Biomedical Research Education & Training
Faculty Member

Wikswo, John P., Ph. D.
A. B. Learned Professor of Living State Physics
Professor of Molecular Physiology and Biophysics
Professor of Biomedical Engineering
A. B. Learned Professor of Living State Physics

Lab Url:

Phone Number: (615) 343-4124

Email Address:

Wikswo, John's picture
Academic history
B.A, University of Virginia
M.S., Stanford University
Ph.D., Stanford University
Fellowship, Stanford University

Office Address   Mailing Address

6809 Stevenson Center

VU Station B 351807 6301 Stevenson Center

Research Keywords
Biophysics, biomedical engineering, cardiac electrophysiology, cellular instrumentation and control, electromagnetism, SQUID magnetometry, and systems biology

Research Specialty
Development and application of microdevices for instrumenting and controlling single living cells

Research Description
John Wikswo and his group are at present working in three areas: the study of the linear and non-linear electrical properties of cardiac tissue during stimulation, propagation, and recovery for threshold- and defibrillation-strength shocks; the magnetic measurement of cellular action currents in cardiac and intestinal tissue, as can be observed using SQUID magnetometry; and the development and application of micro- and nano-scale devices for instrumenting and controlling the single biological cell and small populations of cells. His long-term program to understand the effects of defibrillation-strength shocks on cardiac tissue now includes studies of charge and electroporation and molecular diffusion. The magnetic studies of action currents range from determining the information content of the magnetocardiogram in isolated rabbit hearts to the non-invasive diagnosis of intestinal ischemia in humans. The project to instrument and control single cells is addressing issues as varied as the use of cells to identify and discriminate chemical and biological warfare agents by metabolic phenotype; the development and application of BioMEMS (BioMicroElectroMechanical Systems) devices to understand the molecular signaling associated with chemotaxis, cellular motility, angiogenesis, and metastasis; and the nature of the signaling and metabolic activity associated with the immune response.

E.A. Lima, R.M. Snider, R.S. Reiserer, J.R. McKenzie, D.W. Kimmel, S.E. Eklund, D.E. Cliffel, and J.P. Wikswo. Multichamber Multipotentiostat System for Cellular Microphysiometry". Sensor. Actuat. B-Chem., 204, 536-543, 2014. DOI:10.1016/j.snb.2014.07.126

J.R. McKenzie, D.E. Cliffel, and J.P. Wikswo. "Electrochemical Monitoring of Cellular Metabolism". In Encyclopedia of Applied Electrochemistry, G. Kreysa et al., Eds., Springer Science+Business Media, New York, pp. 522-528, 2014. DOI:10.1007/978-1-4419-6996-5

D. Patel, R. Naik, R. Boyer, J. Wikswo, and E. Vasilevskis. "Method to Identify Saline-Contaminated Electrolyte Profiles". Clin. Chem. Lab. Med., 53(10), 1585-1591, 2015. DOI:10.1515/cclm-2014-0955

K.J. Drake, M.S. Shotwell, J.P. Wikswo, and V.Y. Sidorov. "Glutamine and Glutamate Limit the Shortening of Action Potential Duration in Anoxia-Challenged Rabbit Hearts". Phys. Rep., 3(9), e12535, 2015. DOI:10.14814/phy2.12535

C.C. Marasco, J.R. Enders, K.T. Seale, J.A. McLean, and J.P. Wikswo. "Real-Time Cellular Exometabolome Analysis with a Microfluidic-Mass Spectrometry Platform". PLoS One, 10(2), e0117685, 2015. DOI:10.1371/journal.pone.011768

C.R. Goodwin, B.C. Covington, D.K. Derewacz, C.R. McNees, J.P. Wikswo, J.A. McLean, and B.O. Bachmann. "Structuring Microbial Metabolic Responses to Multiplexed Stimuli Via Self-Organizing Metabolomics Maps". Chem. Biol., 22, 661-670, 2015. DOI:10.1016/j.chembiol.2015.03.020

J.P. Wikswo and A.P. Porter. "Biology Coming Full Circle: Joining the Whole and the Parts". Exp. Biol. Med., 240, 3-7, 2015

J.A. Brown, S.D. Sherrod, C.R. Goodwin, B. Brewer, L. Yang, K.A. Garbett, D. Li, J.A. McLean, J.P. Wikswo, and K. Mirnics. "Metabolic Consequences of Interleukin-6 Challenge in Developing Neurons and Astroglia" . J. Neuroinflammation, 11, 183, 2014. DOI:10.1186/s12974-014-0183-6

J.P. Wikswo. "The Relevance and Potential Roles of Microphysiological Systems in Biology and Medicine". Exp. Biol. Med., 239, 1061-1072, 2014. DOI:10.1177/1535370214542068

C.C. Marasco, C.R. Goodwin, D.G. Winder, N.L. Schramm-Sapyta, J.A. McLean, and J.P. Wikswo. "Systems-Level View of Cocaine Addiction: The Interconnect of the Human and Nervous Systems". Experimental Biology Medicine, 239, 1433-1442, 2014. DOI:10.1177/1535370214537747

M.W. Irvin, A. Zijlstra, J.P. Wikswo, and A. Pozzi. "Techniques and Assays for the Study of Angiogenesis". Experimental Biology Medicine, 239(11), 1476-1488, 2014. DOI:10.1177/1535370214529386

K. Hockemeyer, C. Janetopoulous, A. Terekhov, W. Hofmeister, A. Vilgelm, L. Costa, J.P. Wikswo, and A. Richmond. "Engineered Three-Dimensional Microfluidic Device for Interrogating Cell-Cell Interactions in the Tumor Microenvironment". Biomicrofluidics, 8, 044105, 2014. DOI:10.1063/1.4890330

C.R. Goodwin, S.D. Sherrod, C.C. Marasco, B.O. Bachmann, N. Schramm-Sapyta, J.P. Wikswo, and J.A. McLean. "Phenotypic Mapping of Metabolic Profiles Using Self-Organizing Maps of High-Dimensional Mass Spectrometry Data". Analytical Chemistry, 86, 6563-6571, 2014. DOI:10.1021/ac5010794

Y. Yan, L. Jiang, K.J. Aufderheide, G.A. Wright, A. Terekhov, L. Costa, K. Qin, W.T. McCleery, J.J. Fellenstein, A. Ustione, J.B. Robertson, C.H. Johnson, D.W. Piston, M.S. Hutson, J.P. Wikswo, W. Hofmeister, and C. Janetopoulos. "A Microfluidic-Enabled Mechanical Microcompressor for the Immobilization of Live Single- and Multi-Cellular Specimens". Microscopy and Microanalysis, 20, 141-151, 2014. DOI:10.1017/S1431927613014037

T.F. Byrd, L.T. Hoang, M.E. Pfister, E.M. Werner, S.E. Arndt, J.W. Chamberlain, J.J. Hughey, B.A. Nguyen, E.J. Schneibel, L.L. Wertz, J.S. Whitfield, J.P. Wikswo, and K.T. Seale. "The Microfluidic Multitrap Nanophysiometer for Hematologic Cancer Cell Characterization Reveals Temporal Sensitivity of the Calcein-AM Efflux Assay". Scientific Reports, 4, 5117, 2014. DOI: 10.1038/srep05117

S. Hummel, V. Quaranta, and J. Wikswo. "The Biohacker: A Threat to National Security". CTC Sentinel, 7(1), 8-11, 2014.

M.S. Shotwell, K.J. Drake, V.Y. Sidorov, and J.P. Wikswo. "Mechanistic Analysis of Challenge-Response Experiments". Biometrics, 69, 741-747, 2013. DOI:10.1111/biom.12066

B. He, R. Baird, R. Butera, A. Datta, S. George, B. Hecht, A. Hero, G. Lazzi, R.C. Lee, J. Liang, M. Neuman, G. Peng, E. Perreault, M. Ramasubramanian, M. Wang, J. Wikswo, G.-Z. Yang, and Y.-T. Zhang. "Grand Challenges in Interfacing Engineering with Life Sciences and Medicine". IEEE Transactions on Biomedical Engineering, Special Issue on Grand Challenges in Engineering Life Sciences and Medicine, 60(3), 589-598, 2013. DOI:10.1109/TBME.2913,224886

J.P. Wikswo, F.E. Block III, D.E. Cliffel, C.R. Goodwin, C.C. Marasco, D.A. Markov, D.L. McLean, J.A. McLean, J.R. McKenzie, R.S. Reiserer, P.C. Samson, D.K. Schaffer, K.T. Seale, and S.D. Sherrod. "Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems". IEEE Transactions on Biomedical Engineering, Special Issue on Grand Challenges in Engineering Life Sciences and Medicine, 60(3), 682-690, 2013. DOI:10.1109/TBME.2013.2244891

