Biomedical Research Education & Training
Faculty Member

Goldenring, James R., M.D., Ph.D.
Professor of Surgery
Paul W. Sanger Chair in Experimental Surgery
Professor of Cell and Developmental Biology

Lab Url: http://www.mc.Vanderbilt.Edu/reporter/index.html?ID=2144&keywords=Goldenring&start=1&end=10

Phone Number: 615-936-3726

Email Address: jim.goldenring@vanderbilt.edu

Goldenring, James's picture
Academic history
A.B., Harvard University, Cambridge, MA
PhD, Yale University, New Haven, CT
M.D., Yale University School of Medicine, New Haven, CT
Resident, Yale-New Haven Hospital, New Haven, CT
Fellow, Yale University School of Medicine, New Haven, CT

Office Address   Mailing Address

10-435G MRB IV

10-435G MRB IV 37232


Research Keywords
Gastric cancer Vesicle trafficking Protein kinases Rab proteins A-kinase anchoring proteins Centrosomes Golgi apparatus Membrane recycling Apical recycling systems Endocytosis Myosin V Gastric parietal cell Gastric metaplasia Epithelial biology RNA trafficking stress granules Cancer Protein structure,Biochemistry,Cancer,Cell cycle,Ion transport,Kinase,Knockout,Malignancy,Membrane,Molecular medicine,Pathology,Phosphorylation,Physiology,Post-transcriptional modification,Protein Structure,Proteomics,RNA editing,Signal transduction,Stem cells,Structural Biology

Clinical Research Keywords
Gastric Cancer

Research Description
Our laboratory studies a number of subjects that apply broadly to epithelial biology. We pursue three distinct programmatic areas. First, we are investigating the protein machinery required for the regulation of the recycling to the plasma membrane of receptors, ion transporters and ion channels. These studies focus on the ability of the Rab11 family of small GTPases (Rab11a, Rab11b and Rab25) to initiate and coordinate the assembly of multiprotein complexes regulating vesicle trafficking. Over the past several years, we have identified myosin Vb as the molecular motor involved in movement towards the plasma membrane. We have also identified a family of at least 8 other Rab11 family interacting proteins (Rab11-FIPs) that also participate in the regulation of plasma membrane recycling. Present investigations center on understanding the assembly of endogenous complexes, the regulation of recycling by novel protein kinase activities and the characterization of novel Rab11-FIP proteins. In addition, we have immunoisolated human parietal cell tubulovesicular recycling membrane vesicles and are performing a total proteomic analysis of the vesicle components. These proteomic studies are revealing unrecognized components of the membrane recycling pathways. Second, we have a long commitment to the study of cAMP-dependent protein kinase anchoring proteins (AKAP). Our present investigations focus on a multiply spliced family of 350-450 kDa AKAPs which we have designated AKAP350. We and others have found that AKAP350 is present at the Golgi apparatus and the centrosome and scaffolds a number of kinases and phosphatases including Type II A kinase, PKN, PKC-epsilon, CK1, phosphatase 1 and phosphatase 2a. In addition we have found that AKAP350 scaffolds Transforming acidic coiled-coil protein 3 and 4 at the centrosome, and a Chloride intracellular channel protein (CLIC5B) as well as cdc42-interacting protein 4 (CIP4) at the Golgi. Our present investigations center on both the investigation of the role of AKAP350 in regulating centrosome dynamics and the elucidation of AKAP350 function in regulating Golgi structure and function. Third, we have had a long-standing interest in gastritis, oxyntic atrophy and gastric cancer. We have identified a previously unrecognized metaplastic lineage associated with loss of gastric parietal cells. This lineage, designated Spasmolytic polypeptide expressing metaplasia (SPEM) is associated with gastric cancer in both humans as well as in mouse models of Helicobacter infection. Our present studies are using gene microarray and 2D-DIGE proteomics to analyze metaplastic lineages isoalted by laser capture microdissection. These studies seek to assemble a cohort of putative markers of the SPEM lineage. We will be using these markers to examine the relationship of SPEM with neoplastic transformation in humans.

Clinical Research Description
We have had a long-standing interest in gastritis, oxyntic atrophy and gastric cancer. We have identified a previously unrecognized metaplastic lineage associated with loss of gastric parietal cells. This lineage, designated Spasmolytic polypeptide expressing metaplasia (SPEM) is associated with gastric cancer in both humans as well as in mouse models of Helicobacter infection. Our present studies are using gene microarray and laser capture microdissection to assemble a cohort of putative markers of the SPEM lineage. We will be using these markers to examine the relationship of SPEM with neoplastic transformation. In addition, we will be testing these new markers for their utilitiy in identifying preneoplastic lesions in patients at risk for gastric cancer.

Publications
Aikou, S, Ohmoto, Y, Gunji, T, Matsuhashi, N, Ohtsu, H, Miura, H, Kubota, K, Yamagata, Y, Seto, Y, Nakajima, A, Goldenring, JR, Kaminishi, M, Nomura, S. Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening. Gastroenterology, 2011

Ducharme, NA, Ham, AJ, Lapierre, LA, Goldenring, JR. Rab11-FIP2 influences multiple components of the endosomal system in polarized MDCK cells. Cell Logist, 1(2), 57-68, 2011 PMCID:3116584

Goldenring, JR, Nam, KT. Rab25 as a tumour suppressor in colon carcinogenesis. Br J Cancer, 104(1), 33-6, 2011 PMCID:3041130

Lapierre, LA, Caldwell, CM, Higginbotham, JN, Avant, KM, Hall, J, Beauchamp, RD, Goldenring, JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken), 68(2), 97-111, 2011 PMCID:3041130

Mattaloni, SM, Kolobova, E, Favre, C, Marinelli, RA, Goldenring, JR, Larocca, MC. AKAP350 is involved in the development of apical "canalicular" structures in hepatic cells HepG2. J Cell Physiol, 2011 PMCID:3116584

Roland, JT, Bryant, DM, Datta, A, Itzen, A, Mostov, KE, Goldenring, JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A, 108(7), 2789-94, 2011 PMCID:3041130

Goldenring, JR. Perspective: Innocence and due diligence: managing unfounded allegations of scientific misconduct. Acad Med, 85(3), 527-30, 2010 PMCID:2827957

Goldenring, JR, Nam, KT. Oxyntic atrophy, metaplasia, and gastric cancer. Prog Mol Biol Transl Sci, 96, 117-31, 2010 PMCID:3041130

Goldenring, JR, Nam, KT, Wang, TC, Mills, JC, Wright, NA. Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology, 138(7), 2207-10, 2210.e1, 2010 PMCID:2935280

Lapierre, LA, Caldwell, CM, Higginbotham, JN, Avant, KM, Hall, J, Daniel Beauchamp, R, Goldenring, JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken), 2010 PMCID:3041130

Lee, HJ, Nam, KT, Park, HS, Kim, MA, Lafleur, BJ, Aburatani, H, Yang, HK, Kim, WH, Goldenring, JR. Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology, 139(1), 213-25.e3, 2010 PMCID:2917327

Lennerz, JK, Kim, SH, Oates, EL, Huh, WJ, Doherty, JM, Tian, X, Bredemeyer, AJ, Goldenring, JR, Lauwers, GY, Shin, YK, Mills, JC. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol, 177(3), 1514-33, 2010 PMCID:2997152

