Biomedical Research Education & Training
Faculty Member

Wood, Alastair J., M.B.Ch.B.
Professor of Medicine, Emeritus

Lab Url: N/A

Phone Number: (615) 343-8701

Email Address: alastair.wood@vanderbilt.edu

Wood, Alastair's picture
Academic history
MBChB, St. Andrew University
MRCP, Royal College of Physicians (UK)

Office Address   Mailing Address

550 RRB

550 RRB, 23rd Ave S at Pierce Ave 37232-6602


Clinical Research Keywords
Molecular Genetics of Adrenergic Receptors, Ethnic Differences in Drug Response, Vascular Response, Drug Metabolism and Disposition,

Research Description
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Publications
Muszkat, M, Kurnik, D, Solus, J, Sofowora, GG, Xie, HG, Jiang, L, McMunn, C, Ihrie, P, Harris, JR, Dawson, EP, Williams, SM, Wood, AJ, Michael Stein, C. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. Pharmacogenet Genomics, 15(6), 407-14, 2005

Muszkat, M, Sofowora, GG, Xie, HG, Wood, AJ, Stein, CM. Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. Pharmacogenet Genomics, 15(1), 23-8, 2005

Sofowora, GG, Singh, I, He, HB, Wood, AJ, Stein, CM. Effect of acute transdermal estrogen administration on basal, mental stress and cold pressor-induced sympathetic responses in postmenopausal women. Clin Auton Res, 15(3), 193-9, 2005

Dishy, V, Harris, PA, Pierce, R, Prasad, HC, Sofowora, G, Bonar, HL, Wood, AJ, Stein, CM. Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers. Br J Clin Pharmacol, 57(2), 209-12, 2004 PMCID:1884430

Dishy, V, Landau, R, Sofowora, GG, Xie, HG, Smiley, RM, Kim, RB, Byrne, DW, Wood, AJ, Stein, CM. Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics, 14(8), 517-22, 2004

Drazen, J M, Green, M F, Wood, A J. The FDA, Politics and Plan B. The New England Journal of Medicine, 350, 1565-66, 2004

Muszkat, M, Sofowora, GG, Wood, AJ, Stein, CM. Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites. Hypertension, 43(1), 31-5, 2004

Sofowora, GG, Dishy, V, Landau, R, Xie, HG, Prasad, HC, Byrne, DW, Smiley, RM, Kim, RB, Wood, AJ, Stein, CM. Alpha 1A-adrenergic receptor polymorphism and vascular response. Clin Pharmacol Ther, 75(6), 539-45, 2004

Xie, HG, Wood, AJ, Kim, RB, Stein, CM, Wilkinson, GR. Genetic variability in CYP3A5 and its possible consequences. Pharmacogenomics, 5(3), 243-72, 2004

Dishy, Victor, Gupta, Simi, Landau, Ruth, Xie, Hong-Guang, Kim, Richard B, Smiley, Richard M, Byrne, Daniel W, Wood, Alastair J, Stein, C Michael. G-protein beta3 subunit 825 C/T polymorphism is associated with weight gain during pregnancy. Pharmacogenetics, 13(4), 241-2, 2003

Dishy, Victor, Sofowora, Gbenga G, Imamura, Hitoshi, Nishimi, Yukihide, Xie, Hong-Guang, Wood, Alastair J, Stein, C Michael. Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses. J Hypertens, 21(1), 153-7, 2003

Haas, DW, Wilkinson, GR, Kuritzkes, DR, Richman, DD, Nicotera, J, Mahon, LF, Sutcliffe, C, Siminski, S, Andersen, J, Coughlin, K, Clayton, EW, Haines, J, Marshak, A, Saag, M, Lawrence, J, Gustavson, J, Anne Bennett, J, Christensen, R, Matula, MA, Wood, AJ, , . A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128. HIV Clin Trials, 4(5), 287-300, 2003

Sofowora, G G, Dishy, V, Muszkat, M, Xie, H G, Kim, R B, Harris, P A, Prasad, H C, Byrne, D W, Nair, U B, Wood, A J J, Stein, C M. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin Pharmacol Ther, 73(4), 366-71, 2003

