Biomedical Research Education & Training
Faculty Member

Pozzi, Ambra, Ph.D.
Professor of Medicine
Professor of Molecular Physiology and Biophysics
Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-322-4637

Email Address: ambra.pozzi@vanderbilt.edu

Pozzi, Ambra's picture
Academic history
Diploma, University of Milan, Italy
pre-doctoral student, The Scripps Research Institute, CA, USA
Ph.D., University of Florence, Italy
Postdoc, The Scripps Research Institute, CA, USA

Office Address   Mailing Address

B-3115 MCN

B-3115 MCN 2372


Research Keywords
angiogenesis, tumors, integrins, metalloproteinases, growth factors, lipids,,Cancer,Diabetes,Kidney,Mouse,Receptor,Signal transduction,Vascular Biology

Clinical Research Keywords
integrins, lipids, angiogenesis, tumorigenesis, diabetes

Research Specialty
Role of arachidonic acid derived lipids in angiogenesis and tumorigenesis

Research Description
Our laboratory has established two major lines of research.

To study the molecular mechanisms of kidney fibrosis, focusing on cell-matrix interactions and arachidonic acid-derived eicosanoids in kidney injury.
Cell-matrix interaction in kidney homeostasis: As progressive accumulation of extracellular matrix (ECM), mainly collagens, leads to fibrosis, our goal is to determine how interactions between ECM and cells via specific ECM receptors control ECM synthesis/remodeling in health and disease. Among the collagen receptors, we study integrins and discodin domain receptors (DDRs). We have identified integrin alpha1 beta1 as an anti-fibrotic integrin whose activation leads to downregulation of endogenous collagen synthesis and negatively modulates fibrosis. Recently, we have identified integrin alpha2 beta1 and DDR1 as a positive regulator of kidney fibrosis and provide evidence that mice lacking these receptors are protected from fibrosis following injury. Finally, we study how these matrix receptors crosstalk with pro-fibrotic growth factor receptors, including EGF and TGF-b receptors.

Arachidonic acid-derived eicosanoids in kidney homeostasis: The P450 arachidonic acid monooxygenases oxidize arachidonic acid to a) 19- or 20-HETE (w-hydroxylase or CYP4 isoforms), or b) 5,6-, 8,9-, 11,12-, or 14,15-EET (epoxygenase or CYP2 isoforms). Both EETs and HETEs have markedly divergent biological effects depending on the tissue of origin. For example, 20-HETE causes vasoconstriction and promotes hypertension, while EETs are vasodilators and lower blood pressure. As hypertension and kidney injury are frequently associated, a goal of our research is to determine the relative contribution of EETs vs. HETE to kidney homeostasis by using mice lacking and/or overexpressing key enzymes involved in the synthesis of EETs and/or HETEs. Using these in vivo tools we intend to test the hypothesis that EETs protects from, while 20-HETEs contributes to kidney injury.

To study the molecular mechanisms controlling endothelial cell functions in order to devise valid and better tolerated anti-angiogenic therapy.
In the past 10 years our laboratory has investigated the role of cell-matrix interaction in the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and/or down-regulation is beneficial in the setting of tumor associated angiogenesis. More recently, we have started to investigate the role of arachidonic acid P450 epoxygenases in the control of endothelial cell function in vitro and tumorigenesis in vivo. We provide evidence that the products of P450 epoxygenases are pro-angiogenic in vivo and in vitro and maneuvers to prevent their synthesis plays a beneficial effect in slowing cancer progression in vivo.

