, D B, Jabbour, K, Williams, P E, Wasserman, D H. Role of carotid bodies in control of the neuroendocrine response to exercise. Am J Physiol Endocrinol Metab, 281(4), E742-8, 2001.

Coker, R H, Lacy, D B, Williams, P E, Wasserman, D H. Hepatic alpha- and beta-adrenergic receptors are not essential for the increase in R(a) during exercise in diabetes. Am J Physiol Endocrinol Metab, 278(3), E444-51, 2000.

Davis, S N, Galassetti, P, Wasserman, D H, Tate, D. Effects of antecedent hypoglycemia on subsequent counterregulatory responses to exercise. Diabetes, 49(1), 73-81, 2000.

Davis, S N, Galassetti, P, Wasserman, D H, Tate, D. Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man. J Clin Endocrinol Metab, 85(1), 224-30, 2000.

Halseth, A E, Bracy, D P, Wasserman, D H. Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. Am J Physiol Endocrinol Metab, 279(5), E1064-71, 2000.

Halseth, A E, O'Doherty, R M, Printz, R L, Bracy, D P, Granner, D K, Wasserman, D H. Role of Ca(2+) fluctuations in L6 myotubes in the regulation of the hexokinase II gene. J Appl Physiol, 88(2), 669-73, 2000.

Koyama, Y, Coker, R H, Stone, E E, Lacy, D B, Jabbour, K, Williams, P E, Wasserman, D H. Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes, 49(9), 1434-42, 2000.

Krishna, M G, Coker, R H, Lacy, D B, Zinker, B A, Halseth, A E, Wasserman, D H. Glucagon response to exercise is critical for accelerated hepatic glutamine metabolism and nitrogen disposal. Am J Physiol Endocrinol Metab, 279(3), E638-45, 2000.

Coker, R H, Koyama, Y, Lacy, D B, Williams, P E, Rh??aume, N, Wasserman, D H. Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics. Am J Physiol, 277(6 Pt 1), E1122-9, 1999.

Coker, R H, Lacy, D B, Krishna, M G, Wasserman, D H. Splanchnic glucagon kinetics in exercising alloxan-diabetic dogs. J Appl Physiol, 86(5), 1626-31, 1999.

Galassetti, P, Chu, C A, Neal, D W, Reed, G W, Wasserman, D H, Cherrington, A D. A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am J Physiol, 277(1 Pt 1), E126-34, 1999.

Galassetti, P, Coker, R H, Lacy, D B, Cherrington, A D, Wasserman, D H. Prior exercise increases net hepatic glucose uptake during a glucose load. Am J Physiol, 276(6 Pt 1), E1022-9, 1999.

Galassetti, P, Hamilton, K S, Gibbons, F K, Bracy, D P, Lacy, D B, Cherrington, A D, Wasserman, D H. Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog. Am J Physiol, 276(3 Pt 1), E543-52, 1999.

Galassetti, P, Koyama, Y, Coker, R H, Lacy, D B, Cherrington, A D, Wasserman, D H. Role of a negative arterial-portal venous glucose gradient in the postexercise state. Am J Physiol, 277(6 Pt 1), E1038-45, 1999.

Halseth, A E, Bracy, D P, Wasserman, D H. Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo. Am J Physiol, 276(1 Pt 1), E70-7, 1999.

Puchowicz, MA, Bederman, IR, Comte, B, Yang, D, David, F, Stone, E, Jabbour, K, Wasserman, DH, Brunengraber, H. Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA. Am J Physiol, 277(6 Pt 1), E1022-7, 1999.

Galassetti, P, Gibbons, F K, Hamilton, K S, Lacy, D B, Cherrington, A D, Wasserman, D H. Enhanced muscle glucose uptake facilitates nitrogen efflux from exercised muscle. J Appl Physiol, 84(6), 1952-9, 1998.

Galassetti, P, Shiota, M, Zinker, B A, Wasserman, D H, Cherrington, A D. A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am J Physiol, 275(1 Pt 1), E101-11, 1998.

Halseth, A E, Bracy, D P, Wasserman, D H. Limitations to exercise- and maximal insulin-stimulated muscle glucose uptake. J Appl Physiol, 85(6), 2305-13, 1998.

Halseth, A E, Rh??aume, N, Messina, A B, Reed, E K, Krishna, M G, Flakoll, P J, Lacy, D B, Wasserman, D H. Regulation of hepatic glutamine metabolism during exercise in the dog. Am J Physiol, 275(4 Pt 1), E655-64, 1998.