S. Chowdhury, P. Svec, C. Wang, K. Seale, J.P. Wikswo, W. Losert, and S.K. Gupta. "Automated Cell Transport in Optical Tweezers-Assisted Microfluidic Chambers". IEEE Transactions on Automated Science and Engineering, 10(4), 980-989, 2013. DOI:10.1109/TASE.2013.2239287

J.P. Wikswo, E.L. Curtis, Z.E. Eagleton, B.C. Evans, A. Kole, L.H. Hofmeister, and W.J. Matloff. "Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip". Lab Chip, 13(18), 3796-3511, 2013. DOI:10.1039/c3lc50243k

J. Deng, A. Dhummakupt, P. Samson, J. Wikswo, and L. Shor. "Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Micro-Chemical Conditions". Analytical Chemistry, 85, 5411-5419, 2013. DOI:10.1021/ac303711m

K. Hines, S. Ashfaq, J. Davidson, S. Opalenik, J. Wikswo, and J. McLean. "Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry". Analytical Chemistry, 85(7), 3651-3659, 2013. DOI:10.1021/ac303594m

R.A. Gray, D.N. Mashburn, V.Y. Sidorov, B.J. Roth, P. Pathmanathan, and J.P. Wikswo. "Transmembrane Current Imaging in the Heart During Pacing and Fibrillation". Biophysical Journal, 105, 1710-1719, 2013. DOI:10.1016/j.bpj.2013.08.019

M.C. Woods. I. Uzelac, M.R. Holcomb, J.P. Wikswo, and V.Y. Sidorov. "Diagnostic Field Stimulation: The Role of Shock Duration in Epicardial Activation and Propagation". Biophysical Journal, 105, 523-532, 2013. DOI:10.1016/j.bpj.2013.06.009

R.A. Gray, D.N. Mashburn, V.Y. Sidorov, and J.P. Wikswo. "Quantification of Transmembrane Currents During Action Potential Propagation in the Heart". Biophysical Journal, 104(1), 268-278, 2013. DOI:10.1016/j-bpj.2012.11.007

D.J. Alcendor, F.E. Block III, D.E. Cliffel, J.S. Daniels, K.L.J. Ellacott, C.R. Goodwin, L.H. Hofmeister, D. Li, D.A. Markov, J. May, L.J. McCawley, B.A. McLaughlin, J.A. McLean, K.D. Niswender, V. Pensabene, K.T. Seale, S.D. Sherrod, H-J. Sung, D.L. Tabb. D.J. Webb, and J.P. Wikswo. "Neurovascular Unit on a Chip: Implications for Translational Applications". Stem Cell Research & Therapy, 4(Suppl 1), S18, 2013.

K.J. Drake, V.Y. Sidorov, O.P. McGuinness, D.H. Wasserman, and J.P. Wikswo. "Amino Acids as Metabolic Substrates During Cardiac Ischemia". Experimental Biology and Medicine, 237, 1369-1378, 2012. DOI:10.1258/ebm.2012.012025

W.J. Ashby, J.P. Wikswo, and A. Zijlstra. "Magnetically Attachable Stencils and the Non-Destructive Analysis of the Contribution Made by the Underlying Matrix to Cell Migration". Biomaterials, 33(33), 8189-8203, 2012. DOI:10.1016/j.biomaterials.2012.07.018

W. Georgescu, J.P. Wikswo, and V. Quaranta. "CellAnimation: An Open Source MATLAB Framework for Microscopy Assays". Bioinformatics, 28(1), 138-139, 2012. DOI: 10.1093/bioinformatics/btr633

D.A. Markov, J.Q. Lu, P.C. Samson, J.P. Wikswo, and L.J. McCawley. "Thick-Tissue Bioreactor as a Platform for Long-Term Organotypic Culture and Drug Delivery". Lab Chip, 12, 4560-4568, 2012. DOI: 10.1039/c2lc40304h

J.R. Enders, C.C. Marasco, J.P. Wikswo, and J.A. McLean. "A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry". Analytical Chemistry, 84(20), 8467-8474, 2012. DOI: 10.1021/ac3021032

R. Yang, S.C. Lenaghan, J.P. Wikswo, and M. Zhang. "External Control of the GAL Network in S. cerevisiae: A View from Control Theory". PLoS ONE, 6(4), e19353, 2011. DOI: 10.1371/journal.pone.0019353

V.Y. Sidorov, I. Uzelac, and J.P. Wikswo. "Regional Increase of Extracellular Potassium Leads to Electrical Instability and Reentry Occurence Through the Spatial Heterogeneity of APD Restitution". Am. J. Physiol.-Heart Circ. Physiol., 301, H209-H220, 2011. DOI: 10.1152/ajpheart.01141.2010

P.R. LeDuc, W.C. Messner, and J.P. Wikswo. "How Do Control-Based Approaches Enter into Biology?". Annu. Rev. Biomed. Eng., 13, 369-396, 2011. DOI: 10.1146/annurev-bioeng-071910-124651

M.D. Schmidt, R.R. Vallabhajosyula, J.W. Jenkins, J.E. Hood, A.S. Soni, J.P. Wikswo, and H. Lipson. "Automated Refinement and Inference of Analytical Models for Metabolic Networks". Physical Biology, 8(5), 055011, 2011. DOI: 10.1088/1478-3975/8/5/055011

A.D. Dukes, P.C. Samson, J.D. Keene, L.M. Davis, J.P. Wikswo, and S.J. Rosenthal. "Single-Nanocrystal Spectroscopy of White-Light-Emitting CdSe Nanocrystals". J. Phys. Chem. A, 115(16), 4076-4081, 2011. DOI: 10.1021.jp1109509

M. Velkovsky, R. Snider, D. Cliffel, and J.P. Wikswo. "Modeling the Measurements of Cellular Fluxes in Microbioreactor Devices Using Thin Enzyme Electrodes". J. Math. Chem., 49, 251-275, 2011. DOI: 10.1007/s10910-010-9744-9

Y. Liu, D.A. Markov, J.P. Wikswo, and L.J. McCawley. "Microfabricated Scaffold-Confined Endothelial Morphogenesis in Three-Dimensional Culture" . Biomedical Microdevices, 13, 837-846, 2011. DOI: 10.1007/s10544-011-9554-2

J.R. Enders, C.R. Goodwin, C.C. Marasco, K.T. Seale, J.P. Wikswo, and J.A. McLean. "Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles From Haystacks". Current Trends in Mass Spectrometry, pp. 18-23, 2011

R.A. Gray and J.P. Wikswo. "Several Small Shocks Beat One Large One". Nature, 475, 181-182, 2011

D.A. Markov, P.C. Samson, D.K. Schaffer, A. Dhummakupt, J.P. Wikswo, and L.M. Shor. "Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media". JoVE, 39, 1-4, 2010. DOI: 10.3791/1741

R.M. Snider, J.R. McKenzie, L. Kraft, E. Kozlov, J.P. Wikswo, and D.E. Cliffel. "The Effects of Cholera Toxin on Cellular Energy Metabolism Toxins". Toxins, 2(4), 632-634, 2010. DOI: 10.3390/toxins2040632

B. Ayati, C. Edwards, G.F. Webb, and J.P. Wikswo. "A Mathematical Model of Bone Remodeling Dynamics for Normal Bone Cell Populations and Myeloma Bone Disease". Biology Direct, 5, 28, 2010. DOI: 10.1186/1745-6150-5-28

K.A. Addae-Mensah, S. Retterer, S.R. Opalenik, D. Thomas, N.V. Lavrik, and J.P. Wikswo. "Cryogenic Etching of Silicon: An Alternative Method for Fabrication of Vertical Microcantilever Master Molds". Journal of Microelectromechanical Systems, 19(1), 64-74, 2010. DOI: 10.1109/JMEMS.2009.2037440

J.R. Enders, C.C. Marasco, A. Kole, B. Nguyen, S. Sundarapandian, K.T. Seale, J.P. Wikswo, and J.A. McLean. "Towards Monitoring Real-Time Cellular Response Using an Integrated MALDI/nESI-Ion Mobility-Mass Spectrometery Platforma". IET Systems Biology, 4(6), 416-427, 2010. DOI: 10.1049/iet-syb.2010.0012

S.G. Darby, M.R. Moore, T.A. Friedlander, D.K. Schaffer, R.S. Reiserer, J.P. Wikswo, and K.T. Seale. "A Metering Rotary Nanopump for Microfluidic Systems". Lab Chip, 10, 3218-3226, 2010. DOI: 10.1039/c0lc00087f

D. Jowhar, G. Wright, P.C. Samson, J.P. Wikswo, and C. Janetopoulos. "Open Access Microfluidic Device for the Study of Cell Migration During Chemotaxis". Integrative Biology, 2, 648-658, 2010. DOI: 10.1039/c0ib00110d

