Biomedical Research Education & Training
Faculty Member

Parikh, Alexander A., M.D., M.P.H.
Associate Professor of Surgery

Lab Url: http://Division of Surgical Oncology

Phone Number: 615-322-2391

Email Address:

Parikh, Alexander's picture
Academic history

Office Address   Mailing Address

597 Preston Building, 2220 Pierce Avenue, Nashville, TN 37232-6860

597 PRB 37232-6860

Clinical Research Keywords
Health Services Research, Insurance, Disparities, Quality Improvement, Cancer Epidemiology, Clinical Trials

Patient Care Specialty
Hepatobiliary, Pancreatic and GI Surgical Oncology

Bailey, CE, Fritz, MB, Webb, L, Merchant, NB, Parikh, AA. Gastric duplication cyst masquerading as a mucinous pancreatic cyst: case report and literature review. Ann R Coll Surg Engl, 96(1), 88E-90E, 2014

Kauffmann, RM, Wang, L, Phillips, S, Idrees, K, Merchant, NB, Parikh, AA. Incidence of additional primary malignancies in patients with pancreatic and gastrointestinal neuroendocrine tumors. Ann Surg Oncol, 21(11), 3422-8, 2014

Kooby, DA, Lad, NL, Squires, MH, Maithel, SK, Sarmiento, JM, Staley, CA, Adsay, NV, El-Rayes, BF, Weber, SM, Winslow, ER, Cho, CS, Zavala, KA, Bentrem, DJ, Knab, M, Ahmad, SA, Abbott, DE, Sutton, JM, Kim, HJ, Yeh, JJ, Aufforth, R, Scoggins, CR, Martin, RC, Parikh, AA, Robinson, J, Hashim, YM, Fields, RC, Hawkins, WG, Merchant, NB. Value of intraoperative neck margin analysis during whipple for pancreatic adenocarcinoma: a multicenter analysis of 1399 patients. Ann Surg, 260(3), 494-501; discussion 501-3, 2014

Parikh, AA, Robinson, J, Zaydfudim, VM, Penson, D, Whiteside, MA. The effect of health insurance status on the treatment and outcomes of patients with colorectal cancer. J Surg Oncol, 110(3), 227-32, 2014

Sutton, JM, Kooby, DA, Wilson, GC, Squires, MH, Hanseman, DJ, Maithel, SK, Bentrem, DJ, Weber, SM, Cho, CS, Winslow, ER, Scoggins, CR, Martin, RC, Kim, HJ, Baker, JJ, Merchant, NB, Parikh, AA, Abbott, DE, Edwards, MJ, Ahmad, SA. Perioperative blood transfusion is associated with decreased survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma: a multi-institutional study. J Gastrointest Surg, 18(9), 1575-87, 2014

Kelly, KJ, Winslow, E, Kooby, D, Lad, NL, Parikh, AA, Scoggins, CR, Ahmad, S, Martin, RC, Maithel, SK, Kim, HJ, Merchant, NB, Cho, CS, Weber, SM. Vein involvement during pancreaticoduodenectomy: is there a need for redefinition of "borderline resectable disease". J Gastrointest Surg, 17(7), 1209-17; discussion 1217, 2013

Parikh, AA, Ni, S, Koyama, T, Pawlik, TM, Penson, D. Trends in the multimodality treatment of resectable colorectal liver metastases: an underutilized strategy. J Gastrointest Surg, 17(11), 1938-46, 2013

Ahmad, SA, Edwards, MJ, Sutton, JM, Grewal, SS, Hanseman, DJ, Maithel, SK, Patel, SH, Bentram, DJ, Weber, SM, Cho, CS, Winslow, ER, Scoggins, CR, Martin, RC, Kim, HJ, Baker, JJ, Merchant, NB, Parikh, AA, Kooby, DA. Factors influencing readmission after pancreaticoduodenectomy: a multi-institutional study of 1302 patients. Ann Surg, 256(3), 529-37, 2012

Cannon, RM, LeGrand, R, Chagpar, RB, Ahmad, SA, McClaine, R, Kim, HJ, Rupp, C, Cho, CS, Brinkman, A, Weber, S, Winslow, ER, Kooby, DA, Chu, CK, Staley, CA, Glenn, I, Hawkins, WG, Parikh, AA, Merchant, NB, McMasters, KM, Martin, RC, Callender, GG, Scoggins, CR. Multi-institutional analysis of pancreatic adenocarcinoma demonstrating the effect of diabetes status on survival after resection. HPB (Oxford), 14(4), 228-35, 2012

