Biomedical Research Education & Training
Faculty Member

Harris, Raymond C., M.D.
Director, Division of Nephrology
Professor of Medicine
Ann and Roscoe R. Robinson Chair in Nephrology
Professor of Molecular Physiology and Biophysics

Lab Url: N/A

Phone Number: 615- 322-2150

Email Address:

Harris, Raymond's picture
Academic history
B.S. Summa cumlaude, Yale University
M.D. Magna Cumlaude, Emory University

Office Address   Mailing Address

C-3121 MCN 2372

Clinical Research Keywords
general nephrology, acute and chronic renal failure

Research Specialty
role of cycylooxygenase-2 in renal development and function; role of growth factors in recovery from acute renal injury; role of renin-angiotensin system in regulation of epithelial cell function

Chen, J, Chen, JK, Harris, RC. EGF receptor deletion in podocytes attenuates diabetic nephropathy. J Am Soc Nephrol, 26(5), 1115-25, 2015

Cheng, H, Fan, X, Lawson, WE, Paueksakon, P, Harris, RC. Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy. Kidney Int, 88(1), 85-94, 2015

Fan, Y, Li, X, Xiao, W, Fu, J, Harris, RC, Lindenmeyer, M, Cohen, CD, Guillot, N, Baron, MH, Wang, N, Lee, K, He, JC, Schlondorff, D, Chuang, PY. BAMBI elimination enhances alternative TGF-?? signaling and glomerular dysfunction in diabetic mice. Diabetes, 64(6), 2220-33, 2015

Ma, SK, Wang, Y, Chen, J, Zhang, MZ, Harris, RC, Chen, JK. Overexpression of G-protein-coupled receptor 40 enhances the mitogenic response to epoxyeicosatrienoic acids. PLoS One, 10(2), e0113130, 2015

Neelisetty, S, Alford, C, Reynolds, K, Woodbury, L, Nlandu-Khodo, S, Yang, H, Fogo, AB, Hao, CM, Harris, RC, Zent, R, Gewin, L. Renal fibrosis is not reduced by blocking transforming growth factor-?? signaling in matrix-producing interstitial cells. Kidney Int, 88(3), 503-514, 2015

Singh, SP, Tao, S, Fields, TA, Webb, S, Harris, RC, Rao, R. Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice. Dis Model Mech, 8(8), 931-40, 2015

Wang, H, Chen, X, Su, Y, Paueksakon, P, Hu, W, Zhang, MZ, Harris, RC, Blackwell, TS, Zent, R, Pozzi, A. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int, 87(5), 948-62, 2015

Zhang, MZ, Harris, RC. Antihypertensive mechanisms of intra-renal dopamine. Curr Opin Nephrol Hypertens, 24(2), 117-22, 2015

Capdevila, JH, Pidkovka, N, Mei, S, Gong, Y, Falck, JR, Imig, JD, Harris, RC, Wang, W. The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. J Biol Chem, 289(7), 4377-86, 2014

Cheng, H, Harris, RC. Renal endothelial dysfunction in diabetic nephropathy. Cardiovasc Hematol Disord Drug Targets, 14(1), 22-33, 2014

Grove, KJ, Voziyan, PA, Spraggins, JM, Wang, S, Paueksakon, P, Harris, RC, Hudson, BG, Caprioli, RM. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. J Lipid Res, 55(7), 1375-1385, 2014

Reisin, E, Harris, RC, Rahman, M. Commentary on the 2014 BP guidelines from the panel appointed to the Eighth Joint National Committee (JNC 8). J Am Soc Nephrol, 25(11), 2419-24, 2014

Takahashi, T, Harris, RC. Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice. J Diabetes Res, 2014, 590541, 2014

Trachtman, H, Benzing, T, Sever, S, Harris, RC, Reiser, J. The grand challenge of nephrology. Front Med (Lausanne), 1, 28, 2014

Wang, F, Jiang, R, Takahashi, K, Gore, J, Harris, RC, Takahashi, T, Quarles, CC. Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imaging. Magn Reson Imaging, 32(9), 1125-32, 2014