G. Rachakonda, K.R. Sekhar, D. Jowhar, P.C. Samson, J.P. Wikswo, R.D. Beauchamp, P.K. Datta, and M.L. Freeman. "Increased Cell Migration and Plasticity in Nrf2 Deficienct Cancer Cell Lines". Oncogene, 29(25), 3703-3714, 2010. DOI: 10.1038/onc.2010.118

K.K. McBride, B.J. Roth, V.Y. Sidorov, J.P. Wikswo, and F.J.Baudenbacher. "Measurements of Transmembrane Potential and Magnetic Field at the Apex of the Heart". Biophys. J., 99, 3113-3118, 2010. DOI: 10.1016/j-bpj.2010.08.040

D. Markov, S. Manuel, L. Shor, S. Opalenik, J. Wikswo, and P. Samson. "Tape Underlayment Rotary-Node (TURN) Valves for Simple On-Chip Microfluidic Flow Control". Biomed. Microdevices, 12, 135-144, 2010. DOI: 10.1007/s10544-009-9368-7

D.A. Markov, E.M. Lillie, P.C. Samson, J.P. Wikswo, and L.J. McCawley. "Chips & Tips: A Method for Periodic Sterile Sample Collection During Continuous Cell Culture in Microfluidic Devices". Lab Chip, Published online August 17, 2010

K.T. Seale, S.L. Faley, J. Chamberlain, and J. Wikswo. "Macro to Nano: A Simple Method for Transporting Cultured Cells From Milliliter Scale to Nanoliter Scale". Experimental Biology and Medicine, 235, 777-783, 2010

S.E. Eklund, R.G. Thompson, R.M. Snider, C.K. Carney, D.W. Wright, J.P. Wikswo, and D.E. Cliffel. "Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer". Sensors, 9(3), 2117-2133, 2009. DOI: 10.3390/s90302117

M.R. Holcomb, M.C. Woods, I. Uzelac, J.P. Wikswo, J.M. Gilligan, and V.Y. Sidorov. "The Potential of Dual Camera Systems for Multimodal Imaging of Cardiac Electrophysiology and Metabolism". Experimental Biology and Medicine, 234(11), 1355-1373, 2009. DOI: 10.3181/0902-RM-47

A. Irimia, K.R. Swinney, and J.P. Wikswo. "Partial Independence of Bioelectric and Biomagentic Fields and Its Implications for Encephalography and Cardiography". Phys. Rev. E., 79, 051908-1-051908-13, 2009. DOI: 10.1103/PhysRevE.79.051908

R.A. Gray, J.P. Wikswo, and N.F. Otani. "Origin Choice and Petal Loss in the Flower Garden of Spiral Wave Tip Trajectories". Chaos, 19(3), 033118-1-03118-8, 2009. DOI: 10.1063/1.3204256

S.L. Faley, M. Copland, D. Wlodkowic, W. Kolch, K.T. Seale, J.P. Wikswo, and J.M. Cooper. "Microfluidic Single Cell Arrays to Interrogate Signalling Dynamics of Individual, Patient-derived Hematopoietic Stem Cells". Lab Chip, 9(18), 2659-2664, 2009. DOI: 10.1039/b902083g

D. Wlodkowic, S. Faley, M. Zagnoni, J.P. Wikswo, and J.M. Cooper. "Microfluidic Single-Cell Array Cytometry for the Analysis of Tumor Apoptosis". Anal. Chem., 13(81), 5517-5523, 2009. DOI: 10.1021/ac9008463

M.P. Harris, E. Kim, B. Weidow, J.P. Wikswo, and V. Quaranta. "Migration of Isogenic Cell Lines Quantified by Dynamic Multivariate Analysis of Single-Cell Motility". Cell Adh. Migr., 2(2), 127-136, 2009. ). DOI: 10.4161/cam.2.2.6482 PMCID:2634586

J. Greene, J.W. Henderson, Jr., and J.P. Wikswo. "Rapid and Precise Determination of Cellular Amino Acid Flux Rates Using HPLC with Automated Derivatization with Absorbance Detection". Agilent Technologies, Inc., Application Note: Pharmaceutical, Food Industries, 8 pages, Wilmington, DE, February 9, 2009

J.P. Wikswo and B.J. Roth. "Virtual Electrode Theory of Pacing". In Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, I. Efimov, M. Kroll, and P. Tchou, Eds., (Springer), Chapter 4.3, pp. 283-330, 2009

K.T. Seale, C. Janetopoulos, and J.P. Wikswo. "Micro-Mirrors for Nanoscale Three-Dimensional Microscopy". ACS Nano, 3(3), 493-497, 2009

K.A. Addae-Mensah and J.P. Wikswo. "Measurement Techniques for Cellular Biomechanics In Vitro". Exp Biol Med (Maywood), 233(7), 792-809, 2008. DOI: 10.3181/0710-MR-278. PMC2742888 PMCID:2742888

M.M. Maleckar, M.C. Woods, V.Y. Sidorov, M.R. Holcomb, D.N. Mashburn, J.P. Wikswo, and N.A. Trayanova. "Polarity Reversal Lowers Activation Time During Diastolic Field Stimulation of the Rabbit Ventricles: Insights Into Mechanisms". Am. J. Physiol.-Heart Circ. Physiol., 295, H1626-H1633, 2008. DOI: 10.1152/ajpheart.00706.2008

D.W. Evertson, M.R. Holcomb, M.C. Eames, M.A. Bray, V.Y. Sidorov, J. Xu, H. Wingard, H.M. Dobrovolny, M.C. Woods, D.J. Gauthier, and J.P. Wikswo. "High-Resolution High-Speed Panoramic Cardiac Imaging System". IEEE Trans. Biomed. Eng., 55(3), 1241-1243, 2008. DOI: 10.1109/TBME.2007.912417 PMCID:2561274

J. Xu, R. Reiserer, J. Tellinghuisen, J.P. Wikswo, and F.J. Baudenbacher. "A Microfabricated Nanocalorimeter: Design, Characterization, and Chemical Calibration". Anal. Chem., 80(8), 2728-2733, 2008. DOI: 10.1021/ac702213d PMCID:2742888

A. Irimia and J.P. Wikswo. "Gastrointestinal Arrhythmias are Associated with Statistically Significant Fluctuations in Systemic Information Dimension". Physiol. Meas., 29(5), N33-N40, 2008 PMCID:2742888

B.R. Gorman and J.P. Wikswo. "Characterization of Transport in Microfluidic Gradient Generators". Microfluid Nanofluid, 4(4), 273-285, 2008

J. Sai, D. Raman, Y. Liu, J. Wikswo, and A. Richmond. "Parallel PI3K-Dependent and Src-Dependent Pathways Lead to CXCL8-Mediated Rac2-Activation and Chemotaxis". J. Biological Chemistry, 283(39), 26538-26547, 2008

J.S. Gruver, J.P. Wikswo, and C.Y. Chung. "3-Phosphoinositides Regulate the Coordination of Speed and Accuracy During Chemotaxis". Biophys. J., 95(8), 4057-4067, 2008 PMCID:2553113

K.T. Seale, R.S. Reiserer, D.A. Markov, I.A. Ges, C. Wright, C. Janetopoulos, and J.P. Wikswo. "Mirrored Pyramidal Wells for Simultaneous Multiple Vantage Point Microscopy". J. Microsc., 232(1), 1-6, 2008 PMCID:2736648

M.R. Holcomb, R.Y. Bekele, E.A. Lima, and J.P. Wikswo. "Universal Serial Bus Powered and Controlled Isolated Constant-Current Physiological Stimulator". Rev. Sci. Instrum., 79(12), 126103, 2008 PMCID:2736648

R.A. Abbas, S.F. Lin, D. Mashburn, J. Xu, and J.P. Wikswo. "A Phased-Array Stimulator System for Studying Planar and Curved Cardiac Activation Wavefronts". IEEE Trans. Biomed. Eng., 55(1), 222-229, 2008 PMCID:2742885

S. Faley, K. Seale, J. Hughey, D.K. Schaffer, S. VanCompernolle, B. McKinney, F. Baudenbacher, D. Unutmaz, and J.P. Wikswo. "Microfluidic Platform for Real-Time Signaling Analysis of Multiple Single T Cells in Parallel". Lab Chip, 8(10), 1700-1712, 2008 PMCID:2736648

V.Y. Sidorov, M.R. Holcomb, M.C. Woods, R.A. Gray, and J.P. Wikswo. "Effects of Unipolar Stimulation on Voltage and Calcium Distributions in the Isolated Rabbit Heart". Basic Res. Cardiol., 103(6), 537-551, 2008 PMCID:2742888

W. Georgescu, J. Jourquin, L. Estrada, A.R.A. Anderson, V. Quaranta, and J.P. Wikswo. "Model-Controlled Hydrodynamic Focusing to Generate Multiple Overlapping Gradients of Surface-Immobilized Proteins in Microfluidic Devices". Lab Chip, 8, 238-244, 2008