Matthies, HJ, Moore, JL, Saunders, C, Matthies, DS, Lapierre, LA, Goldenring, JR, Blakely, RD, Galli, A. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. J Neurosci, 30(23), 7863-77, 2010 PMCID:2935280

Nam, KT, Lee, HJ, Smith, JJ, Lapierre, LA, Kamath, VP, Chen, X, Aronow, BJ, Yeatman, TJ, Bhartur, SG, Calhoun, BC, Condie, B, Manley, NR, Beauchamp, RD, Coffey, RJ, Goldenring, JR. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest, 120(3), 840-9, 2010 PMCID:2827957

Nam, KT, Lee, HJ, Sousa, JF, Weis, VG, O''Neal, RL, Finke, PE, Romero-Gallo, J, Shi, G, Mills, JC, Peek, RM, Konieczny, SF, Goldenring, JR. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology, 139(6), 2028-2037.e9, 2010 PMCID:2997152

Quante, M, Marrache, F, Goldenring, JR, Wang, TC. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology, 139(6), 2018-2027.e2, 2010 PMCID:2997152

Shinohara, M, Mao, M, Keeley, TM, El-Zaatari, M, Lee, HJ, Eaton, KA, Samuelson, LC, Merchant, JL, Goldenring, JR, Todisco, A. Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology, 139(6), 2050-2060.e2, 2010 PMCID:2997152

Aikou, S, Fukushima, Y, Ogawa, M, Nozaki, K, Saito, T, Matsui, T, Goldenring, JR, Kaminishi, M, Nomura, S. Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and h(2) histamine receptor-deficient mice. Dig Dis Sci, 54(8), 1625-35, 2009

Eggers, CT, Schafer, JC, Goldenring, JR, Taylor, SS. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem, 284(47), 32869-80, 2009 PMCID:2781703

Fiske, WH, Tanksley, J, Nam, KT, Goldenring, JR, Slebos, RJ, Liebler, DC, Abtahi, AM, La Fleur, B, Ayers, GD, Lind, CD, Washington, MK, Coffey, RJ. Efficacy of cetuximab in the treatment of Menetrier''s disease. Sci Transl Med, 1(8), 8ra18, 2009 PMCID:2917327

Kolobova, E, Efimov, A, Kaverina, I, Rishi, AK, Schrader, JW, Ham, AJ, Larocca, MC, Goldenring, JR. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp Cell Res, 315(3), 542-55, 2009

Nam, KT, Lee, HJ, Mok, H, Romero-Gallo, J, Crowe, JE, Peek, RM, Goldenring, JR. Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology, 136(4), 1288-96, 2009

Nozaki, K, Weis, V, Wang, TC, Falus, A, Goldenring, JR. Altered gastric chief cell lineage differentiation in histamine-deficient mice. Am J Physiol Gastrointest Liver Physiol, 296(6), G1211-20, 2009 PMCID:2697940

Roland, JT, Lapierre, LA, Goldenring, JR. Alternative splicing in class V myosins determines association with Rab10. J Biol Chem, 284(2), 1213-23, 2009 PMCID:2613619

Tzaban, S, Massol, RH, Yen, E, Hamman, W, Frank, SR, Lapierre, LA, Hansen, SH, Goldenring, JR, Blumberg, RS, Lencer, WI. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol, 185(4), 673-84, 2009 PMCID:2711563

Weis, VG, Goldenring, JR. Current understanding of SPEM and its standing in the preneoplastic process. Gastric Cancer, 12(4), 189-97, 2009 PMCID:2827957

Cao, Z, Li, C, Higginbotham, JN, Franklin, JL, Tabb, DL, Graves-Deal, R, Hill, S, Cheek, K, Jerome, WG, Lapierre, LA, Goldenring, JR, Ham, AJ, Coffey, RJ. Use of fluorescence-activated vesicle sorting for isolation of naked2-associated, basolaterally-targeted exocytic vesicles for proteomic analysis. Mol Cell Proteomics, 2008 PMCID:2528074

Khandelwal, P, Ruiz, WG, Balestreire-Hawryluk, E, Weisz, OA, Goldenring, JR, Apodaca, G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A, 105(41), 15773-8, 2008 PMCID:2572972

Nozaki, K, Ogawa, M, Williams, JA, Lafleur, BJ, Ng, V, Drapkin, RI, Mills, JC, Konieczny, SF, Nomura, S, Goldenring, JR. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology, 134(2), 511-22, 2008

Schonteich, E, Wilson, GM, Burden, J, Hopkins, CR, Anderson, K, Goldenring, JR, Prekeris, R. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J Cell Sci, 121(Pt 22), 3824-33, 2008

Utley, TJ, Ducharme, NA, Varthakavi, V, Shepherd, BE, Santangelo, PJ, Lindquist, ME, Goldenring, JR, Crowe, JE. Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2. Proc Natl Acad Sci U S A, 105(29), 10209-14, 2008 PMCID:2481327

Cresawn, KO, Potter, BA, Oztan, A, Guerriero, CJ, Ihrke, G, Goldenring, JR, Apodaca, G, Weisz, OA. Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J, 26(16), 3737-48, 2007 PMCID:1952228

Ducharme, NA, Williams, JA, Oztan, A, Apodaca, G, Lapierre, LA, Goldenring, JR. Rab11-FIP2 regulates differentiable steps in transcytosis. Am J Physiol Cell Physiol, 293(3), C1059-72, 2007

Lapierre, LA, Avant, KM, Caldwell, CM, Ham, AJ, Hill, S, Williams, JA, Smolka, AJ, Goldenring, JR. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol, 2007

Leys, CM, Nomura, S, LaFleur, BJ, Ferrone, S, Kaminishi, M, Montgomery, E, Goldenring, JR. Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer. Surgery, 141(1), 41-50, 2007

Nam, KT, Varro, A, Coffey, RJ, Goldenring, JR. Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology, 132(5), 1804-19, 2007

Nedvetsky, PI, Stefan, E, Frische, S, Santamaria, K, Wiesner, B, Valenti, G, Hammer, JA, Nielsen, S, Goldenring, JR, Rosenthal, W, Klussmann, E. A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic, 8(2), 110-23, 2007

Neel, NF, Lapierre, LA, Goldenring, JR, Richmond, A. RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci, 120(Pt 9), 1559-71, 2007

Oztan, A, Silvis, M, Weisz, OA, Bradbury, NA, Hsu, SC, Goldenring, JR, Yeaman, C, Apodaca, G. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell, 18(10), 3978-92, 2007 PMCID:1995710

Que, J, Okubo, T, Goldenring, JR, Nam, KT, Kurotani, R, Morrisey, EE, Taranova, O, Pevny, LH, Hogan, BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development, 134(13), 2521-31, 2007

Roland, JT, Kenworthy, AK, Peranen, J, Caplan, S, Goldenring, JR. Myosin Vb Interacts with Rab8a on a Tubular Network Containing EHD1 and EHD3. Mol Biol Cell, 2007 PMCID:1949367

Yoshizawa, N, Takenaka, Y, Yamaguchi, H, Tetsuya, T, Tanaka, H, Tatematsu, M, Nomura, S, Goldenring, JR, Kaminishi, M. Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab Invest, 87(12), 1265-76, 2007

Ducharme, NA, Hales, CM, Lapierre, LA, Ham, AJ, Oztan, A, Apodaca, G, Goldenring, JR. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol Biol Cell, 17(8), 3625-37, 2006 PMCID:1525241