Publications
Borza, CM, Pozzi, A. Discoidin domain receptors in disease. Matrix Biol, 34, 185-92, 2014

Irvin, MW, Zijlstra, A, Wikswo, JP, Pozzi, A. Techniques and assays for the study of angiogenesis. Exp Biol Med (Maywood), 2014

Jablonski, CL, Ferguson, S, Pozzi, A, Clark, AL. Integrin ??1??1 participates in chondrocyte transduction of osmotic stress. Biochem Biophys Res Commun, 445(1), 184-90, 2014

Miller, CG, Pozzi, A, Zent, R, Schwarzbauer, JE. Effects of High Glucose on Integrin Activity and Fibronectin Matrix Assembly by Mesangial Cells. Mol Biol Cell, 2014

Parekh, R, Lorenzo, MK, Shin, SY, Pozzi, A, Clark, AL. Integrin ??1??1 differentially regulates cytokine-mediated responses in chondrocytes. Osteoarthritis Cartilage, 22(3), 499-508, 2014

Reinert, RB, Cai, Q, Hong, JY, Plank, JL, Aamodt, K, Prasad, N, Aramandla, R, Dai, C, Levy, SE, Pozzi, A, Labosky, PA, Wright, CV, Brissova, M, Powers, AC. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development, 141(7), 1480-91, 2014

Skrypnyk, N, Chen, X, Hu, W, Su, Y, Mont, S, Yang, S, Gangadhariah, M, Wei, S, Falck, JR, Jat, JL, Zent, R, Capdevila, JH, Pozzi, A. PPAR?? activation can help prevent and treat non-small cell lung cancer. Cancer Res, 74(2), 621-31, 2014

Jiang, L, Yang, S, Yin, H, Fan, X, Wang, S, Yao, B, Pozzi, A, Chen, X, Harris, RC, Zhang, MZ. Epithelial-specific deletion of 11??-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res, 11(9), 1040-50, 2013

Luo, P, Dematteo, A, Wang, Z, Zhu, L, Wang, A, Kim, HS, Pozzi, A, Stafford, JM, Luther, JM. Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice. Diabetologia, 56(4), 901-10, 2013

Pozzi, A, Zent, R. Integrins in kidney disease. J Am Soc Nephrol, 24(7), 1034-9, 2013

Borza, CM, Pozzi, A. The role of cell-extracellular matrix interactions in glomerular injury. Exp Cell Res, 318(9), 1001-10, 2012 PMCID:3386947

Borza, CM, Su, Y, Chen, X, Yu, L, Mont, S, Chetyrkin, S, Voziyan, P, Hudson, BG, Billings, PC, Jo, H, Bennett, JS, Degrado, WF, Eckes, B, Zent, R, Pozzi, A. Inhibition of integrin I?2I?1 ameliorates glomerular injury. J Am Soc Nephrol, 23(6), 1027-38, 2012 PMCID:3386947

Bulus, N, Feral, C, Pozzi, A, Zent, R. CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs. PLoS One, 7(6), e40026, 2012 PMCID:3386947

Carpenter, G, Pozzi, A. Cell responses to growth factors: the role of receptor tyrosine kinase intracellular domain fragments. Sci Signal, 5(243), pe42, 2012

Gewin, L, Vadivelu, S, Neelisetty, S, Srichai, MB, Paueksakon, P, Pozzi, A, Harris, RC, Zent, R. Deleting the TGF-?? receptor attenuates acute proximal tubule injury. J Am Soc Nephrol, 23(12), 2001-11, 2012

Mathew, S, Chen, X, Pozzi, A, Zent, R. Integrins in renal development. Pediatr Nephrol, 27(6), 891-900, 2012 PMCID:3386947

Mathew, S, Lu, Z, Palamuttam, RJ, Mernaugh, G, Hadziselimovic, A, Chen, J, Bulus, N, Gewin, LS, Voehler, M, Meves, A, Ballestrem, C, F??ssler, R, Pozzi, A, Sanders, CR, Zent, R. ??1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol Cell Biol, 32(20), 4080-91, 2012

Pozzi, A, Zent, R. Hold tight or you''ll fall off: CD151 helps podocytes stick in high-pressure situations. J Clin Invest, 122(1), 13-6, 2012 PMCID:3386947

Yu, L, Su, Y, Paueksakon, P, Cheng, H, Chen, X, Wang, H, Harris, RC, Zent, R, Pozzi, A. Integrin I?1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int, 81(11), 1086-97, 2012 PMCID:3386947

