Biomedical Research Education & Training
Faculty Member

Wilson, Keith T., M.D.
Professor of Medicine
Professor of Pathology, Microbiology and Immunology
Thomas F. Frist, Sr. Chair in Medicine
Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-343-5675

Email Address: keith.wilson@vanderbilt.edu

Wilson, Keith's picture
Academic history
B.A., Cornell University, Ithaca, NY
M.D., Harvard Medical School, Boston, MA
Residency, Internal Medicine, Case Western Reserve University Hospitals
Fellowship, Gastroenterology, University of Chicago

Office Address   Mailing Address

1015B MRB IV/ 1015 MRB IV

1030C MRB IV 37232-0252


Research Keywords
Inflammation, DNA damage, Nitric oxide, Oxidative stress, Cancer, Polyamines,Bacteria,Biochemistry,Cancer,Gene regulation,Immunology,Knockout,Microbiology,Mouse,Pathology,Signal transduction,Transcription,Transcription factor,Translation,Tyrosine phosphorylation

Patient Care Specialty
Gastroenterology

Research Specialty
Mucosal immunology, mechanisms of inflammation, oxidative stress and gastrointestinal carcinogenesis, host-pathogen interactions

Research Description
My laboratory is focused on gastrointestinal mucosal inflammation and carcinogenesis. We study the host immune response to the gastric pathogen Helicobacter pylori that causes peptic ulcer disease and gastric cancer. This includes the innate immune response in macrophages and the identification of ways that this response is ineffective. We have also elucidated mechanisms whereby epithelial responses are inappropriate, leading to risk for cancer development. We study novel mechanisms for inflammation and cellular/DNA damage, which leads to increased cancer risk.

We have reported that H. pylori induces the enzyme spermine oxidase (SMO), originally known as polyamine oxidase 1, which utilizes the polyamine spermine as substrate. Generation of H2O2 by SMO results in mitochondrial membrane depolarization, cytochrome c release, and apoptosis. Spermine itself contributes to the inadequacy of the host response, by blocking translation of inducible nitric oxide (NO) synthase (iNOS) and hence NO production that is needed for the killing of H. pylori. Upregulation of SMO causes oxidative stress in gastric epithelial cells that leads to both apoptosis and DNA damage. Induction of ornithine decarboxylase (ODC) that generates polyamines also leads to apoptosis of macrophages, contributing to loss of host innate immunity to H. pylori. We have shown that induction of the transcription factor c-Myc by H. pylori enhances ODC transcription and has a causal role in macrophage apoptosis. We have also implicated formation of a specific AP-1 complex in the activation of c-Myc.

We are utilizing clinical material from a large cohort of human subjects from Colombia, South America where H. pylori infection prevalence is very high, but gastric cancer risk is 25-fold higher in the Andean mountains when compared to the coastal region. We have found that SMO-dependent oxidative stress is increased in gastric epithelial cells in vivo in the subjects at high risk for gastric cancer and that H. pylori clinical strains from these subjects induce more SMO and oxidative DNA damage both in vitro and in vivo in a gerbil model. Studies are ongoing to pursue the mechanisms involved in the differential induction of SMO and DNA damage.

We are also pursuing studies on immune dysregulation in inflammatory bowel disease. This includes work on arginine availability/transport, polyamines, and nitric oxide. We have reported that levels of the amino acid L-arginine are increased in the serum of humans with ulcerative colitis. Because L-arginine is important in regulation of epithelial integrity and immune function a defect in the utilization of L-arginine could contribute to the disease pathogenesis. Consistent with this, we have shown that treatment with L-arginine improves colitis in mouse models and that mice lacking an inducible L-arginine transporter have increased disease activity.