Wood, A J. When increased therapeutic benefit comes at increased cost. The New Encgland Journal of Medicine, 346, 1819-21, 2002

Wood, Alastair J. Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism. J Allergy Clin Immunol, 110(6 Suppl), S318-21, 2002

Dickmann, L J, Rettie, A E, Kneller, M B, Kim, R B, Wood, A J, Stein, C M, Wilkinson, G R, Schwarz, U I. Identification and functional characterization of a new CYP2C9 variant (CYP2C9*51) expressed among African Americans. Molecular Pharmacology, 60, 382-387, 2001

Dishy, V, Sofowora, G G, Xie, H G, Kim, R B, Byrne, D W, Stein, C M, Wood, A J. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med, 345(14), 1030-5, 2001

Dishy, V, Sofowora, G, Harris, P A, Kandcer, M, Zhan, F, Wood, A J, Stein, C M. The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. Clin Pharmacol Ther, 70(3), 270-9, 2001

Sofowora, G, Dishy, V, Xie, H G, Imamura, H, Nishimi, Y, Morales, C R, Morrow, J D, Kim, R B, Stein, C M, Wood, A J. In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism. Pharmacogenetics, 11(9), 809-14, 2001

Stein, C M, Lang, C C, Xie, H G, Wood, A J. Hypertension in black people: study of specific genotypes and phenotypes will provide a greater understanding of interindividual and interethnic variability in blood pressure regulation than studies based on race. Pharmacogenetics, 11(2), 95-110, 2001

Stein, C M, Sadeque, A J, Murray, J J, Wandel, C, Kim, R B, Wood, A J. Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects. Clin Pharmacol Ther, 69(5), 317-23, 2001

Xie, H G, Dishy, V, Sofowora, G, Kim, R B, Landau, R, Smiley, R M, Zhou, H H, Wood, A J, Harris, P, Stein, C M. Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. Pharmacogenetics, 11(3), 191-7, 2001

Xie, H G, Kim, R B, Wood, A J, Stein, C M. Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharmacol Toxicol, 41, 815-50, 2001

Choo, E F, Leake, B, Wandel, C, Imamura, H, Wood, A J, Wilkinson, G R, Kim, R B. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos, 28(6), 655-60, 2000

Editors of The New England Journal of Medicine. Looking back on the millennium in medicine. The New England Journal of Medicine, 352, 42-50, 2000

He, H, Sadeque, A, Erve, J C, Wood, A J, Hachey, D L. Quantitation of loperamide and N-demethyl-loperamide in human plasma using electrospray ionization with selected reaction ion monitoring liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl, 744(2), 323-31, 2000

Sadeque, A J, Wandel, C, He, H, Shah, S, Wood, A J. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther, 68(3), 231-7, 2000

Stein, C M, Lang, C C, Singh, I, He, H B, Wood, A J. Increased vascular adrenergic vasoconstriction and decreased vasodilation in blacks. Additive mechanisms leading to enhanced vascular reactivity. Hypertension, 36(6), 945-51, 2000

Wandel, C, Kim, RB, Guengerich, FP, Wood, AJ. Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. Drug Metab Dispos, 28(8), 895-8, 2000

Wandel, C, Witte, J S, Hall, J M, Stein, C M, Wood, A J, Wilkinson, G R. CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism. Clin Pharmacol Ther, 68(1), 82-91, 2000

Wood, A J. Thrombotic thrombocytopenic purpura and clopidogrel - A need for new approaches to drug safety. New England Journal of Medicine, 343, 1824-1826, 2000

Xie, H G, Stein, C M, Kim, R B, Gainer, J V, Sofowora, G, Dishy, V, Brown, N J, Goree, R E, Haines, J L, Wood, A J. Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin Pharmacol Ther, 67(6), 670-5, 2000

Caraco, Y, Sheller, J, Wood, A J. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J Pharmacol Exp Ther, 290(1), 413-22, 1999

Kim, R B, Wandel, C, Leake, B, Cvetkovic, M, Fromm, M F, Dempsey, P J, Roden, M M, Belas, F, Chaudhary, A K, Roden, D M, Wood, A J, Wilkinson, G R. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res, 16(3), 408-14, 1999