Deery, S, Yates, R, Hata, J, Shi, C, Parikh, AA. Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. Am Surg, 78(8), E379-80, 2012

McMaster, WG, Mukherjee, K, Parikh, AA. Surgical management of a symptomatic foregut duplication cyst. Am Surg, 78(6), E306-7, 2012

Cho, CS, Kooby, DA, Schmidt, CM, Nakeeb, A, Bentrem, DJ, Merchant, NB, Parikh, AA, Martin, RC, Scoggins, CR, Ahmad, SA, Kim, HJ, Hamilton, N, Hawkins, WG, Weber, SM. Laparoscopic versus open left pancreatectomy: can preoperative factors indicate the safer technique. Ann Surg, 253(5), 975-80, 2011

Martin, RC, Kooby, DA, Weber, SM, Merchant, NB, Parikh, AA, Cho, CS, Ahmad, SA, Kim, HJ, Hawkins, W, Scoggins, CR. Analysis of 6,747 pancreatic neuroendocrine tumors for a proposed staging system. J Gastrointest Surg, 15(1), 175-83, 2011

Mayo, SC, Heckman, JE, Shore, AD, Nathan, H, Parikh, AA, Bridges, JF, Anders, RA, Anaya, DA, Becker, NS, Pawlik, TM. Shifting trends in liver-directed management of patients with colorectal liver metastasis: a population-based analysis. Surgery, 150(2), 204-16, 2011

Parikh, AA, Ellis, LM. Circulating angiogenic factors, tumor cells, and outcome after resection of metastatic colorectal cancer--what does it mean. Ann Surg Oncol, 18(8), 2111-3, 2011

Backlund, DC, Berlin, JD, Parikh, AA. Update on adjuvant trials for pancreatic cancer. Surg Oncol Clin N Am, 19(2), 391-409, 2010

Castellanos, JA, Edwards, CM, Shaver, A, Merchant, NB, Parikh, AA. Appendiceal adenocarcinoma presenting as venous thromboembolism: an unusual presentation of a rare carcinoma. Am Surg, 76(5), 543-4, 2010

Kooby, DA, Hawkins, WG, Schmidt, CM, Weber, SM, Bentrem, DJ, Gillespie, TW, Sellers, JB, Merchant, NB, Scoggins, CR, Martin, RC, Kim, HJ, Ahmad, S, Cho, CS, Parikh, AA, Chu, CK, Hamilton, NA, Doyle, CJ, Pinchot, S, Hayman, A, McClaine, R, Nakeeb, A, Staley, CA, McMasters, KM, Lillemoe, KD. A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate. J Am Coll Surg, 210(5), 779-85, 786-7, 2010

Merchant, NB, Parikh, AA, Liu, EH. Adjuvant chemoradiation therapy for pancreas cancer: who really benefits. Adv Surg, 44, 149-64, 2010

Castaldo, ET, Parikh, AA, Pinson, CW, Feurer, ID, Merchant, NB. Improvement of survival with response to neoadjuvant radiation therapy for rectal cancer. Arch Surg, 144(2), 129-34; discussion 134-5, 2009

Merchant, NB, Rymer, J, Koehler, EA, Ayers, GD, Castellanos, J, Kooby, DA, Weber, SH, Cho, CS, Schmidt, CM, Nakeeb, A, Matos, JM, Scoggins, CR, Martin, RC, Kim, HJ, Ahmad, SA, Chu, CK, McClaine, R, Bednarski, BK, Staley, CA, Sharp, K, Parikh, AA. Adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits. J Am Coll Surg, 208(5), 829-38; discussion 838-41, 2009

Bao, PQ, Johnson, JC, Lindsey, EH, Schwartz, DA, Arildsen, RC, Grzeszczak, E, Parikh, AA, Merchant, NB. Endoscopic ultrasound and computed tomography predictors of pancreatic cancer resectability. J Gastrointest Surg, 12(1), 10-6; discussion 16, 2008

Parikh, AA, Johnson, JC, Merchant, NB. Genomics and proteomics in predicting cancer outcomes. Surg Oncol Clin N Am, 17(2), 257-77, vii, 2008

Snyder, RA, Harris, E, Hansen, EN, Merchant, NB, Parikh, AA. Gastric schwannoma. Am Surg, 74(8), 753-6, 2008

Parikh, AA, Abdalla, EK, Vauthey, JN. Operative considerations in resection of hilar cholangiocarcinoma. HPB (Oxford), 7(4), 254-8, 2005