Our funded studies are focused on:
1) Mechanisms of H. pylori induced DNA damage and immune dysregulation, with an emphasis on the effects of polyamines and their oxidation (PI, R01 grant)
2) The role oxidative and nitrosative stress in the development of gastric cancer in Colombia, and the importance of H. pylori strains from regions of low and high gastric cancer risk in modulation of host responses (PI, project on P01)
3) Importance of arginine metabolism in the immune response to H. pylori (PI, VA Merit Review Grant)
4) Role of SMO in EGF signaling and epithelial dysfunction in H. pylori infection (PI, project on P01)
5) Arginine and other amino acids as immunomodulatory agents and potential therapies in colitis and colitis-associated cancer (PI- R01 grant)
6) Prospective clinical study investigating alterations in arginine and other amino acids in ulcerative colitis (PI- R01 supplement; funding completed, analysis ongoing)


Publications
Chaturvedi, R, Asim, M, Piazuelo, MB, Yan, F, Barry, DP, Sierra, JC, Delgado, AG, Hill, S, Casero, RA, Bravo, LE, Dominguez, RL, Correa, P, Polk, DB, Washington, MK, Rose, KL, Schey, KL, Morgan, DR, Peek, RM, Wilson, KT. Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells with DNA Damage. Gastroenterology, 2014

Kodaman, N, Pazos, A, Schneider, BG, Piazuelo, MB, Mera, R, Sobota, RS, Sicinschi, LA, Shaffer, CL, Romero-Gallo, J, de Sablet, T, Harder, RH, Bravo, LE, Peek, RM, Wilson, KT, Cover, TL, Williams, SM, Correa, P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A, 111(4), 1455-60, 2014

Shi, C, Washington, MK, Chaturvedi, R, Drosos, Y, Revetta, FL, Weaver, CJ, Buzhardt, E, Yull, FE, Blackwell, TS, Sosa-Pineda, B, Whitehead, RH, Beauchamp, RD, Wilson, KT, Means, AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest, 2014

Barrett, CW, Ning, W, Chen, X, Smith, JJ, Washington, MK, Hill, KE, Coburn, LA, Peek, RM, Chaturvedi, R, Wilson, KT, Burk, RF, Williams, CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res, 73(3), 1245-55, 2013

Barrett, CW, Singh, K, Motley, AK, Lintel, MK, Matafonova, E, Bradley, AM, Ning, W, Poindexter, SV, Parang, B, Reddy, VK, Chaturvedi, R, Fingleton, BM, Washington, MK, Wilson, KT, Davies, SS, Hill, KE, Burk, RF, Williams, CS. Dietary Selenium Deficiency Exacerbates DSS-Induced Epithelial Injury and AOM/DSS-Induced Tumorigenesis. PLoS One, 8(7), e67845, 2013

Chaturvedi, R, Asim, M, Barry, DP, Frye, JW, Casero, RA, Wilson, KT. Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Amino Acids, 2013

Coburn, LA, Horst, SN, Chaturvedi, R, Brown, CT, Allaman, MM, Scull, BP, Singh, K, Piazuelo, MB, Chitnavis, MV, Hodges, ME, Rosen, MJ, Williams, CS, Slaughter, JC, Beaulieu, DB, Schwartz, DA, Wilson, KT. High-throughput multi-analyte luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS One, 8(12), e82300, 2013

Falaiye, TO, Mitchell, KR, Lu, Z, Saville, BR, Horst, SN, Moulton, DE, Schwartz, DA, Wilson, KT, Rosen, MJ. Outcome Following Infliximab Therapy for Pediatric Patients Hospitalized With Refractory Colitis-Predominant Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr, 2013

Gobert, AP, Verriere, T, de Sablet, T, Peek, RM, Chaturvedi, R, Wilson, KT. Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Cell Microbiol, 15(1), 145-56, 2013

Hardbower, DM, de Sablet, T, Chaturvedi, R, Wilson, KT. Chronic inflammation and oxidative stress: The smoking gun for Helicobacter pylori-induced gastric cancer. Gut Microbes, 4(6), 2013

Noto, JM, Gaddy, JA, Lee, JY, Piazuelo, MB, Friedman, DB, Colvin, DC, Romero-Gallo, J, Suarez, G, Loh, J, Slaughter, JC, Tan, S, Morgan, DR, Wilson, KT, Bravo, LE, Correa, P, Cover, TL, Amieva, MR, Peek, RM. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest, 123(1), 479-92, 2013

