Biomedical Research Education & Training
Faculty Member

Khabele, Dineo, M.D.
Associate Professor of Obstetrics and Gynecology
Associate Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-936-8422

Email Address:

Khabele, Dineo's picture
Academic history
BA, Columbia College, Columbia University, New York, NY
MD, College of Physicians and Surgeons, Columbia University, New York, NY
Resident, The New York Presbyterian Hospital, Weill-Cornell University Medical Center, New York, NY
Clinical Fellow, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY
Research Fellow, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY

Office Address   Mailing Address

1161 21st Ave South, Nashville, TN 37232-2516

1161 21st Ave South 37232

Research Keywords
Ovarian cancer DNA damage response, inflammation, apoptosis Cervical cancer Cancer health disparities,Acetylation,Apoptosis,Cancer,Chromatin,DNA repair,Gene regulation,Molecular medicine

Clinical Research Keywords
Gynecologic Oncology

Patient Care Specialty
Gynecologic Oncology

Research Specialty
Gynecologic Oncology Translational Research

Research Description
Dr. Khabele conducts translational and clinical research studies in gynecologic oncology. The primary goal of the translational research program is to design personalized diagnostics and therapeutics (based on genetic and epigenetic alterations in DNA damage response, inflammatory, and cell death pathways) as molecular targets for ovarian cancer.

Clinical Interests
Ovarian cancer, Cervical cancer, Endometrial Cancer, Vulvar Cancer, Vaginal Cancer, Complex Gynecological Surgical Procedures, Robotic Surgery

Desouki, MM, Khabele, D, Crispens, MA, Fadare, O. Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision. Int J Gynecol Pathol, 34(1), 19-24, 2015

Collins, Y, Holcomb, K, Chapman-Davis, E, Khabele, D, Farley, JH. Gynecologic cancer disparities: a report from the Health Disparities Taskforce of the Society of Gynecologic Oncology. Gynecol Oncol, 133(2), 353-61, 2014

Desouki, MM, Kallas, SJ, Khabele, D, Crispens, MA, Hameed, O, Fadare, O. Differential vimentin expression in ovarian and uterine corpus endometrioid adenocarcinomas: diagnostic utility in distinguishing double primaries from metastatic tumors. Int J Gynecol Pathol, 33(3), 274-81, 2014

Hull, PC, Williams, EA, Khabele, D, Dean, C, Bond, B, Sanderson, M. HPV vaccine use among African American girls: qualitative formative research using a participatory social marketing approach. Gynecol Oncol, 132 Suppl 1, S13-20, 2014

Khabele, D. The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancer. Front Oncol, 4, 111, 2014

Khabele, D, Kabir, SM, Dong, Y, Lee, E, Rice, VM, Son, DS. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer, 5(8), 670-8, 2014

Konstantinopoulos, PA, Wilson, AJ, Saskowski, J, Wass, E, Khabele, D. Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer. Gynecol Oncol, 133(3), 599-606, 2014

Ayuso, A, Fadare, O, Khabele, D. A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease. Case Rep Obstet Gynecol, 2013, 202458, 2013

Fadare, O, Gwin, K, Desouki, MM, Crispens, MA, Jones, HW, Khabele, D, Liang, SX, Zheng, W, Mohammed, K, Hecht, JL, Parkash, V. The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium. Mod Pathol, 26(8), 1101-10, 2013

Fadare, O, James, S, Desouki, MM, Khabele, D. Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas. Ann Diagn Pathol, 17(5), 430-3, 2013

Fadare, O, Khabele, D. Salpingo-oophorectomy specimens for endometrial cancer staging: a comparative analysis of representative sampling versus whole tissue processing. Hum Pathol, 44(4), 643-50, 2013

Fadare, O, Liang, SX, Crispens, MA, Jones, HW, Khabele, D, Gwin, K, Zheng, W, Mohammed, K, Parkash, V, Hecht, JL, Desouki, MM. Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance. Hum Pathol, 44(8), 1508-15, 2013

Fadare, O, Zheng, W, Crispens, MA, Jones, HW, Khabele, D, Gwin, K, Liang, SX, Mohammed, K, Desouki, MM, Parkash, V, Hecht, JL. Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases. Am J Cancer Res, 3(1), 70-95, 2013

Wells, CE, Bhaskara, S, Stengel, KR, Zhao, Y, Sirbu, B, Chagot, B, Cortez, D, Khabele, D, Chazin, WJ, Cooper, A, Jacques, V, Rusche, J, Eischen, CM, McGirt, LY, Hiebert, SW. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One, 8(7), e68915, 2013

Wilson, AJ, Barham, W, Saskowski, J, Tikhomirov, O, Chen, L, Lee, HJ, Yull, F, Khabele, D. Tracking NF-??B activity in tumor cells during ovarian cancer progression in a syngeneic mouse model. J Ovarian Res, 6(1), 63, 2013

Wilson, AJ, Liu, AY, Roland, J, Adebayo, OB, Fletcher, SA, Slaughter, JC, Saskowski, J, Crispens, MA, Jones, HW, James, S, Fadare, O, Khabele, D. TR3 modulates platinum resistance in ovarian cancer. Cancer Res, 73(15), 4758-69, 2013

Zaidi, SS, Lakhani, VT, Fadare, O, Khabele, D. Adrenal gland metastasis is an unusual manifestation of endometrial cancer. Case Rep Surg, 2013, 428456, 2013