Griesser, M, Suzuki, T, Tejera, N, Mont, S, Boeglin, WE, Pozzi, A, Schneider, C. Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways. Proc Natl Acad Sci U S A, 108(17), 6945-50, 2011 PMCID:3084063

Kang, L, Ayala, JE, Lee-Young, RS, Zhang, Z, James, FD, Neufer, PD, Pozzi, A, Zutter, MM, Wasserman, DH. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes, 60(2), 416-26, 2011 PMCID:3028340

Li, B, Pozzi, A, Young, PP. TNFalpha accelerates monocyte to endothelial transdifferentiation in tumors by the induction of integrin alpha5 expression and adhesion to fibronectin. Mol Cancer Res, 9(6), 702-11, 2011 PMCID:3157289

Pozzi, A, Zent, R. TGF-I? sequestration by mesangial cell integrin I?vI?8: A novel mechanism of glomerular endothelial cell regulation. Am J Pathol, 178(2), 485-9, 2011 PMCID:3069894

Pozzi, A, Zent, R. Extracellular matrix receptors in branched organs. Curr Opin Cell Biol, 23(5), 547-53, 2011 PMCID:3386947

Schneider, C, Pozzi, A. Cyclooxygenases and lipoxygenases in cancer. Cancer Metastasis Rev, 30(3-4), 277-94, 2011 PMCID:3386947

Borza, CM, Chen, X, Mathew, S, Mont, S, Sanders, CR, Zent, R, Pozzi, A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J Biol Chem, 285(51), 40114-24, 2010 PMCID:3000994

Chen, X, Whiting, C, Borza, C, Hu, W, Mont, S, Bulus, N, Zhang, MZ, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol, 30(12), 3048-58, 2010 PMCID:2876688

Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. . TGF-I? Receptor Deletion in the Renal Collecting System Exacerbates Fibrosis. . J. A. Soc. Neph,(Jun 24. [Epub ahead of print]), 2010

Gewin, L, Bulus, N, Mernaugh, G, Moeckel, G, Harris, RC, Moses, HL, Pozzi, A, Zent, R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol, 21(8), 1334-43, 2010 PMCID:2938601

Pozzi, A, Popescu, V, Yang, S, Mei, S, Shi, M, Puolitaival, SM, Caprioli, RM, Capdevila, JH. The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated. J Biol Chem, 285(17), 12840-50, 2010 PMCID:2876688

Pozzi, A, Zent, R. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med, 1(2), 254-72, 2010 PMCID:3000994

Riggins, KS, Mernaugh, G, Su, Y, Quaranta, V, Koshikawa, N, Seiki, M, Pozzi, A, Zent, R. MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp Cell Res, 316(17), 2993-3005, 2010 PMCID:2945451

Turner J, Sazonova O, Wang H, Pozzi A, Wagner GF. . Induction of the renal stanniocalcin-1 gene in rodents by water deprivation. . Mol Cell Endocrinol([Epub ahead of print]), 2010

Antar, AA, Konopka, JL, Campbell, JA, Henry, RA, Perdigoto, AL, Carter, BD, Pozzi, A, Abel, TW, Dermody, TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe, 5(1), 59-71, 2009 PMCID:2642927

Crooke, CE, Pozzi, A, Carpenter, GF. PLC-gamma1 regulates fibronectin assembly and cell aggregation. Exp Cell Res, 315(13), 2207-14, 2009 PMCID:2719887

Nystr??m A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. . Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. . Blood, 26;114(23):4897-906. , 2009

Pozzi, A, Voziyan, PA, Hudson, BG, Zent, R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr Pharm Des, 15(12), 1318-33, 2009 PMCID:2719887

Pozzi, A, Zent, R, Chetyrkin, S, Borza, C, Bulus, N, Chuang, P, Chen, D, Hudson, B, Voziyan, P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J Am Soc Nephrol, 20(10), 2119-25, 2009 PMCID:2876688