Wang, F, Jiang, RT, Tantawy, MN, Borza, DB, Takahashi, K, Gore, JC, Harris, RC, Takahashi, T, Quarles, CC. Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease. J Magn Reson Imaging, 39(4), 866-71, 2014

Zeng, F, Harris, RC. Epidermal growth factor, from gene organization to bedside. Semin Cell Dev Biol, 28, 2-11, 2014

Zeng, F, Miyazawa, T, Kloepfer, LA, Harris, RC. Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice. Kidney Int, 86(3), 538-47, 2014

Zhang, MZ, Wang, Y, Paueksakon, P, Harris, RC. Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy. Diabetes, 63(6), 2063-72, 2014

Atochina-Vasserman, EN, Biktasova, A, Abramova, E, Cheng, DS, Polosukhin, VV, Tanjore, H, Takahashi, S, Sonoda, H, Foye, L, Venkov, C, Ryzhov, SV, Novitskiy, S, Shlonimskaya, N, Ikeda, M, Blackwell, TS, Lawson, WE, Gow, AJ, Harris, RC, Dikov, MM, Tchekneva, EE. Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress. Am J Physiol Renal Physiol, 304(10), F1295-307, 2013

Chen, J, Chen, MX, Fogo, AB, Harris, RC, Chen, JK. mVps34 deletion in podocytes causes glomerulosclerosis by disrupting intracellular vesicle trafficking. J Am Soc Nephrol, 24(2), 198-207, 2013

Harris, RC. The best-laid plans. Am J Physiol Renal Physiol, 304(8), F1086-7, 2013

Pidkovka, N, Rao, R, Mei, S, Gong, Y, Harris, RC, Wang, WH, Capdevila, JH. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. J Biol Chem, 288(7), 5223-31, 2013

Zhang, MZ, Wang, Y, Yao, B, Gewin, L, Wei, S, Capdevila, JH, Harris, RC. Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine''s effects in the kidney. Am J Physiol Renal Physiol, 305(12), F1680-6, 2013

Bartlett, CS, Boyd, KL, Harris, RC, Zent, R, Breyer, RM. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension, 60(5), 1184-91, 2012

Chen, J, Chen, JK, Harris, RC. Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol, 32(5), 981-91, 2012

Chen, J, Chen, JK, Harris, RC. Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int, 82(1), 45-52, 2012

Cheng, H, Wang, H, Fan, X, Paueksakon, P, Harris, RC. Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Kidney Int, 82(11), 1176-83, 2012

Gewin, L, Vadivelu, S, Neelisetty, S, Srichai, MB, Paueksakon, P, Pozzi, A, Harris, RC, Zent, R. Deleting the TGF-?? receptor attenuates acute proximal tubule injury. J Am Soc Nephrol, 23(12), 2001-11, 2012

Harris, RC. Abnormalities in renal dopamine signaling and hypertension: the role of GRK4. Curr Opin Nephrol Hypertens, 21(1), 61-5, 2012

Harris, RC. Podocyte ACE2 protects against diabetic nephropathy. Kidney Int, 82(3), 255-6, 2012

Harris, RC, Zhang, MZ. Dopamine, the kidney, and hypertension. Curr Hypertens Rep, 14(2), 138-43, 2012

Howard, C, Tao, S, Yang, HC, Fogo, AB, Woodgett, JR, Harris, RC, Rao, R. Specific deletion of glycogen synthase kinase-3?? in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney Int, 82(9), 1000-9, 2012

Jiang, R, Wang, S, Takahashi, K, Fujita, H, Fruci, CR, Breyer, MD, Harris, RC, Takahashi, T. Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis, 50(9), 685-92, 2012

Tantawy, MN, Jiang, R, Wang, F, Takahashi, K, Peterson, TE, Zemel, D, Hao, CM, Fujita, H, Harris, RC, Quarles, CC, Takahashi, T. Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy. BMC Nephrol, 13, 168, 2012