Parikh, AA, Ellis, LM. The vascular endothelial growth factor family and its receptors. Hematol Oncol Clin North Am, 18(5), 951-71, vii, 2004

Parikh, AA, Fan, F, Liu, WB, Ahmad, SA, Stoeltzing, O, Reinmuth, N, Bielenberg, D, Bucana, CD, Klagsbrun, M, Ellis, LM. Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. Am J Pathol, 164(6), 2139-51, 2004 PMCID:1615754

Akagi, M, Kawaguchi, M, Liu, W, McCarty, MF, Takeda, A, Fan, F, Stoeltzing, O, Parikh, AA, Jung, YD, Bucana, CD, Mansfield, PF, Hicklin, DJ, Ellis, LM. Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer, 88(5), 796-802, 2003 PMCID:2376351

Liu, W, Reinmuth, N, Stoeltzing, O, Parikh, AA, Tellez, C, Williams, S, Jung, YD, Fan, F, Takeda, A, Akagi, M, Bar-Eli, M, Gallick, GE, Ellis, LM. Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. Cancer Res, 63(13), 3632-6, 2003

McCarty, MF, Liu, W, Fan, F, Parikh, A, Reimuth, N, Stoeltzing, O, Ellis, LM. Promises and pitfalls of anti-angiogenic therapy in clinical trials. Trends Mol Med, 9(2), 53-8, 2003

Parikh, AA, Gentner, B, Wu, TT, Curley, SA, Ellis, LM, Vauthey, JN. Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy. J Gastrointest Surg, 7(8), 1082-8, 2003

Parikh, AA, Liu, WB, Fan, F, Stoeltzing, O, Reinmuth, N, Bruns, CJ, Bucana, CD, Evans, DB, Ellis, LM. Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma. Cancer, 98(4), 720-9, 2003

Reinmuth, N, Liu, W, Ahmad, SA, Fan, F, Stoeltzing, O, Parikh, AA, Bucana, CD, Gallick, GE, Nickols, MA, Westlin, WF, Ellis, LM. Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice. Cancer Res, 63(9), 2079-87, 2003

Reinmuth, N, Parikh, AA, Ahmad, SA, Liu, W, Stoeltzing, O, Fan, F, Takeda, A, Akagi, M, Ellis, LM. Biology of angiogenesis in tumors of the gastrointestinal tract. Microsc Res Tech, 60(2), 199-207, 2003

Stoeltzing, O, Ahmad, SA, Liu, W, McCarty, MF, Wey, JS, Parikh, AA, Fan, F, Reinmuth, N, Kawaguchi, M, Bucana, CD, Ellis, LM. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res, 63(12), 3370-7, 2003

Stoeltzing, O, Liu, W, Reinmuth, N, Fan, F, Parikh, AA, Bucana, CD, Evans, DB, Semenza, GL, Ellis, LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am J Pathol, 163(3), 1001-11, 2003 PMCID:1868239

Stoeltzing, O, Liu, W, Reinmuth, N, Fan, F, Parry, GC, Parikh, AA, McCarty, MF, Bucana, CD, Mazar, AP, Ellis, LM. Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer, 104(4), 496-503, 2003

Stoeltzing, O, Liu, W, Reinmuth, N, Parikh, A, Ahmad, SA, Jung, YD, Fan, F, Ellis, LM. Angiogenesis and antiangiogenic therapy of colon cancer liver metastasis. Ann Surg Oncol, 10(7), 722-33, 2003

Ellis, LM, Ahmad, S, Fan, F, Liu, W, Jung, YD, Stoeltzing, O, Reinmuth, N, Parikh, AA. Angiopoietins and their role in colon cancer angiogenesis. Oncology (Williston Park), 16(4 Suppl 3), 31-5, 2002

Ellis, LM, Liu, W, Fan, F, Jung, YD, Reinmuth, N, Stoeltzing, O, Takeda, A, Akagi, M, Parikh, AA, Ahmad, S. Synopsis of angiogenesis inhibitors in oncology. Oncology (Williston Park), 16(5 Suppl 4), 14-22, 2002

Jung, YD, Ahmad, SA, Liu, W, Reinmuth, N, Parikh, A, Stoeltzing, O, Fan, F, Ellis, LM. The role of the microenvironment and intercellular cross-talk in tumor angiogenesis. Semin Cancer Biol, 12(2), 105-12, 2002

Jung, YD, Fan, F, McConkey, DJ, Jean, ME, Liu, W, Reinmuth, N, Stoeltzing, O, Ahmad, SA, Parikh, AA, Mukaida, N, Ellis, LM. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine, 18(4), 206-13, 2002

