Biomedical Research Education & Training
Faculty Member

Lagrange, Andre H., M.D., Ph.D.
Associate Professor of Neurology

Lab Url:

Phone Number: (615) 322-5979

Email Address:

Lagrange, Andre's picture
Academic history
MD, Oregon Health Sciences University
PhD, Oregon Health Sciences University

Office Address   Mailing Address

6140 MRB III

6140 MRB III 37232-3375

Research Keywords
Epilepsy, Sleep,Neuroscience,Pharmacology,Physiology,Signal transduction

Patient Care Specialty
Women's health and epilepsy Sleep and epilepsy

Olmez, I, Moses, H, Sriram, S, Kirshner, H, Lagrange, AH, Pawate, S. Diagnostic and therapeutic aspects of Hashimoto''s encephalopathy. J Neurol Sci, 331(1-2), 67-71, 2013

Boursoulian, LJ, Schenck, CH, Mahowald, MW, Lagrange, AH. Differentiating parasomnias from nocturnal seizures. J Clin Sleep Med, 8(1), 108-12, 2012

Kao, C, Forbes, JA, Jermakowicz, WJ, Sun, DA, Davis, B, Zhu, J, Lagrange, AH, Konrad, PE. Suppression of thalamocortical oscillations following traumatic brain injury in rats. J Neurosurg, 117(2), 316-23, 2012

Azar, NJ, Lagrange, AH, Wang, L, Song, Y, Abou-Khalil, BW. Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance. Epilepsia, 51(5), 811-7, 2010

Lo, WY, Lagrange, AH, Hernandez, CC, Harrison, R, Dell, A, Haslam, SM, Sheehan, JH, Macdonald, RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. J Biol Chem, 285(41), 31348-61, 2010

Azar, NJ, Lagrange, AH, Abou-Khalil, BW. Transitional sharp waves at ictal onset--a neocortical ictal pattern. Clin Neurophysiol, 120(4), 665-72, 2009

Bianchi, MT Botzolakis, EJ Lagrange, AH Macdonald, RL. The Effect of Benzodiazepines on GABAA Receptor Opening Frequency: Differential Modulation Under Synaptic and Extrasynaptic Conditions. . Epilepsy Research, 85, 212-220, 2009

Botzolakis, EJ, Maheshwari, A, Feng, HJ, Lagrange, AH, Shaver, JH, Kassebaum, NJ, Venkataraman, R, Baudenbacher, F, Macdonald, RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. J Neurosci Methods, 177(2), 294-302, 2009

Lagrange, AH. Folic acid supplementation for women with epilepsy who might become pregnant. Nat Clin Pract Neurol, 5(1), 16-7, 2009

Lagrange, AH. Feeling Out the Elephant in the Room: Why Do Temporal Lobe Seizures Cause Unconsciousness?. Epilepsy Currents, In Press, 2009

Williamson, R, Hanif, S, Mathews, GC, Lagrange, AH, Abou-Khalil, B. Generalized-onset seizures with secondary focal evolution. Epilepsia, 2009

Rula, EY, Lagrange, AH, Jacobs, MM, Hu, N, Macdonald, RL, Emeson, RB. Developmental modulation of GABA(A) receptor function by RNA editing. J Neurosci, 28(24), 6196-201, 2008 PMCID:2746000

A.H. Lagrange. Valproate Enhances Neuropeptide Y Expression: Modulating the Modulator. . Epilepsy Currents , 7(2), 23-5, 2007

A.H. Lagrange, P.Pennell. Pregnancy and Seizure Mediations.. , Hallway Conversations at Epilepsy.Com , 2007

Harper, E, Moses, H, Lagrange, A. Occult celiac disease presenting as epilepsy and MRI changes that responded to gluten-free diet. Neurology, 68(7), 533-4, 2007

Lagrange, AH, Botzolakis, EJ, Macdonald, RL. Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABA-A receptors to synaptic and extrasynaptic GABA. J Physiol, 578(3), 655-676, 2007 PMCID:2151343

A.H. Lagrange. Dancing the delta shuffle: Neurosteroids Regulate GABAA Receptor Expression. . Epilepsy Currents , 6, 14-17, 2006

A.H. Lagrange . Genetic Variants In Absence Epilepsy: A Contextual Consideration Of Calcium Current Kinetics.. Epilepsy Currents , 6(3), 12-14, 2006

Lee, GR, Arain, A, Lim, N, Lagrange, A, Singh, P, Abou-Khalil, B. Rhythmic ictal nonclonic hand (RINCH) motions: a distinct contralateral sign in temporal lobe epilepsy. Epilepsia, 47(12), 2189-92, 2006

Ma, S, Blair, MA, Abou-Khalil, B, Lagrange, AH, Gurnett, CA, Hedera, P. Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. Epilepsy Res, 71(2-3), 129-34, 2006

Lagrange, AH. Receptors Gone Bad: The Wrong Place at the Wrong Time . Epilepsy Currents, 5, 91-95, 2005

Lagrange, AH. Retigabine: Bending Potassium Channels To Our Will. Epilepsy Current, 5, 166-169, 2005

Lagrange, A H, Blaivas, M, Gomez-Hassan, D, Malow, B A. Rasmussen''s syndrome and new-onset narcolepsy, cataplexy, and epilepsy in an adult. Epilepsy Behav, 4(6), 788-92, 2003

Kelly, Martin J, Ronnekleiv, Oline K, Ibrahim, Nurhadi, Lagrange, Andre H, Wagner, Edward J. Estrogen modulation of K(+) channel activity in hypothalamic neurons involved in the control of the reproductive axis. Steroids, 67(6), 447-56, 2002

Kelly, M J, Lagrange, A H, Wagner, E J, Ronnekleiv, O K. Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids, 64(1-2), 64-75, 1999

M.J. Kelly, A.H. Lagrange. Nontranscriptional Effects of Estradiol in Neuropeptide Neurons. Curr. Opin. Endo.and Diab , 55, 66-72, 1998

Piatt JH Jr, Lagrange A . Congenital defects of the scalp and skull. Principles and Practice of Pediatric Neurosurgery, 209-218, 1998

Lagrange, A H, Ronnekleiv, O K, Kelly, M J. Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A. Mol Pharmacol, 51(4), 605-12, 1997

Wagner, E J, Zhang, G, Lagrange, A H, R??nnekleiv, O K, Kelly, M J. Tolerance to mu-opioid receptor agonists but not cross-tolerance to gamma-aminobutyric acid(B) receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment. J Pharmacol Exp Ther, 280(2), 1057-64, 1997

Lagrange, A H, Wagner, E J, R??nnekleiv, O K, Kelly, M J. Estrogen rapidly attenuates a GABAB response in hypothalamic neurons. Neuroendocrinology, 64(2), 114-23, 1996

Zhang, G, Lagrange, A H, Ronnnekleiv, O K, Kelly, M J. Tolerance of hypothalamic beta-endorphin neurons to mu-opioid receptor activation after chronic morphine. J Pharmacol Exp Ther, 277(1), 551-8, 1996

Kelly, M.J. Lagrange, A.H. Ronnekleiv, O.K.. Estrogen rapidly uncouples mu-opioid receptors from potassium channels via activation of protein kinase A. Analgesia, 1, 494-497, 1995

Lagrange, A H, Ronnnekleiv, O K, Kelly, M J. Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback. Endocrinology, 136(5), 2341-4, 1995

Lagrange, A H, Ronnekleiv, O K, Kelly, M J. The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol. J Neurosci, 14(10), 6196-204, 1994

Postdoctoral Position Available

Postdoctoral Position Details

Updated Date