Biomedical Research Education & Training
Faculty Member

Niswender, Kevin Dean, M.D., Ph.D.
Associate Professor of Medicine
Associate Professor of Molecular Physiology and Biophysics

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Phone Number: (615) 936-0500

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Niswender, Kevin's picture
Academic history
B.S., Colorado College
Ph.D., Vanderbilt
M.D., Vanderbilt

Office Address   Mailing Address

7435G MRB IV

722 PRB 37232-6303

Research Keywords
Diabetes, Endocrinology, Metabolism

Research Specialty
Diabetes, Endocrinology, and Metabolism

Branecky, KL, Niswender, KD, Pendergast, JS. Disruption of Daily Rhythms by High-Fat Diet Is Reversible. PLoS One, 10(9), e0137970, 2015

Rojas, JM, Bruinstroop, E, Printz, RL, Alijagic-Boers, A, Foppen, E, Turney, MK, George, L, Beck-Sickinger, AG, Kalsbeek, A, Niswender, KD. Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low-density lipoprotein triglyceride secretion via sympathetic innervation. Mol Metab, 4(3), 210-21, 2015

Kocalis, HE, Hagan, SL, George, L, Turney, MK, Siuta, MA, Laryea, GN, Morris, LC, Muglia, LJ, Printz, RL, Stanwood, GD, Niswender, KD. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol Metab, 3(4), 394-407, 2014

Morris, LC, Days, EL, Turney, M, Mi, D, Lindsley, CW, Weaver, CD, Niswender, KD. A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors. J Biomol Screen, 19(6), 847-858, 2014

Morris, LC, Nance, KD, Gentry, PR, Days, EL, Weaver, CD, Niswender, CM, Thompson, AD, Jones, CK, Locuson, CW, Morrison, RD, Daniels, JS, Niswender, KD, Lindsley, CW. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem, 57(23), 10192-7, 2014

Pendergast, JS, Branecky, KL, Huang, R, Niswender, KD, Yamazaki, S. Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior. Front Psychol, 5, 177, 2014

Saunders, C, Siuta, M, Robertson, SD, Davis, AR, Sauer, J, Matthies, HJ, Gresch, PJ, Airey, DC, Lindsley, CW, Schetz, JA, Niswender, KD, Veenstra-Vanderweele, JM, Galli, A. Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function. Neurochem Int, 73, 113-21, 2014

Silver, HJ, Kang, H, Keil, CD, Muldowney, JA, Kocalis, H, Fazio, S, Vaughan, DE, Niswender, KD. Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women. Metabolism, 63(4), 562-73, 2014

Pendergast, JS, Branecky, KL, Yang, W, Ellacott, KL, Niswender, KD, Yamazaki, S. High-fat diet acutely affects circadian organisation and eating behavior. Eur J Neurosci, 37(8), 1350-6, 2013

Pendergast, JS, Niswender, KD, Yamazaki, S. The complex relationship between the light-entrainable and methamphetamine-sensitive circadian oscillators: evidence from behavioral studies of Period-mutant mice. Eur J Neurosci, 38(7), 3044-53, 2013

Silver, HJ, Niswender, KD, Kullberg, J, Berglund, J, Johansson, L, Bruvold, M, Avison, MJ, Welch, EB. Comparison of gross body fat-water magnetic resonance imaging at 3 Tesla to dual-energy X-ray absorptiometry in obese women. Obesity (Silver Spring), 21(4), 765-74, 2013

West, J, Niswender, KD, Johnson, JA, Pugh, ME, Gleaves, L, Fessel, JP, Hemnes, AR. A potential role for insulin resistance in experimental pulmonary hypertension. Eur Respir J, 41(4), 861-71, 2013

Hagan, S, Niswender, KD. Neuroendocrine regulation of food intake. Pediatr Blood Cancer, 58(1), 149-53, 2012 PMCID:3182178

Kocalis, HE, Turney, MK, Printz, RL, Laryea, GN, Muglia, LJ, Davies, SS, Stanwood, GD, McGuinness, OP, Niswender, KD. Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPAR??) in mice leads to increased susceptibility to diet-induced obesity. PLoS One, 7(8), e42981, 2012

Pendergast, JS, Niswender, KD, Yamazaki, S. Tissue-specific function of Period3 in circadian rhythmicity. PLoS One, 7(1), e30254, 2012 PMCID:3256228