O'Doherty, R M, Halseth, A E, Granner, D K, Bracy, D P, Wasserman, D H. Analysis of insulin-stimulated skeletal muscle glucose uptake in conscious rat using isotopic glucose analogs. Am J Physiol, 274(2 Pt 1), E287-96, 1998.

Wasserman, D H, Halseth, A E. An overview of muscle glucose uptake during exercise. Sites of regulation. Adv Exp Med Biol, 441, 1-16, 1998.

Coker, R H, Krishna, M G, Lacy, D B, Allen, E J, Wasserman, D H. Sympathetic drive to liver and nonhepatic splanchnic tissue during heavy exercise. J Appl Physiol, 82(4), 1244-9, 1997.

Coker, R H, Krishna, M G, Lacy, D B, Bracy, D P, Wasserman, D H. Role of hepatic alpha- and beta-adrenergic receptor stimulation on hepatic glucose production during heavy exercise. Am J Physiol, 273(5 Pt 1), E831-8, 1997.

Coker, R H, Krishna, M G, Zinker, B A, Allen, E J, Lacy, D B, Wasserman, D H. Sympathetic drive to liver and nonhepatic splanchnic tissue during prolonged exercise is increased in diabetes. Metabolism, 46(11), 1327-32, 1997.

Halseth, A E, Flakoll, P J, Reed, E K, Messina, A B, Krishna, M G, Lacy, D B, Williams, P E, Wasserman, D H. Effect of physical activity and fasting on gut and liver proteolysis in the dog. Am J Physiol, 273(6 Pt 1), E1073-82, 1997.

Namdaran, K, Bracy, D P, Lacy, D B, Johnson, J L, Bupp, J L, Wasserman, D H. Gut and liver fat metabolism in depancreatized dogs: effects of exercise and acute insulin infusion. J Appl Physiol, 83(4), 1339-47, 1997.

Zinker, B A, Allison, R G, Lacy, D B, Wasserman, D H. Interaction of exercise, insulin, and hypoglycemia studied using euglycemic and hypoglycemic insulin clamps. Am J Physiol, 272(4 Pt 1), E530-42, 1997.

Hamilton, K S, Gibbons, F K, Bracy, D P, Lacy, D B, Cherrington, A D, Wasserman, D H. Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. J Clin Invest, 98(1), 125-35, 1996. PMCID:507408

O'Doherty, R M, Bracy, D P, Granner, D K, Wasserman, D H. Transcription of the rat skeletal muscle hexokinase II gene is increased by acute exercise. J Appl Physiol, 81(2), 789-93, 1996.

Williams, BD, Wolfe, RR, Bracy, DP, Wasserman, DH. Gut proteolysis contributes essential amino acids during exercise. Am J Physiol, 270(1 Pt 1), E85-90, 1996.

Bracy, D P, Zinker, B A, Jacobs, J C, Lacy, D B, Wasserman, D H. Carbohydrate metabolism during exercise: influence of circulating fat availability. J Appl Physiol, 79(2), 506-13, 1995.

Goldstein, R E, Abumrad, N N, Lacy, D B, Wasserman, D H, Cherrington, A D. Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Diabetes, 44(6), 672-81, 1995.

Wasserman, D H. Regulation of glucose fluxes during exercise in the postabsorptive state. Annu Rev Physiol, 57, 191-218, 1995.

Wasserman, D H, O'Doherty, R M, Zinker, B A. Role of the endocrine pancreas in control of fuel metabolism by the liver during exercise. Int J Obes Relat Metab Disord, 19 Suppl 4, S22-30, 1995.

Zinker, B A, Wilson, R D, Wasserman, D H. Interaction of decreased arterial PO2 and exercise on carbohydrate metabolism in the dog. Am J Physiol, 269(3 Pt 1), E409-17, 1995.

Zinker, B A, Wilson, R, Wasserman, D H. Contribution of pancreatic hormone responses to the elevation in carbohydrate metabolism with reduced PaO2. Am J Physiol, 268(6 Pt 1), E1174-83, 1995.

Berger, C M, Sharis, P J, Bracy, D P, Lacy, D B, Wasserman, D H. Sensitivity of exercise-induced increase in hepatic glucose production to glucose supply and demand. Am J Physiol, 267(3 Pt 1), E411-21, 1994.

