Biomedical Research Education & Training
Faculty Member

Brantley-Sieders, Dana M., Ph.D.
Research Assistant Professor of Medicine

Lab Url: N/A

Phone Number: 615-343-3820

Email Address:

Brantley-Sieders, Dana's picture
Academic history
B.A., Maryville College, Maryville TN
Ph.D., Vanderbilt University
, Vanderbilt University

Office Address   Mailing Address

A-4323 MCN, 1161 21st Avenue South

A-4323 MCN 2363

Brantley-Sieders, DM, Fang, WB, Hicks, DJ, Zhuang, G, Shyr, Y, Chen, J. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J, 19(13), 1884-6, 2005

Fang, WB, Brantley-Sieders, DM, Parker, MA, Reith, AD, Chen, J. A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene, 24(53), 7859-68, 2005

Brantley-Sieders, D, Parker, M, Chen, J. Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des, 10(27), 3431-42, 2004

Brantley-Sieders, DM, Caughron, J, Hicks, D, Pozzi, A, Ruiz, JC, Chen, J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci, 117(Pt 10), 2037-49, 2004

Brantley-Sieders, DM, Chen, J. Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis, 7(1), 17-28, 2004

Schneider, C, Strayhorn, WD, Brantley, DM, Nanney, LB, Yull, FE, Brash, AR. Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. J Invest Dermatol, 122(3), 691-8, 2004

Muraoka, RS, Koh, Y, Roebuck, LR, Sanders, ME, Brantley-Sieders, D, Gorska, AE, Moses, HL, Arteaga, CL. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol, 23(23), 8691-703, 2003 PMCID:262670

Brantley, DM, Cheng, N, Thompson, EJ, Lin, Q, Brekken, RA, Thorpe, PE, Muraoka, RS, Cerretti, DP, Pozzi, A, Jackson, D, Lin, C, Chen, J. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene, 21(46), 7011-26, 2002

Cheng, N, Brantley, DM, Chen, J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev, 13(1), 75-85, 2002

Cheng, N, Brantley, DM, Liu, H, Lin, Q, Enriquez, M, Gale, N, Yancopoulos, G, Cerretti, DP, Daniel, TO, Chen, J. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res, 1(1), 2-11, 2002

Muraoka, RS, Dumont, N, Ritter, CA, Dugger, TC, Brantley, DM, Chen, J, Easterly, E, Roebuck, LR, Ryan, S, Gotwals, PJ, Koteliansky, V, Arteaga, CL. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest, 109(12), 1551-9, 2002 PMCID:151012

Muraoka, RS, Lenferink, AE, Law, B, Hamilton, E, Brantley, DM, Roebuck, LR, Arteaga, CL. ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol, 22(7), 2204-19, 2002 PMCID:133673

Brantley, DM, Chen, CL, Muraoka, RS, Bushdid, PB, Bradberry, JL, Kittrell, F, Medina, D, Matrisian, LM, Kerr, LD, Yull, FE. Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell, 12(5), 1445-55, 2001 PMCID:34596

Bushdid, PB, Chen, CL, Brantley, DM, Yull, F, Raghow, R, Kerr, LD, Barnett, JV. NF-kappaB mediates FGF signal regulation of msx-1 expression. Dev Biol, 237(1), 107-15, 2001

Muraoka, RS, Lenferink, AE, Simpson, J, Brantley, DM, Roebuck, LR, Yakes, FM, Arteaga, CL. Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. J Cell Biol, 153(5), 917-32, 2001 PMCID:2174338

Brantley, DM, Yull, FE, Muraoka, RS, Hicks, DJ, Cook, CM, Kerr, LD. Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech Dev, 97(1-2), 149-55, 2000

Muraoka, RS, Bushdid, PB, Brantley, DM, Yull, FE, Kerr, LD. Mesenchymal expression of nuclear factor-kappaB inhibits epithelial growth and branching in the embryonic chick lung. Dev Biol, 225(2), 322-38, 2000

Bushdid, PB, Brantley, DM, Yull, FE, Blaeuer, GL, Hoffman, LH, Niswander, L, Kerr, LD. Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature, 392(6676), 615-8, 1998

Dana M Brantley. Apolipoprotein E synthesis by transplanted bone marrow derived cells in apolipoprotein E deficient mice. BIOS, 67, 74-82, 1996

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