Pendergast, JS, Oda, GA, Niswender, KD, Yamazaki, S. Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s). Proc Natl Acad Sci U S A, 109(35), 14218-23, 2012

Silver, HJ, Niswender, KD, Keil, CD, Jiang, L, Feng, Q, Chiu, S, Krauss, RM, Wilke, RA. CNR1 Genotype Influences HDL-Cholesterol Response to Change in Dietary Fat Intake. PLoS One, 7(5), e36166, 2012 PMCID:3342253

Niswender, KD. Basal insulin: physiology, pharmacology, and clinical implications. Postgrad Med, 123(4), 17-26, 2011 PMCID:3182178

Niswender, KD. Basal insulin: beyond glycemia. Postgrad Med, 123(4), 27-37, 2011 PMCID:3182178

Niswender, KD, Daws, LC, Avison, MJ, Galli, A. Insulin regulation of monoamine signaling: pathway to obesity. Neuropsychopharmacology, 36(1), 359-60, 2011 PMCID:3055525

Silver, HJ, Dietrich, MS, Niswender, KD. Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults. Nutr Metab (Lond), 8(1), 8, 2011 PMCID:3039556

Speed, N, Saunders, C, Davis, AR, Owens, WA, Matthies, HJ, Saadat, S, Kennedy, JP, Vaughan, RA, Neve, RL, Lindsley, CW, Russo, SJ, Daws, LC, Niswender, KD, Galli, A. Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding. PLoS One, 6(9), e25169, 2011 PMCID:3182178

Silver, HJ, Welch, EB, Avison, MJ, Niswender, KD. Imaging body composition in obesity and weight loss: challenges and opportunities. Diabetes Metab Syndr Obes, 3, 337-47, 2010 PMCID:3047979

Siuta, MA, Robertson, SD, Kocalis, H, Saunders, C, Gresch, PJ, Khatri, V, Shiota, C, Kennedy, JP, Lindsley, CW, Daws, LC, Polley, DB, Veenstra-Vanderweele, J, Stanwood, GD, Magnuson, MA, Niswender, KD, Galli, A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol, 8(6), e1000393, 2010 PMCID:2882427

Posey, KA, Clegg, DJ, Printz, RL, Byun, J, Morton, GJ, Vivekanandan-Giri, A, Pennathur, S, Baskin, DG, Heinecke, JW, Woods, SC, Schwartz, MW, Niswender, KD. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab, 296(5), E1003-12, 2009 PMCID:2681305

Robinson, JR, Niswender, KD. What are the risks and the benefits of current and emerging weight-loss medications. Curr Diab Rep, 9(5), 368-75, 2009 PMCID:3047979

Huizinga, MM, Niswender, KD, Gebretsadik, T, Rothman, RL, Shintani, AK, Elasy, TA. Insulin Use and Weight Maintenance in Well-controlled Type 2 Diabetes: A Prospective Cohort Study. Obesity (Silver Spring), 16(8), 1933-1937, 2008 PMCID:2694404

Niswender, KD, Beech, BM. Obesity: increasing awareness of novel environmental factors. Diabetes, 57(7), 1786-7, 2008 PMCID:2453635

Stafford, JM, Yu, F, Printz, R, Hasty, AH, Swift, LL, Niswender, KD. Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes, 57(6), 1482-90, 2008

Niswender, KD, Magnuson, MA. Obesity and the beta cell: lessons from leptin. J Clin Invest, 117(10), 2753-6, 2007 PMCID:1994637

Saraswathi, V, Gao, L, Morrow, JD, Chait, A, Niswender, KD, Hasty, AH. Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr, 137(7), 1776-82, 2007

Gelling, RW, Morton, GJ, Morrison, CD, Niswender, KD, Myers, MG, Rhodes, CJ, Schwartz, MW. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab, 3(1), 67-73, 2006

Morrison, CD, Morton, GJ, Niswender, KD, Gelling, RW, Schwartz, MW. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab, 289(6), E1051-7, 2005

Morton, GJ, Blevins, JE, Williams, DL, Niswender, KD, Gelling, RW, Rhodes, CJ, Baskin, DG, Schwartz, MW. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest, 115(3), 703-10, 2005 PMCID:548313

