Biomedical Research Education & Training
Faculty Member

Hayward, Simon William, Ph.D.
Adjunct Professor of Urologic Surgery

Lab Url: N/A

Phone Number: 322-5823

Email Address:

Hayward, Simon's picture
Academic history
B.Sc., University of London
M.Sc., University of London
Ph.D., Imperial Cancer Research Fund

Office Address   Mailing Address

MCN T1120

A1302 MCN 2765

Research Keywords
Stromal-epithelial interactions, Prostate, Cancer, Endocrinology, Gene regulation, Immortalization, Malignancy, Mouse, Pathology, Reproduction, Stem cells, Transformation, Virus

Research Specialty
Prostate cancer, Stromal-epithelial interactions, in vivo models, tissue recombination, retroviral vectors.

Research Description
Research interests in my laboratory center around the relationships between the various cell types which comprise developing and adult prostate and the ways in which these change in development, benign disease and carcinogenesis. We can understand many aspects of biology only in a "whole organism" context and thus to examine these complex intercellular interaction problems in vivo models are essential. We use a number of different in vivo systems including xenografts of benign and malignant human tissues and applications of tissue recombination technology, an expertise for which we have been recognized by the National Cancer Institute as a national training resource.

Stromal-epithelial interactions are central determinants of organogenesis, development, and growth quiescence in adulthood. Such interactions also play a pivotal role in cancer progression. Stromal cells surrounding prostate tumors act to promote the growth of cancer foci. Much of the current work in the laboratory centers around the elucidating the mechanisms underlying this process. We are beginning to appreciate that signaling occurs between many different cell types. Previous studies have focussed upon paracrine signaling between stromal and epithelial cell populations, however we are now also starting to appreciate the role of juxtacrine signaling between different populations of stromal cells in informing the overall paracrine signaling environment. One of the long term aims of this laboratory is to understand the nature of these interactions and thus identify targets which direct therapy at the stromal compartment of the affected organ rather than at the tumor epithelium. This brings the prospect of perhaps restraining tumor growth and turning cancer into a chronic but treatable disease.

Tissue recombination and grafting, allows us to "mix and match" stromal and epithelial cells from different sources (different species, tissues and disease states) and to grow these in immunocompromised mice. We are able to genetically manipulate cells, either expressing or suppressing genes of interest in specific cell populations or sub-populations, to examine tissue specific gene functions. A number of examples of this technique are described in the references below.

Current projects in the laboratory include an examination of the role of TGF? signaling as a master regulator of the tumor microenvironment in prostatic carcinogenesis. This work is a part of the National Cancer Institute?s Tumor Microenvironment Network, a multi-center program which, at Vanderbilt, includes the Matrisian, Moses, Mundy, Bhowmick and Hayward laboratories. We are also interested in the role of TGF? signaling in benign prostatic hyperplasia. Additional projects include explorations of the potential of various oncogenes expressed in either stromal or epithelial cells to promote prostatic carcinogenesis and an examination of the potential of regulation of PPAR-gamma as a chemopreventive approach to prostate cancer.

Pruitt, FL, He, Y, Franco, OE, Jiang, M, Cates, JM, Hayward, SW. Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium. Prostate, 73(5), 476-88, 2013

Stephany, HA, Strand, DW, Ching, CB, Tanaka, ST, Milne, GL, Cajaiba, MM, Thomas, JC, Pope, JC, Adams, MC, Brock, JW, Hayward, SW, Matusik, RJ, Clayton, DB. Chronic cyclic bladder over distention up-regulates hypoxia dependent pathways. J Urol, 190(4 Suppl), 1603-9, 2013

Strand, DW, DeGraff, DJ, Jiang, M, Sameni, M, Franco, OE, Love, HD, Hayward, WJ, Lin-Tsai, O, Wang, AY, Cates, JM, Sloane, BF, Matusik, RJ, Hayward, SW. Deficiency in metabolic regulators PPAR?? and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration. Am J Pathol, 182(2), 449-59, 2013