Noto, JM, Khizanishvili, T, Chaturvedi, R, Piazuelo, MB, Romero-Gallo, J, Delgado, AG, Khurana, SS, Sierra, JC, Krishna, US, Suarez, G, Powell, AE, Goldenring, JR, Coffey, RJ, Yang, VW, Correa, P, Mills, JC, Wilson, KT, Peek, RM. Helicobacter pylori promotes the expression of kr??ppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One, 8(1), e54344, 2013

Noto, JM, Piazuelo, MB, Chaturvedi, R, Bartel, CA, Thatcher, EJ, Delgado, A, Romero-Gallo, J, Wilson, KT, Correa, P, Patton, JG, Peek, RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the anti-apoptotic protein, Mcl-1. Am J Physiol Gastrointest Liver Physiol, 2013

Parekh, VV, Wu, L, Olivares-Villag??mez, D, Wilson, KT, Van Kaer, L. Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells. J Immunol, 2013

Peek RM, Bimczok D, Wilson KT. Helicobacter pylori infection. In: Principles of Mucosal Immunology. Smith PD, MacDonald TT, Blumberg RS. Garland Science: New York.. , 363-376, 2013

Rosen, MJ, Chaturvedi, R, Washington, MK, Kuhnhein, LA, Moore, PD, Coggeshall, SS, McDonough, EM, Weitkamp, JH, Singh, AB, Coburn, LA, Williams, CS, Yan, F, Van Kaer, L, Peebles, RS, Wilson, KT. STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines. J Immunol, 190(4), 1849-58, 2013

Schneider, BG, Piazuelo, MB, Sicinschi, LA, Mera, R, Peng, DF, Roa, JC, Romero-Gallo, J, Delgado, AG, de Sablet, T, Bravo, LE, Wilson, KT, El-Rifai, W, Peek, RM, Correa, P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics, 8(11), 2013

Sheh, A, Chaturvedi, R, Merrell, DS, Correa, P, Wilson, KT, Fox, JG. Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cells. Infect Immun, 2013

Sheh, A, Piazuelo, MB, Wilson, KT, Correa, P, Fox, JG. Draft Genome Sequences of Helicobacter pylori Strains Isolated from Regions of Low and High Gastric Cancer Risk in Colombia. Genome Announc, 1(5), 2013

Sierra, JC, Hobbs, S, Chaturvedi, R, Yan, F, Wilson, KT, Peek, RM, Polk, DB. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol, 305(2), G196-203, 2013

Singh, K, Coburn, LA, Barry, DP, Asim, M, Scull, BP, Allaman, MM, Lewis, ND, Washington, MK, Rosen, MJ, Williams, CS, Chaturvedi, R, Wilson, KT. DELETION OF CATIONIC AMINO ACID TRANSPORTER 2 EXACERBATES DEXTRAN SULFATE SODIUM COLITIS AND LEADS TO AN IL-17-PREDOMINANT T CELL RESPONSE. Am J Physiol Gastrointest Liver Physiol, 2013

Barrett, CW, Smith, JJ, Lu, LC, Markham, N, Stengel, KR, Short, SP, Zhang, B, Hunt, AA, Fingleton, BM, Carnahan, RH, Engel, ME, Chen, X, Beauchamp, RD, Wilson, KT, Hiebert, SW, Reynolds, AB, Williams, CS. Kaiso Directs the Transcriptional Corepressor MTG16 to the Kaiso Binding Site in Target Promoters. PLoS One, 7(12), e51205, 2012

Chaturvedi, R, de Sablet, T, Coburn, LA, Gobert, AP, Wilson, KT. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids, 42(2-3), 627-40, 2012 PMCID:3237590

Chaturvedi, R, de Sablet, T, Peek, RM, Wilson, KT. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes, 3(1), 48-56, 2012

Coburn, LA, Gong, X, Singh, K, Asim, M, Scull, BP, Allaman, MM, Williams, CS, Rosen, MJ, Washington, MK, Barry, DP, Piazuelo, MB, Casero, RA, Chaturvedi, R, Zhao, Z, Wilson, KT. L-arginine Supplementation Improves Responses to Injury and Inflammation in Dextran Sulfate Sodium Colitis. PLoS One, 7(3), e33546, 2012 PMCID:3299802