W. Wang, L.M. Shor, E.J. LeBoeuf, J.P. Wikswo, G.L. Taghon, and D.S. Kosson. "Protozoan Migration in Bent Microfluidic Channels". Applied and Environmental Microbiology, 74(6), 1945-1949, 2008

Y. Liu, J. Sai, A. Richmond, and J. Wikswo. "Microfluidic Switching System for Analyzing Chemotaxis Responses of Wortmannin-Inhibited HL-60 Cells". Biomedical Microdevices, 10, 499-507, 2008

D.F. Salisbury, A. Price, R.D. Collins, and J.P. Wikswo. "Max at Vanderbilt". Max Delbruck and the New Perception of Biology, 1906-1981: A Centenary Celebration, University of Salamanca, October 9-10, 2006, W. Shropshire, Jr., Ed. (AuthorHouse, Bloomington, IN), Chapter 22, pp. 213-235, 2007

D.N. Mashburn, S.J. Hinkson, M.C. Woods, J.M. Gilligan, M.R. Holcomb, and J.P. Wikswo. "A High Voltage Cardiac Stimulator for Field Shocks of a Whole Heart in a Bath". Rev. Sci. Instrum., 78, 104302, 2007

K.A. Addae-Mensah, N.J. Kassenbaum, M.J. Bowers II, R.S. Reiserer, S.J. Rosenthal, P.E. Moore, and J.P. Wikswo. "A Flexible, Quantum Dot-Labeled Cantilever Post Array for Studying Cellular Microforces". Sensors and Actuators, 136, 385-397, 2007

K.A. Addae-Mensah, R.S. Reiserer, and J.P. Wikswo. "Poly(Vinyl Alcohol) as a Structure Release Layer for Microfabrication of Polymer Composite Structures". J. Micromech. Microeng., 17, N41-N46, 2007

S. Huang and J. Wikswo. "Dimensions of Systems Biology". Reviews of Physiology, Biochemistry, and Pharmacology, 157, 81-104, 2007

S.K. Vajandar, D. Xu, D.A. Markov, J.P. Wikswo, W. Hofmeister, and D. Li. "SiO2-Coated Porous Anodic Alumina Membranes for High Flow Rate Electroosmotic Pumping". Nanotechnology, 18, 275705, 2007

J. Wikswo, A. Prokop, F. Baudenbacher, D. Cliffel, B. Csukas, and M. Velkovsky. "Engineering Challenges of BioNEMS: The Integration of Microfluidics, and Micro- and Nanodevices, Models, and External Control for Systems Biology". IEE Proc. Nanobiotechnology, 153(4), 81-101, 2006. DOI: 10.1049/ip-nbt:20050045

E. Juzeliunas, Y.P. Ma, and J.P. Wikswo. "Magnetometric Corrosion Sensing Under Hydrodynamic Conditions". J. Solid State Electrochemistry, 10, 700-707, 2006

E.A. Lima, A. Irimia, and J.P. Wikswo, Jr. "The Magnetic Inverse Problem". The SQUID Handbook, J. Clarke and A. Braginski, Eds., (Wiley-VCH, Verlag, Berlin), Vol. 2, Chap. 10, pp. 139-267, 2006

J. Sai, G. Walker, J. Wikswo, and A. Richmond. "The IL Sequence in the LLKIL Motif in CXCR2 is Required for Full Ligand Induced Activation of Erk, Akt and Chemotaxis in HL60 Cells". J. Biol. Chem., 281(47), 35931-35942, 2006

M.C. Woods, V.Y. Sidorov, M.R. Holcomb, D.L. Beaudoin, B.J. Roth, and J.P. Wikswo. "Virtual Electrode Effects Around an Artificial Heterogeneity During Field Stimulation of Cardiac Tissue". Heart Rhythm, 3(6), 751-752, 2006

M.R. Warnement, S.L. Faley, J.P. Wikswo, and S.J. Rosenthal. "Quantum Dot Probes for Monitoring Dynamic Cellular Response: Reporters of T Cell Activation". IEEE Trans. NanoBioscience, 5(4), 268-272, 2006

R.A. Gray, A. Iyer, M.-A. Bray, and J.P. Wikswo. "Voltage-Calcium State-Space Dynamics During Initiation of Reentry". Heart Rhythm, 3(2), 247-248, 2006

R.A. Malkin, D.X. Guan, and J.P. Wikswo. "Experimental Evidence of Improved Transthoracic Defibrillation with Electroporation-Type Pulses". IEEE Trans. BME, 53(10), 1901-1910, 2006

S.E. Eklund, J. Wikswo, F. Baudenbacher, A. Prokop, and D.E. Cliffel. "Multianalyte Microphysiometry as a Tool in Metabolomics and Systems Biology". J. Electroanalytical Chemistry, 587, 333-339, 2006

Z. Yang, W. Shen, J.N. Rottman, J.P. Wikswo, and K.T. Murray. "Rapid Stimulation Causes Electrical Remodeling in Cultured Atrial Myocytes". J. Mol. Cell. Cardiol., 38(2), 299-308, 2005. DOI: 10.1016/j-yjmcc.2004.11.015

G.M. Walker, J. Sai, A. Richmond, M. Stremler, C.Y. Chung, and J.P. Wikswo. "Effects of Flow and Diffusion on Chemotaxis Studies in a Microfabricated Gradient Generator". Lab Chip, 5(6), 611-618, 2005 PMCID:2665276

L.A. Bradshaw, A. Myers, W.O. Richards, W., Drake, and J.P. Wikswo. "Vector Projection of Biomagnetic Fields". Med. Biol. Eng. Comput., 43(1), 85-93, 2005

L.A. Bradshaw, O.P. Roy, G.P. O'Mahony, A.G. Myers, J.G. McDowell, J.P. Wikswo, and W.O. Richards. "Biomagnetic Detection of Injury Currents in Rabbit Ischemic Intestine". Dig. Dis. Sci., 50(9), 1561-1568, 2005

W. Wang, L.M. Shor, E.J. LeBoeuf, J.P. Wikswo, and D.S. Kosson. "Mobility of Protozoa Through Narrow Channels". Appl. Environ. Microbiol., 71(8), 4628-4637, 2005 PMCID:1183301

A.A. Werdich, E.A. Lima, B. Ivanov, I. Ges, J.P. Wikswo, and F.J. Baudenbacher. "A Microfluidic Device to Confine a Single Cardiac Myocyte in a Sub-Nanoliter Volume on a Planar Microelectrode Array for Cellular Activity Detection". Lab Chip, 4, 357-362, 2004. DOI: 10.1039/b315648f

A. Prokop, Z. Prokop, D. Schaffer, E. Kozlov, J.P. Wikswo, D. Cliffel, and F. Baudenbacher. "NanoLiterBioReactor: Monitoring of Long-Term Mammalian Cell Physiology at Nanofabricated Scale". Biomedical Microdevices, 6(4), 325-339, 2004

E. Juzeliũnas, Y.P. Ma, and J.P. Wikswo. "Remote Sensing of Aluminum Alloy Corrosion by SQUID Magnetometry". J. Solid State Electrochem., 8, 435-441, 2004

E.B. Chancellor, J.P. Wikswo, F. Baudenbacher, M. Radparvar, and D. Osterman. "Heat Conduction Calorimeter for Massively Parallel High Throughput Measurements with Picoliter Sample Volumes". Applied Physics Letters, 85(12), 2408-2410, 2004

J.P. Wikswo. "SQUIDs Remain Best Tools for Measuring Brains Magnetic Field". Physics Today, 52(2), 15-17, 2004

J.R. Holzer, L.E. Fong, V.Y. Sidorov, J.P. Wikswo, and F. Baudenbacher. "High Resolution Magnetic Images of Planar Wave Fronts Reveal Bidomain Properties of Cardiac Tissue". Biophys. J., 87(6), 4326-4332, 2004 PMCID:1304939

K.R. Cooper, Y. Ma, J.P. Wikswo, and R.G. Kelly. "Simultaneous Monitoring of the Corrosion Activity and Moisture Inside Aircraft Lap Joints". Corrosion Engineering, Science and Technology, 39(4), 339-345, 2004

J.K. Ladipo, S.A. Seidel, L.A. Bradshaw, S. Halter, J.P. Wikswo, and W.O. Richards. "Histopathologic Changes During Mesenteric Ischemia and Reperfusion". West Afr. J. Med., 22, 59-62, 2003

L.A. Bradshaw, A.G. Myers, A. Redmond, J.P. Wikswo, and W.O. Richards. "Biomagnetic Detection of Gastric Electrical Activity in Normal and Vagotomized Rabbits". Neurogastroenterol. Motil., 15(5), 475-482, 2003