Goldenring, JR, Nomura, S. Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Am J Physiol Gastrointest Liver Physiol, 291(6), G999-1004, 2006

Jin, M, Goldenring, JR. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Biochim Biophys Acta, 1759(6), 281-95, 2006

Lang, MR, Lapierre, LA, Frotscher, M, Goldenring, JR, Knapik, EW. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat Genet, 38(10), 1198-203, 2006

Leys, CM, Nomura, S, Rudzinski, E, Kaminishi, M, Montgomery, E, Washington, MK, Goldenring, JR. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Hum Pathol, 37(9), 1162-8, 2006

Lis??, MF, Wong, TP, Trinh, A, Hines, RM, Liu, L, Kang, R, Hines, DJ, Lu, J, Goldenring, JR, Wang, YT, El-Husseini, A. Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem, 281(6), 3669-78, 2006

Ogawa, M, Nomura, S, Car, BD, Goldenring, JR. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci, 51(3), 431-9, 2006

Pooley, RD, Reddy, S, Soukoulis, V, Roland, JT, Goldenring, JR, Bader, DM. CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25. Mol Biol Cell, 17(7), 3176-86, 2006 PMCID:1483049

Varthakavi, V, Smith, RM, Martin, KL, Derdowski, A, Lapierre, LA, Goldenring, JR, Spearman, P. The Pericentriolar Recycling Endosome Plays a Key Role in Vpu-mediated Enhancement of HIV-1 Particle Release. Traffic, 7(3), 298-307, 2006

Welch, DC, Wirth, PS, Goldenring, JR, Ness, E, Jagasia, M, Washington, K. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation. Am J Surg Pathol, 30(4), 444-9, 2006

Cecilia Larocca, M, Jin, M, Goldenring, JR. AKAP350 modulates microtubule dynamics. Eur J Cell Biol, 2005

Greengauz-Roberts, O, St??ppler, H, Nomura, S, Yamaguchi, H, Goldenring, JR, Podolsky, RH, Lee, JR, Dynan, WS. Saturation labeling with cysteine-reactive cyanine fluorescent dyes provides increased sensitivity for protein expression profiling of laser-microdissected clinical specimens. Proteomics, 5(7), 1746-57, 2005

Nomura, S, Settle, SH, Leys, CM, Means, AL, Peek, RM, Leach, SD, Wright, CV, Coffey, RJ, Goldenring, JR. Evidence for repatterning of the gastric fundic epithelium associated with M??n??trier''s disease and TGFalpha overexpression. Gastroenterology, 128(5), 1292-305, 2005

Nomura, S, Yamaguchi, H, Ogawa, M, Wang, TC, Lee, JR, Goldenring, JR. Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol, 288(2), G362-75, 2005

Ogawa, M, Nomura, S, Varro, A, Wang, TC, Goldenring, JR. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am J Physiol Gastrointest Liver Physiol, 2005

Robert, ME, Washington, MK, Lee, JR, Goldenring, JR, Bronner, MP, Goldblum, JR, Greenson, JK, Haber, MM, Hart, JA, Lamps, LW, Lauwers, GY, Lewin, D, Lazenby, AJ, Montgomery, E, Crawford, JM. Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus. Am J Clin Pathol, 124(4), 519-27, 2005

Fan, Guo-Huang, Lapierre, Lynne A, Goldenring, James R, Sai, Jiqing, Richmond, Ann. Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Mol Biol Cell, 15(5), 2456-69, 2004 PMCID:404037

Houghton, Jeanmarie, Stoicov, Calin, Nomura, Sachiyo, Rogers, Arlin B, Carlson, Jane, Li, Hanchen, Cai, Xun, Fox, James G, Goldenring, James R, Wang, Timothy C. Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568-71, 2004

Larocca, M Cecilia, Shanks, Ryan A, Tian, Lan, Nelson, David L, Stewart, Donn M, Goldenring, James R. AKAP350 interaction with cdc42 interacting protein 4 at the golgi apparatus. Mol Biol Cell, 15(6), 2771-81, 2004 PMCID:420101

Li, Yi, Wandinger-Ness, Angela, Goldenring, James R, Cover, Timothy L. Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Mol Biol Cell, 15(4), 1946-59, 2004 PMCID:379289

Nomura, S, Yamaguchi, H., Wang, T.C, Lee, J.R. and Goldenring, J.R.. Alterations in gastric mucosal lineages by acute oxyntic atrophy in wild type and gastrin deficient mice. Amer. J. Physiol.(in press), 2004

Nomura, Sachiyo, Baxter, Tammy, Yamaguchi, Hirokazu, Leys, Charles, Vartapetian, Andrey B, Fox, James G, Lee, Jeffrey R, Wang, Timothy C, Goldenring, James R. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology, 127(2), 582-94, 2004

Provance, D William, Gourley, Christopher R, Silan, Colleen M, Cameron, L C, Shokat, Kevan M, Goldenring, James R, Shah, Kavita, Gillespie, Peter G, Mercer, John A. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A, 101(7), 1868-73, 2004 PMCID:357019

Smolka, Adam J, Goldenring, James R, Gupta, Sandeep, Hammond, Charles E. Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC Gastroenterol, 4(1), 4, 2004 PMCID:368434

Berryman, Mark A, Goldenring, James R. CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells. Cell Motil Cytoskeleton, 56(3), 159-72, 2003

Brock, Sean C, Goldenring, James R, Crowe, James E. Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells. Proc Natl Acad Sci U S A, 100(25), 15143-8, 2003 PMCID:299925

Fan, Guo-Huang, Lapierre, Lynne A, Goldenring, James R, Richmond, Ann. Differential regulation of CXCR2 trafficking by Rab GTPases. Blood, 101, 2115-24, 2003

Halldorsdottir, Anna Margrat, Siggurdsdottir, Margrat, Jonasson, Jan Gunnlaugur, Oddsdottir, Margrat, Magnusson, Janas, Lee, Jeffrey R, Goldenring, James R. Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland. Dig Dis Sci, 48, 431-41, 2003

Hobdy-Henderson, Karen C, Hales, Chadwick M, Lapierre, Lynne A, Cheney, Richard E, Goldenring, James R. Dynamics of the apical plasma membrane recycling system during cell division. Traffic, 4(10), 681-93, 2003

Lapierre, Lynne A, Dorn, Matthew C, Zimmerman, C Faith, Navarre, Jennifer, Burnette, Jason O, Goldenring, James R. Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Exp Cell Res, 290(2), 322-31, 2003

Lee, Jeffrey, Baxter, Tammy, Yamaguchi, Hirokazu, Wang, Timothy, Goldenring, James, Anderson, Mark. Differential Protein Analysis of Spasomolytic Polypeptide Expressing Metaplasia Using Laser Capture Microdissection and Two-dimensional Difference Gel Electrophoresis. Appl Immunohistochem Mol Morphol, 11, 188-193, 2003

Hales, Chadwick M, Vaerman, Jean-Pierre, Goldenring, James R. Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling. J Biol Chem, 277, 50415-21, 2002

Shanks, Ryan A, Larocca, M Cecilia, Berryman, Mark, Edwards, John C, Urushidani, Tetsuro, Navarre, Jennifer, Goldenring, James R. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. J Biol Chem, 277, 40973-80, 2002