Cherrington, AD, Wasserman, DH, McGinness, OP. Renal contribution to glucose production after a brief fast: fact or fancy. J Clin Invest, 93(6), 2303, 1994. PMCID:294432

Goldstein, R E, Cherrington, A D, Reed, G W, Lacy, D B, Wasserman, D H, Abumrad, N N. Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency. Am J Physiol, 266(4 Pt 1), E618-27, 1994.

Goldstein, R E, Wasserman, D H, Reed, G W, Lacy, D B, Abumrad, N N, Cherrington, A D. The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency. Horm Metab Res, 26(1), 9-13, 1994.

O'Doherty, R M, Bracy, D P, Osawa, H, Wasserman, D H, Granner, D K. Rat skeletal muscle hexokinase II mRNA and activity are increased by a single bout of acute exercise. Am J Physiol, 266(2 Pt 1), E171-8, 1994.

Wasserman, D H, Ruzumna, P A, Bracy, D P, Lacy, D B, Boothe, H W, Williams, P E, Abumrad, N N. Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism. Metabolism, 43(10), 1266-74, 1994.

Wasserman, D H, Zinman, B. Exercise in individuals with IDDM. Diabetes Care, 17(8), 924-37, 1994.

Zinker, B A, Mohr, T, Kelly, P, Namdaran, K, Bracy, D P, Wasserman, D H. Exercise-induced fall in insulin: mechanism of action at the liver and effects on muscle glucose metabolism. Am J Physiol, 266(5 Pt 1), E683-9, 1994.

Zinker, B A, Namdaran, K, Wilson, R, Lacy, D B, Wasserman, D H. Acute adaptation of carbohydrate metabolism to decreased arterial PO2. Am J Physiol, 266(6 Pt 1), E921-9, 1994.

Connolly, C C, Stevenson, R W, Neal, D W, Wasserman, D H, Cherrington, A D. The effects of lactate loading on alanine and glucose metabolism in the conscious dog. Metabolism, 42(2), 154-61, 1993.

Goldstein, R E, Wasserman, D H, McGuinness, O P, Lacy, D B, Cherrington, A D, Abumrad, N N. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am J Physiol, 264(1 Pt 1), E119-27, 1993.

Moore, M C, Pagliassotti, M J, Wasserman, D H, Goldstein, R, Asher, J, Neal, D W, Cherrington, A D. Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs. J Nutr, 123(10), 1739-46, 1993.

Wasserman, D H, Johnson, J L, Bupp, J L, Lacy, D B, Bracy, D P. Regulation of gluconeogenesis during rest and exercise in the depancreatized dog. Am J Physiol, 265(1 Pt 1), E51-60, 1993.

Wasserman, D H, Lacy, D B, Bracy, D P. Relationship between arterial and portal vein immunoreactive glucagon during exercise. J Appl Physiol, 75(2), 724-9, 1993.

Zinker, B A, Lacy, D B, Bracy, D P, Wasserman, D H. Role of glucose and insulin loads to the exercising limb in increasing glucose uptake and metabolism. J Appl Physiol, 74(6), 2915-21, 1993.

Zinker, B A, Lacy, D B, Bracy, D, Jacobs, J, Wasserman, D H. Regulation of glucose uptake and metabolism by working muscle. An in vivo analysis. Diabetes, 42(7), 956-65, 1993.

Goldstein, R E, Reed, G W, Wasserman, D H, Williams, P E, Lacy, D B, Buckspan, R, Abumrad, N N, Cherrington, A D. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metabolism, 41(12), 1295-303, 1992.

Hendrick, G K, Wasserman, D H, Frizzell, R T, Williams, P E, Lacy, D B, Jaspan, J B, Cherrington, A D. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Am J Physiol, 263(3 Pt 1), E541-9, 1992.

Wasserman, D H, Bupp, J L, Johnson, J L, Bracy, D, Lacy, D B. Glucoregulation during rest and exercise in depancreatized dogs: role of the acute presence of insulin. Am J Physiol, 262(5 Pt 1), E574-82, 1992.

Wasserman, D H, Lacy, D B, Bracy, D, Williams, P E. Metabolic regulation in peripheral tissues and transition to increased gluconeogenic mode during prolonged exercise. Am J Physiol, 263(2 Pt 1), E345-54, 1992.

Wasserman, D H, Mohr, T, Kelly, P, Lacy, D B, Bracy, D. Impact of insulin deficiency on glucose fluxes and muscle glucose metabolism during exercise. Diabetes, 41(10), 1229-38, 1992.