Kinirons, M T, Krivruk, Y, Wilkinson, G R, Wood, A J. Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio. British Journal of Clinical Pharmacology, 47, 223-225, 1999

Kinirons, M T, O'Shea, D, Kim, R B, Groopman, J D, Thummel, K E, Wood, A J, Wilkinson, G R. Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A. Clin Pharmacol Ther, 66(3), 224-31, 1999

Stein, C M, Murray, J J, Wood, A J. Inhibition of stimulated interleukin-2 production in whole blood: a practical measure of cyclosporine effect. Clin Chem, 45(9), 1477-84, 1999

Wandel, C, Kim, R B, Kajiji, S, Guengerich, P, Wilkinson, G R, Wood, A J. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res, 59(16), 3944-8, 1999

Wood A J. The Safety of new Medicines: The importance of asking the right questions. Journal of the American Medical Association, 281, 1753-1754, 1999

Xie, H G, Kim, R B, Stein, C M, Gainer, J V, Brown, N J, Wood, A J. Alpha1A-adrenergic receptor polymorphism: association with ethnicity but not essential hypertension. Pharmacogenetics, 9(5), 651-6, 1999

Xie, H G, Kim, R B, Stein, C M, Wilkinson, G R, Wood, A J. Genetic polymorphism of (S)-mephenytoin 4'-hydroxylation in populations of African descent. Br J Clin Pharmacol, 48(3), 402-8, 1999 PMCID:2014331

Xie, H G, Stein, C M, Kim, R B, Wilkinson, G R, Flockhart, D A, Wood, A J. Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world. Pharmacogenetics, 9(5), 539-49, 1999

Xie, H G, Stein, C M, Kim, R B, Xiao, Z S, He, N, Zhou, H H, Gainer, J V, Brown, N J, Haines, J L, Wood, A J. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics, 9(4), 511-6, 1999

Brown, N J, Griffin, M R, Ray, W A, Meredith, S, Beers, M H, Marren, J, Robles, M, Stergachis, A, Wood, A J, Avorn, J. A model for improving medication use in home health care patients. J Am Pharm Assoc (Wash), 38(6), 696-702, 1998

Choy, A M, Lang, C C, Roden, D M, Robertson, D, Wood, A J, Robertson, R M, Biaggioni, I. Abnormalities of the QT interval in primary disorders of autonomic failure. Am Heart J, 136(4 Pt 1), 664-71, 1998

He, H, Shay, S D, Caraco, Y, Wood, M, Wood, A J. Simultaneous determination of codeine and its seven metabolites in plasma and urine by high-performance liquid chromatography with ultraviolet and electrochemical detection. J Chromatogr B Biomed Sci Appl, 708(1-2), 185-93, 1998

Kim, R B, Fromm, M F, Wandel, C, Leake, B, Wood, A J, Roden, D M, Wilkinson, G R. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest, 101(2), 289-94, 1998 PMCID:508566

Robbins, I M, Cuiper, L L, Stein, C M, Wood, A J, He, H B, Parker, R, Christman, B W. Angiotensin II mediates systemic rebound hypertension after cessation of prostacyclin infusion in sheep. J Appl Physiol, 85(2), 731-7, 1998

Stein, C M, Brown, N, Vaughan, D E, Lang, C C, Wood, A J. Regulation of local tissue-type plasminogen activator release by endothelium-dependent and endothelium-independent agonists in human vasculature. J Am Coll Cardiol, 32(1), 117-22, 1998

Stein, C M, He, H B, Wood, A J. Basal and stimulated sympathetic responses after epinephrine: no evidence of augmented responses. Hypertension, 32(6), 1016-21, 1998

Wandel, C, Lang, C C, Cowart, D C, Girard, A F, Bramer, S, Flockhart, D A, Wood, A J. Effect of CYP3A inhibition on vesnarinone metabolism in humans. Clin Pharmacol Ther, 63(5), 506-11, 1998

Wood, A J. Ethnic differences in drug disposition and response. Ther Drug Monit, 20(5), 525-6, 1998

Wood, A J, Stein, C M, Woosley, R. Making medicines safer--the need for an independent drug safety board. N Engl J Med, 339(25), 1851-4, 1998