Shanks, Ryan A, Steadman, Brent T, Schmidt, P Henry, Goldenring, James R. AKAP350 at the Golgi apparatus. I. Identification of a distinct Golgi apparatus targeting motif in AKAP350. J Biol Chem, 277, 40967-72, 2002

Steadman, Brent T, Schmidt, P Henry, Shanks, Ryan A, Lapierre, Lynne A, Goldenring, James R. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J Biol Chem, 277, 30165-76, 2002

Volpicelli, Laura A, Lah, James J, Fang, Guofu, Goldenring, James R, Levey, Allan I. Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. J Neurosci, 22, 9776-84, 2002

Wang, Timothy C, Goldenring, James R. Inflammation intersection: gp130 balances gut irritation and stomach cancer. Nat Med, 8, 1080-2, 2002

Yamaguchi, H., GOLDENRING, J.R., Kaminishi, M. and Lee, J.R. Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig. Dis. Sci., 47, 573-578, 2002

Yamaguchi, Hirokazu, Goldenring, James R, Kaminishi, Michio, Lee, Jeffrey R. Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in rats. Lab Invest, 82, 1045-52, 2002

Yamaguchi, Hirokazu, Goldenring, James R, Kaminishi, Michio, Lee, Jeffrey R, . Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig Dis Sci, 47, 573-8, 2002

GOLDENRING, J.R., Aron, L.M., Lapierre, L.A., Navarre, J. and Casanova, J.E. Expression and properties of Rab25 in polarized Madin-Darby canine kidney cells. Meth. Enzymol, 329, 225-234, 2001

Goldenring, J M, Allred, G, . Post-rape care in hospital emergency rooms. Am J Public Health, 91, 1169-70, 2001 PMCID:1446730

Goldenring, J R. Pools of actin in polarized cells: some filaments are more stable than others. Focus on 'Functionally distinct pools of actin in secretory cells'. Am J Physiol Cell Physiol, 281(2), C386-7, 2001

Goldenring, J R, Aron, L M, Lapierre, L A, Navarre, J, Casanova, J E. Expression and properties of Rab25 in polarized Madin-Darby canine kidney cells. Methods Enzymol, 329, 225-34, 2001

Hales, C M, Griner, R, Hobdy-Henderson, K C, Dorn, M C, Hardy, D, Kumar, R, Navarre, J, Chan, E K, Lapierre, L A, Goldenring, J R. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem, 276(42), 39067-75, 2001

Hales, C.M., Griner, R., Navarre, J., Dorn, M.C., Hardy, D., Kumar, R., Chan, E.K.L., Lapierre, L.A. and GOLDENRING, J.R. Identification and characterization of a family of Rab11 interacting proteins. J. Biol. Chem., 276, 39067-75, 2001

Lapierre, L A, Kumar, R, Hales, C M, Navarre, J, Bhartur, S G, Burnette, J O, Provance, D W, Mercer, J A, B??hler, M, Goldenring, J R. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell, 12(6), 1843-57, 2001 PMCID:37346

Lapierre, L.A., Kumar, R., Hales, C.M., Navarre, J., Bhartur, S.G., Burnette, J.O., Provance, W., Jr., Mercer, J., Bahler, M. and GOLDENRING, J.R. Myosin Vb is associated with plasma membrane recycling systems. Mol. Biol. Cell., 12, 1843-1857, 2001

Wang, E, Pennington, J G, Goldenring, J R, Hunziker, W, Dunn, K W, . Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J Cell Sci, 114, 3309-21, 2001

Wang, E., Pennington, J.G., GOLDENRING, J.R., Hunziker, W. and Dunn, K.W. Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J. Cell Sci., 114, 3309-21, 2001

Bhartur, S G, Calhoun, B C, Woodrum, J, Kurkjian, J, Iyer, S, Lai, F, Goldenring, J R. Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun, 269(2), 611-7, 2000

Bhartur, S.G., Calhoun, B.C., Woodrum, J., Kurkjian, J., Iyer, S., Lai, F. and GOLDENRING, J.R. Genomic structure of murine Rab11 family members. Biochem. Biophys. Res. Commun, 269, 611-617, 2000

Burdick, J S, Chung, E, Tanner, G, Sun, M, Paciga, J E, Cheng, J Q, Washington, K, Goldenring, J R, Coffey, R J. Treatment of Menetrier's disease with a monoclonal antibody against the epidermal growth factor receptor. N Engl J Med, 343(23), 1697-701, 2000

Burdick, J.S., Chung, E., Lindberg, G., Tanner, G., Washington, K., GOLDENRING, J.R and Coffey, R.J. Treatament of Menetrier?s disease with a monoclonal antibody against epidermal growth factor receptor. New Eng. J. Med., 343, 1697-1701, 2000

GOLDENRING, J.R., Ray, G .S., Coffey, R.J., Jr., Meunier, P., Haley, P., Barnes, T.B., Car, B.D. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology, 118, 1080-1093, 2000

Goldenring, J R, Ray, G S, Coffey, R J, Meunier, P C, Haley, P J, Barnes, T B, Car, B D. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology, 118(6), 1080-93, 2000

Goldenring, J R, Ray, G S, Lee, J R. Rab11 in dysplasia of Barrett''s epithelia. Yale J Biol Med, 72(2-3), 113-20, 2000 PMCID:2579020

Lee, M P, Ravenel, J D, Hu, R J, Lustig, L R, Tomaselli, G, Berger, R D, Brandenburg, S A, Litzi, T J, Bunton, T E, Limb, C, Francis, H, Gorelikow, M, Gu, H, Washington, K, Argani, P, Goldenring, J R, Coffey, R J, Feinberg, A P. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest, 106(12), 1447-55, 2000 PMCID:387258

Lee, M.P., Ravenal, J.D., Hu, R., Lustig, L.R., Tomaeli, G., Brandenburg, S.A., Litzi, T.J., Bunton, T.E., Limb, C., Francis, H., Gorelikow, M., Gu, H., Washington, K., Argani, P., GOLDENRING, J.R., Coffey, R.J., and Feinberg, A.P. Targeted disruption of the Kvlqt1 gene cause deafness and gastric hyperplasia in mice. J. Clin. Invest., 106, 1447-1455, 2000

Wang, T C, Dangler, C A, Chen, D, Goldenring, J R, Koh, T, Raychowdhury, R, Coffey, R J, Ito, S, Varro, A, Dockray, G J, Fox, J G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology, 118(1), 36-47, 2000

Wang, T.C., Dangler, C.A., Chen, D., GOLDENRING, J.R., Koh, T., Raychowdhury, R., Coffey, R.J., Ito, S., Varro, A., Cockray, G.J. and Fox, J.G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a gastric cancer mouse model. Gastroenterology, 118, 36-47, 2000

Wang, X, Kumar, R, Navarre, J, Casanova, J E, Goldenring, J R. Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25. J Biol Chem, 275(37), 29138-46, 2000

Wang, X., Kumar, R., Navarre, J., Casanova, J.E. and GOLDENRING, J.R. Regulation of membrane trafficking in MDCK cells by Rab11a and Rab25. J. Biol. Chem., 275, 29138-29146, 2000

Casanova, J E, Wang, X, Kumar, R, Bhartur, S G, Navarre, J, Woodrum, J E, Altschuler, Y, Ray, G S, Goldenring, J R. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell, 10(1), 47-61, 1999 PMCID:25153