L.A. Bradshaw, A.G. Myers, J.P. Wikswo, Jr., and W.O. Richards. "A SpatioTemporal Dipole Simulation of Gastriointestinal Magnetic Fields". IEEE Trans. Biomed. Engr., 50(7), 836-847, 2003

M.-A. Bray and J.P. Wikswo. "Examination of Optical Depth Effects on Fluorescence Imaging of Cardiac Propagation". Biophys. J., 85(6), 4134-4145, 2003 PMCID:1303712

M.-A. Bray and J.P. Wikswo. "Interaction Dynamics of a Pair of Vortex Filament Rings". Phys. Rev. Lett., 90(23), 238303-1-238303-4, 2003

S.E. Eklund, D.E. Cliffel, E. Kozlov, A. Prokop, J. Wikswo, and F. Baudenbacher. "Modification of the CytosensorTM Microphysiometer to Simultaneously Measure Extracellular Acidification and Oxygen Consumption Rates". Analytica Chimica Acta, 496, 93-101, 2003

V.Y. Sidorov, M.C. Woods, and J.P. Wikswo. "Effects of Elevated Extracellular Potassium on the Stimulation Mechanism of Diastolic Cardiac Tissue". Biophys. J., 84, 3470-3479, 2003 PMCID:1302903

V.Y. Sidorov, R.R. Aliev, M.C. Woods, F. Baudenbacher, P. Baudenbacher, and J.P. Wikswo. "Spatiotemporal Dynamics of Damped Propagation in Excitable Cardiac Tissue". Phys. Rev. Lett., 91(20), 208104-1-208104-4, 2003

F. Baudenbacher, N.T. Peters, P. Baudenbacher, and J.P. Wikswo. "High Resolution Imaging of Biomagnetic Fields Generated by Action Currents in Cardiac Tissue Using a LTS-SQUID Microscope". Physica C, 368, 24-31, 2002

F. Baudenbacher, N.T. Peters, and J.P. Wikswo, Jr. "High Resolution Low-Temperature Superconductivity SQUID Microscopes for Imaging Magnetic Fields of Samples at Room Temperature". Rev. Sci. Instrum., 73(3), 1247-1254, 2002

G. Choudhury, W.G. Jenks, J.P. Wikswo, Jr., and C.G. Bublitz. "Effects of Parasite Attributes and Injected Current Parameters on Electromagnetic Detection of Parasites in Fish Muscle". J. Food Science: Food Engineering and Physical Properties, 67(9), 3381-3387, 2002

M.-A. Bray and J.P. Wikswo. "Use of Topological Charge to Determine Singularity and Filament Location in a Numerical Model of Scroll Wave Activity". IEEE Trans. BME, 49(10), 1086-1093, 2002

M.-A. Bray and J.P. Wikswo, Jr. "Three-Dimensional Visualization of Phase Singularities on the Isolated Rabbit Heart" . J. Cardiovas. Electrophysiol., 13(12), 1311, 2002

M.A. Bray, J.P. Wikswo. "Considerations in Phase Plane Analysis for Nonstationary Reentrant Cardiac Behavior". Phys. Rev. E, 65, 051902-1-051902-8, 2002

Y.P. Ma, J.P. Wikswo, M. Samuleviiene, K. Leinartas, and E. Juzeliunas. "Magnetic Fields Induced by Electrochemical Reactions: Aluminum Alloy Corrosion Sensing by SQUID Magnetometry on a Macroscopic Scale". J. Phys. Chem. B, 106(48), 12549-12555, 2002

B.P. Weiss, F.J. Baudenbacher, J.P. Wikswo, and J.L. Kirschvink. "Magnetic Microscopy Promises a Leap in Sensitivity and Resolution". EoS, 82, 513-518, 2001

K.K. Parker, L.K. Taylor, J.B. Atkinson, D.E. Hansen, and J.P. Wikswo, Jr. "The Effects of Tubulin-Binding Agents on Stretch-Induced Ventricular Arrhythmias". European Journal of Pharmacology, 417, 131-140, 2001

L.A. Bradshaw and J.P. Wikswo, Jr. "Spatial Filter Approach for Evaluation of the Surface Laplacian of the Electroencephalogram and Magnetoencephalogram". Annals of Biomed. Eng., 29, 202-213, 2001

L.A. Bradshaw, R.S. Wijesinghe, and J.P. Wikswo, Jr. "Spatial Filter Approach for Comparison of the Forward and Inverse Problems of Electroencephalography and Magnetoencephalography". Annals of Biomed. Eng., 29, 214-226, 2001

L.A. Bradshaw, W.O. Richards, and J.P. Wikswo, Jr. "Volume Conductor Effects on the Spatial Resolution of Magnetic Fields and Electric Potentials from Gastrointestinal Electrical Activity". Med. Biol. Eng. Comput., 39, 35-43, 2001

M.-A. Bray, S.-F.Lin, R.R. Aliev, B.J. Roth, and J.P. Wikswo, Jr. "Experimental and Theoretical Analysis of Phase Singularity Dynamics in Cardiac Tissue". J. Cardiovasc. Electrophysiol., 12, 716-722, 2001

S.-F. Lin and J.P. Wikswo, Jr. "New Perspectives in Electrophysiology from the Cardiac Bidomain". In: Optical Mapping of Cardiac Excitation and Arrhythmias, D.S. Rosenbaum and J. Jalife, Eds., (Futura Publishing Co., Inc., New York, Chapter 19), pp. 335-359, 2001

B.P. Weiss, J.L. Kirschvink F.J. Baudenbacher, H. Vali, N.T. Peters, F.A. Macdonald, and J.P. Wikswo, Jr. "A Low-Temperature Transfer of ALH84001 from Mars to Earth". Science, 290(5492), 791-795, 2000

G. Skennerton, A. Abedi, R.G. Kelly, and J.P. Wikswo, Jr. "Magnetic Measurements of the Response of Corrosion Activity within Aircraft Lap Joints to Accelerated Corrosion Testing". J. Corrosion Science and Engr., on http://, 2000

J. Wu, D.M. Roden, and J.P. Wikswo, Jr. "Delayed Activation and Retrograde Propagation in Cardiac Muscle: Implication of Virtual Electrode Effects". Annals of Biomed. Eng., 28, 1318-1325, 2000

J.P. Wikswo. "Applications of SQUID Magnetometers to Biomagnetism and Nondestructive Evaluation". In: Applications of Superconductivity, H. Weinstock, Ed., (Kluwer Academic Publishers, The Netherlands), pp. 139-228, 2000

M.-A. Bray, S.-F. Lin, and J.P. Wikswo, Jr. "Three-Dimensional Surface Reconstruction and Fluorescent Visualization of Cardiac Activation". IEEE Trans. BME, 47(10), 1382-1391, 2000

R.R. Aliev, W.O. Richards, and J.P. Wikswo, Jr. "A Simple Non-Linear Model of Electrical Activity in the Intestine". J. Theor. Biology, 204, 21-28, 2000

A. Abedi, J.J. Fellenstein, A.J. Lucas, and J.P. Wikswo, Jr. "A SQUID Magnetometer System for Quantitative Analysis and Imaging of Hidden Corrosion Activity in Aircraft Aluminum Structures". Rev. Sci. Instrum., 70(12), 4640-4651, 1999

J.R. Kirtley and J.P. Wikswo, Jr. "Scanning SQUID Microscopy". Annu. Rev. Mater. Sci., 29, 117-148, 1999

L.A. Bradshaw, J.K. Ladipo, D.J. Staton, J.P. Wikswo, and W.O. Richards. "The Human Vector Magnetogastrogram and Magnetoenterogram". IEEE Trans. Biomed. Eng., 46, 959-970, 1999

S.A. Seidel, L.A. Bradshaw, J.K. Ladipo, J.P. Wikswo, Jr., and W.O. Richards. "Noninvasive Detection of Ischemic Bowel". J. Vascular Surgery, 30(2), 309-319, 1999

S.F. Lin and J.P. Wikswo, J. "Panoramic Optical Imaging of Electrical Propagation in Isolated Heart". J. Biomed. Opt., 4(2), 200-207, 1999

S.F. Lin, B.J. Roth, and J.P. Wikswo, Jr. "Quatrefoil Reentry in Myocardium: An Optical Imaging Study of the Induction Mechanism". J. Cardiovasc. Electrophysiol., 10, 574-586, 1999

T.A. Cruse, A.P. Ewing, and J.P. Wikswo, Jr. "Green's Function Formulation of Laplace's Equation for Electromagnetic Crack Detection". Computational Mechanics, 23(5/6), 420-429, 1999

B.J. Roth and J.P. Wikswo. "Comments on 'Hall-Effect Imaging'". IEEE Trans. BME, 45(10), 1294-1296, 1998