Yang, S, Yao, B, Zhou, Y, Yin, H, Zhang, MZ, Harris, RC. Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury. Am J Physiol Renal Physiol, 302(6), F742-9, 2012

Yu, L, Su, Y, Paueksakon, P, Cheng, H, Chen, X, Wang, H, Harris, RC, Zent, R, Pozzi, A. Integrin ??1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int, 81(11), 1086-97, 2012

Zhang, MZ, Wang, S, Yang, S, Yang, H, Fan, X, Takahashi, T, Harris, RC. Role of blood pressure and the renin-angiotensin system in development of diabetic nephropathy (DN) in eNOS-/- db/db mice. Am J Physiol Renal Physiol, 302(4), F433-8, 2012

Zhang, MZ, Yao, B, Yang, S, Jiang, L, Wang, S, Fan, X, Yin, H, Wong, K, Miyazawa, T, Chen, J, Chang, I, Singh, A, Harris, RC. CSF-1 signaling mediates recovery from acute kidney injury. J Clin Invest, 122(12), 4519-32, 2012

Zhang, MZ, Yao, B, Yang, S, Yang, H, Wang, S, Fan, X, Yin, H, Fogo, AB, Moeckel, GW, Harris, RC. Intrarenal dopamine inhibits progression of diabetic nephropathy. Diabetes, 61(10), 2575-84, 2012

Breyer, MD, Tchekneva, E, Qi, Z, Takahashi, T, Fogo, AB, Zhao, HJ, Harris, RC. Genetics of diabetic nephropathy: lessons from mice. Semin Nephrol, 27(2), 237-47, 2007

Chen, J, Chen, JK, Falck, JR, Anjaiah, S, Capdevila, JH, Harris, RC. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Mol Cell Biol, 27(8), 3023-34, 2007 PMCID:1899952

Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A. Integrin {alpha}1{beta}1 Controls Reactive Oxygen Species Synthesis by Negatively Regulating Epidermal Growth Factor Receptor-Mediated Rac Activation. Mol Cell Biol, 27(9), 3313-26, 2007 PMCID:1899972

Cheng, H, Wang, S, Jo, YI, Hao, CM, Zhang, M, Fan, X, Kennedy, C, Breyer, MD, Moeckel, GW, Harris, RC. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol, 18(2), 551-9, 2007

Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007 PMCID:1854944

Chen, J, Chen, JK, Neilson, EG, Harris, RC. Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy. J Am Soc Nephrol, 17(6), 1615-23, 2006

Cheng, H, Harris, RC. Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers. Expert Opin Drug Saf, 5(5), 631-41, 2006

Harris, RC. COX-2 and the kidney. J Cardiovasc Pharmacol, 47 Suppl 1, S37-42, 2006

Harris, RC, Neilson, EG. Toward a unified theory of renal progression. Annu Rev Med, 57, 365-80, 2006

Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006

Yao, B, Xu, J, Qi, Z, Harris, RC, Zhang, MZ. Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake. Am J Physiol Renal Physiol, 291(2), F368-74, 2006

Zhang, MZ, Yao, B, Cheng, HF, Wang, SW, Inagami, T, Harris, RC. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A, 103(43), 16045-50, 2006 PMCID:1635124

Zhao, HJ, Wang, S, Cheng, H, Zhang, MZ, Takahashi, T, Fogo, AB, Breyer, MD, Harris, RC. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol, 17(10), 2664-9, 2006

Breyer, MD, B??ttinger, E, Brosius, FC, Coffman, TM, Fogo, A, Harris, RC, Heilig, CW, Sharma, K. Diabetic nephropathy: of mice and men. Adv Chronic Kidney Dis, 12(2), 128-45, 2005

Breyer, MD, B??ttinger, E, Brosius, FC, Coffman, TM, Harris, RC, Heilig, CW, Sharma, K, , . Mouse models of diabetic nephropathy. J Am Soc Nephrol, 16(1), 27-45, 2005