Gobert, AP, Wilson, KT. Editorial: Orchestration of macrophage polarization by polyamines. J Leukoc Biol, 91(5), 677-9, 2012 PMCID:3344856

Loh, JT, Friedman, DB, Piazuelo, MB, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, Cover, TL. Analysis of Helicobacter pylori cagA Promoter Elements Required for Salt-Induced Upregulation of CagA Expression. Infect Immun, 80(9), 3094-106, 2012

Peng, D, Belkhiri, A, Hu, T, Chaturvedi, R, Asim, M, Wilson, KT, Zaika, A, El-Rifai, W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut, 61(9), 1250-60, 2012 PMCID:3237590

Sicinschi, LA, Correa, P, Bravo, LE, Peek, RM, Wilson, KT, Loh, JT, Yepez, MC, Gold, BD, Thompson, DT, Cover, TL, Schneider, BG. Non-invasive Genotyping of Helicobacter pylori cagA, vacA, and hopQ from Asymptomatic Children. Helicobacter, 17(2), 96-106, 2012 PMCID:3299802

Singh, K, Coburn, LA, Barry, DP, Boucher, JL, Chaturvedi, R, Wilson, KT. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am J Physiol Gastrointest Liver Physiol, 302(9), G1061-73, 2012 PMCID:3299802

Wang, L, Liu, L, Shi, Y, Cao, H, Chaturvedi, R, Calcutt, MW, Hu, T, Ren, X, Wilson, KT, Polk, DB, Yan, F. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One, 7(5), e36418, 2012 PMCID:3344856

Williams, CS, Bradley, AM, Chaturvedi, R, Singh, K, Piazuelo, MB, Chen, X, McDonough, EM, Schwartz, DA, Brown, CT, Allaman, MM, Coburn, LA, Horst, SN, Beaulieu, DB, Choksi, YA, Washington, MK, Williams, AD, Fisher, MA, Zinkel, SS, Peek, RM, Wilson, KT, Hiebert, SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut, 2012

Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res, 71(4), 1302-12, 2011 PMCID:3069756

Barry, DP, Asim, M, Leiman, DA, de Sablet, T, Singh, K, Casero, RA, Chaturvedi, R, Wilson, KT. Difluoromethylornithine Is a Novel Inhibitor of Helicobacter pylori Growth, CagA Translocation, and Interleukin-8 Induction. PLoS One, 6(2), e17510, 2011 PMCID:3046249

Barry, DP, Asim, M, Scull, BP, Piazuelo, MB, de Sablet, T, Lewis, ND, Coburn, LA, Singh, K, Ellies, LG, Gobert, AP, Chaturvedi, R, Wilson, KT. Cationic Amino Acid Transporter 2 Enhances Innate Immunity during Helicobacter pylori Infection. PLoS One, 6(12), e29046, 2011 PMCID:3237590

Chaturvedi, R, Asim, M, Romero-Gallo, J, Barry, DP, Hoge, S, de Sablet, T, Delgado, AG, Wroblewski, LE, Piazuelo, MB, Yan, F, Israel, DA, Casero, RA, Correa, P, Gobert, AP, Polk, DB, Peek, RM, Wilson, KT. Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA. Gastroenterology, 141(5), 1696-1708.e2, 2011

Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, JJ, Midha, R, Mittal, MK, Krishnan, M, Chen, X, Eschrich, S, Yeatman, TJ, Harris, RC, Washington, MK, Wilson, KT, Beauchamp, RD, Singh, AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene, 30(29), 3234-47, 2011 PMCID:3046249

Gobert, AP, Asim, M, Piazuelo, MB, Verriere, T, Scull, BP, de Sablet, T, Glumac, A, Lewis, ND, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT. Disruption of Nitric Oxide Signaling by Helicobacter pylori Results in Enhanced Inflammation by Inhibition of Heme Oxygenase-1. J Immunol, 187(10), 5370-9, 2011

Gobert, AP, Chaturvedi, R, Wilson, KT. Methods to evaluate alterations in polyamine metabolism caused by Helicobacter pylori infection. Methods Mol Biol, 720, 409-25, 2011 PMCID:3069756