Casanova, J.E., Wang, X., Kumar, R., Bhartur, S.G., Navarre, J., Woodrum, J.E., Ray, G.S. and GOLDENRING, J.R. Rab11a and Rab25 association with the apical recycling system of polarized MDCK cells. Mol. Biol. Cell., 10, 47-61, 1999

Lapierre, L A, Tuma, P L, Navarre, J, Goldenring, J R, Anderson, J M. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. J Cell Sci, 112 ( Pt 21), 3723-32, 1999

Schmidt, P H, Dransfield, D T, Claudio, J O, Hawley, R G, Trotter, K W, Milgram, S L, Goldenring, J R. AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. J Biol Chem, 274(5), 3055-66, 1999

Schmidt, P H, Lee, J R, Joshi, V, Playford, R J, Poulsom, R, Wright, N A, Goldenring, J R. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest, 79(6), 639-46, 1999

Schmidt, P.H., Dransfield, D.T., Claudio, J.T., Hawley, R.G., Trotter, K.W., Milgram, S.L. and GOLDENRING, J.R. AKAP350: A multiply spliced A-kinase anchoring protein associated with centrosomes. J. Biol. Chem. , 274, 3055-3066, 1999

Schmidt, P.H., Lee, J.R., Joshi, V., Playford, R.J., Poulsom, R., Wright, N.A. and GOLDENRING, J.R. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab. Invest., 79, 639-646, 1999

Song, S Y, Gannon, M, Washington, M K, Scoggins, C R, Meszoely, I M, Goldenring, J R, Marino, C R, Sandgren, E P, Coffey, R J, Wright, C V, Leach, S D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999

Song, S.Y., Gannon, M., Washington, M.K., Scogins, C.R., Meszoely, I.M., GOLDENRING, J.R., Marino, C.R., Sandgren, E.P., Coffey, R.J., Jr., Wright, C.V.E. and Leach, S.D. Expansion of pdx1-expressing pancreatic epithelium and initiation of islet neogenesis in transgenic mice overexpressing TGF. Gastroenterology. , 117, 1416-1426, 1999

Bhartur, S G, Goldenring, J R. Mapping of ezrin dimerization using yeast two-hybrid screening. Biochem Biophys Res Commun, 243(3), 874-7, 1998

Calhoun, B C, Lapierre, L A, Chew, C S, Goldenring, J R. Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells. Am J Physiol, 275(1 Pt 1), C163-70, 1998

Calhoun, B.C. and GOLDENRING, J.R. Rab11 redistributes to the apical secretory canaliculus during stimulation of gastric parietal cells. Amer. J. Physiol., 275, C163-C170, 1998

Majumdar, A P, Goldenring, J R. Localization and significance of pp55, a gastric mucosal membrane protein with tyrosine kinase activity. Am J Physiol, 274(5 Pt 1), G863-70, 1998

Okamoto, C T, Karam, S M, Jeng, Y Y, Forte, J G, Goldenring, J R. Identification of clathrin and clathrin adaptors on tubulovesicles of gastric acid secretory (oxyntic) cells. Am J Physiol, 274(4 Pt 1), C1017-29, 1998

Okamoto, C. T., Karam, S. M., Jeng, Y. Y., Forte, J.G. and GOLDENRING, J.R. Identification of a clathrin adapter (AP-1)-related complex on tubulovesicles of gastric acid secretory (oxyntic) cells. Am. J. Physiol., 274, C1017-C1029, 1998

Wang, T C, Goldenring, J R, Dangler, C, Ito, S, Mueller, A, Jeon, W K, Koh, T J, Fox, J G. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology, 114(4), 675-89, 1998

Wang, T.C., GOLDENRING, J.R., Dangler, C., Millar, A., Jeon, W.K., Ito, S., Koh, T.J. and Fox, J.G. C57BL/6 mice deficient in secretory phospholipase A2 show increased apoptosis and altered cellular differentiation during Helicobacter felis infection. Gastroenterology, 114, 675-689, 1998

Beall, A C, Kato, K, Goldenring, J R, Rasmussen, H, Brophy, C M. Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein. J Biol Chem, 272(17), 11283-7, 1997

Calhoun, B C, Goldenring, J R. Rab proteins in gastric parietal cells: evidence for the membrane recycling hypothesis. Yale J Biol Med, 69(1), 1-8, 1997 PMCID:2588980

Calhoun, B C, Goldenring, J R. Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles. Biochem J, 325 ( Pt 2), 559-64, 1997 PMCID:1218595

Calhoun, B.C. and GOLDENRING, J.R. Two rab proteins, VAMP-2 and SCAMPs are present on immunoisolated parietal cell tubulovesicles. Biochem. J., 325, 559-564, 1997

Dransfield, D T, Bradford, A J, Smith, J, Martin, M, Roy, C, Mangeat, P H, Goldenring, J R. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J, 16(1), 35-43, 1997 PMCID:1169611

Dransfield, D T, Yeh, J L, Bradford, A J, Goldenring, J R. Identification and characterization of a novel A-kinase-anchoring protein (AKAP120) from rabbit gastric parietal cells. Biochem J, 322 ( Pt 3), 801-8, 1997 PMCID:1218258

Dransfield, D.T., Bradford, A.J., Martin, M., Mangeat, P.H. and GOLDENRING, J.R. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein (AKAP). EMBO J., 16, 35-43, 1997

Dransfield, D.T., Bradford, A.J., Yeh, J., and GOLDENRING, J.R. Identification and characterization of a novel A-kinase anchoring protein (AKAP120). Biochem J., 322, 801-807, 1997

Green, E G, Ramm, E, Riley, N M, Spiro, D J, Goldenring, J R, Wessling-Resnick, M. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem Biophys Res Commun, 239(2), 612-6, 1997

Green, E.G., Ramm, E., Riley, N.M., Spiro, D.J., Goldenring, J.R. and Wessling-Resnick, M. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem. Biophys. Res. Commun., 239, 612-617, 1997

Joshi, V, Ray, G S, Goldenring, J R. Inhibition of parietal cell acid secretion is mediated by the classical epidermal growth factor receptor. Dig Dis Sci, 42(6), 1194-8, 1997

Koh, T J, Goldenring, J R, Ito, S, Mashimo, H, Kopin, A S, Varro, A, Dockray, G J, Wang, T C. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology, 113(3), 1015-25, 1997

Ray, G S, Lee, J R, Nwokeji, K, Mills, L R, Goldenring, J R. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett''s epithelia. Lab Invest, 77(5), 503-11, 1997

Ray, G.S., Lee, J., Nwokeji, K., Mills, L. and GOLDENRING, J.R. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low grade dysplasic Barrett?s epithelia. Lab. Invest., 77, 503-511, 1997

Canfield, V, West, A B, Goldenring, J R, Levenson, R. Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. Proc Natl Acad Sci U S A, 93(6), 2431-5, 1996 PMCID:39814

GOLDENRING, J.R., Ray, G.S., Soroka, C.J., Smith, J., Modlin, I.M., Meise, K.S. and Coffey, R.J., Jr. Over-expression of transforming growth factor-alpha alters the differentiation of gastric cell lineages. Dig. Dis. Sci., 41, 773-784, 1996

GOLDENRING, J.R., Smith, J., Vaughan, H.D., Cameron, P., Hawkins, W. and Navarre, J. Rab11 is an apically located small GTP-binding protein in epithelial tissues. Amer. J. Physiol., 270, G515-G525, 1996