Chen, JK, Chen, J, Neilson, EG, Harris, RC. Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol, 16(5), 1384-91, 2005

Cheng, H, Zhang, M, Moeckel, GW, Zhao, Y, Wang, S, Qi, Z, Breyer, MD, Harris, RC. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron Exp Nephrol, 101(3), e75-85, 2005

Cheng, HF, Harris, RC. Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors. Curr Pharm Des, 11(14), 1795-804, 2005


Rao, R, Zhang, MZ, Zhao, M, Cai, H, Harris, RC, Breyer, MD, Hao, CM. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol, 288(4), F642-9, 2005

Singh, AB, Harris, RC. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal, 17(10), 1183-93, 2005

Yao, B, Harris, RC, Zhang, MZ. Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Am J Physiol Regul Integr Comp Physiol, 288(6), R1767-73, 2005

Zhang, MZ, Yao, B, McKanna, JA, Harris, RC. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. Am J Physiol Renal Physiol, 288(4), F840-5, 2005

Chen, D, Roberts, R, Pohl, M, Nigam, S, Kreidberg, J, Wang, Z, Heino, J, Ivaska, J, Coffa, S, Harris, RC, Pozzi, A, Zent, R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, 287(4), F602-11, 2004

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004 PMCID:1618576

Cheng, HF, Harris, RC. Cyclooxygenases, the kidney, and hypertension. Hypertension, 43(3), 525-30, 2004

Fisher, ME, Rossini, M, Simmons, E, Harris, RC, Moeckel, G, Zent, R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am J Kidney Dis, 44(3), 567-73, 2004

Harris, RC, Zhang, MZ, Cheng, HF. Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol Scand, 181(4), 543-7, 2004

Qi, Z, Whitt, I, Mehta, A, Jin, J, Zhao, M, Harris, RC, Fogo, AB, Breyer, MD. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol, 286(3), F590-6, 2004

Shivakumar, BR, Wang, Z, Hammond, TG, Harris, RC. EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. Cell Biochem Funct, 23(3), 195-204, 2004

Singh, AB, Harris, RC. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem, 279(5), 3543-52, 2004

Singh, AB, Tsukada, T, Zent, R, Harris, RC. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci, 117(Pt 8), 1365-79, 2004

Zhang, MZ, Mai, W, Li, C, Cho, SY, Hao, C, Moeckel, G, Zhao, R, Kim, I, Wang, J, Xiong, H, Wang, H, Sato, Y, Wu, Y, Nakanuma, Y, Lilova, M, Pei, Y, Harris, RC, Li, S, Coffey, RJ, Sun, L, Wu, D, Chen, XZ, Breyer, MD, Zhao, ZJ, McKanna, JA, Wu, G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A, 101(8), 2311-6, 2004 PMCID:356947

Zhang, MZ, Sanchez Lopez, P, McKanna, JA, Harris, RC. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology, 145(3), 1402-9, 2004

Cheng, HF, Harris, RC. Does cyclooxygenase-2 affect blood pressure. Curr Hypertens Rep, 5(1), 87-92, 2003

Harris, RC. Interactions between COX-2 and the renin-angiotensin system in the kidney. Acta Physiol Scand, 177(4), 423-7, 2003

Harris, RC, Chung, E, Coffey, RJ. EGF receptor ligands. Exp Cell Res, 284(1), 2-13, 2003

Means, AL, Ray, KC, Singh, AB, Washington, MK, Whitehead, RH, Harris, RC, Wright, CV, Coffey, RJ, Leach, SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology, 124(4), 1020-36, 2003

Wang, Z, Chen, JK, Wang, SW, Moeckel, G, Harris, RC. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol, 14(12), 3147-54, 2003

Zhang, MZ, Wang, SW, Cheng, H, Zhang, Y, McKanna, JA, Harris, RC. Regulation of renal cortical cyclooxygenase-2 in young rats. Am J Physiol Renal Physiol, 285(5), F881-8, 2003