Caraco, Y, Sheller, J, Wood, A J. Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects. J Pharmacol Exp Ther, 281(1), 330-6, 1997

He, H, Stein, C M, Christman, B, Wood, A J. Determination of catecholamines in sheep plasma by high-performance liquid chromatography with electrochemical detection: comparison of deoxyepinephrine and 3,4-dihydroxybenzylamine as internal standard. J Chromatogr B Biomed Sci Appl, 701(1), 115-9, 1997

Lang, C C, Rayos, G H, Chomsky, D B, Wood, A J, Wilson, J R. Effect of sympathoinhibition on exercise performance in patients with heart failure. Circulation, 96(1), 238-45, 1997

Lang, C C, Stein, C M, He, H B, Belas, F J, Blair, I A, Wood, M, Wood, A J. Blunted blood pressure response to central sympathoinhibition in normotensive blacks: increased importance of nonsympathetic factors in blood pressure maintenance in blacks. Hypertension, 30(2 Pt 1), 157-62, 1997

Lang, C C, Stein, C M, Nelson, R A, He, H B, Belas, F J, Blair, I A, Wood, M, Wood, A J. Sympathoinhibitory response to clonidine is blunted in patients with heart failure. Hypertension, 30(3 Pt 1), 392-7, 1997

Stein, C M, Brown, N, Carlson, M G, Campbell, P, Wood, A J. Coadministration of glyburide and minoxidil, drugs with opposing effects on potassium channels. Clin Pharmacol Ther, 61(6), 662-8, 1997

Stein, C M, Deegan, R, Wood, A J. Lack of correlation between arterial and venous beta-adrenergic receptor sensitivity. Hypertension, 29(6), 1273-7, 1997

Stein, C M, Lang, C C, Nelson, R, Brown, M, Wood, A J. Vasodilation in black Americans: attenuated nitric oxide-mediated responses. Clin Pharmacol Ther, 62(4), 436-43, 1997

Stein, C M, Nelson, R, He, H B, Wood, M, Wood, A J. Norepinephrine release in the human forearm: effects of epinephrine. Hypertension, 30(5), 1078-84, 1997

Stein, C M, Wood, A J, Pincus, T. Implementation of multiple outpatient formularies: undesirable effects. Clin Pharmacol Ther, 61(1), 1-7, 1997

Tateishi, T, Soucek, P, Caraco, Y, Guengerich, F P, Wood, A J. Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem Pharmacol, 53(1), 111-6, 1997

Caraco, Y, Lagerstrom, P O, Wood, A J. Ethnic and genetic determinants of omeprazole disposition and effect. Clin Pharmacol Ther, 60(2), 157-67, 1996

Caraco, Y, Sheller, J, Wood, A J. Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. J Pharmacol Exp Ther, 278(3), 1165-74, 1996

Caraco, Y, Tateishi, T, Guengerich, F P, Wood, A J. Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos, 24(7), 761-4, 1996

Caraco, Y, Wilkinson, G R, Wood, A J. Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole. Clin Pharmacol Ther, 60(4), 396-404, 1996

Kinirons, M T, Lang, C C, He, H B, Ghebreselasie, K, Shay, S, Robin, D W, Wood, A J. Triazolam pharmacokinetics and pharmacodynamics in Caucasians and Southern Asians: ethnicity and CYP3A activity. Br J Clin Pharmacol, 41(1), 69-72, 1996

Lang, C C, Brown, R M, Kinirons, M T, Deathridge, M A, Guengerich, F P, Kelleher, D, O'Briain, D S, Ghishan, F K, Wood, A J. Decreased intestinal CYP3A in celiac disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism. Clin Pharmacol Ther, 59(1), 41-6, 1996

Lang, C C, Stein, C M, He, H B, Wood, A J. Angiotensin converting enzyme inhibition and sympathetic activity in healthy subjects. Clin Pharmacol Ther, 59(6), 668-74, 1996

Robin, D W, Hasan, S S, Edeki, T, Lichtenstein, M J, Shiavi, R G, Wood, A J. Increased baseline sway contributes to increased losses of balance in older people following triazolam. J Am Geriatr Soc, 44(3), 300-4, 1996