Goldenring, J R, Poulsom, R, Ray, G S, Wright, N, Meise, K S, Coffey, R J. Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha. Growth Factors, 13(1-2), 111-9, 1996

Goldenring, J R, Ray, G S, Soroka, C J, Smith, J, Modlin, I M, Meise, K S, Coffey, R J. Overexpression of transforming growth factor-alpha alters differentiation of gastric cell lineages. Dig Dis Sci, 41(4), 773-84, 1996

Goldenring, J R, Smith, J, Vaughan, H D, Cameron, P, Hawkins, W, Navarre, J. Rab11 is an apically located small GTP-binding protein in epithelial tissues. Am J Physiol, 270(3 Pt 1), G515-25, 1996

Matovcik, L M, Maranto, A R, Soroka, C J, Gorelick, F S, Smith, J, Goldenring, J R. Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. J Histochem Cytochem, 44, 1243-50, 1996

Modlin, I M, Zhu, Z, Tang, L H, Kidd, M, Lawton, G P, Miu, K, Powers, R E, Goldenring, J R, Pasikhov, D, Soroka, C J. Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia. Digestion, 57, 310-21, 1996

Navarre, J, Bradford, A J, Calhoun, B C, Goldenring, J R. Quenching of endogenous peroxidase in western blot. Biotechniques, 21(6), 990-2, 1996

Parente, J A, Goldenring, J R, Petropoulos, A C, Hellman, U, Chew, C S. Purification, cloning, and expression of a novel, endogenous, calcium-sensitive, 28-kDa phosphoprotein. J Biol Chem, 271(33), 20096-101, 1996

Parente, J.A., GOLDENRING, J.R., Petropoulos, A.C., Hellman, U. and Chew, C.S. Purification, cloning and expression of a novel endogenous, calcium-sensitive, 28 kDa phosphoprotein. J. Biol. Chem., 271, 20096-20101, 1996

Ray, G S, Jackson, M W, Goldenring, J R. Foveolar hyperplasia following partial gastrectomy results from expansion of surface mucous cell compartment. Dig Dis Sci, 41(10), 2016-24, 1996

Sheehan, D, Ray, G S, Calhoun, B C, Goldenring, J R. A somatodendritic distribution of Rab11 in rabbit brain neurons. Neuroreport, 7(7), 1297-300, 1996

Bergh, C M, Brophy, C M, Dransfield, D T, Lincoln, T, Goldenring, J R, Rasmussen, H. Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle. Am J Physiol, 268(1 Pt 2), H202-12, 1995

Dransfield, D T, Bradford, A J, Goldenring, J R. Distribution of A-kinase anchoring proteins in parietal cells. Biochim Biophys Acta, 1269(3), 215-20, 1995

Quin, J A, Sgambati, S A, Goldenring, J R, Basson, M D, Fielding, L P, Modlin, I M, Ballantyne, G H. PYY inhibition of VIP-stimulated ion transport in the rabbit distal ileum. J Surg Res, 58, 111-5, 1995

Tang, L H, Modlin, I M, Caulfield, T A, Goldenring, J R. A novel serine-specific kinase activity associated with exocrine secretory granules. Am J Physiol, 269, G481-9, 1995

GOLDENRING, J.R., Soroka, C.J., Shen, R.K., Tang, L.H., Rodriguez, W., Vaughan, J.D., Stoche, S.A. and Modlin, I.M. Enrichment of rab11, a low molecular weight GTPase, in gastric parietal cells. Amer. J. Physiol., 267, G187-G194, 1994

Goldenring, J R, Soroka, C J, Shen, K R, Tang, L H, Rodriguez, W, Vaughan, H D, Stoch, S A, Modlin, I M. Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells. Am J Physiol, 267(2 Pt 1), G187-94, 1994

Modlin, I M, Goldenring, J R, Lawton, G P, Hunt, R. Aspects of the theoretical basis and clinical relevance of low acid states. Am J Gastroenterol, 89(3), 308-18, 1994

Modlin, I M, Kumar, R R, Soroka, C J, Ahlman, H, Nilsson, O, Goldenring, J R. Histamine as an intermediate growth factor in genesis of gastric ECLomas associated with hypergastrinemia in mastomys. Dig Dis Sci, 39(7), 1446-53, 1994

Ballantyne, G H, Goldenring, J R, Fleming, F X, Rush, S, Flint, J S, Fielding, L P, Binder, H J, Modlin, I M. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. Am J Physiol, 264(5 Pt 1), G848-54, 1993

Ballantyne, G H, Goldenring, J R, Savoca, P E, Kranz, H K, Adrian, T E, Bilchik, A J, Modlin, I M. Cyclic AMP-mediated release of peptide YY (PYY) from the isolated perfused rabbit distal colon. Regul Pept, 47(2), 117-26, 1993

Chough, S P, Goldenring, J R, Hurst, R D, Ballantyne, G H, Modlin, I M. Calcium modulation of the effects of serotonin, carbachol, and histamine on rabbit ileal ion transport. Yale J Biol Med, 66(6), 525-40, 1993 PMCID:2588855

GOLDENRING, J.R., Shen, R.K., Vaughan, H.D. and Modlin, I.M. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney and lung. J. Biol. Chem., 268, 18419-18422, 1993

Goldenring, J R, Shen, K R, Vaughan, H D, Modlin, I M. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem, 268(25), 18419-22, 1993

Goldenring, J R, Tsunoda, Y, Stoch, S A, Coffey, R J, Modlin, I M. Transforming growth factor-alpha (TGF alpha) inhibition of parietal cell secretion: structural requirements for activity. Regul Pept, 43(1-2), 37-47, 1993

Mamiya, N, Goldenring, J R, Tsunoda, Y, Modlin, I M, Yasui, K, Usuda, N, Ishikawa, T, Natsume, A, Hidaka, H. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93. Biochem Biophys Res Commun, 195(2), 608-15, 1993

Matovcik, L M, Haimowitz, B, Goldenring, J R, Czernik, A J, Gorelick, F S. Distribution of calcium/calmodulin-dependent protein kinase II in rat ileal enterocytes. Am J Physiol, 264(4 Pt 1), C1029-36, 1993

Soroka, C J, Chew, C S, Hanzel, D K, Smolka, A, Modlin, I M, Goldenring, J R. Characterization of membrane and cytoskeletal compartments in cultured parietal cells: immunofluorescence and confocal microscopic examination. Eur J Cell Biol, 60(1), 76-87, 1993

Soroka, C.J., Chew, C.S., Modlin, I.M., Hanzel, D., Smolka, A. and GOLDENRING, J.R. Characterization of membrane and cytoskeletal compartments in cultured parietal cells using immunofluoresence and confocal microscopy. Eur. J. Cell Biol., 60, 76-87, 1993

Tang, L H, Miller, M D, Goldenring, J R, Modlin, I M, Hersey, S J. Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion. Am J Physiol, 265(5 Pt 1), G865-72, 1993

Tsunoda, Y, Modlin, I M, Goldenring, J R. Tyrosine kinase activities in the modulation of stimulated parietal cell acid secretion. Am J Physiol, 264(2 Pt 1), G351-6, 1993

Tsunoda, Y., Modlin, I.M. and GOLDENRING, J.R. Tyrosine kinase activities in the modulation of stimulated parietal cell secretion. Am. J. Physiol., 264, G351-G356, 1993