Goettel, JA, Scott Algood, HM, Olivares-Villag??mez, D, Washington, MK, Chaturvedi, R, Wilson, KT, Van Kaer, L, Polk, DB. KSR1 Protects From Interleukin-10 Deficiency-Induced Colitis in Mice by Suppressing T-Lymphocyte Interferon-I? Production. Gastroenterology, 140(1), 265-74, 2011

Lewis, ND, Asim, M, Barry, DP, de Sablet, T, Singh, K, Piazuelo, MB, Gobert, AP, Chaturvedi, R, Wilson, KT. Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II. J Immunol, 186, 3632-3641, 2011

Olivares-Villag??mez, D, Algood, HM, Singh, K, Parekh, VV, Ryan, KE, Piazuelo, MB, Wilson, KT, Van Kaer, L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J Immunol, 187(8), 4051-60, 2011 PMCID:3186831

Rana, T, Misra, S, Mittal, MK, Farrow, AL, Wilson, KT, Linton, MF, Fazio, S, Willis, IM, Chaudhuri, G. Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. J Biol Chem, 286(8), 6614-26, 2011 PMCID:3069806

Rosen, MJ, Frey, MR, Washington, MK, Chaturvedi, R, Kuhnhein, LA, Matta, P, Revetta, FL, Wilson, KT, Polk, DB. STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis, 17(11), 2224-34, 2011 PMCID:3133872

Singh, K, Chaturvedi, R, Barry, DP, Coburn, LA, Asim, M, Lewis, ND, Piazuelo, MB, Washington, MK, Vitek, MP, Wilson, KT. The Apolipoprotein E-Mimetic Peptide COG112 Inhibits NF-{kappa}B Signaling, Proinflammatory Cytokine Expression, and Disease Activity in Murine Models of Colitis. J Biol Chem, 286(5), 3839-50, 2011

Yan, F, Cao, H, Cover, TL, Washington, MK, Shi, Y, Liu, L, Chaturvedi, R, Peek, RM, Wilson, KT, Polk, DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest, 121(6), 2242-53, 2011 PMCID:3104743

Yan, F, Wang, L, Shi, Y, Cao, H, Liu, L, Washington, MK, Chaturvedi, R, Israel, DA, Cao, H, Wang, B, Peek, RM, Wilson, KT, Polk, DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol, 2011

de Sablet, T, Piazuelo, MB, Shaffer, CL, Schneider, BG, Asim, M, Chaturvedi, R, Bravo, LE, Sicinschi, LA, Delgado, AG, Mera, RM, Israel, DA, Romero-Gallo, J, Peek, RM, Cover, TL, Correa, P, Wilson, KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, 60(9), 1189-95, 2011 PMCID:3133872

Asim, M, Chaturvedi, R, Hoge, S, Lewis, ND, Singh, K, Barry, DP, Algood, HS, de Sablet, T, Gobert, AP, Wilson, KT. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J Biol Chem, 285(26), 20343-57, 2010 PMCID:2888446

Chaturvedi, R, Asim, M, Hoge, S, Lewis, ND, Singh, K, Barry, DP, de Sablet, T, Piazuelo, MB, Sarvaria, AR, Cheng, Y, Closs, EI, Casero, RA, Gobert, AP, Wilson, KT. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology, 139(5), 1686-98, 1698.e1-6, 2010 PMCID:2990353

Correa P, Piazuelo MB, Wilson KT. Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol, 105(3), 493-498, 2010

Hong, SK, Chaturvedi, R, Piazuelo, MB, Coburn, LA, Williams, CS, Delgado, AG, Casero, RA, Schwartz, DA, Wilson, KT. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Inflamm Bowel Dis, 16(9), 1557-66, 2010 PMCID:2894261

Hong, SK, Maltz, BE, Coburn, LA, Slaughter, JC, Chaturvedi, R, Schwartz, DA, Wilson, KT. Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity. Inflamm Bowel Dis, 16(1), 105-11, 2010 PMCID:2795785

Lewis, ND, Asim, M, Barry, DP, Singh, K, de Sablet, T, Boucher, JL, Gobert, AP, Chaturvedi, R, Wilson, KT. Arginase II Restricts Host Defense to Helicobacter pylori by Attenuating Inducible Nitric Oxide Synthase Translation in Macrophages. J Immunol, 184(5), 2572-82, 2010

