Biomedical Research Education & Training
Faculty Member

Nagathihalli, Nagaraj S, PhD
Research Assistant Professor of Surgery
Research Assistant Professor of Cancer Biology

Lab Url:

Phone Number: 615-343-8401

Email Address:

Nagathihalli, Nagaraj's picture
Academic history
MS, University of Mysore, India
PhD, University of Mysore, India
Postdoc, University of Louisville, Kentucky, USA
Instructor, Vanderbilt University, Tennessee, USA

Office Address   Mailing Address

D2300 MCN

1161, 21st Ave S., D2300 MCN, Division of Surgical Oncology, Nashville, TN 37232

Research Keywords
Pancreatic cancer, Molecular targets, Therapeutics, Drug resistance, Tumor microenvironment, DNA damage, DNA repair, Genomic instability, Genomics, Proteomics, Microarray, Apoptosis, Signal transduction, Oncogenes, Nutrition and Cancer, Receptor signaling, Tyrosine phosphorylation, Knockout, Mouse, Biomarkers, Drug delivery, Molecular imaging

Nagathihalli, NS, Beesetty, Y, Lee, W, Washington, MK, Chen, X, Lockhart, AC, Merchant, NB. Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-??: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids. Cancer Res, 2014

Castellanos, J, Merchant, NB, Nagathihalli, NS. Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells. OncoTargets and Therapy, 2013(6), 1261 - 1267, 2013

Castellanos, J, Nagathihalli, NS, Merchant, NB. Altered Signaling Pathways and Potential Therapeutic Targets in Pancreatic Cancer. In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, Linda McManus and Richard Mitchell (eds), Elsevier, Oxford, UK, 2013

Nagathihalli, NS, Brown, ET. Pancreatic Cancer Stem Cells in Tumor Progression, Metastasis, Epithelial-Mesenchymal Transition and DNA Repair. In: DNA Repair of Cancer Stem Cells, Mathews, LA, Cabarcas, SM and Hurt, EM (eds.), Springer, USA, 141-155, 2013

Nagathihalli, NS, Massion, PP, Gonzalez, AL, Lu, P, Datta, PK. Smoking Induces Epithelial-to-Mesenchymal Transition in Non-Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-cadherin. Mol Cancer Ther, 11(11), 2362-72, 2012

Nagathihalli, NS, Merchant, NB. Src-mediated regulation of E-cadherin and EMT in pancreatic cancer. Front Biosci, 17, 2059-69, 2012

Samanta, D, Gonzalez, AL, Nagathihalli, N, Ye, F, Carbone, DP, Datta, PK. Smoking attenuates transforming growth factor-I?-mediated tumor suppression function through downregulation of Smad3 in lung cancer. Cancer Prev Res (Phila), 5(3), 453-63, 2012 PMCID:3269147

Nagaraj NS, Washington MK, Merchant NB. Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth. Clin Cancer Res, 17(3), 483-93, 2011 PMCID:3079196

Nagathihalli, N. Translational research in gastrointestinal oncology: a focus on signaling pathways in pancreas cancer. Gastrointest Cancer Res, 4(5-6), 197-8, 2011 PMCID:3269147

Nagathihalli, NS, Nagaraju, G. RAD51 as a potential biomarker and therapeutic target for pancreatic cancer. Biochim Biophys Acta, 1816(2), 209-18, 2011

Singh, OV*, Nagaraj NS*, Gabani, P. Systems Biology: Integrating a??-omicsa?? oriented approaches to determine food borne microbial toxins. Systems Toxicology: From Omics Technology to Nanotechnology, In: Handbook of Systems Toxicology, Casciano, DA and Sahu, SC (eds.), Wiley Publishers, NJ, USA, 2011

Nagaraj NS, Smith JJ, Revetta F, Washington MK, Merchant NB. Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis. Mol Cancer Ther, 9(8), 2322-32, 2010

Nagaraj, NS*, Anilakumar, KR, Singh, OV. Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway. J Nutr Biochem, 21(5), 405-412, 2010

Nagaraj, NS*, Singh, OV. Using Genomics to Develop Novel Antibacterial Therapeutics. Crit Rev Microbiol, 36(4), 340-8, 2010

Nagaraj, NS, Datta, PK. Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs, 19(1), 77-91, 2010

Nagaraj, NS, Singh, OV, Merchant, NB. Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy. Expert Rev Proteomics, 7(4), 613-23, 2010 PMCID:3269147

Nagaraj, NS. Evolving omics technologies for diagnostics of head and neck cancer. Brief Funct Genomic Proteomic, 8(1), 49-59, 2009