Liu, W, Reinmuth, N, Stoeltzing, O, Parikh, AA, Fan, F, Ahmad, SA, Jung, YD, Ellis, LM. Antiangiogenic therapy targeting factors that enhance endothelial cell survival. Semin Oncol, 29(3 Suppl 11), 96-103, 2002

Parikh, AA, Curley, SA, Fornage, BD, Ellis, LM. Radiofrequency ablation of hepatic metastases. Semin Oncol, 29(2), 168-82, 2002

Reinmuth, N, Fan, F, Liu, W, Parikh, AA, Stoeltzing, O, Jung, YD, Bucana, CD, Radinsky, R, Gallick, GE, Ellis, LM. Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. Lab Invest, 82(10), 1377-89, 2002

Reinmuth, N, Stoeltzing, O, Liu, W, Ahmad, SA, Jung, YD, Fan, F, Parikh, A, Ellis, LM. Endothelial survival factors as targets for antineoplastic therapy. Cancer J, 7 Suppl 3, S109-19, 2002

Stoeltzing, O, Ahmad, SA, Liu, W, McCarty, MF, Parikh, AA, Fan, F, Reinmuth, N, Bucana, CD, Ellis, LM. Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis. Br J Cancer, 87(10), 1182-7, 2002 PMCID:2376191

Takeda, A, Stoeltzing, O, Ahmad, SA, Reinmuth, N, Liu, W, Parikh, A, Fan, F, Akagi, M, Ellis, LM. Role of angiogenesis in the development and growth of liver metastasis. Ann Surg Oncol, 9(7), 610-6, 2002

Moon, MR, Parikh, AA, Pritts, TA, Kane, C, Fischer, JE, Salzman, AL, Hasselgren, PO. Interleukin-1beta induces complement component C3 and IL-6 production at the basolateral and apical membranes in a human intestinal epithelial cell line. Shock, 13(5), 374-8, 2000

Parikh, AA, Moon, MR, Pritts, TA, Fischer, JE, Szab??, C, Hasselgren, PO, Salzman, AL. IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock, 13(1), 8-13, 2000

Moon, MR, Parikh, AA, Pritts, TA, Fischer, JE, Cottongim, S, Szabo, C, Salzman, AL, Hasselgren, PO. Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha. J Surg Res, 82(1), 48-55, 1999

Moon, R, Pritts, TA, Parikh, AA, Fischer, JE, Salzman, AL, Ryan, M, Wong, HR, Hasselgren, PO. Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci (Lond), 97(3), 331-7, 1999

Parikh, AA, Lowy, AM. Pancreatic cancer: can we screen? How should we stage. Curr Gastroenterol Rep, 1(2), 166-74, 1999

Pritts, TA, Nussbaum, MS, Flesch, LV, Fegelman, EJ, Parikh, AA, Fischer, JE. Implementation of a clinical pathway decreases length of stay and cost for bowel resection. Ann Surg, 230(5), 728-33, 1999 PMCID:1420929

Parikh, AA, Moon, MR, Kane, CD, Salzman, AL, Fischer, JE, Hasselgren, PO. Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. J Surg Res, 77(1), 40-4, 1998

Moon, R, Parikh, AA, Szabo, C, Fischer, JE, Salzman, AL, Hasselgren, PO. Complement C3 production in human intestinal epithelial cells is regulated by interleukin 1beta and tumor necrosis factor alpha. Arch Surg, 132(12), 1289-93, 1997

Parikh, AA, Luchette, FA, Valente, JF, Johnson, RC, Anderson, GL, Blebea, J, Rosenthal, GJ, Hurst, JM, Johannigman, JA, Davis, K. Blunt carotid artery injuries. J Am Coll Surg, 185(1), 80-6, 1997

Parikh, AA, Salzman, AL, Fischer, JE, Szab??, C, Hasselgren, PO. Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock, 8(4), 249-55, 1997

Parikh, AA, Salzman, AL, Kane, CD, Fischer, JE, Hasselgren, PO. IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B. J Surg Res, 69(1), 139-44, 1997

Postdoctoral Position Available

Postdoctoral Position Details
A postdoctoral position is available immediately to investigate tissue biomarkers in pancreatic cancer using proteomic and genomic technology. These projects will include assistance with collection and processing of human tissue specimens, tissue RNA and protein as well as the use of proteomics and gene microarray. In addition, immunohistochemical studies will also be performed. This position will be in combination with Dr. John Phay in the study of the molecular mechanisms of increased glucose metabolism in malignancy. Interested applicants should send a CV to

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