Cheng, H-F., Wang, J-L., Zhang, M-Z, McKanna, J.A. and Harris, R.C. Extracellular Chloride Regulates Renal Cortical Cyclooxygenase-2 (COX-2) Expression: Role of p38. Journal of Clinical Investigation. In Press

Burleigh, ME, Babaev, VR, Oates, JA, Harris, RC, Gautam, S, Riendeau, D, Marnett, LJ, Morrow, JD, Fazio, S, Linton, MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation, 105(15), 1816-23, 2002

Capdevila, JH, Harris, RC, Falck, JR. Microsomal cytochrome P450 and eicosanoid metabolism. Cell Mol Life Sci, 59(5), 780-9, 2002

Chen, JK, Capdevila, J, Harris, RC. Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proc Natl Acad Sci U S A, 99(9), 6029-34, 2002 PMCID:122896

Cheng, HF, Harris, RC. Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. J Biol Chem, 277(47), 45638-43, 2002

Cheng, HF, Wang, CJ, Moeckel, GW, Zhang, MZ, McKanna, JA, Harris, RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney Int, 62(3), 929-39, 2002

Cheng, HF, Wang, SW, Zhang, MZ, McKanna, JA, Breyer, R, Harris, RC. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Am J Physiol Regul Integr Comp Physiol, 283(3), R638-46, 2002

Harris, RC. Cyclooxygenase-2 inhibition and renal physiology. Am J Cardiol, 89(6A), 10D-17D, 2002

Harris, RC. Cyclooxygenase-2 and the kidney: functional and pathophysiological implications. J Hypertens Suppl, 20(6), S3-9, 2002

Zhang, MZ, Hao, CM, Breyer, MD, Harris, RC, McKanna, JA. Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla. Am J Physiol Renal Physiol, 283(3), F509-16, 2002

Breyer, MD, Harris, RC. Cyclooxygenase 2 and the kidney. Curr Opin Nephrol Hypertens, 10(1), 89-98, 2001

Chen, J-K, Zimpelmann, J., Harris, R.C. and Burns, K.D. Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. Am. J. Physiol. , 280, F980-988, 2001

Chen, JK, Capdevila, J, Harris, RC. Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol, 21(18), 6322-31, 2001 PMCID:87364

Cheng, HF, Wang, JL, Zhang, MZ, Wang, SW, McKanna, JA, Harris, RC. Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Am J Physiol Renal Physiol, 280(3), F449-56, 2001

Harris, RC, Breyer, MD. Physiological regulation of cyclooxygenase-2 in the kidney. Am J Physiol Renal Physiol, 281(1), F1-11, 2001

Sakai, M. Tsukada, T. and Harris, R.C. Induction of HB-EGF expression by reactive oxygen species: role of AP-1-mediated transcriptional activation. Experimental Nephrology , 9, 28-30, 2001

Takemura, T., Hino, S., Kuwajima, H., Yanagida, H, Okada, M., Nagata, M, Sasaki, S., Barasch, J., Harris, R.C. and Yoshioka, K. Induction of collecting duct morphogenesis in vitro by heparin-binding EGF-like growth factor. J.A.S.N., 12, 964-972, 2001

Capdevila, JH, Falck, JR, Harris, RC. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res, 41(2), 163-81, 2000

Chen, JK, Capdevila, J, Harris, RC. Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. J Biol Chem, 275(18), 13789-92, 2000

Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. J Clin Invest, 106(5), 681-8, 2000 PMCID:381289

Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC. Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Am J Physiol Renal Physiol, 279(1), F122-9, 2000

Haralson, MA, DiMari, SJ, Hoover, RL, Harris, RC. Effects of epidermal growth factor on collagen expression by rat kidney mesangial cells in culture. Matrix Biol, 19(1), 47-59, 2000

Harris, RC. Cyclooxygenase-2 in the kidney. J Am Soc Nephrol, 11(12), 2387-94, 2000

