Biomedical Research Education & Training
Faculty Member

Burk, Raymond F., M.D.
Professor of Medicine
Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: (615) 343-4748

Email Address: raymond.burk@vanderbilt.edu

Burk, Raymond's picture
Academic history
B.A., Mississippi
M.D., Vanderbilt

Office Address   Mailing Address

1075 Medical Research Bldg IV

1030C Medical Research Bldg IV 37221-0252


Research Keywords
Selenium, Biochemistry, Drug metabolism, Enzyme action, Pathology, Toxicology, Biochemistry

Research Specialty
Selenium metabolism and function in animals and human beings.

Publications
Nakayama, A, Hill, KE, Austin, LM, Motley, AK, Burk, RF. All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium. J Nutr, 137(3), 690-3, 2007

Burk, RF, Christensen, JM, Maguire, MJ, Austin, LM, Whetsell, WO, May, JM, Hill, KE, Ebner, FF. A combined deficiency of vitamins E and C causes severe central nervous system damage in guinea pigs. J Nutr, 136(6), 1576-81, 2006

Burk, RF, Hill, KE, Motley, AK, Austin, LM, Norsworthy, BK. Deletion of selenoprotein P upregulates urinary selenium excretion and depresses whole-body selenium content. Biochim Biophys Acta, 1760(12), 1789-93, 2006 PMCID:1761947

Burk, RF, Norsworthy, BK, Hill, KE, Motley, AK, Byrne, DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev, 15(4), 804-10, 2006

Peters, MM, Hill, KE, Burk, RF, Weeber, EJ. Altered hippocampus synaptic function in selenoprotein P deficient mice. Mol Neurodegener, 1, 12, 2006 PMCID:1594565

Burk, RF, Hill, KE. Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr, 25, 215-35, 2005

Ma, S, Hill, KE, Burk, RF, Caprioli, RM. Mass spectrometric determination of selenenylsulfide linkages in rat selenoprotein P. J Mass Spectrom, 40(3), 400-4, 2005

Olson, GE, Winfrey, VP, Nagdas, SK, Hill, KE, Burk, RF. Selenoprotein P is required for mouse sperm development. Biol Reprod, 73(1), 201-11, 2005

Valentine, WM, Hill, KE, Austin, LM, Valentine, HL, Goldowitz, D, Burk, RF. Brainstem axonal degeneration in mice with deletion of selenoprotein p. Toxicol Pathol, 33(5), 570-6, 2005

Burk, RF, Hill, KE. Selenoprotein P: An Extracellular Protein with Unique Physical Characteristics and a Role in Selenium Homeostasis. Annu Rev Nutr, 2004

Hill, KE, Zhou, J, McMahan, WJ, Motley, AK, Burk, RF. Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. J Nutr, 134(1), 157-61, 2004

Olson, GE, Winfrey, VP, Hill, KE, Burk, RF. Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats. Reproduction, 127(3), 335-42, 2004

Burk, Raymond F, Hill, Kristina E, Motley, Amy K. Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. J Nutr, 133(5 Suppl 1), 1517S-20S, 2003

Hill, KE, Montine, TJ, Motley, AK, Li, X, May, JM, Burk, RF. Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Am J Clin Nutr, 77(6), 1484-8, 2003

Hill, Kristina E, Zhou, Jiadong, McMahan, Wendy J, Motley, Amy K, Atkins, John F, Gesteland, Raymond F, Burk, Raymond F. Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem, 278(16), 13640-6, 2003

Ma, S, Hill, KE, Burk, RF, Caprioli, RM. Mass spectrometric identification of N- and O-glycosylation sites of full-length rat selenoprotein P and determination of selenide-sulfide and disulfide linkages in the shortest isoform. Biochemistry, 42(32), 9703-11, 2003

Ma, Shuguang, Caprioli, Richard M, Hill, Kristina E, Burk, Raymond F. Loss of selenium from selenoproteins: conversion of selenocysteine to dehydroalanine in vitro. J Am Soc Mass Spectrom, 14(6), 593-600, 2003

Mostert, Volker, Hill, Kristina E, Burk, Raymond F. Loss of activity of the selenoenzyme thioredoxin reductase causes induction of hepatic heme oxygenase-1. FEBS Lett, 541(1-3), 85-8, 2003