Red Brewer, M, Choi, SH, Alvarado, D, Moravcevic, K, Pozzi, A, Lemmon, MA, Carpenter, G. The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell, 34(6), 641-51, 2009 PMCID:2719887

Smith, JP, Pozzi, A, Dhawan, P, Singh, AB, Harris, RC. Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2. Am J Physiol Renal Physiol, 296(5), F957-65, 2009 PMCID:2681361

Yang, S, Wei, S, Pozzi, A, Capdevila, JH. The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Arch Biochem Biophys, 489(1-2), 82-91, 2009 PMCID:2719887

Zhang, MZ, Xu, J, Yao, B, Yin, H, Cai, Q, Shrubsole, MJ, Chen, X, Kon, V, Zheng, W, Pozzi, A, Harris, RC. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest, 119(4), 876-85, 2009 PMCID:2662561

Zhang, X, Mernaugh, G, Yang, DH, Gewin, L, Srichai, MB, Harris, RC, Iturregui, JM, Nelson, RD, Kohan, DE, Abrahamson, D, F??ssler, R, Yurchenco, P, Pozzi, A, Zent, R. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development, 136(19), 3357-66, 2009 PMCID:2876688

Abair, TD, Bulus, N, Borza, C, Sundaramoorthy, M, Zent, R, Pozzi, A. Functional Analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood, 2008 PMCID:2569176

Abair, TD, Sundaramoorthy, M, Chen, D, Heino, J, Ivaska, J, Hudson, BG, Sanders, CR, Pozzi, A, Zent, R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp Cell Res, 314(19), 3593-604, 2008 PMCID:2729514

Borza, CM, Borza, DB, Pedchenko, V, Saleem, MA, Mathieson, PW, Sado, Y, Hudson, HM, Pozzi, A, Saus, J, Abrahamson, DR, Zent, R, Hudson, BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol, 19(4), 677-84, 2008 PMCID:2390958

Cosgrove, D, Meehan, DT, Delimont, D, Pozzi, A, Chen, X, Rodgers, KD, Tempero, RM, Zallocchi, M, Rao, VH. Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome. Am J Pathol, 172(3), 761-73, 2008 PMCID:2258247

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res, 68(15), 6224-31, 2008

Macias-Perez, I, Borza, C, Chen, X, Yan, X, Ibanez, R, Mernaugh, G, Matrisian, LM, Zent, R, Pozzi, A. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res, 68(15), 6127-35, 2008

Macias-Perez, IM, Zent, R, Carmosino, M, Breyer, MD, Breyer, RM, Pozzi, A. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem, 283(18), 12538-45, 2008 PMCID:2335350

Pozzi, A, Capdevila, JH. PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents. PPAR Res, 2008, 906542, 2008 PMCID:2517125

Pozzi, A, Jarad, G, Moeckel, GW, Coffa, S, Zhang, X, Gewin, L, Eremina, V, Hudson, BG, Borza, DB, Harris, RC, Holzman, LB, Phillips, CL, Fassler, R, Quaggin, SE, Miner, JH, Zent, R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol, 316(2), 288-301, 2008 PMCID:2396524

Pozzi, A, Zent, R. Integrins, extracellular matrix, and terminal differentiation of renal epithelial cells. J Am Soc Nephrol, 19(6), 1043-4, 2008

Pyle, AL, Atkinson, JB, Pozzi, A, Reese, J, Eckes, B, Davidson, JM, Crimmins, DL, Young, PP. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Am J Pathol, 173(5), 1577-88, 2008 PMCID:2570146

Woodall, BP, Nystr??m, A, Iozzo, RA, Eble, JA, Niland, S, Krieg, T, Eckes, B, Pozzi, A, Iozzo, RV. Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem, 283(4), 2335-43, 2008

Zhang, Z, Ramirez, NE, Yankeelov, TE, Li, Z, Ford, LE, Qi, Y, Pozzi, A, Zutter, MM. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Blood, 111(4), 1980-8, 2008 PMCID:2234046

Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol, 27(9), 3313-26, 2007 PMCID:1899972

