Biomedical Research Education & Training
Faculty Member

Greer, John P., M.D.
Professor of Medicine
Professor of Pediatrics

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Phone Number: 615-936-1803

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Greer, John's picture
Academic history
B.A., Vanderbilt University, Nashville, Tennessee
M.D., Vanderbilt University School of Medicine, Nashville, Tennessee
, Tulane University, New Orleans, Louisiana
, Tulane University, New Orleans, Louisiana
, Medical College of Virginia, Richmond, Virginia
, Vanderbilt University, Nashville, Tennessee

Office Address   Mailing Address

1301 22nd Ave. S., 2665 TVC, Nashville, TN 37232-5505

Vanderbilt University Medical Center 2665 TVC, 1301 22nd Ave. South 37232-5505

Research Keywords
hematologic malignancies, leukemia, lymphoma, Hodgkin's Disease, multiple myeloma, hemostasis and thrombosis, stem cell transplantation,Cancer,Stem cells,Transplantation

Clinical Research Keywords
hematologic malignancies, hemostasis and thrombosis,

Research Specialty
Lymphoma, Leukemia, Clinical Trials, Bone Marrow Transplantation, Stem Cell Transplantation

Research Description
My research interests are in the clinicopathologic descriptions of hematologic neoplasms and in the development of therapeutic strategies to treat these disorders. Specific entities we have helped recognize include anaplastic large cell lymphoma, T-cell-rich B-cell lymphoma, and natural killer-like T-cell lymphoma/leukemia. Since the early 1980's, we have evaluated short course, dose intensive therapy (MEGA) for intermediate to high grade lymphomas, the use of high dose cytarabine consolidation in acute nonlymphocytic leukemia, and the role of transplantation in hematologic neoplasms. We actively participate in phase I-III trials through cooperative groups (Eastern Cooperative Oncology Group and Children's Oncology Group) and with the pharmaceutical industry. We have an emphasis in studies evaluating novel agents directed at molecular pathways, immunotherapy, and transplantation.

Clinical Interests
Non-Hodgkin's lymphoma: anaplastic large cell, peripheral T-cell, cutaneous lymphomas, T-cell-rich B-cell, natural killer-like T-cell lymphoma.
Acute and chronic leukemias.
Hodgkin's disease.
Bone marrow failure syndromes: myelodysplasia and aplastic anemia.
Stem cell transplantation.
Dose intensive therapy for hematologic malignancies.
Cooperative group trials (ECOG, CCG)

Engelhardt, BG, Holland, DW, Brandt, SJ, Chinratanalab, W, Goodman, SA, Greer, JP, Jagasia, MH, Kassim, AA, Morgan, DS, Ruffner, KL, Schuening, FG, Wolff, S, Bitting, R, Sulur, P, Stein, RS. High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leuk Lymphoma, 48(9), 1728-35, 2007

Sepmeyer, JA, Greer, JP, Koyama, T, Zic, JA. Open-label pilot study of combination therapy with rosiglitazone and bexarotene in the treatment of cutaneous T-cell lymphoma. J Am Acad Dermatol, 56(4), 584-7, 2007

Greer, JP. Therapy of peripheral T/NK neoplasms. Hematology Am Soc Hematol Educ Program, 331-7, 2006

Salmon, JS, Thompson, MA, Arildsen, RC, Greer, JP. Non-Hodgkin''s lymphoma involving the liver: clinical and therapeutic considerations. Clin Lymphoma Myeloma, 6(4), 273-80, 2006

Schmidt, AN, Robbins, JB, Greer, JP, Zic, JA. Conjugal transformed mycosis fungoides: the unknown role of viral infection and environmental exposures in the development of cutaneous T-cell lymphoma. J Am Acad Dermatol, 54(5 Suppl), S202-5, 2006

Jagasia, MH, Greer, JP, Morgan, DS, Mineishi, S, Kassim, AA, Ruffner, KL, Chen, H, Schuening, FG. Pegfilgrastim after high-dose chemotherapy and autologous peripheral blood stem cell transplant: phase II study. Bone Marrow Transplant, 35(12), 1165-9, 2005