B.J. Roth, S.-F. Lin, and J.P. Wikswo, Jr. "Unipolar Stimulation of Cardiac Tissue". J. Electrocardiol., 31, 6-12, 1998

D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Detection of Hidden Corrosion of Aircraft Aluminum Alloys by Magnetometry Using a Superconducting Quantum Interference Device". Corrosion, 53(2), 93-98, 1997

J. Wu and J.P. Wikswo. "Effects of Bath Resistance on Action Potentials in the Squid Giant Axon: Myocardial Implications". Biophys. J., 73, 2347-2358, 1997

K.K. Parker and J.P. Wikswo, Jr. "A Model of the Magnetic Fields Created by Single Motor Unit Compound Action Potentials in Skeletal Muscle". IEEE Trans. Biomed. Eng., 44(10), 948-957, 1997

L.A. Bradshaw, S.H. Allos, J.P. Wikswo, Jr., and W.O. Richards. "Correlation and Comparison of Magnetic and Electric Detection of Small Intestinal Electrical Activity". Am. J. Physiol., 272, G1159-G1167, 1997

S.F. Lin, R.A. Abbas, and J.P. Wikswo, Jr. "High-Resolution High-Speed Synchronous Epifluorescence Imaging of Cardiac Activation". Rev. Sci. Instr., 68(1), 213-217, 1997

S.H. Allos, D.J. Staton, L.A. Bradshaw, S. Halter, J.P. Wikswo, Jr., and W.O. Richards. "Superconducting Quantum Interference Device Magnetometer for Diagnosis of Ischemia Caused by Mesenteric Venous Thrombosis". World J. Surg., 21, 173-178, 1997

W.G. Jenks, I.M. Thomas, and J.P. Wikswo, Jr. "SQUIDs". Encyclopedia of Applied Physics, G.L. Trigg, E.S. Vera, and W. Greulich, Eds., (VCH Publishers, Inc., New York, NY), pp. 457-468, 1997

W.G. Jenks, S.S.H. Sadeghi, and J.P. Wikswo, Jr. "SQUIDs for Non-Destructive Evaluation". J. Physics D: Applied Physics, 30(3), 293-323, 1997

B.J. Roth and J.P. Wikswo, Jr. "The Effect of Externally Applied Electrical Fields on Myocardial Tissue" . Proceedings of the IEEE, 84, 379-391, 1996

D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Application of Superconducting Magnetometry in the Study of Aircraft Aluminum Alloy Corrosion". Corrosion, 52(3), 219-231, 1996

J.P. Wikswo, Jr. "High-Resolution Magnetic Imaging: Cellular Action Currents and Other Applications". In: SQUID Sensors: Fundamentals, Fabrication and Applications, H. Weinstock, Ed., (Kluwer Academic Publishers, The Netherlands), pp. 307-360, 1996

J.P. Wikswo, Jr. "The Magnetic Inverse Problem". In: SQUID Sensors: Fundamentals, Fabrication and Applications, H. Weinstock, Ed.,(Kluwer Academic Publishers, The Netherlands), pp. 629-695, 1996

N.G. Sepulveda and J.P. Wikswo, Jr. "A Numerical Study of the Use of Magnetometers to Detect Hidden Flaws in Conducting Objects". J. Applied Physics, 79(4), 2122-2135, 1996

P.H. Bunton, W.P. Henry, and J.P. Wikswo, Jr. "A Simple Integrated Circuit Model of Propagation Along an Excitable Axon". Am. J. Phys., 64(5), 602-606, 1996

S. Tan, Y.P. Ma, I.M. Thomas, and J.P. Wikswo, Jr. "Reconstruction of Two-Dimensional Magnetization and Susceptibility Distributions from the Magnetic Field of Soft Magnetic Materials". IEEE Trans. Mag., 32(1), 230-234, 1996

W.G. Jenks, C.G. Bublitz, G.S. Choudhury, Y.P. Ma, and J.P. Wikswo, Jr. "Detection of Parasites in Fish by Superconducting Quantum Interference Device Magnetometry". Journal of Food Science, 61(5), 865-869, 1996

W.O. Richards, L.A. Bradshaw, D.J. Staton, C.L. Garrard, F. Liu, S. Buchanan, and J.P. Wikswo, Jr. "Magnetoenterography (MENG): Noninvasive Measurement of Bioelectric Activity in Human Small Intestine". Digestive Diseases and Sciences, 41(12), 2293-2301, 1996

J.P. Wikswo, Jr. "SQUID Magnetometers for Biomagnetism and Non-Destructive Testing: Important Questions and Initial Answers". IEEE Trans. on Applied Supercond., 5(2), 74-120, 1995 (Plenary Lecture)

D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Detecting In-Situ Active Corrosion by a SQUID Magnetometer". Journal of Minerals, Metals, and Materials, 47(9), 36-39, 1995

J.P. Wikswo, Jr. "Tissue Anisotropy, the Cardiac Bidomain and the Virtual Cathode Effect". In: Cardiac Electrophysiology: From Cell to Bedside, Second Edition, D.P. Zipes and J. Jalife, Eds.(W.B. Sauders, Orlando), 348-361, 1995

J.P. Wikswo, Jr., S.F. Lin, and R.A. Abbas. "Virtual Electrodes in Cardiac Tissue: A Common Mechanism for Anodal and Cathodal Stimulation". Biophys. J., 69, 2195-2210, 1995

N.G. Sepulveda and J.P. Wikswo, Jr. "Line Follower for Finite Element Post-Processing and Current Imaging". Communications in Numerical Methods and Engineering, 11, 1025-1032, 1995

S. Tan, N.G. Sepulveda, and J.P. Wikswo, Jr. "A New Finite-Element Approach to Reconstruct a Bounded and Discontinuous Two-Dimensional Current Image From a Magnetic Field Map". J. Comp. Phys., 122, 150-164, 1995

W.O. Richards, C.L. Garrard, S.H. Allos, L.A. Bradshaw, D.J. Staton, and J.P. Wikswo, Jr. "Noninvasive Diagnosis of Mesenteric Ischemia Using a SQUID Magnetometer". Annals of Surgery, 221(6), 696-705, 1995

Y.P. Ma and J.P. Wikswo, Jr. "Techniques for Depth-Selective, Low-Frequency Eddy Current Analysis for SQUID-Based Non-Destructive Testing". J. Nondestr. Eval., 14(3), 149-167, 1995

B.J. Roth and J.P. Wikswo, Jr. "Electrical Stimulation of Cardiac Tissue: A Bidomain Model With Active Membrane Properties". IEEE Trans. Biomed. Eng., 41(3), 232-240, 1994

B.J. Roth, P.J. Basser and J.P. Wikswo, Jr. "A Theoretical Model of Magneto-Acoustic Imaging of Bioelectric Currents". IEEE Trans. Biomed. Eng., 41(8), 723-728, 1994

J. Golzarian, D.J. Staton, J.P. Wikswo, Jr., R.N. Friedman, and W.O. Richards. "Diagnosing Intestinal Ischemia Using a Noncontact Superconducting Quantum Interference Device". Am. J. Surgery, 167, 586-592, 1994

J.P. Barach and J.P. Wikswo, Jr. "Magnetic Fields From Simulated Cardiac Action Currents" . IEEE Trans. Biomed. Eng., 41, 969-974, 1994

J.P. Wikswo. "The Complexities of Cardiac Cables: Virtual Electrode Effects". Biophys. J., 66(3 Pt 1), 551-553, 1994 PMCID:1275753

J.P. Wikswo, Jr. and S.J. Williamson. "Biomagnetism". 1994 McGraw-Hill Yearbook of Science & Technology(McGraw-Hill, Inc., New York), pp. 48-51, 1994

N.G. Sepulveda and J.P. Wikswo, Jr. "Bipolar Stimulation of Cardiac Tissue Using an Anisotropic Bidomain Model". J. Cardiovasc. Electrophys., 5(3), 258-267, 1994

N.G. Sepulveda, I.M. Thomas, and J.P. Wikswo, Jr. "Magnetic Susceptibility Tomography for Three-Dimensional Imaging of Diamagnetic and Paramagnetic Objects". IEEE Trans. Mag., 30(6), 5062-5069, 1994

I.M. Thomas, S.M. Freake, S.J. Swithenby, and J.P. Wikswo, Jr.. "A Distributed Quasi-static Ionic Current Source in the 3-4 Day Old Chicken Embryo". Phys. Med. Biol., 38, 1311-1328, 1993

D.C. Hurley, Y.P. Ma, S. Tan, and J.P. Wikswo, Jr. "Imaging of Small Defects in Nonmagnetic Tubing Using a SQUID Magnetometer". Res. Nondestr. Eval., 5, 1-29, 1993