Ogden, SR, Noto, JM, Allen, SS, Patel, DA, Romero-Gallo, J, Washington, MK, Fingleton, B, Israel, DA, Lewis, ND, Wilson, KT, Chaturvedi, R, Zhao, Z, Shyr, Y, Peek, RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res, 70(1), 30-5, 2010

Peek, RM, Fiske, C, Wilson, KT. Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol Rev, 90(3), 831-58, 2010

Schneider, BG, Peng, DF, Camargo, MC, Piazuelo, MB, Sicinschi, LA, Mera, R, Romero-Gallo, J, Delgado, AG, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, El-Rifai, W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer, 127(11), 2588-97, 2010 PMCID:2916942

Wroblewski, LE, Peek, RM, Wilson, KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev, 23(4), 713-39, 2010

Yan, F, Cao, H, Chaturvedi, R, Krishna, U, Hobbs, SS, Dempsey, PJ, Peek, RM, Cover, TL, Washington, MK, Wilson, KT, Polk, DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology, 136(4), 1297-1307, e1-3, 2009

O'Brien, DP, Romero-Gallo, J, Schneider, BG, Chaturvedi, R, Delgado, A, Harris, EJ, Krishna, U, Ogden, SR, Israel, DA, Wilson, KT, Peek, RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J Biol Chem, 283, 23922-23930, 2008 PMCID:2527108

Singh, K, Chaturvedi, R, Asim, M, Barry, DP, Lewis, ND, Vitek, MP, Wilson, KT. The Apolipoprotein E-mimetic Peptide COG112 Inhibits the Inflammatory Response to Citrobacter rodentium in Colonic Epithelial Cells by Preventing NF-{kappa}B Activation. J Biol Chem, 283(24), 16752-61, 2008 PMCID:2423260

Algood, HM, Gallo-Romero, J, Wilson, KT, Peek, RM, Cover, TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol, 51(3), 577-86, 2007

Chaturvedi, R, Asim, M, Lewis, ND, Algood, HM, Cover, TL, Kim, PY, Wilson, KT. L-Arginine Availability Regulates Inducible Nitric Oxide Synthase-dependent Host Defense Against Helicobacter pylori. Infect Immun, 75(9), 4305-15, 2007 PMCID:1951193

Wilson, KT, Crabtree, JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology, 133(1), 288-308, 2007

Bussiere, FI, Chaturvedi, R, Asim, M, Hoek, KL, Cheng, Y, Gainor, J, Scholz, A, Khan, WN, Wilson, KT. Low multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytes. Cancer Res, 66(13), 6834-42, 2006

Chaturvedi, R, Wilson, KT. Implication of polyamines in apoptosis of immunoresponse cells. In Wang, JY, Casero, RA, Jr., eds., Polyamine Cell Signalling: Physiology, Pharmacology, and Cancer Research. Totowa, NJ: Human Press., p. 293-311, 2006

Bussi??re, FI, Chaturvedi, R, Cheng, Y, Gobert, AP, Asim, M, Blumberg, DR, Xu, H, Kim, PY, Hacker, A, Casero, RA, Wilson, KT. Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation. J Biol Chem, 280(4), 2409-12, 2005

Cheng, Y, Chaturvedi, R, Asim, M, Bussi??re, FI, Scholz, A, Xu, H, Casero, RA, Wilson, KT. Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. J Biol Chem, 280(23), 22492-6, 2005

Cross, RK, Wilson, KT, Binion, DG. Polypharmacy and Crohn''s disease. Aliment Pharmacol Ther, 21(10), 1211-6, 2005

Cross, RK, Wilson, KT, Binion, DG. Narcotic use in patients with Crohn''s disease. Am J Gastroenterol, 100(10), 2225-9, 2005

Gobert, AP, Wilson, KT, Martin, C. Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system. Arch Immunol Ther Exp (Warsz), 53(3), 234-44, 2005

Chaturvedi, R, Cheng, Y, Asim, M, Bussi??re, FI, Xu, H, Gobert, AP, Hacker, A, Casero, RA, Wilson, KT. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J Biol Chem, 279(38), 40161-73, 2004