Mostert, Volker, Hill, Kristina E, Ferris, Christopher D, Burk, Raymond F. Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats. Biol Chem, 384(4), 681-7, 2003

Burk, Raymond F. Selenium, an antioxidant nutrient. Nutr Clin Care, 5(2), 75-9, 2002

Ma, Shuguang, Hill, Kristina E, Caprioli, Richard M, Burk, Raymond F. Mass spectrometric characterization of full-length rat selenoprotein P and three isoforms shortened at the C terminus. Evidence that three UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination. J Biol Chem, 277(15), 12749-54, 2002

May, James M, Morrow, Jason D, Burk, Raymond F. Thioredoxin reductase reduces lipid hydroperoxides and spares alpha-tocopherol. Biochem Biophys Res Commun, 292(1), 45-9, 2002

Atkinson, J B, Hill, K E, Burk, R F. Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Lab Invest, 81(3), 193-200, 2001

Atkinson, J B, Hill, K E, Burk, R F. Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Lab Invest, 81(2), 193-200, 2001

Burk, R F, Hill, K E, Motley, A K. Plasma selenium in specific and non-specific forms. Biofactors, 14(1-4), 107-14, 2001

Burk, Raymond. Selenium: recent clinical advances. Curr Opin Gastroenterol, 17(2), 162-166, 2001

Hill, K E, Motley, A K, Li, X, May, J M, Burk, R F. Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs. J Nutr, 131(6), 1798-802, 2001

Hondal, R J, Ma, S, Caprioli, R M, Hill, K E, Burk, R F. Heparin-binding histidine and lysine residues of rat selenoprotein P. J Biol Chem, 276(19), 15823-31, 2001

Li, X, Cobb, C E, Hill, K E, Burk, R F, May, J M. Mitochondrial uptake and recycling of ascorbic acid. Arch Biochem Biophys, 387(1), 143-53, 2001

Li, X, Hill, K E, Burk, R F, May, J M. Selenium spares ascorbate and alpha-tocopherol in cultured liver cell lines under oxidant stress. FEBS Lett, 508(3), 489-92, 2001

Yang, X, Hill, K E, Maguire, M J, Burk, R F. Synthesis and secretion of selenoprotein P by cultured rat astrocytes. Biochim Biophys Acta, 1474(3), 390-6, 2000

Yang, X., K.E. Hill, M.J. Maguire, and R.F. Burk. Synthesis and secretion of selenoprotein P by cultured rat astrocytes. Biochim Biophys Acta, 1474, 390-396, 2000

Burk, R F, Hill, K E. Orphan selenoproteins. Bioessays, 21(3), 231-7, 1999

Hondal, R J, Motley, A K, Hill, K E, Burk, R F. Failure of selenomethionine residues in albumin and immunoglobulin G to protect against peroxynitrite. Arch Biochem Biophys, 371(1), 29-34, 1999

Hondal, R.J., A.K. Motley, K.E. Hill, and R.F. Burk. Failure of selenomethionine residues in albumin to protect against peroxynitrite oxidation of dihydrorhodamine 123. Arch Biochem Biophys , 37, 29-34, 1999

Burk, R F, Early, D S, Hill, K E, Palmer, I S, Boeglin, M E. Plasma selenium in patients with cirrhosis. Hepatology, 27(3), 794-8, 1998

May, J M, Cobb, C E, Mendiratta, S, Hill, K E, Burk, R F. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. J Biol Chem, 273(36), 23039-45, 1998

May, J.M., C.E. Cobb, S. Mendiratta, K.E. Hill, and R.F. Burk. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. J Biol Chem, 273, 23039-23045, 1998

Morrow, J D, Roberts, L J, Daniel, V C, Awad, J A, Mirochnitchenko, O, Swift, L L, Burk, R F. Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. Arch Biochem Biophys, 353(1), 160-71, 1998

Burk, R F, Hill, K E, Boeglin, M E, Ebner, F F, Chittum, H S. Selenoprotein P associates with endothelial cells in rat tissues. Histochem Cell Biol, 108(1), 11-5, 1997

Hill, K E, Burk, R F. Selenoprotein P: recent studies in rats and in humans. Biomed Environ Sci, 10(2-3), 198-208, 1997