Wasserman, D H, Connolly, C C, Pagliassotti, M J. Regulation of hepatic lactate balance during exercise. Med Sci Sports Exerc, 23(8), 912-9, 1991.

Wasserman, D H, Geer, R J, Rice, D E, Bracy, D, Flakoll, P J, Brown, L L, Hill, J O, Abumrad, N N. Interaction of exercise and insulin action in humans. Am J Physiol, 260(1 Pt 1), E37-45, 1991.

Wasserman, D H, Geer, R J, Williams, P E, Becker, T, Lacy, D B, Abumrad, N N. Interaction of gut and liver in nitrogen metabolism during exercise. Metabolism, 40(3), 307-14, 1991.

Wasserman, D H, Lacy, D B, Colburn, C A, Bracy, D, Cherrington, A D. Efficiency of compensation for absence of fall in insulin during exercise. Am J Physiol, 261(5 Pt 1), E587-97, 1991.

Wasserman, DH, Cherrington, AD. Hepatic fuel metabolism during muscular work: role and regulation. Am J Physiol, 260(6 Pt 1), E811-24, 1991.

Wasserman, D H, Williams, P E, Lacy, D B, Bracy, D, Cherrington, A D. Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Am J Physiol, 259(2 Pt 1), E195-203, 1990.

Wasserman, D H, Abumrad, N N. Physiological bases for the treatment of the physically active individual with diabetes. Sports Med, 7(6), 376-92, 1989.

Wasserman, D H, Lacy, D B, Goldstein, R E, Williams, P E, Cherrington, A D. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes, 38(4), 484-90, 1989.

Wasserman, D H, Spalding, J A, Bracy, D, Lacy, D B, Cherrington, A D. Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work. Diabetes, 38(6), 799-807, 1989.

Wasserman, D H, Spalding, J A, Lacy, D B, Colburn, C A, Goldstein, R E, Cherrington, A D. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol, 257(1 Pt 1), E108-17, 1989.

Wasserman, D H, Williams, P E, Lacy, D B, Goldstein, R E, Cherrington, A D. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am J Physiol, 256(4 Pt 1), E500-9, 1989.

Moates, J M, Lacy, D B, Goldstein, R E, Cherrington, A D, Wasserman, D H. Metabolic role of the exercise-induced increment in epinephrine in the dog. Am J Physiol, 255(4 Pt 1), E428-36, 1988.

Wasserman, D H, Williams, P E, Lacy, D B, Green, D R, Cherrington, A D. Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am J Physiol, 254(4 Pt 1), E518-25, 1988.

Wasserman, D H, Lacy, D B, Green, D R, Williams, P E, Cherrington, A D. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J Appl Physiol, 63(6), 2411-7, 1987.

Cooper, DM, Wasserman, DH, Vranic, M, Wasserman, K. Glucose turnover in response to exercise during high- and low-FIO2 breathing in man. Am J Physiol, 251(2 Pt 1), E209-14, 1986.

Norwich, KH, Wasserman, DH. Calculation of metabolic fluxes with anatomically separated sources of tracer and tracee. Am J Physiol, 251(6 Pt 1), E715-20, 1986.

Wasserman, DH, Vranic, M. Interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise. Diabetes Metab Rev, 1(4), 359-84, 1986.

Wasserman, DH, Lavina, H, Lickley, A, Vranic, M. Effect of hematocrit reduction on hormonal and metabolic responses to exercise. J Appl Physiol, 58(4), 1257-62, 1985.

Wasserman, DH, Lickley, HL, Vranic, M. Important role of glucagon during exercise in diabetic dogs. J Appl Physiol, 59(4), 1272-81, 1985.

Wasserman, DH, Lickley, HL, Vranic, M. Role of beta-adrenergic mechanisms during exercise in poorly controlled diabetes. J Appl Physiol, 59(4), 1282-9, 1985.

Wasserman, DH, Lickley, HL, Vranic, M. Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. J Clin Invest, 74(4), 1404-13, 1984. PMCID:425308

Wasserman, DH, Whipp, BJ. Coupling of ventilation to pulmonary gas exchange during nonsteady-state work in men. J Appl Physiol, 54(2), 587-93, 1983.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
04/23/2014



Vanderbilt University is committed to principles of equal opportunity and affirmative action.
Copyright 2012 Vanderbilt University School of Medicine
The office of Biomedical Research Education & Training All rights reserved.
For questions or problems concerning this page, please submit a help ticket.