Morton, GJ, Gelling, RW, Niswender, KD, Morrison, CD, Rhodes, CJ, Schwartz, MW. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab, 2(6), 411-20, 2005

Niswender, KD, Baskin, DG, Schwartz, MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab, 15(8), 362-9, 2004

Schwartz, MW, Niswender, KD. Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance. J Clin Endocrinol Metab, 89(12), 5889-97, 2004

Morton, GJ, Niswender, KD, Rhodes, CJ, Myers, MG, Blevins, JE, Baskin, DG, Schwartz, MW. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology, 144(5), 2016-24, 2003

Niswender, KD, Gallis, B, Blevins, JE, Corson, MA, Schwartz, MW, Baskin, DG. Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem, 51(3), 275-83, 2003

Niswender, KD, Morrison, CD, Clegg, DJ, Olson, R, Baskin, DG, Myers, MG, Seeley, RJ, Schwartz, MW. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes, 52(2), 227-31, 2003

Niswender, KD, Schwartz, MW. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol, 24(1), 1-10, 2003

Niswender, KD, Morton, GJ, Stearns, WH, Rhodes, CJ, Myers, MG, Schwartz, MW. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature, 413(6858), 794-5, 2001

Kupershmidt, S, Yang, T, Anderson, ME, Wessels, A, Niswender, KD, Magnuson, MA, Roden, DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res, 84(2), 146-52, 1999

Lu, JT, Son, YJ, Lee, J, Jetton, TL, Shiota, M, Moscoso, L, Niswender, KD, Loewy, AD, Magnuson, MA, Sanes, JR, Emeson, RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci, 14(2), 99-120, 1999

Postic, C, Shiota, M, Niswender, KD, Jetton, TL, Chen, Y, Moates, JM, Shelton, KD, Lindner, J, Cherrington, AD, Magnuson, MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274(1), 305-15, 1999

Evans, TJ, Miller, MA, Ganjam, VK, Niswender, KD, Ellersieck, MR, Krause, WJ, Youngquist, RS. Morphometric analysis of endometrial periglandular fibrosis in mares. Am J Vet Res, 59(10), 1209-14, 1998

Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997 PMCID:20311

Niswender, KD, Li, J, Powell, MR, Loos, KR, Roberts, RM, Keisler, DH, Smith, MF. Effect of variants of interferon-tau with mutations near the carboxyl terminus on luteal life span in sheep. Biol Reprod, 56(1), 214-20, 1997

Niswender, KD, Postic, C, Jetton, TL, Bennett, BD, Piston, DW, Efrat, S, Magnuson, MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem, 272(36), 22564-9, 1997

Niswender, KD, Postic, C, Shiota, M, Jetton, TL, Magnuson, MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochem Soc Trans, 25(1), 113-7, 1997

Niswender, KD, Shiota, M, Postic, C, Cherrington, AD, Magnuson, MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem, 272(36), 22570-5, 1997

Qu, S, Niswender, KD, Ji, Q, van der Meer, R, Keeney, D, Magnuson, MA, Wisdom, R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development, 124(20), 3999-4008, 1997

Hawkins, DE, Niswender, KD, Oss, GM, Moeller, CL, Odde, KG, Sawyer, HR, Niswender, GD. An increase in serum lipids increases luteal lipid content and alters the disappearance rate of progesterone in cows. J Anim Sci, 73(2), 541-5, 1995

Niswender, KD, Blackman, SM, Rohde, L, Magnuson, MA, Piston, DW. Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc, 180 ( Pt 2), 109-16, 1995

Postic, C, Niswender, KD, Decaux, JF, Parsa, R, Shelton, KD, Gouhot, B, Pettepher, CC, Granner, DK, Girard, J, Magnuson, MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics, 29(3), 740-50, 1995

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest, 94(4), 1373-82, 1994 PMCID:295259

Niswender, GD, McNatty, KP, Smith, P, Niswender, KD, Farin, CE, Sawyer, HR. Numbers of steroidogenic luteal cells in Booroola Merino ewes. J Reprod Fertil, 90(1), 185-90, 1990

Sawyer, HR, Niswender, KD, Braden, TD, Niswender, GD. Nuclear changes in ovine luteal cells in response to PGF2 alpha. Domest Anim Endocrinol, 7(2), 229-37, 1990

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