Xiang, Y, Qiu, Q, Jiang, M, Jin, R, Lehmann, BD, Strand, DW, Jovanovic, B, Degraff, DJ, Zheng, Y, Yousif, DA, Simmons, CQ, Case, TC, Yi, J, Cates, JM, Virostko, J, He, X, Jin, X, Hayward, SW, Matusik, RJ, George, AL, Yi, Y. SPARCL1 suppresses metastasis in prostate cancer. Mol Oncol, 2013

Anderson, PD, McKissic, SA, Logan, M, Roh, M, Franco, OE, Wang, J, Doubinskaia, I, van der Meer, R, Hayward, SW, Eischen, CM, Eltoum, IE, Abdulkadir, SA. Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J Clin Invest, 122(5), 1907-19, 2012

Franco, OE, Hayward, SW. Targeting the tumor stroma as a novel therapeutic approach for prostate cancer. Adv Pharmacol, 65, 267-313, 2012

Li, X, Sterling, JA, Fan, KH, Vessella, RL, Shyr, Y, Hayward, SW, Matrisian, LM, Bhowmick, NA. Loss of TGF-?? responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res, 10(4), 494-503, 2012

Strand, DW, Jiang, M, Murphy, TA, Yi, Y, Konvinse, KC, Franco, OE, Wang, Y, Young, JD, Hayward, SW. PPAR?? isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation. Cell Death Dis, 3, e361, 2012

Franco, OE, Jiang, M, Strand, DW, Peacock, J, Fernandez, S, Jackson, RS, Revelo, MP, Bhowmick, NA, Hayward, SW. Altered TGF-I? signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis. Cancer Res, 71(4), 1272-81, 2011 PMCID:3097930

Jiang, M, Strand, DW, Franco, OE, Clark, PE, Hayward, SW. PPARI?: A molecular link between systemic metabolic disease and benign prostate hyperplasia. Differentiation, 2011

Kiskowski, MA, Jackson, RS, Banerjee, J, Li, X, Kang, M, Iturregui, JM, Franco, OE, Hayward, SW, Bhowmick, NA. Role for stromal heterogeneity in prostate tumorigenesis. Cancer Res, 71(10), 3459-70, 2011 PMCID:3097930

Franco, OE, Shaw, AK, Strand, DW, Hayward, SW. Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol, 21(1), 33-9, 2010 PMCID:2823834

Hayward, SW. Preclinical assessment of fibroblast activation protein as a target for antitumor therapy. Future Oncol, 6(3), 347-9, 2010 PMCID:3097930

Jiang, M, Fernandez, S, Jerome, WG, He, Y, Yu, X, Cai, H, Boone, B, Yi, Y, Magnuson, MA, Roy-Burman, P, Matusik, RJ, Shappell, SB, Hayward, SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ, 17(3), 469-81, 2010 PMCID:2821953

Jiang, M, Jerome, WG, Hayward, SW. Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis. Autophagy, 6(1), 175-6, 2010 PMCID:2962907

Jiang, M, Min, Y, Debusk, L, Fernandez, S, Strand, DW, Hayward, SW, Lin, PC. Spontaneous immortalization of human dermal microvascular endothelial cells. World J Stem Cells, 2(5), 114-20, 2010 PMCID:3097930

Jiang, M, Strand, DW, Fernandez, S, He, Y, Yi, Y, Birbach, A, Qiu, Q, Schmid, J, Tang, DG, Hayward, SW. Functional remodeling of benign human prostatic tissues in vivo by spontaneously immortalized progenitor and intermediate cells. Stem Cells, 28(2), 344-56, 2010 PMCID:2962907

Strand, DW, Franco, OE, Basanta, D, Anderson, AR, Hayward, SW. Perspectives on tissue interactions in development and disease. Curr Mol Med, 10(1), 95-112, 2010 PMCID:3097930

Strand, DW, Hayward, SW. Modeling stromal-epithelial interactions in disease progression. Discov Med, 9(49), 504-11, 2010 PMCID:3097930

Tanaka, ST, Ishii, K, Demarco, RT, Pope, JC, Brock, JW, Hayward, SW. Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interaction. J Urol, 183(1), 386-91, 2010 PMCID:2794964

Wang, J, Kim, J, Roh, M, Franco, OE, Hayward, SW, Wills, ML, Abdulkadir, SA. Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma. Oncogene, 29(17), 2477-87, 2010 PMCID:2861731