Khabele, D, Fadare, O, Liu, AY, Wilson, AJ, Wass, E, Osteen, K, Crispens, MA. An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma. Int J Clin Exp Pathol, 5(1), 37-45, 2012 PMCID:3267484

Vargis, E, Tang, YW, Khabele, D, Mahadevan-Jansen, A. Near-infrared Raman Microspectroscopy Detects High-risk Human Papillomaviruses. Transl Oncol, 5(3), 172-9, 2012

Wilson, AJ, Cheng, YQ, Khabele, D. Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy. J Ovarian Res, 5(1), 12, 2012

Wilson, AJ, Lalani, AS, Wass, E, Saskowski, J, Khabele, D. Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancer. Gynecol Oncol, 127(3), 579-86, 2012

Fadare, O, Khabele, D. Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. Int J Gynecol Pathol, 30(3), 282-7, 2011

Vargis, E, Byrd, T, Logan, Q, Khabele, D, Mahadevan-Jansen, A. Sensitivity of Raman spectroscopy to normal patient variability. J Biomed Opt, 16(11), 117004, 2011

Wilson, AJ, Holson, E, Wagner, F, Zhang, YL, Fass, DM, Haggarty, SJ, Bhaskara, S, Hiebert, SW, Schreiber, SL, Khabele, D. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol Ther, 12(6), 2011

Bhaskara, S, Knutson, SK, Jiang, G, Chandrasekharan, MB, Wilson, AJ, Zheng, S, Yenamandra, A, Locke, K, Yuan, JL, Bonine-Summers, AR, Wells, CE, Kaiser, JF, Washington, MK, Zhao, Z, Wagner, FF, Sun, ZW, Xia, F, Holson, EB, Khabele, D, Hiebert, SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell, 18(5), 436-47, 2010

Son, DS, Wilson, AJ, Parl, AK, Khabele, D. The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. Cancer Biol Ther, 9(11), 2010

Klugman, SD, Gross, SJ, Liang, J, Livne, K, Gross, B, Khabele, D, Lopez-Jones, M, Cordero, DR, Reznik, S. Expression of Keratin 8 and TNF-Related Apoptosis-I Inducing Ligand (TRAIL) in Down Syndrome Placentas. Placenta, 29(4), 382-4, 2008 PMCID:2475678

Daikoku, T, Tranguch, S, Chakrabarty, A, Wang, D, Khabele, D, Orsulic, S, Morrow, JD, Dubois, RN, Dey, SK. Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res, 67(11), 5285-92, 2007 PMCID:2475678

Khabele, D, Son, DS, Parl, AK, Goldberg, GL, Augenlicht, LH, Mariadason, JM, Rice, VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol Ther, 6(5), 795-801, 2007 PMCID:2475678

Lyshchik, A, Hobbs, SB, Fleischer, AC, Khabele, D, Son, DS, Gore, JC, Price, RR. Ovarian volume measurements in mice with high-resolution ultrasonography. J Ultrasound Med, 26(10), 1419-25, 2007 PMCID:2475678

Son, DS, Parl, AK, Rice, VM, Khabele, D. Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. Cancer Biol Ther, 6(8), 1302-12, 2007 PMCID:2475678

Gorelick, C, Lopez-Jones, M, Goldberg, GL, Romney, SL, Khabele, D. Coenzyme Q10 and lipid-related gene induction in HeLa cells. Am J Obstet Gynecol, 190(5), 1432-4, 2004 PMCID:2475678

Khabele, D, Lopez-Jones, M, Yang, W, Arango, D, Gross, SJ, Augenlicht, LH, Goldberg, GL. Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer. Gynecol Oncol, 93(1), 19-26, 2004 PMCID:2475678

Khabele, D, Runowicz, CD, Fields, AL, Anderson, PS, Goldberg, GL. Evaluation of low-dose intraperitoneal interferon-alpha for palliation of ascites in patients with non-ovarian gynecologic malignancies. Gynecol Oncol, 89(3), 420-3, 2003 PMCID:2475678

Sood, BM, Jones, J, Gupta, S, Khabele, D, Guha, C, Runowicz, C, Goldberg, G, Fields, A, Anderson, P, Vikram, B. Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma. Int J Radiat Oncol Biol Phys, 57(1), 208-16, 2003 PMCID:2475678

Gross, SJ, Ferreira, JC, Morrow, B, Dar, P, Funke, B, Khabele, D, Merkatz, I. Gene expression profile of trisomy 21 placentas: a potential approach for designing noninvasive techniques of prenatal diagnosis. Am J Obstet Gynecol, 187(2), 457-62, 2002 PMCID:2475678

Khabele, D, Runowicz, CD. Genetic counseling, testing, and screening for breast and ovarian cancer: practical and social considerations. Curr Womens Health Rep, 2(3), 163-9, 2002 PMCID:2475678

Khabele, D, Chasen, S. Cardiac tamponade as an unusual presentation of advanced breast cancer in pregnancy. J Reprod Med, 44(11), 989-91, 1999 PMCID:2475678

Xiao, E, Xia, L, Shanen, D, Khabele, D, Ferin, M. Stimulatory effects of interleukin-induced activation of the hypothalamo-pituitary-adrenal axis on gonadotropin secretion in ovariectomized monkeys replaced with estradiol. Endocrinology, 135(5), 2093-8, 1994 PMCID:2475678

Postdoctoral Position Available

Postdoctoral Position Details

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