Biomedical Research Education & Training
Faculty Member

Andl, Thomas, Ph.D.
Assistant Professor of Medicine

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Phone Number: 615-322-1716

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Andl, Thomas's picture
Academic history
PhD, Ruprecht-Karls Universieat Heidelberg
MS, Ruprecht-Karls

Office Address   Mailing Address

A2310 MCN

Vanderbilt University Medical Center A2310 Medical Center North 37232

Research Keywords
microRNA biology,Cancer,Chromatin,Developmental biology,Gene therapy,Mouse

Research Specialty
the role of microRNAs in normal and pathological conditions of the skin

Research Description
My major interests are in understanding how epithelial cells of the surface ectoderm can form many different appendages, how this capability is altered in the adult organism, how this relates to malignant transformation of epithelial stem cells in the course of tumorigenesis, and how human primary keratinocytes can be genetically engineered for gene therapy purposes. In particular I am interested in the role of Dicer and microRNAs in squamous epithelial carcinogenesis.
Additionally, Dicer has important functions in the control of the epigenome by regulating the formation and maintenance of heterochromatin. Therefore, another aspect of my research interest is to determine how changes in the epigenome during lifetime affect aging and susceptibility to diseases like cancer.

Benetti, R, Gonzalo, S, Jaco, I, Mu??oz, P, Gonzalez, S, Schoeftner, S, Murchison, E, Andl, T, Chen, T, Klatt, P, Li, E, Serrano, M, Millar, S, Hannon, G, Blasco, MA. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol, 15(3), 268-79, 2008

Liu, F, Chu, EY, Watt, B, Zhang, Y, Gallant, NM, Andl, T, Yang, SH, Lu, MM, Piccolo, S, Schmidt-Ullrich, R, Taketo, MM, Morrisey, EE, Atit, R, Dlugosz, AA, Millar, SE. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol, 313(1), 210-24, 2008

Ito, M, Yang, Z, Andl, T, Cui, C, Kim, N, Millar, SE, Cotsarelis, G. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature, 447(7142), 316-20, 2007

Liu, F, Thirumangalathu, S, Gallant, NM, Yang, SH, Stoick-Cooper, CL, Reddy, ST, Andl, T, Taketo, MM, Dlugosz, AA, Moon, RT, Barlow, LA, Millar, SE. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet, 39(1), 106-12, 2007

Stark, J, Andl, T, Millar, SE. Hairy math: insights into hair-follicle spacing and orientation. Cell, 128(1), 17-20, 2007

Andl, T, Murchison, EP, Liu, F, Zhang, Y, Yunta-Gonzalez, M, Tobias, JW, Andl, CD, Seykora, JT, Hannon, GJ, Millar, SE. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol, 16(10), 1041-9, 2006

de Guzman Strong, C, Wertz, PW, Wang, C, Yang, F, Meltzer, PS, Andl, T, Millar, SE, Ho, IC, Pai, SY, Segre, JA. Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol, 175(4), 661-70, 2006 PMCID:2064601

Shu, W, Guttentag, S, Wang, Z, Andl, T, Ballard, P, Lu, MM, Piccolo, S, Birchmeier, W, Whitsett, JA, Millar, SE, Morrisey, EE. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol, 283(1), 226-39, 2005

Andl, T, Ahn, K, Kairo, A, Chu, EY, Wine-Lee, L, Reddy, ST, Croft, NJ, Cebra-Thomas, JA, Metzger, D, Chambon, P, Lyons, KM, Mishina, Y, Seykora, JT, Crenshaw, EB, Millar, SE. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development, 131(10), 2257-68, 2004

Chu, EY, Hens, J, Andl, T, Kairo, A, Yamaguchi, TP, Brisken, C, Glick, A, Wysolmerski, JJ, Millar, SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development, 131(19), 4819-29, 2004

Reddy, ST, Andl, T, Lu, MM, Morrisey, EE, Millar, SE. Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol, 123(2), 275-82, 2004

Millar, SE, Koyama, E, Reddy, ST, Andl, T, Gaddapara, T, Piddington, R, Gibson, CW. Over- and ectopic expression of Wnt3 causes progressive loss of ameloblasts in postnatal mouse incisor teeth. Connect Tissue Res, 44 Suppl 1, 124-9, 2003

Andl, T, Reddy, ST, Gaddapara, T, Millar, SE. WNT signals are required for the initiation of hair follicle development. Dev Cell, 2(5), 643-53, 2002

Reddy, S, Andl, T, Bagasra, A, Lu, MM, Epstein, DJ, Morrisey, EE, Millar, SE. Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev, 107(1-2), 69-82, 2001

Hsu, M, Andl, T, Li, G, Meinkoth, JL, Herlyn, M. Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Sci, 113 ( Pt 9), 1535-42, 2000

Helbig, M, Andl, T, Kahn, T, Klein-K??hne, W, Conradt, C, Dietz, A, Bosch, FX. [The role of oncogenic human papillomaviruses in tonsillar squamous cell carcinomas with functional inactivation of the retinoblastoma protein. HNO, 47(9), 796-803, 1999

Herold-Mende, C, Andl, T, Laemmler, F, Reisser, C, Eichhorn, S. [Expression and localization profile of tenascin in squamous cell carcinomas of the head and neck. HNO, 47(8), 723-9, 1999

Herold-Mende, C, Andl, T, Laemmler, F, Reisser, C, Mueller, MM. [Functional expression of vascular endothelial growth factor receptor Flt-1 on squamous cell carcinoma of the head and neck. HNO, 47(8), 706-11, 1999

Herold-Mende, C, Steiner, HH, Andl, T, Riede, D, Buttler, A, Reisser, C, Fusenig, NE, Mueller, MM. Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab Invest, 79(12), 1573-82, 1999

Nesbit, M, Nesbit, HK, Bennett, J, Andl, T, Hsu, MY, Dejesus, E, McBrian, M, Gupta, AR, Eck, SL, Herlyn, M. Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes. Oncogene, 18(47), 6469-76, 1999

Andl, T, Kahn, T, Pfuhl, A, Nicola, T, Erber, R, Conradt, C, Klein, W, Helbig, M, Dietz, A, Weidauer, H, Bosch, FX. Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res, 58(1), 5-13, 1998

Spanbroek, R, Stark, HJ, Janssen-Timmen, U, Kraft, S, Hildner, M, Andl, T, Bosch, FX, Fusenig, NE, Bieber, T, R?Ydmark, O, Samuelsson, B, Habenicht, AJ. 5-Lipoxygenase expression in Langerhans cells of normal human epidermis. Proc Natl Acad Sci U S A, 95(2), 663-8, 1998 PMCID:18477

Erber, R, Klein, W, Andl, T, Enders, C, Born, AI, Conradt, C, Bartek, J, Bosch, FX. Aberrant p21(CIP1/WAF1) protein accumulation in head-and-neck cancer. Int J Cancer, 74(4), 383-9, 1997

Homann, N, Andl, T, Nees, M, Schuhmann, A, Herold-Mende, C, Bosch, FX. [Significance of aberrant p53 protein in head-neck tumors and its effect on proliferation and differentiation. HNO, 41(5), 254-60, 1993

Nees, M, Homann, N, Discher, H, Andl, T, Enders, C, Herold-Mende, C, Schuhmann, A, Bosch, FX. Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Res, 53(18), 4189-96, 1993

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