Stein, C M, Kinirons, M T, Pincus, T, Wilkinson, G R, Wood, A J. Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine. Clin Pharmacol Ther, 59(1), 47-51, 1996

Tateishi, T, Krivoruk, Y, Ueng, Y F, Wood, A J, Guengerich, F P, Wood, M. Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesth Analg, 82(1), 167-72, 1996

Caraco, Y, Tateishi, T, Wood, A J. Interethnic difference in omeprazole's inhibition of diazepam metabolism. Clin Pharmacol Ther, 58(1), 62-72, 1995

Deegan, R, He, H B, Krivoruk, Y, Wood, A J, Wood, M. Regulation of norepinephrine release by beta 2-adrenergic receptors during halothane anesthesia. Anesthesiology, 82(6), 1417-25, 1995

Lang, C C, Stein, C M, Brown, R M, Deegan, R, Nelson, R, He, H B, Wood, M, Wood, A J. Attenuation of isoproterenol-mediated vasodilatation in blacks. N Engl J Med, 333(3), 155-60, 1995

Stein, C M, He, H, Pincus, T, Wood, A J. Cyclosporine impairs vasodilation without increased sympathetic activity in humans. Hypertension, 26(4), 705-10, 1995

Stein, C M, Nelson, R, Brown, M, He, H, Wood, M, Wood, A J. Dietary sodium intake modulates systemic but not forearm norepinephrine release. Clin Pharmacol Ther, 58(4), 425-33, 1995

Stein, C M, Nelson, R, Brown, M, Wood, M, Wood, A J. Dietary sodium intake modulates vasodilation mediated by nitroprusside but not by methacholine in the human forearm. Hypertension, 25(6), 1220-3, 1995

Stein, C M, Nelson, R, Deegan, R, He, H, Inagami, T, Frazer, M, Badr, K F, Wood, M, Wood, A J. Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. Hypertension, 25(6), 1294-300, 1995

Stein, C M, Nelson, R, Deegan, R, He, H, Wood, M, Wood, A J. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Clin Invest, 96(1), 579-85, 1995 PMCID:185232

Tateishi, T, Wood, A J, Guengerich, F P, Wood, M. Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol. Biochem Pharmacol, 50(11), 1921-4, 1995

Wood, A J. Mechanisms for interethnic differences in antihypertensive drug response. Am J Hypertens, 8(12 Pt 2), 128s, 1995

Zhou, H H, Wood, A J. Stereoselective disposition of carvedilol is determined by CYP2D6. Clin Pharmacol Ther, 57(5), 518-24, 1995

Deegan, R, Wood, A J. Beta-receptor antagonism does not fully explain esmolol-induced hypotension. Clin Pharmacol Ther, 56(2), 223-8, 1994

He, H, Edeki, T I, Wood, A J. Determination of low plasma timolol concentrations following topical application of timolol eye drops in humans by high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl, 661(2), 351-6, 1994

Krivoruk, Y, Kinirons, M T, Wood, A J, Wood, M. Metabolism of cytochrome P4503A substrates in vivo administered by the same route: lack of correlation between alfentanil clearance and erythromycin breath test. Clin Pharmacol Ther, 56(6 Pt 1), 608-14, 1994

Deegan, R, He, H B, Wood, A J, Wood, M. Effect of enflurane and isoflurane on norepinephrine kinetics: a new approach to assessment of sympathetic function during anesthesia. Anesth Analg, 77(1), 49-54, 1993

Kinirons, M T, O'Shea, D, Downing, T E, Fitzwilliam, A T, Joellenbeck, L, Groopman, J D, Wilkinson, G R, Wood, A J. Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men. Clin Pharmacol Ther, 54(6), 621-9, 1993

Robin, D W, Lee, M, Hasan, S S, Wood, A J. Triazolam in cirrhosis: pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther, 54(6), 630-7, 1993

Stein, M, Deegan, R, He, H, Wood, A J. Beta-adrenergic receptor-mediated release of norepinephrine in the human forearm. Clin Pharmacol Ther, 54(1), 58-64, 1993

Stein, M, Deegan, R, Wood, A J. Long-term exposure to beta 2-receptor agonist specifically desensitizes beta-receptor-mediated venodilation. Clin Pharmacol Ther, 54(2), 187-93, 1993