Anumanthan, G, Tanaka, ST, Adams, CM, Thomas, JC, Wills, ML, Adams, MC, Hayward, SW, Matusik, RJ, Bhowmick, NA, Brock, JW, Pope, JC. Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. J Urol, 182(4 Suppl), 1775-80, 2009 PMCID:2821953

Love, HD, Booton, SE, Boone, BE, Breyer, JP, Koyama, T, Revelo, MP, Shappell, SB, Smith, JR, Hayward, SW. Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer. PLoS One, 4(12), e8384, 2009 PMCID:2793011

Jin, RJ, Lho, Y, Wang, Y, Ao, M, Revelo, MP, Hayward, SW, Wills, ML, Logan, SK, Zhang, P, Matusik, RJ. Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res, 68(10), 3601-8, 2008

Mullins, C, Lucia, MS, Hayward, SW, Lee, JY, Levitt, JM, Lin, VK, Liu, BC, Chinnaiyan, AM, Rubin, MA, Slawin, K, Star, RA, Getzenberg, RH, , . A comprehensive approach toward novel serum biomarkers for benign prostatic hyperplasia: the MPSA Consortium. J Urol, 179(4), 1243-56, 2008

Placencio, VR, Sharif-Afshar, AR, Li, X, Huang, H, Uwamariya, C, Neilson, EG, Shen, MM, Matusik, RJ, Hayward, SW, Bhowmick, NA. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res, 68(12), 4709-18, 2008

Ao, M, Franco, OE, Park, D, Raman, D, Williams, K, Hayward, SW. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res, 67(9), 4244-53, 2007

Cannon, GW, Mullins, C, Lucia, MS, Hayward, SW, Lin, V, Liu, BC, Slawin, K, Rubin, MA, Getzenberg, RH. A preliminary study of JM-27: a serum marker that can specifically identify men with symptomatic benign prostatic hyperplasia. J Urol, 177(2), 610-4; discussion 614, 2007

He, Y, Franco, OE, Jiang, M, Williams, K, Love, HD, Coleman, IM, Nelson, PS, Hayward, SW. Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression. Cancer Res, 67(17), 8188-97, 2007

Oottamasathien, S, Wang, Y, Williams, K, Franco, OE, Wills, ML, Thomas, JC, Saba, K, Sharif-Afshar, AR, Makari, JH, Bhowmick, NA, Demarco, RT, Hipkens, S, Magnuson, M, Brock, JW, Hayward, SW, Pope, JC, Matusik, RJ. Directed differentiation of embryonic stem cells into bladder tissue. Dev Biol, 2007 PMCID:1994155

Oottamasathien, S, Williams, K, Franco, OE, Wills, ML, Thomas, JC, Sharif-Afshar, AR, DeMarco, RT, Brock, JW, Bhowmick, NA, Hayward, SW, Pope, JC. Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model. J Urol, 178(4 Pt 2), 1643-9, 2007

Vanpoucke, G, Orr, B, Grace, OC, Chan, R, Ashley, GR, Williams, K, Franco, OE, Hayward, SW, Thomson, AA. Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease. Genome Biol, 8(10), R213, 2007 PMCID:2246287

Ao, M, Williams, K, Bhowmick, NA, Hayward, SW. Transforming Growth Factor-{beta} Promotes Invasion in Tumorigenic but not in Nontumorigenic Human Prostatic Epithelial Cells. Cancer Res, 66(16), 8007-16, 2006

Oottamasathien, S, Williams, K, Franco, OE, Thomas, JC, Saba, K, Bhowmick, NA, Staack, A, Demarco, RT, Brock, JW, Hayward, SW, Pope, JC. Bladder tissue formation from cultured bladder urothelium. Dev Dyn, 235(10), 2795-801, 2006

Sun, H, Chang, Y, Schweers, B, Dyer, MA, Zhang, X, Hayward, SW, Goodrich, DW. An E2F Binding-Deficient Rb1 Protein Partially Rescues Developmental Defects Associated with Rb1 Nullizygosity. Mol Cell Biol, 26(4), 1527-37, 2006 PMCID:1367194

Wang, Y, Kasper, S, Yuan, J, Jin, RJ, Zhang, J, Ishii, K, Wills, ML, Hayward, SW, Matusik, RJ. Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer. Lab Invest, 86(10), 1074-88, 2006

