Biomedical Research Education & Training
Faculty Member

Parikh, Alexander A., M.D.
Associate Professor of Surgery

Lab Url: http://Division of Surgical Oncology

Phone Number: 615-322-2391

Email Address: alexander.parikh@vanderbilt.edu

Parikh, Alexander's picture
Academic history
B.A., Honors, Johns Hopkins University
, University of Edinburgh
M.D., University of Pennsylvania
, University of Cincinnati School of Medicine
, University of Texas M.D. Anderson Cancer Center

Office Address   Mailing Address

597 Preston Building, 2220 Pierce Avenue, Nashville, TN 37232-6860

597 PRB 37232-6860


Publications
Parikh, AA, Ellis, LM. The vascular endothelial growth factor family and its receptors. Hematol Oncol Clin North Am, 18(5), 951-71, vii, 2004

Parikh, AA, Fan, F, Liu, WB, Ahmad, SA, Stoeltzing, O, Reinmuth, N, Bielenberg, D, Bucana, CD, Klagsbrun, M, Ellis, LM. Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. Am J Pathol, 164(6), 2139-51, 2004 PMCID:1615754

Akagi, M, Kawaguchi, M, Liu, W, McCarty, MF, Takeda, A, Fan, F, Stoeltzing, O, Parikh, AA, Jung, YD, Bucana, CD, Mansfield, PF, Hicklin, DJ, Ellis, LM. Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer, 88(5), 796-802, 2003 PMCID:2376351

Liu, W, Reinmuth, N, Stoeltzing, O, Parikh, AA, Tellez, C, Williams, S, Jung, YD, Fan, F, Takeda, A, Akagi, M, Bar-Eli, M, Gallick, GE, Ellis, LM. Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. Cancer Res, 63(13), 3632-6, 2003

McCarty, MF, Liu, W, Fan, F, Parikh, A, Reimuth, N, Stoeltzing, O, Ellis, LM. Promises and pitfalls of anti-angiogenic therapy in clinical trials. Trends Mol Med, 9(2), 53-8, 2003

Parikh, AA, Gentner, B, Wu, TT, Curley, SA, Ellis, LM, Vauthey, JN. Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy. J Gastrointest Surg, 7(8), 1082-8, 2003

Parikh, AA, Liu, WB, Fan, F, Stoeltzing, O, Reinmuth, N, Bruns, CJ, Bucana, CD, Evans, DB, Ellis, LM. Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma. Cancer, 98(4), 720-9, 2003

Reinmuth, N, Liu, W, Ahmad, SA, Fan, F, Stoeltzing, O, Parikh, AA, Bucana, CD, Gallick, GE, Nickols, MA, Westlin, WF, Ellis, LM. Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice. Cancer Res, 63(9), 2079-87, 2003

Reinmuth, N, Parikh, AA, Ahmad, SA, Liu, W, Stoeltzing, O, Fan, F, Takeda, A, Akagi, M, Ellis, LM. Biology of angiogenesis in tumors of the gastrointestinal tract. Microsc Res Tech, 60(2), 199-207, 2003

Stoeltzing, O, Ahmad, SA, Liu, W, McCarty, MF, Wey, JS, Parikh, AA, Fan, F, Reinmuth, N, Kawaguchi, M, Bucana, CD, Ellis, LM. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res, 63(12), 3370-7, 2003

Stoeltzing, O, Liu, W, Reinmuth, N, Fan, F, Parikh, AA, Bucana, CD, Evans, DB, Semenza, GL, Ellis, LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am J Pathol, 163(3), 1001-11, 2003 PMCID:1868239

Stoeltzing, O, Liu, W, Reinmuth, N, Fan, F, Parry, GC, Parikh, AA, McCarty, MF, Bucana, CD, Mazar, AP, Ellis, LM. Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer, 104(4), 496-503, 2003

Stoeltzing, O, Liu, W, Reinmuth, N, Parikh, A, Ahmad, SA, Jung, YD, Fan, F, Ellis, LM. Angiogenesis and antiangiogenic therapy of colon cancer liver metastasis. Ann Surg Oncol, 10(7), 722-33, 2003

Ellis, LM, Ahmad, S, Fan, F, Liu, W, Jung, YD, Stoeltzing, O, Reinmuth, N, Parikh, AA. Angiopoietins and their role in colon cancer angiogenesis. Oncology (Williston Park), 16(4 Suppl 3), 31-5, 2002

Ellis, LM, Liu, W, Fan, F, Jung, YD, Reinmuth, N, Stoeltzing, O, Takeda, A, Akagi, M, Parikh, AA, Ahmad, S. Synopsis of angiogenesis inhibitors in oncology. Oncology (Williston Park), 16(5 Suppl 4), 14-22, 2002

Jung, YD, Ahmad, SA, Liu, W, Reinmuth, N, Parikh, A, Stoeltzing, O, Fan, F, Ellis, LM. The role of the microenvironment and intercellular cross-talk in tumor angiogenesis. Semin Cancer Biol, 12(2), 105-12, 2002