J.M. van Egeraat and J.P. Wikswo, Jr. "A Model for Axonal Propagation Incorporating Both Radial and Axial Ionic Transport". Biophys. J., 64, 1287-1298, 1993

J.M. van Egeraat, R. Stasaski, J.P. Barach, R.N. Friedman, and J.P. Wikswo, Jr. "The Biomagnetic Signature of a Crushed Axon: A Comparison of Theory and Experiment". Biophys. J., 64, 1299-1305, 1993

J.P. Wikswo, A. Gevins, and S.J. Williamson. "The Future of the EEG and MEG". Electroencephalogr. Clin. Neurophysiol., 87(1), 1-9, 1993

J.P. Wikswo, Jr., D.B. Crum, W.P. Henry, Y.P. Ma, N.G. Sepulveda, and D.J. Staton. "An Improved Method for Magnetic Identification and Localization of Cracks in Conductors". J. Nondestr. Eval., 12(2), 109-119, 1993

S.F. Lin, R.A. Abbas, and J.P. Wikswo. "Magnetic Locailization of the Origin of Self-Sustained Oscillation in SQUID Giant Axons". Biol. Bull., 185, 300-301, 1993

I.M. Thomas, T.C. Moyer, and J.P. Wikswo, Jr. "High Resolution Magnetic Susceptibility Imaging of Geological Thin Sections: Pilot Study of a Pyroclastic Sample from the Bishop Tuff". Geophys. Res. Letters, 19(21), 2139-2142, 1992

J. Turgeon, T.A. Wisialowski, W. Wong, W.A. Altemeier, J.P. Wikswo, Jr., and D.M. Roden. "Suppression of Longitudinal Versus Transverse Conduction by Sodium Channel Block: Effects of Sodium Bolus". Circulation, 85, 2221-2226, 1992

J.P. Barach and J.P. Wikswo, Jr. "A Numerical Reconstruction of the Effects of Late Stimulation on a Cardiac Ventricular Action Potential". Comp. & Biomed. Res., 25, 212-217, 1992

J.P. Wikswo, Jr. and S.J. Williamson. "Magnetic Source Imaging: Cell, Tissue, and Brain". In: Physics News in 1991, P.F. Schewe, Ed.(American Institute of Physics, New York), pp. 21-24, 1992

N.G. Sepulveda, D.J. Staton, and J.P. Wikswo, Jr. "A Mathematical Analysis of the Magnetic Field Produced By Flaws in Two-Dimensional Current-Carrying Conductors". J. Nondestr. Eval., 11(2), 89-101, 1992

D.J. Staton, Y.P. Ma, N.G. Sepulveda, and J.P. Wikswo, Jr. "High-Resolution Magnetic Mapping Using a SQUID Magnetometer Array". IEEE Trans. Mag., MAG-27(2), 3237-3240, 1991

F.L.H. Gielen, R.N. Friedman, and J.P. Wikswo, Jr. "In Vivo Magnetic and Electric Recordings from Nerve Bundles and Single Motor Units in Mammalian Skeletal Muscle: Correlations with Muscle Force" . J. Gen. Physiol., 98, 1043-1061, 1991

J.P. Barach and J.P. Wikswo, Jr. "The Effect of Action Potential Propagation on a Numerical Simulation of a Cardiac Fiber Subjected to Secondary External Stimulus". Comp. & Biomed. Res., 24, 435-452, 1991

J.P. Wikswo, Jr. and J.M. vanEgeraat. "Cellular Magnetic Fields: Fundamental and Applied Measurements on Nerve Axons, Peripheral Nerve Bundles, and Skeletal Muscle". J. Clin. Neurophysiology, 8(2), 170-188, 1991

J.P. Wikswo, Jr., W. Altemeier, J.R. Balser, H.A. Kopelman, T. Wisialowski, and D.M. Roden. "Virtual Cathode Effects During Stimulation of Cardiac Muscle: Two-Dimensional In Vivo Measurements". Circ. Res., 68, 513-530, 1991

R.S. Wijesinghe and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle II: A Sensitivity Analysis of Model Parameters for the Forward and Inverse Calculations". Annals of Biomed. Eng., 19, 73-96, 1991

R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle III: A Comparison of the Conduction Velocity Distributions Calculated from Compound Action Currents and Potentials". Annals of Biomed. Eng., 19, 97-121, 1991

R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle I: The Forward Calculation". Annals of Biomed. Eng., 19, 43-72, 1991

Y.P. Ma and J.P. Wikswo, Jr. "Magnetic Shield for Wide-Bandwidth Magnetic Measurements for Nondestructive Testing and Biomagnetism". Rev. Sci. Instr., 62(11), 2654-2661, 1991

B.J. Roth and J.P. Wikswo, Jr. "Apodized Pickup Coils for Improved Spatial Resolution of SQUID Magnetometers" . Rev. Sci. Instr., 61, 2439-2448, 1990

J.M. van Egeraat, R.N. Friedman, and J.P. Wikswo, Jr. "Magnetic Field of a Single Muscle Fiber: First Measurements and a Core Conductor Model" . Biophys. J., 57, 663-667, 1990

J.P. Wikswo, Jr. "Biomagnetic Sources and Their Models". , S.J. Williamson, M. Hoke, G. Stroink, and M. Kotani, Eds., (Plenum, New York), pp. 1-18, 1990

N.G. Sepulveda, J.P. Wikswo, Jr., and D.S. Echt. "Finite Element Analysis of Cardiac Defibrillation Current Distributions". IEEE Trans. Biomed. Eng., 37, 354-365, 1990

S. Tan, B.J. Roth, and J.P. Wikswo, Jr. "The Magnetic Field of Cortical Current Sources: The Application of a Spatial Filtering Model to the Forward and Inverse Problem". Electroencep. and Clin. Neurophys., 76, 73-85, 1990

B.J. Roth and J.P. Wikswo, Jr. "Longitudinal Resistance in Cardiac Muscle and its Effects on Propagation". Cell Interactions and Gap Junctions, N. Sperelakis and W.C. Cole, Eds., (CRC Press, Boca Raton), pp. 165-178, 1989

B.J. Roth, N.G. Sepulveda, and J.P. Wikswo, Jr. "Using a Magnetometer to Image a Two-dimensional Current Distribution". J. Appl. Phys., 65, 361-372, 1989

J.P. Wikswo, Jr. "A Review of Intermediate Physics for Medicine and Biology by R.K. Hobbie". Physics Today(42), 75-76, 1989

N.G. Sepulveda, B.J. Roth, and J.P. Wikswo, Jr. "Current Injection into a Two-Dimensional Anisotropic Bidomain". Biophys. J., 55, 987-999, 1989

B.J. Roth, F.L.H. Gielen, and J.P. Wikswo, Jr. "Spatial and Temporal Frequency-Dependent Conductivities in Volume Conduction Calculations of Skeletal Muscle" . Mathematical Biosciences, 88, 159-189, 1988

B.J. Roth, W.-Q. Guo, and J.P. Wikswo, Jr. "The Effects of Spiral Anisotropy on the Electric Potential and the Magnetic Field at the Apex of the Heart" . Mathematical Biosciences, 88, 191-221, 1988

J.P. Wikswo, Jr. and B.J. Roth. "Magnetic Determination of the Spatial Extent of a Single Cortical Current Source: A Theoretical Analysis". Electroenceph. and Clin. Neurophys., 69, 266-276, 1988

R. Maniewski, T. Katila, T. Poutanen, P. Siltanen, T. Varpula, and J.P. Wikswo, Jr. "Magnetic Measurements of Cardiac Mechanical Activity" . IEEE Trans. Biomed. Eng, 35, 662-670, 1988

A.K. Bajaj, H.A. Kopelman, J.P. Wikswo, Jr., F. Cassidy, R.L. Woosley, and D.M. Roden. "Frequency- and Orientation-Dependent Effects of Mexiletine and Quinidine on Conduction in the Intact Dog Heart". Circulation, 75, 1065-1073, 1987

J.P. Barach and J.P. Wikswo, Jr. "Computer Simulation of Action Potential Propagation in Septated Nerve Fibers" . Biophys. J., 51, 177-183, 1987

N.G. Sepulveda and J.P. Wikswo, Jr. "Electric and Magnetic Fields from Two-Dimensional Anisotropic Bisyncytia". Biophys. J., 51, 557-568, 1987

B.J. Roth and J.P. Wikswo, Jr. "A Bi-Domain Model for the Extracellular Potential and Magnetic Field of Cardiac Tissue". IEEE Trans. Biomed. Eng, BME-33, 467-469, 1986

B.J. Roth and J.P. Wikswo, Jr. "Electrically-Silent Magnetic Fields". Biophys. J., 50, 739-745, 1986