Cheng, N, Bhowmick, NA, Chytil, A, Gorksa, AE, Brown, KA, Muraoka, R, Arteaga, CL, Neilson, EG, Hayward, SW, Moses, HL. Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene, 24, 5053-5068, 2005

Davis, JN, McCabe, MT, Hayward, SW, Park, JM, Day, ML. Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells. Cancer Res, 65(9), 3633-42, 2005

Gao, N, Ishii, K, Mirosevich, J, Kuwajima, S, Oppenheimer, SR, Roberts, RL, Jiang, M, Yu, X, Shappell, SB, Caprioli, RM, Stoffel, M, Hayward, SW, Matusik, RJ. Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development, 132(15), 3431-43, 2005

Ishii, K, Shappell, SB, Matusik, RJ, Hayward, SW. Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma. Lab Invest, 85, 1086-1103, 2005

Joesting, MS, Perrin, S, Elenbaas, B, Fawell, SE, Rubin, JS, Franco, OE, Hayward, SW, Cunha, GR, Marker, PC. Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res, 65(22), 10423-30, 2005

Ricke, WA, Ishii, K, Ricke, EA, Simko, J, Wang, Y, Hayward, SW, Cunha, GR. Steroid hormones stimulate human prostate cancer progression and metastasis. Int J Cancer, 2005

Ricke, WA, Wang, Y, Kurita, T, Hayward, SW, Cunha, GR. Hormonal and stromal regulation of normal and neoplastic prostatic growth. Prog Mol Subcell Biol, 40, 183-216, 2005

Staack, A, Hayward, SW, Baskin, LS, Cunha, GR. Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration. Differentiation, 73(4), 121-33, 2005

Wang, Y, Revelo, MP, Sudilovsky, D, Cao, M, Chen, WG, Goetz, L, Xue, H, Sadar, M, Shappell, SB, Cunha, GR, Hayward, SW. Development and characterization of efficient xenograft models for benign and malignant human prostate tissue. Prostate, 64(2), 149-59, 2005

Wang, Y, Xue, H, Cutz, JC, Bayani, J, Mawji, NR, Chen, WG, Goetz, LJ, Hayward, SW, Sadar, MD, Gilks, CB, Gout, PW, Squire, JA, Cunha, GR, Wang, YZ. An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab Invest, 85(11), 1392-404, 2005

Williams, K, Fernandez, S, Stien, X, Ishii, K, Love, HD, Lau, YF, Roberts, RL, Hayward, SW. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. Prostate, 63(4), 369-84, 2005

Cunha, GR, Ricke, W, Thomson, A, Marker, PC, Risbridger, G, Hayward, SW, Wang, YZ, Donjacour, AA, Kurita, T. Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development. J Steroid Biochem Mol Biol, 92(4), 221-36, 2004

Ishii, Kenichiro, Otsuka, Takashi, Iguchi, Kazuhiro, Usui, Shigeyuki, Yamamoto, Hajime, Sugimura, Yoshiki, Yoshikawa, Kazuhiro, Hayward, Simon W, Hirano, Kazuyuki. Evidence that the prostate-specific antigen (PSA)/Zn2+ axis may play a role in human prostate cancer cell invasion. Cancer Lett, 207(1), 79-87, 2004

Jiang, Ming, Shappell, Scott B, Hayward, Simon W. Approaches to understanding the importance and clinical implications of peroxisome proliferator-activated receptor gamma (PPARgamma) signaling in prostate cancer. J Cell Biochem, 91(3), 513-27, 2004

Jin, RJ, Wang, Y, Masumori, N, Ishii, K, Tsukamoto, T, Shappell, SB, Hayward, SW, Kasper, S, Matusik, RJ. NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Cancer Res, 64(15), 5489-95, 2004

Cunha, Gerald R, Hayward, Simon W, Wang, Y Z, Ricke, William A. Role of the stromal microenvironment in carcinogenesis of the prostate. Int J Cancer, 107(1), 1-10, 2003

Hayward, Simon W, Wang, Yuzhuo, Day, Mark L. Rescue and isolation of Rb-deficient prostate epithelium by tissue recombination. Methods Mol Biol, 218, 17-33, 2003