Duleu, S, Vincendeau, P, Courtois, P, Semballa, S, Lagroye, I, Daulou??de, S, Boucher, JL, Wilson, KT, Veyret, B, Gobert, AP. Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect. J Immunol, 172(10), 6298-303, 2004

Gobert, AP, Cheng, Y, Akhtar, M, Mersey, BD, Blumberg, DR, Cross, RK, Chaturvedi, R, Drachenberg, CB, Boucher, JL, Hacker, A, Casero, RA, Wilson, KT. Protective role of arginase in a mouse model of colitis. J Immunol, 173(3), 2109-17, 2004

Ma, X, Yang, Q, Wilson, KT, Kundu, N, Meltzer, SJ, Fulton, AM. Promoter methylation regulates cyclooxygenase expression in breast cancer. Breast Cancer Res, 6(4), R316-21, 2004 PMCID:468630

Xu, H, Chaturvedi, R, Cheng, Y, Bussiere, FI, Asim, M, Yao, MD, Potosky, D, Meltzer, SJ, Rhee, JG, Kim, SS, Moss, SF, Hacker, A, Wang, Y, Casero, RA, Wilson, KT. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res, 64(23), 8521-5, 2004

Yan, F, John, SK, Wilson, G, Jones, DS, Washington, MK, Polk, DB. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest, 114(9), 1272-80, 2004 PMCID:524224

Corredor, J, Yan, F, Shen, CC, Tong, W, John, SK, Wilson, G, Whitehead, R, Polk, DB. Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am J Physiol Cell Physiol, 284(4), C953-61, 2003 PMCID:524224

Cross, RK, Wilson, KT. Nitric oxide in inflammatory bowel disease. Inflamm Bowel Dis, 9(3), 179-89, 2003

Meyer, F, Ramanujam, KS, Gobert, AP, James, SP, Wilson, KT. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. J Immunol, 171(8), 3913-7, 2003

Panchal, PC, Forman, JS, Blumberg, DR, Wilson, KT. Helicobacter pylori infection: pathogenesis. Curr Opin Gastroenterol, 19(1), 4-10, 2003

Gobert, AP, Cheng, Y, Wang, JY, Boucher, JL, Iyer, RK, Cederbaum, SD, Casero, RA, Newton, JC, Wilson, KT. Helicobacter pylori induces macrophage apoptosis by activation of arginase II. J Immunol, 168(9), 4692-700, 2002

Gobert, AP, Mersey, BD, Cheng, Y, Blumberg, DR, Newton, JC, Wilson, KT. Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase. J Immunol, 168(12), 6002-6, 2002

Rafiee, P, Johnson, CP, Li, MS, Ogawa, H, Heidemann, J, Fisher, PJ, Lamirand, TH, Otterson, MF, Wilson, KT, Binion, DG. Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. J Biol Chem, 277(38), 35605-15, 2002

Wilson, KT. Angiogenic markers, neovascularization and malignant deformation of Barrett''s esophagus. Dis Esophagus, 15(1), 16-21, 2002

Akhtar, M, Cheng, Y, Magno, RM, Ashktorab, H, Smoot, DT, Meltzer, SJ, Wilson, KT. Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. Cancer Res, 61(6), 2399-403, 2001

Fleisher, AS, Esteller, M, Tamura, G, Rashid, A, Stine, OC, Yin, J, Zou, TT, Abraham, JM, Kong, D, Nishizuka, S, James, SP, Wilson, KT, Herman, JG, Meltzer, SJ. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Oncogene, 20(3), 329-35, 2001

Gobert, AP, McGee, DJ, Akhtar, M, Mendz, GL, Newton, JC, Cheng, Y, Mobley, HL, Wilson, KT. Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Proc Natl Acad Sci U S A, 98(24), 13844-9, 2001 PMCID:61129

Binion, DG, Rafiee, P, Ramanujam, KS, Fu, S, Fisher, PJ, Rivera, MT, Johnson, CP, Otterson, MF, Telford, GL, Wilson, KT. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic Biol Med, 29(9), 881-8, 2000