Dempsey, P J, Goldenring, J R, Soroka, C J, Modlin, I M, McClure, R W, Lind, C D, Ahlquist, D A, Pittelkow, M R, Lee, D C, Sandgren, E P. Possible role of transforming growth factor alpha in the pathogenesis of M??n??trier''s disease: supportive evidence form humans and transgenic mice. Gastroenterology, 103(6), 1950-63, 1992

Funasaka, M, Fox, L M, Tang, L H, Modlin, I M, Goldenring, J R. The major calmodulin-binding protein in rabbit parietal cells is Ca2+/calmodulin-dependent protein kinase II. Biochem Int, 27(6), 1101-9, 1992

GOLDENRING, J.R., Asher, V.A., Barreuther, M.F., Lewis, J.J., Lohmann, S., Walter, U. and Modlin, I.M. Stimulation of isolated gastric parietal cells activates dephosphorylation of membrane-bound Type II regulatory subunit of cyclic AMP-dependent protein kinase. Am. J. Physiol., 279, 763-773, 1992

Goldenring, J R, Asher, V A, Barreuther, M F, Lewis, J J, Lohmann, S M, Walter, U, Modlin, I M. Dephosphorylation of cAMP-dependent protein kinase regulatory subunit in stimulated parietal cells. Am J Physiol, 262(4 Pt 1), G763-73, 1992

Goldenring, J R, Tang, L H, Modlin, I M. Small GTP-binding proteins in parietal cells: candidate modulators of parietal cell membrane dynamics. Yale J Biol Med, 65(6), 597-605, 1992 PMCID:2589774

Modlin, I M, Kumar, R, Nangia, A, Soroka, C J, Pasikhov, D, Goldenring, J R. Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas. Surgery, 112(6), 1048-56; discussion 1056-8, 1992

Reubi, J C, Waser, B, Horisberger, U, Halter, F, Soroka, C J, Kumar, R R, Goldenring, J R, Modlin, I M. Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors. Endocrinology, 131(1), 166-72, 1992

Tang, L H, Stoch, S A, Modlin, I M, Goldenring, J R. Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells. Biochem J, 285 ( Pt 3), 715-9, 1992 PMCID:1132853

Tang, L.H., Stoch, S.A., Modlin, I.M. and GOLDENRING, J.R. Identification of rab2 as a tubulovesicle-membrane associated protein in rabbit parietal cells. Biochem. J., 285, 715-719, 1992

Tsunoda, Y, Funasaka, M, Modlin, I M, Hidaka, H, Fox, L M, Goldenring, J R. An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion. Am J Physiol, 262(1 Pt 1), G118-22, 1992

Basson, M D, Goldenring, J R, Tang, L H, Lewis, J J, Padfield, P, Jamieson, J D, Modlin, I M. Redistribution of 23 kDa tubulovesicle-associated GTP-binding proteins during parietal cell stimulation. Biochem J, 279 ( Pt 1), 43-8, 1991 PMCID:1151544

Basson, M.D., GOLDENRING, J.R., Tang, L.H., Lewis, J.J., Padfield, P., Jamieson, J.J. and Modlin, I.M. Movement of a 23 kDa tubulovesicle-associated GTP-binding protein during parietal cell stimulation. Biochem. J., 279, 43-48, 1991

Modlin, I M, Esterline, W, Kim, H, Goldenring, J R. Enterochromaffin-like cells and gastric argyrophil carcinoidosis. Acta Oncol, 30(4), 493-8, 1991

Nilsson, O, Bilchik, A J, Goldenring, J R, Ballantyne, G H, Adrian, T E, Modlin, I M. Distribution and immunocytochemical colocalization of peptide YY and enteroglucagon in endocrine cells of the rabbit colon. Endocrinology, 129(1), 139-48, 1991

Flint, J S, Ballantyne, G H, Goldenring, J R, Fielding, L P, Modlin, I M. Neuropeptide Y inhibition of vasoactive intestinal polypeptide-stimulated ion transport in the rabbit distal colon. Arch Surg, 125(12), 1561-3, 1990

Lewis, J J, Goldenring, J R, Asher, V A, Modlin, I M. Effects of epidermal growth factor on signal transduction in rabbit parietal cells. Am J Physiol, 258(3 Pt 1), G476-83, 1990

Lewis, J J, Goldenring, J R, Modlin, I M, Coffey, R J. Inhibition of parietal cell H+ secretion by transforming growth factor alpha: a possible autocrine regulatory mechanism. Surgery, 108(2), 220-6; discussion 226-7, 1990

Lewis, J.J., GOLDENRING, J.R., Asher, V.A. and Modlin, I.M. The effects of epidermal growth factor (EGF) on signal transduction in the rabbit parietal cell. Amer. J. Physiol., 258, G476-483, 1990

Adrian, T E, Goldenring, J R, Oddsdottir, M, Zdon, M J, Zucker, K A, Lewis, J J, Modlin, I M. A micromethod for the assay of cellular secretory physiology: application to rabbit parietal cells. Anal Biochem, 182(2), 346-52, 1989

Adrian, T.E., GOLDENRING, J.R., Oddsdottir, M., Zdon, M.J., Zucker, K.A., Lewis, J.J., Modlin, I. M. A micromethod for the assay of cellular secretory physiology: Application to rabbit parietal cells. Anal. Biochem., 182, 346-352, 1989

Goldenring, J R, Cahow, C E. Intrahepatic cholangiojejunostomy as a palliative procedure in primary sclerosing cholangitis. Arch Surg, 124(5), 565-7, 1989

Lewis, J J, Goldenring, J R, Asher, V A, Modlin, I M. Pancreastatin: a novel peptide inhibitor of parietal cell signal transduction. Biochem Biophys Res Commun, 163(2), 667-73, 1989

Oddsdottir, M, Goldenring, J R, Adrian, T E, Zdon, M J, Zucker, K A, Modlin, I M. Identification and characterization of a cytosolic 30 kDa histamine stimulated phosphoprotein in parietal cell cytosol. Biochem Biophys Res Commun, 154(2), 489-96, 1988

Goldenring, J R, Oddsdottir, M, Modlin, I M. A novel protein kinase activity in rabbit gastric gland cytosol. Biochem Biophys Res Commun, 142(2), 559-66, 1987

Kreutter, D, Kim, J Y, Goldenring, J R, Rasmussen, H, Ukomadu, C, DeLorenzo, R J, Yu, R K. Regulation of protein kinase C activity by gangliosides. J Biol Chem, 262(4), 1633-7, 1987

Modlin, I M, Oddsdottir, M, Adrian, T E, Zdon, M J, Zucker, K A, Goldenring, J R. A specific histamine-stimulated phosphoprotein in isolated parietal cells. J Surg Res, 42(4), 348-53, 1987

Oddsdottir, M, Modlin, I M, Zucker, K A, Zdon, M J, Goldenring, J R. A calmodulin dependent protein kinase in parietal cells. Biochem Biophys Res Commun, 148(3), 1390-7, 1987

Taft, W C, Goldenring, J R, DeLorenzo, R J. Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity. Adv Exp Med Biol, 221, 409-25, 1987

GOLDENRING, J.R., Lasher, R.S., Vallano, M.L., Udea, T., Naito, S., Sternberger, N.H., Sternberger, L.A. and DeLorenzo, R.J. Association of synapsin I with neuronal cytoskeleton: Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J. Biol. Chem., 261, 8495 8504, 1986