F.L.H. Gielen, B.J. Roth, and J.P. Wikswo, Jr. "Capabilities of a Toroid-Amplifier System for Magnetic Measurement of Current in Biological Tissue" . IEEE Trans. Biomed. Eng., BME-33, 910-921, 1986

M.C. Leifer, J.P. Wikswo, Jr., J. Griffin, W.M. Barry, and D.C. Harrison. "The Effects of the Heart-Lung Boundary on the Magnetocardiogram" . J. Electrocard., 19, 23-32, 1986

V.R. Hentz, J.P. Wikswo, Jr., and G.S. Abraham. "Magnetic Measurements of Nerve Action Current: A New Intraoperative Technique". Peripheral Nerve Repair and Regeneration, 1, 27-36, 1986

B.J. Roth and J.P. Wikswo, Jr. "The Magnetic Field of a Single Axon: A Comparison of Theory and Experiment" . Biophys. J., 48, 93-109, 1985

B.J. Roth and J.P. Wikswo, Jr. "The Electrical Potential and the Magnetic Field of an Axon in a Nerve Bundle". Mathematical Biosciences, 76, 37-57, 1985

D.P. Russell and J.P. Wikswo, Jr. "Optimisation of State Selection and Focusing of a Neutral Atomic Hydrogen Beam by a Hexapole Magnet" . J. Physics, 18, 933-940, 1985

J.A. Freeman, P.B. Manis, G.J. Snipes, B.N. Mayes, P.C. Samson, J.P. Wikswo, Jr., and D.B. Freeman. "Steady Growth Cone Currents Revealed by a Novel Circularly Vibrating Probe: A Possible Mechanism Underlying Neurite Growth". In: Biology of the Nerve Growth Cone. S.B. Kater and P. Letourneau, Eds., J. Neuroscience Res., (Special Monongraph), pp. 26-38 (1984), and J. Neuroscience Res., 13: 257-283, 1985

J.E. Barnhill, J.P. Wikswo, Jr., A.K. Dawson, S. Gundersen, R.M.S. Robertson, D. Robertson, R. Virmani, and R.F. Smith. "The QRS Complex During Transient Myocardial Ischemia: Studies in Patients with Variant Angina Pectoris and in a Canine Preparation" . Circulation, 71(5), 901-911, 1985

J.K. Woosley, B.J. Roth, and J.P. Wikswo, Jr. "The Magnetic Field of a Single Nerve Axon: A Volume Conductor Model" . Mathematical Biosciences, 76, 1-36, 1985

J.P. Barach, B.J. Roth, and J.P. Wikswo, Jr. "Magnetic Measurement of Action Currents in a Single Nerve Axon: A Core Conductor Model" . IEEE Trans. Biomed. Eng., BME-32, 136-140, 1985

J.P. Wikswo, Jr. and K.R. Swinney. "Scalar Multipole Expansions and Their Dipole Equivalents" . J. Appl. Phys., 57, 4301-4308, 1985

J.P. Wikswo, Jr. and K.R. Swinney. "A Comparison of Scalar Multipole Expansions". J. Appl. Phys., 56, 3039-3049, 1984

R.F. Smith, J.E. Barnhill, and J.P. Wikswo, Jr. "Early Use of Timolol in Acute Myocardial Infarction". N. England J. Med., 310, 1667, 1984

J.P. Wikswo, Jr. "Cellular Action Currents". In: Biomagnetism, An Interdisciplinary Approach, S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds., (Plenum, New York), pp. 173-207, 1983

J.P. Wikswo, Jr. "Theoretical Aspects of the ECG-MCG Relationship". In: Biomagnetism, An Interdisciplinary Approach, S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds., (Plenum, New York), pp. 311-326, 1983

J.P. Wikswo, Jr., P.C. Samson, and R.P. Giffard. "A Low-Noise, Low Input Impedance Amplifier for Magnetic Measurements of Nerve Action Currents" . IEEE Trans. Biomed. Eng., BME-30, 215-221, 1983

M.C. Leifer and J.P. Wikswo, Jr. "Optimization of a SQUID Clip-On Current Probe" . Rev. Sci. Instr., 54, 1017-1022, 1983

J.P. Wikswo, Jr. "Improved Instrumentation for Measuring the Magnetic Field of Cellular Action Currents". Rev. Sci. Instr., 53, 1846-1850, 1982

J.P. Wikswo, Jr. and J.P. Barach. "Possible Sources of New Information in the Magnetocardiogram" . J. Theoretical Biol., 95, 721-729, 1982

J.P. Wikswo, Jr., S.C. Gundersen, W. Murphy, A.K. Dawson, and R.F. Smith. "Sequential QRS Vector Subtractions in Acute Myocardial Infarction in Humans" . Circ. Res., 49, 1055-1062, 1981

L.J. Schaad, B.A. Hess, J.P. Wikswo, Jr., and W.M. Fairbank. "Quark Chemistry" . Phys. Rev. A, 23, 1600-1607, 1981

J.P. Barach, J.A. Freeman and J.P. Wikswo, Jr. "Experiments on the Magnetic Field of Nerve Action Potentials". J. Appl. Phys., 51, 4532-4538, 1980

J.P. Wikswo, Jr. "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Theory". Medical Physics, 7, 297-306, 1980

J.P. Wikswo, Jr. and J.P. Barach. "An Estimate of the Steady Magnetic Field Strength Required to Influence Nerve Conduction" . IEEE Trans. Biomed. Eng., BME-27, 722-723, 1980

J.P. Wikswo, Jr., J.E. Opfer, and W.M. Fairbank. "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Experiment". Medical Physics, 7, 307-314, 1980

J.P. Wikswo, Jr., J.P. Barach, and J.A. Freeman. "Magnetic Field of a Nerve Impulse: First Measurements". Science, 208, 53-55, 1980

K.R. Swinney and J.P. Wikswo, Jr. "A Calculation of the Magnetic Field of a Nerve Action Potential". Biophys. J., 32, 719-732, 1980

J.P. Wikswo, Jr., J.A.V. Malmivuo, W.H. Barry, M.C. Leifer, and W.M. Fairbank. "Theory and Application of Magnetocardiography". In: Cardiovascular Physics, D.N. Ghista, E. Van Vollenhoven, and W. Yang, Eds., (Karger, Basil), pp. 1-67, 1979

J.P. Wikswo, Jr. "The Calculation of the Magnetic Field from a Current Distribution: Application to Finite Element Techniques". IEEE Trans. Mag., MAG-14, 1076-1077, 1978

J.A.V. Malmivuo and J.P. Wikswo, Jr. "A New Practical Lead System for Vector Magnetocardiography". Proc. IEEE, 65, 809-811, 1977

J.A.V. Malmivuo, J.P. Wikswo, Jr., W.H. Barry, D.C. Harrison, and W.M. Fairbank. "Consistent System of Rectangular and Spherical Co-ordinates for Electrocardiography and Magnetocardiography". Med. Biol. Eng. and Comput., 15, 413-415, 1977

W.H. Barry, D.C. Harrison, W.M. Fairbank, K. Lehrman, J.A.V. Malmivuo, and J.P. Wikswo, Jr. "Measurement of the Human Magnetic Heart Vector". Science, 198, 1159-1162, 1977

R.D. Sandell, J.P. Wikswo, Jr., J.M. Pickler, and B.S. Deaver, Jr. "Quantized Fluctuations in the Josephson Oscillations of a Shunted Superconducting Point Contact". J. Appl. Phys., 44, 3312-3318, 1973

Postdoctoral Position Available

Postdoctoral Position Details
EMD Millipore Research Associate in Automated Systems Biology

With the support of EMD Millipore Bioscience, the Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE) is seeking candidates for a research associate in either of the Departments of Physics & Astronomy, Biomedical Engineering, or Molecular Physiology & Biophysics. The successful candidate will be expected to conduct both experimental and computational research as a part of a long-term project in the automated inference of mathematical models of metabolic and signaling dynamics of small populations of cells. Techniques being used include microfabricated bioreactors with optical, electrochemical, and mass spectrometric sensing, closed-loop control, microfluidics, numerical modeling, and bioinformatics. A doctoral degree in a related field is required. Apply at Review of applications will begin on 1 July, 2011 and will continue until the position is filled.
VIIBRE is a transinstitutional initiative created in 2001 to foster and enhance interdisciplinary research in the biophysical sciences, bioengineering, and medicine at Vanderbilt University, integrated with a strong focus on undergraduate, graduate, and postdoctoral education. VIIBREa??s primary focus is the use of microfluidics and advanced analytical systems to instrument and control single cells and small populations of cells. Founded in 1873, Vanderbilt is a private, coeducational university with approximately 6,000 undergraduates and 5,000 graduate and professional students. Vanderbilt University is an equal-opportunity, affirmative-action employer. Women and minority candidates are particularly encouraged to apply. For more information, please visit our web site or contact Prof. John P. Wikswo (please email both and

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