Zhou, H H, Sheller, J R, Nu, H, Wood, M, Wood, A J. Ethnic differences in response to morphine. Clin Pharmacol Ther, 54(5), 507-13, 1993

Bluhm, R E, Bobbitt, R G, Welch, L W, Wood, A J, Bonfiglio, J F, Sarzen, C, Heath, A J, Branch, R A. Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part I: History, neuropsychological findings and chelator effects. Hum Exp Toxicol, 11(3), 201-10, 1992

Bluhm, R E, Breyer, J A, Bobbitt, R G, Welch, L W, Wood, A J, Branch, R A. Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part II: Hyperchloraemia and genitourinary symptoms. Hum Exp Toxicol, 11(3), 211-5, 1992

Edeki, T, Robin, D W, Prakash, C, Blair, I A, Wood, A J. Sensitive assay for triazolam in plasma following low oral doses. J Chromatogr, 577(1), 190-4, 1992

He, H B, Deegan, R J, Wood, M, Wood, A J. Optimization of high-performance liquid chromatographic assay for catecholamines. Determination of optimal mobile phase composition and elimination of species-dependent differences in extraction recovery of 3,4-dihydroxybenzylamine. J Chromatogr, 574(2), 213-8, 1992

Yun, C H, Wood, M, Wood, A J, Guengerich, F P. Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. Anesthesiology, 77(3), 467-74, 1992

Zhou, H H, Adedoyin, A, Wood, A J. Differing effect of atropine on heart rate in Chinese and white subjects. Clin Pharmacol Ther, 52(2), 120-4, 1992

Zhou, H H, Whelan, E, Wood, A J. Lack of effect of ageing on the stereochemical disposition of propranolol. Br J Clin Pharmacol, 33(1), 121-3, 1992 PMCID:1381211

Deegan, R, He, H B, Wood, A J, Wood, M. Effects of anesthesia on norepinephrine kinetics. Comparison of propofol and halothane anesthesia in dogs. Anesthesiology, 75(3), 481-8, 1991

Perry, S M, Whelan, E, Shay, S, Wood, A J, Wood, M. Effect of i.v. anaesthesia with propofol on drug distribution and metabolism in the dog. Br J Anaesth, 66(1), 66-72, 1991

Robin, D W, Hasan, S S, Lichtenstein, M J, Shiavi, R G, Wood, A J. Dose-related effect of triazolam on postural sway. Clin Pharmacol Ther, 49(5), 581-8, 1991

Wood, A J, Zhou, H H. Ethnic differences in drug disposition and responsiveness. Clin Pharmacokinet, 20(5), 350-73, 1991

Zhou, H H, Wood, A J. Increased suppression of exercise-induced increase in renin by propranolol in Chinese subjects. Clin Pharmacol Ther, 50(2), 150-6, 1991

Funck-Brentano, C, Silberstein, D J, Roden, D M, Wood, A J, Woosley, R L. A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism. Br J Clin Pharmacol, 30(2), 195-202, 1990 PMCID:1368218

Lee, J T, Kroemer, H K, Silberstein, D J, Funck-Brentano, C, Lineberry, M D, Wood, A J, Roden, D M, Woosley, R L. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med, 322(25), 1764-8, 1990

Merrell, W J, Gordon, L, Wood, A J, Shay, S, Jackson, E K, Wood, M. The effect of halothane on morphine disposition: relative contributions of the liver and kidney to morphine glucuronidation in the dog. Anesthesiology, 72(2), 308-14, 1990

Murray, K T, Reilly, C, Koshakji, R P, Roden, D M, Lineberry, M D, Wood, A J, Siddoway, L A, Barbey, J T, Woosley, R L. Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade. J Clin Invest, 85(3), 836-42, 1990 PMCID:296501

Naslund, T, Silberstein, D J, Merrell, W J, Nadeau, J H, Wood, A J. Low sodium intake corrects abnormality in beta-receptor-mediated arterial vasodilation in patients with hypertension: correlation with beta-receptor function in vitro. Clin Pharmacol Ther, 48(1), 87-95, 1990

Zhou, H H, Anthony, L B, Roden, D M, Wood, A J. Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation. Clin Pharmacol Ther, 47(6), 686-93, 1990