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem, 282(38), 27713-20, 2007

Kanjanabuch, T, Ma, LJ, Chen, J, Pozzi, A, Guan, Y, Mundel, P, Fogo, AB. PPAR-gamma agonist protects podocytes from injury. Kidney Int, 2007

Pozzi, A, Ibanez, MR, Gatica, AE, Yang, S, Wei, S, Mei, S, Falck, JR, Capdevila, JH. Peroxisomal proliferator activated receptor(alpha)-dependent inhibition of endothelial cell proliferation and tumorigenesis. J Biol Chem, 2007

Rao, R, Redha, R, Macias-Perez, I, Su, Y, Hwang, MT, Hao, C, Zent, R, Breyer, MD, Pozzi, A. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J Biol Chem, 2007

Zent, R, Pozzi, A. Angiogenesis in diabetic nephropathy. Semin Nephrol, 27(2), 161-71, 2007

Zhang, H, Lawson, WE, Polosukhin, VV, Pozzi, A, Blackwell, TS, Litingtung, Y, Chiang, C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol, 171(4), 1113-26, 2007 PMCID:1988863

Acuff, HB, Sinnamon, M, Fingleton, B, Boone, B, Levy, SE, Chen, X, Pozzi, A, Carbone, DP, Schwartz, DR, Moin, K, Sloane, BF, Matrisian, LM. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res, 66(16), 7968-75, 2006

Borza, CM, Pozzi, A, Borza, DB, Pedchenko, V, Hellmark, T, Hudson, BG, Zent, R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J Biol Chem, 281(30), 20932-9, 2006

Kamiyama, M, Pozzi, A, Yang, L, DeBusk, LM, Breyer, RM, Lin, PC. EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival. Oncogene, 25(53), 7019-28, 2006

Liang, XB, Ma, LJ, Naito, T, Wang, Y, Madaio, M, Zent, R, Pozzi, A, Fogo, AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol, 17(7), 1886-95, 2006

Moeckel, GW, Zhang, L, Chen, X, Rossini, M, Zent, R, Pozzi, A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Am J Physiol Renal Physiol, 290(1), F223-31, 2006

Mu??oz, NM, Upton, M, Rojas, A, Washington, MK, Lin, L, Chytil, A, Sozmen, EG, Madison, BB, Pozzi, A, Moon, RT, Moses, HL, Grady, WM. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res, 66(20), 9837-44, 2006

Nakagawa, K, Holla, VR, Wei, Y, Wang, WH, Gatica, A, Wei, S, Mei, S, Miller, CM, Cha, DR, Price, E, Zent, R, Pozzi, A, Breyer, MD, Guan, Y, Falck, JR, Waterman, MR, Capdevila, JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest, 116(6), 1696-702, 2006 PMCID:1459070

Pozzi, A, Coffa, S, Bulus, N, Zhu, W, Chen, D, Chen, X, Mernaugh, G, Su, Y, Cai, S, Singh, A, Brissova, M, Zent, R. H-Ras, R-Ras, and TC21 Differentially Regulate Ureteric Bud Cell Branching Morphogenesis. Mol Biol Cell, 2006 PMCID:1415315

Zent, R, Pozzi, A. Antiangiogenic Therapy in Diabetic Nephropathy. J Am Soc Nephrol, 2006

Zent, R, Yan, X, Su, Y, Hudson, BG, Borza, DB, Moeckel, GW, Qi, Z, Sado, Y, Breyer, MD, Voziyan, P, Pozzi, A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int, 70(3), 460-70, 2006

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Orthotopic models of lung cancer to follow primary and metastatic NSCLC growth in integrin α1-null mice. Clin. Exp. Metastasis, 2005, In press

Br?!bek, J, Constancio, SS, Siesser, PF, Shin, NY, Pozzi, A, Hanks, SK. Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol Cancer Res, 3(6), 307-15, 2005

Cai, S, Bulus, N, Fonseca-Siesser, PM, Chen, D, Hanks, SK, Pozzi, A, Zent, R. CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci, 118(Pt 5), 889-99, 2005