Harris, RC, Cheng, H, Wang, J, Zhang, M, McKanna, JA. Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Acta Physiol Scand, 168(1), 47-51, 2000

K??mhoff, M, Wang, JL, Cheng, HF, Langenbach, R, McKanna, JA, Harris, RC, Breyer, MD. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kidney Int, 57(2), 414-22, 2000

Wang, JL, Cheng, HF, Shappell, S, Harris, RC. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Kidney Int, 57(6), 2334-42, 2000

Becker, BN, Kondo, S, Chen, JK, Harris, RC. Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. J Recept Signal Transduct Res, 19(6), 975-93, 1999

Chen, JK, Wang, DW, Falck, JR, Capdevila, J, Harris, RC. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. J Biol Chem, 274(8), 4764-9, 1999

Cheng, HF, Wang, JL, Zhang, MZ, Miyazaki, Y, Ichikawa, I, McKanna, JA, Harris, RC. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest, 103(7), 953-61, 1999 PMCID:408259

Gibbs, SR, Goins, RA, Belvin, EL, Dimari, SJ, Merriam, AP, Bowling-Brown, S, Harris, RC, Haralson, MA. Characterization of the collagen phenotype of rabbit proximal tubule cells in culture. Connect Tissue Res, 40(3), 173-88, 1999

Harris, RC. Potential mechanisms and physiologic actions of intracellular angiotensin II. Am J Med Sci, 318(6), 374-9, 1999

Takemura, T, Hino, S, Murata, Y, Yanagida, H, Okada, M, Yoshioka, K, Harris, RC. Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Kidney Int, 55(1), 71-81, 1999

Wang, JL, Cheng, HF, Harris, RC. Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Hypertension, 34(1), 96-101, 1999

Zhang, MZ, Harris, RC, McKanna, JA. Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Proc Natl Acad Sci U S A, 96(26), 15280-5, 1999 PMCID:24811

Becker, BN, Yasuda, T, Kondo, S, Vaikunth, S, Homma, T, Harris, RC. Mechanical stretch/relaxation stimulates a cellular renin-angiotensin system in cultured rat mesangial cells. Exp Nephrol, 6(1), 57-66, 1998

Chen, JK, Falck, JR, Reddy, KM, Capdevila, J, Harris, RC. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem, 273(44), 29254-61, 1998

Cheng, HF, Wang, JL, Vinson, GP, Harris, RC. Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule. Am J Physiol, 274(1 Pt 2), F10-7, 1998

Harris, RC, Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA. Prostaglandins in macula densa function. Kidney Int Suppl, 67, S49-52, 1998

McKanna, JA, Zhang, MZ, Wang, JL, Cheng, H, Harris, RC. Constitutive expression of cyclooxygenase-2 in rat vas deferens. Am J Physiol, 275(1 Pt 2), R227-33, 1998

Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, JC, Harris, RC, McKanna, JM, Inagami, T, Hogan, BL, Fogo, A, Ichikawa, I. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102(8), 1489-97, 1998 PMCID:508998

Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA, Harris, RC. Selective increase of cyclooxygenase-2 expression in a model of renal ablation. Am J Physiol, 275(4 Pt 2), F613-22, 1998

Becker, BN, Cheng, HF, Harris, RC. Apical ANG II-stimulated PLA2 activity and Na+ flux: a potential role for Ca2+-independent PLA2. Am J Physiol, 273(4 Pt 2), F554-62, 1997

Becker, BN, Kondo, S, Cheng, HF, Harris, RC. Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells. Kidney Int, 52(1), 87-92, 1997

Harris, RC. Growth factors and cytokines in acute renal failure. Adv Ren Replace Ther, 4(2 Suppl 1), 43-53, 1997

Harris, RC, Becker, BN, Cheng, HF. Acute and chronic mechanisms for regulating proximal tubule angiotensin II receptor expression. J Am Soc Nephrol, 8(2), 306-13, 1997

Sakai, M, Zhang, M, Homma, T, Garrick, B, Abraham, JA, McKanna, JA, Harris, RC. Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest, 99(9), 2128-38, 1997 PMCID:508043