Jung, YD, Fan, F, McConkey, DJ, Jean, ME, Liu, W, Reinmuth, N, Stoeltzing, O, Ahmad, SA, Parikh, AA, Mukaida, N, Ellis, LM. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine, 18(4), 206-13, 2002

Liu, W, Reinmuth, N, Stoeltzing, O, Parikh, AA, Fan, F, Ahmad, SA, Jung, YD, Ellis, LM. Antiangiogenic therapy targeting factors that enhance endothelial cell survival. Semin Oncol, 29(3 Suppl 11), 96-103, 2002

Parikh, AA, Curley, SA, Fornage, BD, Ellis, LM. Radiofrequency ablation of hepatic metastases. Semin Oncol, 29(2), 168-82, 2002

Reinmuth, N, Fan, F, Liu, W, Parikh, AA, Stoeltzing, O, Jung, YD, Bucana, CD, Radinsky, R, Gallick, GE, Ellis, LM. Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. Lab Invest, 82(10), 1377-89, 2002

Reinmuth, N, Stoeltzing, O, Liu, W, Ahmad, SA, Jung, YD, Fan, F, Parikh, A, Ellis, LM. Endothelial survival factors as targets for antineoplastic therapy. Cancer J, 7 Suppl 3, S109-19, 2002

Stoeltzing, O, Ahmad, SA, Liu, W, McCarty, MF, Parikh, AA, Fan, F, Reinmuth, N, Bucana, CD, Ellis, LM. Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis. Br J Cancer, 87(10), 1182-7, 2002 PMCID:2376191

Takeda, A, Stoeltzing, O, Ahmad, SA, Reinmuth, N, Liu, W, Parikh, A, Fan, F, Akagi, M, Ellis, LM. Role of angiogenesis in the development and growth of liver metastasis. Ann Surg Oncol, 9(7), 610-6, 2002

Moon, MR, Parikh, AA, Pritts, TA, Kane, C, Fischer, JE, Salzman, AL, Hasselgren, PO. Interleukin-1beta induces complement component C3 and IL-6 production at the basolateral and apical membranes in a human intestinal epithelial cell line. Shock, 13(5), 374-8, 2000

Parikh, AA, Moon, MR, Pritts, TA, Fischer, JE, Szab??, C, Hasselgren, PO, Salzman, AL. IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock, 13(1), 8-13, 2000

Moon, MR, Parikh, AA, Pritts, TA, Fischer, JE, Cottongim, S, Szabo, C, Salzman, AL, Hasselgren, PO. Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha. J Surg Res, 82(1), 48-55, 1999

Moon, R, Pritts, TA, Parikh, AA, Fischer, JE, Salzman, AL, Ryan, M, Wong, HR, Hasselgren, PO. Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci (Lond), 97(3), 331-7, 1999

Parikh, AA, Lowy, AM. Pancreatic cancer: can we screen? How should we stage. Curr Gastroenterol Rep, 1(2), 166-74, 1999

Pritts, TA, Nussbaum, MS, Flesch, LV, Fegelman, EJ, Parikh, AA, Fischer, JE. Implementation of a clinical pathway decreases length of stay and cost for bowel resection. Ann Surg, 230(5), 728-33, 1999 PMCID:1420929

Parikh, AA, Moon, MR, Kane, CD, Salzman, AL, Fischer, JE, Hasselgren, PO. Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. J Surg Res, 77(1), 40-4, 1998

Moon, R, Parikh, AA, Szabo, C, Fischer, JE, Salzman, AL, Hasselgren, PO. Complement C3 production in human intestinal epithelial cells is regulated by interleukin 1beta and tumor necrosis factor alpha. Arch Surg, 132(12), 1289-93, 1997

Parikh, AA, Luchette, FA, Valente, JF, Johnson, RC, Anderson, GL, Blebea, J, Rosenthal, GJ, Hurst, JM, Johannigman, JA, Davis, K. Blunt carotid artery injuries. J Am Coll Surg, 185(1), 80-6, 1997

Parikh, AA, Salzman, AL, Fischer, JE, Szab??, C, Hasselgren, PO. Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock, 8(4), 249-55, 1997

Parikh, AA, Salzman, AL, Kane, CD, Fischer, JE, Hasselgren, PO. IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B. J Surg Res, 69(1), 139-44, 1997


Postdoctoral Position Available
Yes

Postdoctoral Position Details
A postdoctoral position is available immediately to investigate tissue biomarkers in pancreatic cancer using proteomic and genomic technology. These projects will include assistance with collection and processing of human tissue specimens, tissue RNA and protein as well as the use of proteomics and gene microarray. In addition, immunohistochemical studies will also be performed. This position will be in combination with Dr. John Phay in the study of the molecular mechanisms of increased glucose metabolism in malignancy. Interested applicants should send a CV to alexander.parikh@vanderbilt.edu

Updated Date
11/29/2007