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer, 116(1), 52-61, 2005

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin Exp Metastasis, 22(2), 185-93, 2005

Frank, DB, Abtahi, A, Yamaguchi, DJ, Manning, S, Shyr, Y, Pozzi, A, Baldwin, HS, Johnson, JE, de Caestecker, MP. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res, 97(5), 496-504, 2005

Mernaugh, RL, Yan, H, Chen, D, Edl, J, Hanley, G, Pozzi, A, Zent, R. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. J Immunol Methods, 306(1-2), 115-27, 2005

Pozzi, A, Macias-Perez, I, Abair, T, Wey, S, Su, Y, Zent, R, Falk, JR, Capdevila, JH. Charaterization of 5,6-and 8,9-Epoxyeicosatrienoic acids (5,6- AND 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem, 2005

Thomas, EK, Nakamura, M, Wienke, D, Isacke, CM, Pozzi, A, Liang, P. Endo180 binds to the C-terminal region of alpha 1(I) collagen. J Biol Chem, 2005

Brantley-Sieders, DM, Caughron, J, Hicks, D, Pozzi, A, Ruiz, JC, Chen, J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci, 117(Pt 10), 2037-49, 2004

Br?!bek, J, Constancio, SS, Shin, NY, Pozzi, A, Weaver, AM, Hanks, SK. CAS promotes invasiveness of Src-transformed cells. Oncogene, 23(44), 7406-15, 2004

Chen, D, Roberts, R, Pohl, M, Nigam, S, Kreidberg, J, Wang, Z, Heino, J, Ivaska, J, Coffa, S, Harris, RC, Pozzi, A, Zent, R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, 287(4), F602-11, 2004

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004 PMCID:1618576

Ma, LJ, Jha, S, Ling, H, Pozzi, A, Ledbetter, S, Fogo, AB. Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int, 65(1), 106-15, 2004

Pozzi, A, Yan, X, Macias-Perez, I, Wei, S, Hata, AN, Breyer, RM, Morrow, JD, Capdevila, JH. Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. J Biol Chem, 279(28), 29797-804, 2004

Moeckel, GW, Zhang, L, Fogo, AB, Hao, CM, Pozzi, A, Breyer, MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem, 278(21), 19352-7, 2003

Pozzi, A, Zent, R. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol, 94(3), e77-84, 2003

Brantley, DM, Cheng, N, Thompson, EJ, Lin, Q, Brekken, RA, Thorpe, PE, Muraoka, RS, Cerretti, DP, Pozzi, A, Jackson, D, Lin, C, Chen, J. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene, 21(46), 7011-26, 2002

Pozzi, A, LeVine, WF, Gardner, HA. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis. Oncogene, 21(2), 272-81, 2002

Pozzi A, Moberg PE, Miles LA, Wagner S, Soloway P, Gardner HA. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A, 97(5), 2202-7, 2000

Rose D.M., A. Pozzi, and R. Zent. Integrins as Therapeutic targets. Emerging Therapeutic Target. , 4(3), 387-411, 2000

Gardner H, Broberg A, Pozzi A, Laato M, Heino J. Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis. J Cell Sci., 112, 263-72, 1999

Giannelli G, Pozzi A, Stetler-Stevenson WG, Gardner HA, Quaranta V. Expression of matrix metalloprotease-2-cleaved laminin-5 in breast remodeling stimulated by sex steroids. Am J Pathol, 154(4), 1193-201, 1999

Pozzi A, Wary KK, Giancotti FG, Gardner HA. Integrin alpha1beta1 mediates a unique collagen- dependent proliferation pathway in vivo. J Cell Biol, 142(2), 587-94, 1998

Pozzi A, Risek B, Kiang DT, Gilula NB, Kumar NM. Analysis of multiple gap junction gene products in the rodent and human mammary gland. Exp Cell Res, 220(1), 212-9, 1995


Postdoctoral Position Available
Yes

Postdoctoral Position Details


Updated Date
09/29/2014