Takemura, T, Kondo, S, Homma, T, Sakai, M, Harris, RC. The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. J Biol Chem, 272(49), 31036-42, 1997

Zhang, MZ, Wang, JL, Cheng, HF, Harris, RC, McKanna, JA. Cyclooxygenase-2 in rat nephron development. Am J Physiol, 273(6 Pt 2), F994-1002, 1997

Becker, BN, Harris, RC. A potential mechanism for proximal tubule angiotensin II-mediated sodium flux associated with receptor-mediated endocytosis and arachidonic acid release. Kidney Int Suppl, 57, S66-72, 1996

Cheng, HF, Becker, BN, Harris, RC. Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest, 97(12), 2745-52, 1996 PMCID:507367

Harris, RC. The macula densa: recent developments. J Hypertens, 14(7), 815-22, 1996

Harris, RC, Cheng, HF. The intrarenal renin-angiotensin system: a paracrine system for the local control of renal function separate from the systemic axis. Exp Nephrol, 4 Suppl 1, 2-7, 1996

Yasuda, T, Kondo, S, Homma, T, Harris, RC. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest, 98(9), 1991-2000, 1996 PMCID:507642

Becker, BN, Cheng, HF, Burns, KD, Harris, RC. Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. Am J Physiol, 269(4 Pt 1), C1048-56, 1995

Burns, KD, Capdevila, J, Wei, S, Breyer, MD, Homma, T, Harris, RC. Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. Am J Physiol, 269(4 Pt 1), C831-40, 1995

Cheng, HF, Becker, BN, Burns, KD, Harris, RC. Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest, 95(5), 2012-9, 1995 PMCID:295780

Harris, RC, Martinez-Maldonado, M. Angiotensin II-mediated renal injury. Miner Electrolyte Metab, 21(4-5), 328-35, 1995

Homma, T, Sakai, M, Cheng, HF, Yasuda, T, Coffey, RJ, Harris, RC. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J Clin Invest, 96(2), 1018-25, 1995 PMCID:185290

Threadgill, D.W., Dlugosz, A.A., Hansen, L., Tennenbaum, T., Lichi, U., Yee, D, LeMantia, C., Mourton, T., Herrup, K., Harris, RC, Barnard, J.A., Yuspa,S.H., Coffey, and Magnuson, T. Targeted disruption of mouse EGF-receptor: Evidence that genetic background affects mutant phenotype. Science, 269, 230-234, 1995

Akai, Y, Homma, T, Burns, KD, Yasuda, T, Badr, KF, Harris, RC. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol, 267(2 Pt 1), C482-90, 1994

Cheng, HF, Burns, KD, Harris, RC. Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus. Kidney Int, 46(6), 1603-10, 1994

Harris, R.C., McKanna, J.A., Akai, Y., Jacobson, H.R., Dubois, R.N. and Breyer, M.D. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J. Clin. Invest, 94, 2504-2510, 1994

Harris, RC, Akai, Y, Yasuda, T, Homma, T. The role of physical forces in alterations of mesangial cell function. Kidney Int Suppl, 45, S17-21, 1994

Harris, RC, Akai, Y, Yasuda, T, Homma, T. Role of physical factors in the regulation of mesangial cell growth and the interaction with vasoactive agents. Exp Nephrol, 2(2), 104, 1994

Harris, RC, Ismail, N. Extrarenal complications of the nephrotic syndrome. Am J Kidney Dis, 23(4), 477-97, 1994

Harris, RC, McKanna, JA, Akai, Y, Jacobson, HR, Dubois, RN, Breyer, MD. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest, 94(6), 2504-10, 1994 PMCID:330084

Burns, KD, Homma, T, Harris, RC. The intrarenal renin-angiotensin system. Semin Nephrol, 13(1), 13-30, 1993

Burns, KD, Inagami, T, Harris, RC. Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Am J Physiol, 264(4 Pt 2), F645-54, 1993