Delbeke D, Martin WH, Morgan DS, Kinney JC, Feurer I, Kovalsky E, Arrowsmith T, Greer JP. 18F-Flourodeoxyglucose imaging with positron emission tomography for initial staging of Hodgkins disease and lymphoma. Clin Positron Imaging(3), 10-10, 2001

Dorr R, Karanes C, Spier C, Grogan T, Greer J, Moore J, Weinberger B, Schiller G, Pearce T, Litchman M, Dalton W, Roe D, List AF. Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. J Clin Oncol(19), 1589-1599, 2001

Pavletic, ZS, Arrowsmith, ER, Bierman, PJ, Goodman, SA, Vose, JM, Tarantolo, SR, Stein, RS, Bociek, G, Greer, JP, Wu, CD, Kollath, JP, Weisenburger, DD, Kessinger, A, Wolff, SN, Armitage, JO, Bishop, MR. Outcome of allogeneic stem cell transplantation for B cell chronic lymphocytic leukemia. Bone Marrow Transplant, 25(7), 717-22, 2000

Stein, RS, Greer, JP, Goodman, S, Brandt, SJ, Morgan, DS, Macon, WR, McCurley, TL, Wolff, SN. Intensified preparative regimens and autologous transplantation in refractory or relapsed intermediate grade non-Hodgkin''s lymphoma. Bone Marrow Transplant, 25(3), 257-62, 2000

Stein RS, Greer JP, Goodman S, Kallianpur A, Ahmed MS, Wolff SN. High -dose therapy with autologous or allogeneic transplantation as salvage therapy for small cleaved cell lymphoma of follicular center cell origin.. Bone Marrow Transplant, 23227-233, 1999

Kravtsov, VD, Greer, JP, Whitlock, JA, Koury, MJ. Use of the microculture kinetic assay of apoptosis to determine chemosensitivities of leukemias. Blood, 92(3), 968-80, 1998

Whitlock, JA, Wells, RJ, Hord, JD, Janco, RL, Greer, JP, Gay, JC, Edwards, JR, McCurley, TL, Lukens, JN. High-dose cytosine arabinoside and etoposide: an effective regimen without anthracyclines for refractory childhood acute non-lymphocytic leukemia. Leukemia, 11(2), 185-9, 1997

List, AF, Spier, CS, Grogan, TM, Johnson, C, Roe, DJ, Greer, JP, Wolff, SN, Broxterman, HJ, Scheffer, GL, Scheper, RJ, Dalton, WS. Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood, 87(6), 2464-9, 1996

Macon WR, Williams ME, Greer JP, Hammer RD, Glick AD, Collins RD, Cousar JB. Natrual killer-like T-cell lymphomas: Aggressive CD56+ peripheral T-cell lymphomas of large granular lymphocytes, possibly arising from thymic-independent T-cells.. Blood, 871474-1483, 1996

Stein, RS, Greer, JP, Flexner, JM, Goodman, S, Wolff, SN. Etoposide and mitoxantrone as a second cycle of consolidation therapy following high dose cytosine arabinoside and daunorubicin in patients with acute non-lymphocytic leukemia in remission: a pilot study. Leuk Lymphoma, 23(1-2), 93-8, 1996

Greer, JP, Macon, WR, Lamar, RE, Wolff, SN, Stein, RS, Flexner, JM, Collins, RD, Cousar, JB. T-cell-rich B-cell lymphomas: diagnosis and response to therapy of 44 patients. J Clin Oncol, 13(7), 1742-50, 1995

List AF, Spier C, Greer J, Wolff S, Hutter J, Door R, Salmon S, Futscher B, Baer M, Dalton W. Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.. J Clinc Oncol(11), 1652-1660, 1993