Nagaraj, NS, Singh, OV. Integrating Genomics and Proteomics oriented Biomarkers to Comprehend Lung Cancer. Expert Opinion on Medical Diagnostics, 2(3), 167-180, 2009

Anilakumar, KR, Nagaraj, NS, Santhanam, K. Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn. Indian J Exp Biol, 45(5), 450-4, 2007

Nagaraj, NS, Vigneswaran, N, Zacharias, W. Hypoxia inhibits TRAIL-induced tumor cell apoptosis: involvement of lysosomal cathepsins. Apoptosis, 12(1), 125-39, 2007

Nagaraj, NS, Zacharias, W. Cathepsin Regulated Cell Death Pathways: Lysosomes as Targets for Cancer Therapy. (Editor: Albina W. Taylor). Nova Science Publishers Inc, Cell Apoptosis and Cancer, pp.155-180, New York, 2007

Nagaraj, NS, Zacharias, W. Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells. Toxicol Lett, 170(2), 134-45, 2007 PMCID:1952681

Nagaraj, NS*, Santhanam, K. The effects of muscle proteases, endogenous protease inhibitors and myofibril fragmentation on postmortem aging of goat meat. J Food Biochem, 30(3), 269-291, 2006

Nagaraj, NS*, Santhanam, K. Effect of frozen temperature and storage time on calpains, cathepsins (B, B+L, H and D) and their endogenous inhibitors in goat muscles. J Food Biochem, 30(2), 155-173, 2006

Nagaraj, NS, Anilakumar, KR, Santhanam, K. Biochemical and physicochemical changes of goat meat during ageing. J Muscle Foods, 17(2), 198-213, 2006

Nagaraj, NS, Beckers, S, Mensah, JK, Waigel, S, Vigneswaran, N, Zacharias, W. Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells. Toxicol Lett, 165(2), 182-94, 2006

Nagaraj, NS, Vigneswaran, N, Zacharias, W. Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells. J Cancer Res Clin Oncol, 132(3), 171-83, 2006

Singh, OV, Nagaraj, NS. Transcriptomics, proteomics and interactomics: unique approaches to track the insights of bioremediation. Brief Funct Genomic Proteomic, 4(4), 355-62, 2006

Vigneswaran, N, Wu, J, Nagaraj, N, James, R, Zeeuwen, P, Zacharias, W. Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion. Life Sci, 78(8), 898-907, 2006

Nagaraj, NS*, Anilakumar, KR, Santhanam, K . Post-mortem changes in myofibrillar proteins of goat skeletal muscles. J Food Biochem, 29(2), 152-170, 2005

Vigneswaran, N, Wu, J, Nagaraj, N, Adler-Storthz, K, Zacharias, W. Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis. Int J Oncol, 26(1), 103-12, 2005

Wickramasinghe, NS, Banerjee, K, Nagaraj, NS, Vigneswaran, N, Zacharias, W. Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines. Anticancer Res, 25(4), 2841-9, 2005

Wickramasinghe, NS, Nagaraj, NS, Vigneswaran, N, Zacharias, W. Cathepsin B promotes both motility and invasiveness of oral carcinoma cells. Arch Biochem Biophys, 436(1), 187-95, 2005

Anilakumar, KR, Nagaraj, NS, Santhanam, K. Protective effect of amla on oxidative stress and cytotoxicity in rats challenged with dimethyl hydrazine. Nutrition Res, 24(4), 313-319, 2004

Nagaraj, NS, Vigneswaran, N, Zacharias, W. Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways. Mol Cancer, 3(1), 38, 2004 PMCID:544893

Anilakumar, KR, Nagaraj, NS, Prasad, NN, Jeevaratnam, K . Changes in fatty acid composition of some processed ration on storage. The Indian Journal of Nutrition and Dietetics, 40(1), 168-173, 2003

Nagaraj, NS, Anilakumar, KR, Santhanam, K. Changes in the calpain-calpastatin and cathepsin (B, B+L, H and D) during post-mortem storage of goat muscles. J Food Biochem, 26(1), 75-89, 2002

Anilakumar, KR, Nagaraj, NS, Santhanam, K. Effect of coriander seeds on hexachloro cyclohexane induced lipid peroxidation in rat liver. Nutrition Res, 21(11), 1455-1462, 2001

Nagaraj, NS, Anilakumar, KR, Santhanam, K. Effect of temperature on myofibril fragmentation during postmortem storage of muscle. J Food Sc Tech, 38(1), 55-56, 2001

Postdoctoral Position Available

Postdoctoral Position Details

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