Staack, Andrea, Kassis, Adrienne P, Olshen, Adam, Wang, Yuzhuo, Wu, David, Carroll, Peter R, Grossfeld, Gary D, Cunha, Gerald R, Hayward, Simon W. Quantitation of apoptotic activity following castration in human prostatic tissue in vivo. Prostate, 54(3), 212-9, 2003

Cunha, Gerald R, Hayward, Simon W, Wang, Y Z. Role of stroma in carcinogenesis of the prostate. Differentiation, 70(9-10), 473-85, 2002

Day, Kathleen C, McCabe, Michael T, Zhao, Xin, Wang, Yuzhuo, Davis, Joanne N, Phillips, John, Von Geldern, Marion, Ried, Thomas, KuKuruga, Mark A, Cunha, Gerald R, Hayward, Simon W, Day, Mark L. Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis. J Biol Chem, 277(46), 44475-84, 2002

Hayward, Simon W. Approaches to modeling stromal-epithelial interactions. J Urol, 168(3), 1165-72, 2002

Kim, Minjung J, Bhatia-Gaur, Rajula, Banach-Petrosky, Whitney A, Desai, Nishita, Wang, Yuzhuo, Hayward, Simon W, Cunha, Gerald R, Cardiff, Robert D, Shen, Michael M, Abate-Shen, Cory. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res, 62(11), 2999-3004, 2002

Shou, Jianyong, Soriano, Robert, Hayward, Simon W, Cunha, Gerald R, Williams, P Mickey, Gao, Wei-Qiang. Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A, 99(5), 2830-5, 2002 PMCID:122433

Cunha, G R, Wang, Y Z, Hayward, S W, Risbridger, G P. Estrogenic effects on prostatic differentiation and carcinogenesis. Reprod Fertil Dev, 13(4), 285-96, 2001

Hayward, S W, Wang, Y, Cao, M, Hom, Y K, Zhang, B, Grossfeld, G D, Sudilovsky, D, Cunha, G R. Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res, 61(22), 8135-42, 2001

Phillips, J L, Hayward, S W, Wang, Y, Vasselli, J, Pavlovich, C, Padilla-Nash, H, Pezullo, J R, Ghadimi, B M, Grossfeld, G D, Rivera, A, Linehan, W M, Cunha, G R, Ried, T. The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. Cancer Res, 61(22), 8143-9, 2001

Wang, Y, Sudilovsky, D, Zhang, B, Haughney, P C, Rosen, M A, Wu, D S, Cunha, T J, Dahiya, R, Cunha, G R, Hayward, S W. A human prostatic epithelial model of hormonal carcinogenesis. Cancer Res, 61(16), 6064-72, 2001

Hayward, S W, Cunha, G R. The prostate: development and physiology. Radiol Clin North Am, 38(1), 1-14, 2000

Li, Y, Liu, W, Hayward, S W, Cunha, G R, Baskin, L S. Plasticity of the urothelial phenotype: effects of gastro-intestinal mesenchyme/stroma and implications for urinary tract reconstruction. Differentiation, 66(2-3), 126-35, 2000

Wang, Y, Hayward, S W, Donjacour, A A, Young, P, Jacks, T, Sage, J, Dahiya, R, Cardiff, R D, Day, M L, Cunha, G R. Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue. Cancer Res, 60(21), 6008-17, 2000

Baskin, L S, Hayward, S W, DiSandro, M S, Li, Y W, Cunha, G R. Epithelial-mesenchymal interactions in the bladder. Implications for bladder augmentation. Adv Exp Med Biol, 462, 49-61, 1999

Hayward, S W. Overview of cancer of the bladder. Adv Exp Med Biol, 462, 395-7, 1999

Hayward, S W, Haughney, P C, Lopes, E S, Danielpour, D, Cunha, G R. The rat prostatic epithelial cell line NRP-152 can differentiate in vivo in response to its stromal environment. Prostate, 39(3), 205-12, 1999

Olumi, A F, Grossfeld, G D, Hayward, S W, Carroll, P R, Tlsty, T D, Cunha, G R. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res, 59(19), 5002-11, 1999