Hill, K E, McCollum, G W, Boeglin, M E, Burk, R F. Thioredoxin reductase activity is decreased by selenium deficiency. Biochem Biophys Res Commun, 234(2), 293-5, 1997

Hill, K E, McCollum, G W, Burk, R F. Determination of thioredoxin reductase activity in rat liver supernatant. Anal Biochem, 253(1), 123-5, 1997

May, J M, Mendiratta, S, Hill, K E, Burk, R F. Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase. J Biol Chem, 272(36), 22607-10, 1997

Awad, J A, Roberts, L J, Burk, R F, Morrow, J D. Isoprostanes--prostaglandin-like compounds formed in vivo independently of cyclooxygenase: use as clinical indicators of oxidant damage. Gastroenterol Clin North Am, 25(2), 409-27, 1996

Chittum, H S, Himeno, S, Hill, K E, Burk, R F. Multiple forms of selenoprotein P in rat plasma. Arch Biochem Biophys, 325(1), 124-8, 1996

Hill, K E, Chittum, H S, Lyons, P R, Boeglin, M E, Burk, R F. Effect of selenium on selenoprotein P expression in cultured liver cells. Biochim Biophys Acta, 1313(1), 29-34, 1996

Hill, K E, Dasouki, M, Phillips, J A, Burk, R F. Human selenoprotein P gene maps to 5q31. Genomics, 36(3), 550-1, 1996

Hill, K E, Xia, Y, Akesson, B, Boeglin, M E, Burk, R F. Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects. J Nutr, 126(1), 138-45, 1996

Himeno, S, Chittum, H S, Burk, R F. Isoforms of selenoprotein P in rat plasma. Evidence for a full-length form and another form that terminates at the second UGA in the open reading frame. J Biol Chem, 271(26), 15769-75, 1996

Payne, J L, McCarty, K R, Drougas, J G, Chapman, W C, Wright, J K, Pinson, N Y, Beliles, K E, Newsom, V L, Hunter, E B, Raiford, D S, Awad, J A, Burk, R F, Donovan, K L, Van Buren, D H, Pinson, C W. Outcomes analysis for 50 liver transplant recipients: the Vanderbilt experience. Am Surg, 62(4), 320-5, 1996

Burk, R F, Hill, K E. Reduced glutathione release into rat plasma by extrahepatic tissues. Am J Physiol, 269(3 Pt 1), G396-9, 1995

Burk, R F, Hill, K E, Awad, J A, Morrow, J D, Kato, T, Cockell, K A, Lyons, P R. Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Hepatology, 21(2), 561-9, 1995

Burk, R F, Hill, K E, Awad, J A, Morrow, J D, Lyons, P R. Liver and kidney necrosis in selenium-deficient rats depleted of glutathione. Lab Invest, 72(6), 723-30, 1995

Akesson, B, Bellew, T, Burk, R F. Purification of selenoprotein P from human plasma. Biochim Biophys Acta, 1204(2), 243-9, 1994

Awad, J A, Burk, R F, Roberts, L J. Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats. J Pharmacol Exp Ther, 270(3), 858-64, 1994

Awad, J A, Morrow, J D, Hill, K E, Roberts, L J, Burk, R F. Detection and localization of lipid peroxidation in selenium- and vitamin E-deficient rats using F2-isoprostanes. J Nutr, 124(6), 810-6, 1994

Burk, R F, Hill, K E. Selenoprotein P. A selenium-rich extracellular glycoprotein. J Nutr, 124(10), 1891-7, 1994

Drougas, J G, Hunter, E B, Raiford, D S, Burk, R F, Awad, J A, Wright, J K, Lopez, R R, Donovan, K L, Franks, J J, Thomas, A T. Liver transplantation: results with Vanderbilt's first 25 liver recipients. J Tenn Med Assoc, 87(1), 7-10, 1994

Longmire, A W, Swift, L L, Roberts, L J, Awad, J A, Burk, R F, Morrow, J D. Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol, 47(7), 1173-7, 1994

Burk, R F. Clinical effects of selenium deficiency. Prog Clin Biol Res, 380, 181-90, 1993

Burk, R F, Hill, K E. Regulation of selenoproteins. Annu Rev Nutr, 13, 65-81, 1993

