Biomedical Research Education & Training
Faculty Member

Dhawan, Punita, Ph.D.
Assistant Professor of Surgery
Assistant Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-322-4755

Email Address:

Dhawan, Punita's picture
Academic history
B.S., Delhi Univ, India
M.S., India Institute
Ph.D., Univ of Arkansas

Office Address   Mailing Address

B-2211 MCN

T-2211, MCN 37232

Research Keywords
Colon cancer, Tight junctions, Claudin, Cancer biology, ,Cancer

Research Specialty
Role of Tight junction proteins in Colon Cancer

Research Description
The focus of our research is to understand the role and molecular mechanisms of tight junction protein in colon cancer initiation, progression and recurrence. We use genetically engineered mice and colon cancer cells to study these processes.

Dhawan, P, Su, Y, Thu, YM, Yu, Y, Baugher, P, Ellis, DL, Sobolik-Delmaire, T, Kelley, M, Cheung, TC, Ware, CF, Richmond, A. The Lymphotoxin-{beta} Receptor Is an Upstream Activator of NF-{kappa}B-mediated Transcription in Melanoma Cells. J Biol Chem, 283(22), 15399-15408, 2008 PMCID:2397477

Smith, JJ, Deane, NG, Dhawan, P, Beauchamp, RD. Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery, 144(3), 353-66, 2008 PMCID:2594010

Shiou, SR, Singh, AB, Moorthy, K, Datta, PK, Washington, MK, Beauchamp, RD, Dhawan, P. Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9, 2007

Singh, AB, Sugimoto, K, Dhawan, P, Harris, RC. Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Am J Physiol Cell Physiol, 293(5), C1660-8, 2007

Shiou, SR, Datta, PK, Dhawan, P, Law, BK, Yingling, JM, Dixon, DA, Beauchamp, RD. Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem, 281(45), 33971-81, 2006

Dhawan, P, Singh, AB, Deane, NG, No, Y, Shiou, SR, Schmidt, C, Neff, J, Washington, MK, Beauchamp, RD. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76, 2005 PMCID:1150288

Dhawan P, Singh AB, Ellis DL, Richmond A. . Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res. , (24): (Dec 15;62), 7335-42., 2002

Dhawan P, Richmond A. Role of CXCL1 in tumorigenesis of melanoma. J Leukoc Biol. , Jul; 72(1): , 9-18., 2002

Dhawan P, Richmond A. . A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. . J Biol Chem. , 10: (Mar 8; 277), 7920-8. , 2002

Dhawan, P, Singh, AB, Ellis, DL, Richmond, A. Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res, 62(24), 7335-42, 2002

Nirodi, C, Hart, J, Dhawan, P, Moon , NS, Nepveu, A, Richmond, A. The role of CDP in the negative regulation of CXCL1 gene expression. J Biol Chem, 276(28), 26122-31, 2001 PMCID:2665279

Dhawan P, Bell A, Kumar A, Golden C, Mehta KD. Critical role of p42/44(MAPK) activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf-1/Mek-1/p42/44(MAPK) cascade alone is sufficient to induce LDL receptor expression. J Lipid Res. , (10): (Oct; 40), 1911-9. , 1999

Singh RP, Dhawan P, Golden C, Kapoor GS, Mehta KD. One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade. J Biol Chem. ., (28): (Jul 9; 274), 19593-600, 1999

Dhawan P, Yang E, Kumar A, Mehta KD. Genetic complexity of the human geranylgeranyltransferase I beta-subunit gene: a multigene family of pseudogenes derived from mis-spliced transcripts. . Gene. , (1): (Mar 27;), 2109-15. , 1998

Dhawan P, Chang R, Mehta KD. . Identification of essential nucleotides of the FP1 element responsible for enhancement of low density lipoprotein receptor gene transcription. . Nucleic Acids Res. , (20): (Oct 15; 25), 4132-8., 1997

Kumar A, Beresini MH, Dhawan P, Mehta KD.. Alpha-subunit of farnesyltransferase is phosphorylated in vivo: effect of protein phosphatase-1 on enzymatic activity. . Biochem Biophys Res Commun. , 222(2): (May 15;), 445-52, 1996

Nirodi C, Hart J, Dhawan P, Moon NS, Nepveu A, Richmond A.. The role of CDP in the negative regulation of CXCL1 gene expression. J Biol Chem. , 276(28(Jul 13;), 26122-31. , 2001

Postdoctoral Position Available

Postdoctoral Position Details
A postdoctoral position is available to investigate the role of Claudin-1 in Colon cancer Progression and Metastasis. Evidence of experience in molecular biology and Cellular Biology is required. Experience in working with animal models is desirable.

Interested Candidates should send their CV and three references to

Punita Dhawan, Ph.D

Assistant Professor,

Dept. of Surgery/Division of Surgical Oncology,

Vanderbilt University Medical Center,

1161 21st Ave. South, MCN

Nashville, TN-37232, USA


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