Haughney, P C, Hayward, S W, Dahiya, R, Cunha, G R. Species-specific detection of growth factor gene expression in developing murine prostatic tissue. Biol Reprod, 59(1), 93-9, 1998

Hayward, S W. A simple method for freezing and storing viable tissue fragments. In Vitro Cell Dev Biol Anim, 34(1), 28-9, 1998

Hayward, S W, Grossfeld, G D, Tlsty, T D, Cunha, G R. Genetic and epigenetic influences in prostatic carcinogenesis (review). Int J Oncol, 13(1), 35-47, 1998

Hayward, S W, Haughney, P C, Rosen, M A, Greulich, K M, Weier, H U, Dahiya, R, Cunha, G R. Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model. Differentiation, 63(3), 131-40, 1998

Kopachik, W, Hayward, S W, Cunha, G R. Expression of hepatocyte nuclear factor-3alpha in rat prostate, seminal vesicle, and bladder. Dev Dyn, 211(2), 131-40, 1998

Baskin, L S, Hayward, S W, Sutherland, R A, DiSandro, M S, Thomson, A A. Cellular signaling in the bladdeR. Front Biosci, 2, d592-5, 1997

Baskin, L S, Sutherland, R S, DiSandro, M J, Hayward, S W, Lipschutz, J, Cunha, G R. The effect of testosterone on androgen receptors and human penile growth. J Urol, 158(3 Pt 2), 1113-8, 1997

Baskin, L S, Sutherland, R S, Thomson, A A, Nguyen, H T, Morgan, D M, Hayward, S W, Hom, Y K, DiSandro, M, Cunha, G R. Growth factors in bladder wound healing. J Urol, 157(6), 2388-95, 1997

Hayward, S W, Rosen, M A, Cunha, G R. Stromal-epithelial interactions in the normal and neoplastic prostate. Br J Urol, 79 Suppl 2, 18-26, 1997

Sutherland, R S, Baskin, L S, Elfman, F, Hayward, S W, Cunha, G R. The role of type IV collagenases in rat bladder development and obstruction. Pediatr Res, 41(3), 430-4, 1997

Baskin, L S, Hayward, S W, Sutherland, R A, DiSandro, M J, Thomson, A A, Goodman, J, Cunha, G R. Mesenchymal-epithelial interactions in the bladder. World J Urol, 14(5), 301-9, 1996

Baskin, L S, Hayward, S W, Young, P F, Cunha, G R. Ontogeny of the rat bladder: smooth muscle and epithelial differentiation. Acta Anat (Basel), 155(3), 163-71, 1996

Baskin, L S, Hayward, S W, Young, P, Cunha, G R. Role of mesenchymal-epithelial interactions in normal bladder development. J Urol, 156(5), 1820-7, 1996

Baskin, L S, Sutherland, R S, Thomson, A A, Hayward, S W, Cunha, G R. Growth factors and receptors in bladder development and obstruction. Lab Invest, 75(2), 157-66, 1996

Cunha, G R, Hayward, S W, Dahiya, R, Foster, B A. Smooth muscle-epithelial interactions in normal and neoplastic prostatic development. Acta Anat (Basel), 155(1), 63-72, 1996

Hayward, S W, Cunha, G R, Dahiya, R. Normal development and carcinogenesis of the prostate. A unifying hypothesis. Ann N Y Acad Sci, 784, 50-62, 1996

Hayward, SW, Baskin, LS, Haughney, PC, Cunha, AR, Foster, BA, Dahiya, R, Prins, GS, Cunha, GR. Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle. Acta Anat (Basel), 155(2), 81-93, 1996

Hayward, SW, Baskin, LS, Haughney, PC, Foster, BA, Cunha, AR, Dahiya, R, Prins, GS, Cunha, GR. Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat. Acta Anat (Basel), 155(2), 94-103, 1996

Hayward, SW, Brody, JR, Cunha, GR. An edgewise look at basal epithelial cells: three-dimensional views of the rat prostate, mammary gland and salivary gland. Differentiation, 60(4), 219-27, 1996

Sutherland, RS, Baskin, LS, Hayward, SW, Cunha, GR. Regeneration of bladder urothelium, smooth muscle, blood vessels and nerves into an acellular tissue matrix. J Urol, 156(2 Pt 2), 571-7, 1996

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