Hill, K E, Lloyd, R S, Burk, R F. Conserved features of selenoprotein P cDNA. Biochem Soc Trans, 21(4), 832-5, 1993

Hill, K E, Lloyd, R S, Burk, R F. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. Proc Natl Acad Sci U S A, 90(2), 537-41, 1993 PMCID:45698

Burk, R F, Hill, K E. Some properties of selenoprotein P. Biol Trace Elem Res, 33, 151-3, 1992

Hill, K E, Hunt, R W, Jones, R, Hoover, R L, Burk, R F. Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase. Biochem Pharmacol, 43(3), 561-6, 1992

Hill, K E, Lyons, P R, Burk, R F. Differential regulation of rat liver selenoprotein mRNAs in selenium deficiency. Biochem Biophys Res Commun, 185(1), 260-3, 1992

Kato, T, Read, R, Rozga, J, Burk, R F. Evidence for intestinal release of absorbed selenium in a form with high hepatic extraction. Am J Physiol, 262(5 Pt 1), G854-8, 1992

Morrow, J D, Awad, J A, Kato, T, Takahashi, K, Badr, K F, Roberts, L J, Burk, R F. Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J Clin Invest, 90(6), 2502-7, 1992 PMCID:443408

Burk, R F. Molecular biology of selenium with implications for its metabolism. FASEB J, 5(9), 2274-9, 1991

Burk, R F, Hill, K E, Read, R, Bellew, T. Response of rat selenoprotein P to selenium administration and fate of its selenium. Am J Physiol, 261(1 Pt 1), E26-30, 1991

Hill, K E, Lloyd, R S, Yang, J G, Read, R, Burk, R F. The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. J Biol Chem, 266(16), 10050-3, 1991

Morrow, J D, Hill, K E, Burk, R F, Nammour, T M, Badr, K F, Roberts, L J. Formation of unique biologically active prostaglandins in vivo by a non-cyclooxygenase free radical catalyzed mechanism. Adv Prostaglandin Thromboxane Leukot Res, 21A, 125-8, 1991

Burk, R F. Protection against free radical injury by selenoenzymes. Pharmacol Ther, 45(3), 383-5, 1990

Burk, R F, Hill, K E, Hunt, R W, Martin, A E. Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it. Res Commun Chem Pathol Pharmacol, 69(1), 115-8, 1990

Morrow, J D, Hill, K E, Burk, R F, Nammour, T M, Badr, K F, Roberts, L J. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A, 87(23), 9383-7, 1990 PMCID:55169

Piao, JH, Hill, KE, Hunt, RW, Burk, RF. Effect of selenium deficiency on tissue taurine concentration and urinary taurine excretion in the rat. J Nutr Biochem, 1(8), 427-32, 1990

Read, R, Bellew, T, Yang, J G, Hill, K E, Palmer, I S, Burk, R F. Selenium and amino acid composition of selenoprotein P, the major selenoprotein in rat serum. J Biol Chem, 265(29), 17899-905, 1990

Williams, A T, Burk, R F. Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury. Semin Liver Dis, 10(4), 279-84, 1990

Burk, R F. Recent developments in trace element metabolism and function: newer roles of selenium in nutrition. J Nutr, 119(7), 1051-4, 1989

Burk, R F, Ludden, T M. Exhaled alkanes as indices of in vivo lipid peroxidation. Biochem Pharmacol, 38(7), 1029-32, 1989

Hill, K E, Ziegler, D M, Konz, K H, Haap, M, Hunt, R W, Burk, R F. Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver. Biochem Pharmacol, 38(21), 3807-10, 1989

Konz, K H, Haap, M, Hill, K E, Burk, R F, Walsh, R A. Diastolic dysfunction of perfused rat hearts induced by hydrogen peroxide. Protective effect of selenium. J Mol Cell Cardiol, 21(8), 789-95, 1989

Yang, J G, Hill, K E, Burk, R F. Dietary selenium intake controls rat plasma selenoprotein P concentration. J Nutr, 119(7), 1010-2, 1989

Burk, R F. Selenium deficiency in search of a disease. Hepatology, 8(2), 421-3, 1988

Burk, R F, Hill, K E, Lane, J M. Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450. Biochem Biophys Res Commun, 152(3), 1463-7, 1988


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
05/21/2013