Goldenring, J R, DeLorenzo, R J. Phosphorylation of MAP-2 at distinct sites by calmodulin- and cyclic AMP-dependent kinases. Ann N Y Acad Sci, 466, 457-9, 1986

Goldenring, J R, Lasher, R S, Vallano, M L, Ueda, T, Naito, S, Sternberger, N H, Sternberger, L A, DeLorenzo, R J. Association of synapsin I with neuronal cytoskeleton. Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J Biol Chem, 261(18), 8495-504, 1986

Goldenring, J R, Modlin, I M, Tyshkov, M, Zdon, M J, Schafer, D E, Ballantyne, G H. A manganese-dependent protein kinase in gastric gland cytosol. Surgery, 100(2), 181-7, 1986

Goldenring, J R, Vallano, M L, Lasher, R S, Ueda, T, DeLorenzo, R J. Association of calmodulin-dependent kinase II and its substrate proteins with neuronal cytoskeleton. Prog Brain Res, 69, 341-54, 1986

Goldenring, J R, Wasterlain, C G, Oestreicher, A B, de Graan, P N, Farber, D B, Glaser, G, DeLorenzo, R J. Kindling induces a long-lasting change in the activity of a hippocampal membrane calmodulin-dependent protein kinase system. Brain Res, 377(1), 47-53, 1986

Kim, J Y, Goldenring, J R, DeLorenzo, R J, Yu, R K. Gangliosides inhibit phospholipid-sensitive Ca2+-dependent kinase phosphorylation of rat myelin basic proteins. J Neurosci Res, 15(2), 159-66, 1986

Sakakibara, M, Alkon, D L, DeLorenzo, R, Goldenring, J R, Neary, J T, Heldman, E. Modulation of calcium-mediated inactivation of ionic currents by Ca2+/calmodulin-dependent protein kinase II. Biophys J, 50(2), 319-27, 1986 PMCID:1329748

Vallano, M L, Goldenring, J R, Lasher, R S, Delorenzo, R J. Association of calcium/calmodulin-dependent kinase with cytoskeletal preparations: phosphorylation of tubulin, neurofilament, and microtubule-associated proteins. Ann N Y Acad Sci, 466, 357-74, 1986

Billingsley, M L, Velletri, P A, Lovenberg, W, Kuhn, D, Goldenring, J R, DeLorenzo, R J. Is Ca2+-calmodulin-dependent protein phosphorylation in rat brain modulated by carboxylmethylation. J Neurochem, 44(5), 1442-50, 1985

GOLDENRING, J.R., Vallano, M.L. and DeLorenzo, R.J. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J. Neurochem., 45, 900-905, 1985

Goldenring, J R, Otis, L C, Yu, R K, DeLorenzo, R J. Calcium/ganglioside-dependent protein kinase activity in rat brain membrane. J Neurochem, 44(4), 1229-34, 1985

Goldenring, J R, Vallano, M L, DeLorenzo, R J. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J Neurochem, 45(3), 900-5, 1985

Larson, R E, Goldenring, J R, Vallano, M L, DeLorenzo, R J. Identification of endogenous calmodulin-dependent kinase and calmodulin-binding proteins in cold-stable microtubule preparations from rat brain. J Neurochem, 44(5), 1566-74, 1985

Vallano, M L, Goldenring, J R, Buckholz, T M, Larson, R E, DeLorenzo, R J. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc Natl Acad Sci U S A, 82(10), 3202-6, 1985 PMCID:397743

Vallano, M.L., GOLDENRING, J.R., Buckholz, T.M., Larson, R.E. and DeLorenzo, R.J. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc. Natl. Acad. Sci., USA., 82, 3202-3206, 1985

Goldenring, J R, Casanova, J E, DeLorenzo, R J. Tubulin-associated calmodulin-dependent kinase: evidence for an endogenous complex of tubulin with a calcium-calmodulin-dependent kinase. J Neurochem, 43(6), 1669-79, 1984

Goldenring, J R, McGuire, J S, DeLorenzo, R J. Identification of the major postsynaptic density protein as homologous with the major calmodulin-binding subunit of a calmodulin-dependent protein kinase. J Neurochem, 42(4), 1077-84, 1984

GOLDENRING, J.R., Gonzalez, B., McGuire, J.S., Jr. and DeLorenzo, R.J. 258: 12632-12640. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule associated proteins. . J. Biol. Chem., 258, 12632-12640, 1983

Goldenring, J R, Gonzalez, B, McGuire, J S, DeLorenzo, R J. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins. J Biol Chem, 258(20), 12632-40, 1983

Goldenring, J R, Batter, D K, Shaywitz, B A. Sulfanilic acid: behavioral change related to azo food dyes in developing rats. Neurobehav Toxicol Teratol, 4(1), 43-9, 1982

Goldenring, J R, Gonzalez, B, DeLorenzo, R J. Isolation of brain Ca2+-calmodulin tubulin kinase containing calmodulin binding proteins. Biochem Biophys Res Commun, 108(1), 421-8, 1982

Goldenring, J R, Shaywitz, B A, Wool, R S, Batter, D K, Anderson, G M, Cohen, D J. Environmental and biologic interactions on behavior: effects of artificial rearing in rat pups treated with 6-hydroxydopamine. Dev Psychobiol, 15(4), 297-307, 1982

Goldenring, J R, Wool, R S, Shaywitz, B A, Batter, D K, Cohen, D J, Young, J G, Teicher, M H. Effects of continuous gastric infusion of food dyes on developing rat pups. Life Sci, 27(20), 1897-904, 1980

Shaywitz, B A, Goldenring, J R, Wool, R S. Effects of chronic administration of food colorings on activity levels and cognitive performance in developing rat pups treated with 6-hydroxydopamine. Neurobehav Toxicol, 1(1), 41-7, 1979


Postdoctoral Position Available
Yes

Postdoctoral Position Details
1) Postdoctoral Associate Position Available

Research in an NIH-funded program to investigate the roles of A-kinase Anchoring Protein 350 (AKAP350), a large multi-functional scaffolding protein, in regulation of RNA trafficking. RNA trafficking studies seek to examine the role of AKAP350 and its associated proteins CCAR1 and caprin-1 in microtubule dependent RNA movement in cells under both baseline physiology and stress. Studies involve a range of cell biological techniques including subcellular fractionation, live cell microscopy and confocal fluorescence microscopy. Biochemical techniques include yeast two-hybrid approaches (both conventional and split ubiquitin), direct protein interaction studies and analysis of 3''''-untranslated region interactions with protein including live cell imaging of RNA movement. Studies will also seek to evaluate the role of AKAP350 in speciific tissues using a newly developed knockout mouse modelSalary commensurate with experience.

Contact: James R. Goldenring, MD, PhD, Epithelial Biology Center, MRB IV, Rm 10435G, Vanderbilt University School of Medicine, 2213 Garland Ave, S., Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.

2) Postdoctoral Associate Positions Available

Research in an NIH-funded program to investigate the Roles of class V myosin motors in regulating membrane trafficking. Projects are focused on determining the structural basis of myosin Vb interaction with Rab proteins and their effectors using recombinant proteins co-expressed in bacteria as a substrate fo r structure determinations by crystallography and/or cryo-EM. Salary commensurate with experience.

Contact: James R. Goldenring, MD, PhD, Epithelial Biology Center, MRB IV, Rm 10435G, Vanderbilt University School of Medicine, 2213 Garland Ave, S., Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.


Updated Date
08/25/2011