Fleisher, AS, Esteller, M, Harpaz, N, Leytin, A, Rashid, A, Xu, Y, Liang, J, Stine, OC, Yin, J, Zou, TT, Abraham, JM, Kong, D, Wilson, KT, James, SP, Herman, JG, Meltzer, SJ. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res, 60(17), 4864-8, 2000

Malamud, A, Wilson, KT. Treatment of gastrointestinal infections. Curr Opin Gastroenterol, 16(1), 51-5, 2000

Meyer, F, Wilson, KT, James, SP. Modulation of innate cytokine responses by products of Helicobacter pylori. Infect Immun, 68(11), 6265-72, 2000 PMCID:97708

Tamura, G, Yin, J, Wang, S, Fleisher, AS, Zou, T, Abraham, JM, Kong, D, Smolinski, KN, Wilson, KT, James, SP, Silverberg, SG, Nishizuka, S, Terashima, M, Motoyama, T, Meltzer, SJ. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst, 92(7), 569-73, 2000

Tsuchiya, T, Tamura, G, Sato, K, Endoh, Y, Sakata, K, Jin, Z, Motoyama, T, Usuba, O, Kimura, W, Nishizuka, S, Wilson, KT, James, SP, Yin, J, Fleisher, AS, Zou, T, Silverberg, SG, Kong, D, Meltzer, SJ. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia. Oncogene, 19(32), 3642-6, 2000

Fleisher, AS, Esteller, M, Wang, S, Tamura, G, Suzuki, H, Yin, J, Zou, TT, Abraham, JM, Kong, D, Smolinski, KN, Shi, YQ, Rhyu, MG, Powell, SM, James, SP, Wilson, KT, Herman, JG, Meltzer, SJ. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res, 59(5), 1090-5, 1999

Fu, S, Ramanujam, KS, Wong, A, Fantry, GT, Drachenberg, CB, James, SP, Meltzer, SJ, Wilson, KT. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology, 116(6), 1319-29, 1999

Wilson, KT, Fantry, GT. Pathogenesis of Helicobacter pylori infection. Curr Opin Gastroenterol, 15(1), 66-71, 1999

Binion, DG, Fu, S, Ramanujam, KS, Chai, YC, Dweik, RA, Drazba, JA, Wade, JG, Ziats, NP, Erzurum, SC, Wilson, KT. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am J Physiol, 275(3 Pt 1), G592-603, 1998

Kundu, N, Dorsey, R, Jackson, MJ, Guiterrez, P, Wilson, K, Fu, S, Ramanujam, K, Thomas, E, Fulton, AM. Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide. Int J Cancer, 76(5), 713-9, 1998

Varanasi, RV, Fantry, GT, Wilson, KT. Decreased prevalence of Helicobacter pylori infection in gastroesophageal reflux disease. Helicobacter, 3(3), 188-94, 1998

Wilson, KT, Fu, S, Ramanujam, KS, Meltzer, SJ. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett''s esophagus and associated adenocarcinomas. Cancer Res, 58(14), 2929-34, 1998

Wilson, KT, Ramanujam, KS, Mobley, HL, Musselman, RF, James, SP, Meltzer, SJ. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology, 111(6), 1524-33, 1996

Wilson, KT, Vaandrager, AB, De Vente, J, Musch, MW, De Jonge, HR, Chang, EB. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Am J Physiol, 270(3 Pt 1), C832-40, 1996

Wilson, KT, Chang, EB. Immune regulation of intestinal secretion. Practical Gastroenterol, 3, 22J-22Q, 1994

Wilson, KT, Xie, Y, Musch, MW, Chang, EB. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J Pharmacol Exp Ther, 266(1), 224-30, 1993

Wilson, KT, Musch, MW, Chang, EB. Diarrhea in inflammatory bowel diseases: Pathogenesis and treatment . In MacDermott, R, Stenson, W, eds., Inflammatory Bowel Disease. New York: Elsevier, 273-299, 1992


Postdoctoral Position Available
Yes

Postdoctoral Position Details
Postdoctoral position available to study mucosal immunology, inflammation, and carcinogenesis. Expertise in molecular biology, immunology, microbiology, and/or biochemistry is highly desirable.

Updated Date
02/25/2014