Zhou, H H, Anthony, L B, Wood, A J, Wilkinson, G R. Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin. Br J Clin Pharmacol, 30(3), 471-5, 1990 PMCID:1368151

Zhou, H H, Wood, A J. Differences in stereoselective disposition of propranolol do not explain sensitivity differences between white and Chinese subjects: correlation between the clearance of (-)- and (+)-propranolol. Clin Pharmacol Ther, 47(6), 719-23, 1990

Anthony, L, Koshakji, R, Wood, A J. Multiple pathways of propranolol's metabolism are inhibited by debrisoquin. Clin Pharmacol Ther, 46(3), 297-300, 1989

Bullington, J, Mouton Perry, S M, Rigby, J, Pinkerton, M, Rogers, D, Lewis, T C, Preganz, P, Wood, A J, Wood, M. The effect of advancing age on the sympathetic response to laryngoscopy and tracheal intubation. Anesth Analg, 68(5), 603-8, 1989

Kroemer, H K, Funck-Brentano, C, Silberstein, D J, Wood, A J, Eichelbaum, M, Woosley, R L, Roden, D M. Stereoselective disposition and pharmacologic activity of propafenone enantiomers. Circulation, 79(5), 1068-76, 1989

Prakash, C, Koshakji, R P, Wood, A J, Blair, I A. Simultaneous determination of propranolol enantiomers in plasma by high-performance liquid chromatography with fluorescence detection. J Pharm Sci, 78(9), 771-5, 1989

Rigby, J W, Wood, A J. Use of N-ethylmaleimide to directly determine the proportion of beta-adrenergic receptors exhibiting high affinity for agonists on human mononuclear leukocyte membranes. Biochem Pharmacol, 38(17), 2755-61, 1989

Shaheen, O, Biollaz, J, Koshakji, R P, Wilkinson, G R, Wood, A J. Influence of debrisoquin phenotype on the inducibility of propranolol metabolism. Clin Pharmacol Ther, 45(4), 439-43, 1989

Silberstein, D J, Rigby, J, Merrell, J, Naslund, T, Wood, A J. Altered beta-adrenoceptor internalization does not explain reduced beta-adrenergic responsiveness in the elderly. J Clin Endocrinol Metab, 68(1), 131-4, 1989

Whelan, E, Wood, A J, Koshakji, R, Shay, S, Wood, M. Halothane inhibition of propranolol metabolism is stereoselective. Anesthesiology, 71(4), 561-4, 1989

Whelan, E, Wood, A J, Shay, S, Wood, M. Lack of effect of spinal anesthesia on drug metabolism. Anesth Analg, 69(3), 307-12, 1989

Wood, A J. Calcium antagonists. Pharmacologic differences and similarities. Circulation, 80(6 Suppl), IV184-8, 1989

Zhou, H H, Koshakji, R P, Silberstein, D J, Wilkinson, G R, Wood, A J. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. N Engl J Med, 320(9), 565-70, 1989

Zhou, H H, Silberstein, D J, Koshakji, R P, Wood, A J. Interindividual differences in beta-receptor density contribute to variability in response to beta-adrenoceptor antagonists. Clin Pharmacol Ther, 45(6), 587-92, 1989

Naslund, T C, Merrell, W J, Nadeau, J H, Wood, A J. Alpha-adrenergic blockade makes minimal contribution to ketanserin's hypotensive effect. Clin Pharmacol Ther, 44(6), 699-703, 1988

Reilly, C S, Merrell, J, Wood, A J, Koshakji, R P, Wood, M. Comparison of the effects of isoflurane or fentanyl-nitrous oxide anaesthesia on propranolol disposition in dogs. Br J Anaesth, 60(7), 791-6, 1988

Wood, A J. Drug interactions in hypertension. Hypertension, 11(3 Pt 2), II1-3, 1988

Koshakji, R P, Wood, A J. Improved high-performance liquid chromatographic method for the simultaneous determination of propranolol and 4-hydroxypropranolol in plasma with fluorescence detection. J Chromatogr, 422, 294-300, 1987


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Postdoctoral Position Details
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Updated Date
07/12/2005