Waits, TM, Greco, FA, Greer, JP, Johnson, DH, Wolff, SN, Stein, RS, McMaster, ML, Hainsworth, JD. Effective therapy for poor-prognosis non-Hodgkin''s lymphoma with 8 weeks of high-dose-intensity combination chemotherapy. J Clin Oncol, 11(5), 943-9, 1993

Greer, JP, Kinney, MC, Collins, RD, Salhany, KE, Wolff, SN, Hainsworth, JD, Flexner, JM, Stein, RS. Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma. J Clin Oncol, 9(4), 539-47, 1991

McMaster, ML, Greer, JP, Wolff, SN, Johnson, DH, Greco, FA, Stein, RS, Cousar, JB, Flexner, JM, Hainsworth, JD. Results of treatment with high intensity, brief duration chemotherapy in poor prognosis non-Hodgkin''s lymphoma. Cancer, 68(2), 233-41, 1991

Reece DE, Barnett MJ, Conners JM, Fairey RN, Greer JP, Herzig GP, Herzig RH, Klingerman HC, OReilly SE, Shepherd JD, Spinelli JJ, Voss NJ, Wolff SN, Phillips GP. Intensive chemotherapy with cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkins disease. J Clinc Oncol(9), 1871-1879, 1991

Whitlock, JA, Greer, JP, Lukens, JN. Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia. Cancer, 68(3), 600-4, 1991

Stein, RS, Greer, JP, Flexner, JM, Hainsworth, JD, Collins, RD, Macon, WR, Cousar, JB. Large-cell lymphomas: clinical and prognostic features. J Clin Oncol, 8(8), 1370-9, 1990

Armitage, JO, Greer, JP, Levine, AM, Weisenburger, DD, Formenti, SC, Bast, M, Conley, S, Pierson, J, Linder, J, Cousar, JB. Peripheral T-cell lymphoma. Cancer, 63(1), 158-63, 1989

Wolff, SN, Herzig, RH, Fay, JW, Phillips, GL, Lazarus, HM, Flexner, JM, Stein, RS, Greer, JP, Cooper, B, Herzig, GP. High-dose cytarabine and daunorubicin as consolidation therapy for acute myeloid leukemia in first remission: long-term follow-up and results. J Clin Oncol, 7(9), 1260-7, 1989

Greer, JP, Cousar, JB, Miller, RF, Vogler, LB, Goodin, JC, Graber, SE, Collins, RD. T4+ (helper phenotype) chronic lymphocytic leukemia: case report with liver failure and literature review. Med Pediatr Oncol, 16(5), 356-62, 1988

McCurley TL, Greer JP, Glick AD. Terminal deoxynucleotidyl transferase (TdT) in acute nonlymphocytic leukemia. A clinical, morphologic, cytochemical, immunologic and ultrastructural study. Am J Clin Pathol(90), 421-430, 1988

Stein, RS, Magee, MJ, Lenox, RK, Cousar, JB, Collins, RD, Flexner, JM, Ray, W, Greer, JP. Malignant lymphomas of follicular center cell origin in man. VI. Large cleaved cell lymphoma. Cancer, 60(11), 2704-11, 1987

Wolff SN, Herzig RH, Phillips GL, Lazarus HM, Greer JP, Stein RS, Ray WA, Herzig GP. High-dose cytosine arabinoside and daunorubicin as consolidation therapy for acute nonlymphocytic leukemia in first remission: An up date. Sem Oncol(2), 12-17, 1987

Greer, JP, Kinney, MC, Cousar, JB, Flexner, JM, Dupont, WD, Graber, SE, Greco, FA, Collins, RD, Stein, RS. Lymphocyte-depleted Hodgkin''s disease. Clinicopathologic review of 25 patients. Am J Med, 81(2), 208-14, 1986

Greer, JP, York, JC, Cousar, JB, Mitchell, RT, Flexner, JM, Collins, RD, Stein, RS. Peripheral T-cell lymphoma: a clinicopathologic study of 42 cases. J Clin Oncol, 2(7), 788-98, 1984

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