Harris, RC, Burns, KD, Alattar, M, Homma, T, Nakamura, T. Hepatocyte growth factor stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells. Life Sci, 52(13), 1091-100, 1993

Homma, T, Zhang, JY, Shimizu, T, Prakash, C, Blair, IA, Harris, RC. Cyclooxygenase-derived metabolites of 8,9-epoxyeicosatrienoic acid are potent mitogens for cultured rat glomerular mesangial cells. Biochem Biophys Res Commun, 191(1), 282-8, 1993

Takahashi, K, Harris, RC, Capdevila, JH, Karara, A, Makita, K, Jacobson, HR, Munger, KA, Badr, KF. Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration. J Am Soc Nephrol, 3(8), 1496-500, 1993

Harris, R.C. S6 kinase activity in proximal tubule cells. Evidence for activation by epidermal growth factor and angiotensin II in vitro and by contralateral nephrectomy in vivo. Am. J. Physiol., 263, F127-F134, 1992

Harris, RC, Haralson, MA, Badr, KF. Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity. Lab Invest, 66(5), 548-54, 1992

Homma, T, Akai, Y, Burns, KD, Harris, RC. Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. J Biol Chem, 267(32), 23129-35, 1992

McKanna, JA, Chuncharunee, A, Munger, KA, Breyer, JA, Cohen, S, Harris, RC. Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia. J Cell Physiol, 153(3), 467-76, 1992

Awazu, M, Kon, V, Harris, RC, Imada, T, Inagami, T, Ichikawa, I. Renal sympathetic nerves modulate glomerular ANP receptors and filtration. Am J Physiol, 261(1 Pt 2), F29-35, 1991

Harris, RC. Potential physiologic roles for epidermal growth factor in the kidney. Am J Kidney Dis, 17(6), 627-30, 1991

Homma, T, Harris, RC. Time-dependent biphasic regulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. J Biol Chem, 266(21), 13553-9, 1991

Harris, RC, Badr, KF. Recovery of prostaglandin synthesis in rat glomerular mesangial cells after aspirin inhibition: induction of cyclooxygenase activity by serum and epidermal growth factor. Prostaglandins, 39(2), 213-22, 1990

Harris, RC, Homma, T, Jacobson, HR, Capdevila, J. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. J Cell Physiol, 144(3), 429-37, 1990

Harris, RC, Munger, KA, Badr, KF, Takahashi, K. Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. FASEB J, 4(6), 1654-60, 1990

Homma, T., Burns, K. and Harris R.C. Agonist stimulation of Na/K/Cl cotransport in cultured rat mesangial cells: Evidence for protein kinase C-dependent and calcium/calmodulin-dependent pathways. J. Biol. Chem., 265:, 17613-17620, 1990

Kon, V, Harris, RC, Ichikawa, I. A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. J Clin Invest, 85(6), 1728-33, 1990 PMCID:296633

Badr, KF, DeBoer, DK, Takahashi, K, Harris, RC, Fogo, A, Jacobson, HR. Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. Am J Physiol, 256(1 Pt 2), F35-43, 1989

Badr, KF, Mong, S, Hoover, RL, Schwartzberg, M, Ebert, J, Jacobson, HR, Harris, RC. Leukotriene D4 binding and signal transduction in rat glomerular mesangial cells. Am J Physiol, 257(2 Pt 2), F280-7, 1989

Badr, KF, Murray, JJ, Breyer, MD, Takahashi, K, Inagami, T, Harris, RC. Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. J Clin Invest, 83(1), 336-42, 1989 PMCID:303681

Harris, RC, Daniel, TO. Epidermal growth factor binding, stimulation of phosphorylation, and inhibition of gluconeogenesis in rat proximal tubule. J Cell Physiol, 139(2), 383-91, 1989

Harris, R.C., Hoover, R.L., Jacobson, H.R. and Badr, K.F. Evidence for glomerular actions of epidermal growth factor in the rat. J. Clin Invest., 82, 1028-1039, 1988

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