Biomedical Research Education & Training
Faculty Member

Grogan, Eric L, MD, MPH
Assistant Professor of Thoracic Surgery
Assistant Professor of Medicine

Lab Url: http://www.thoracic.vanderbilt.edu

Phone Number: 615-322-0248

Email Address: eric.grogan@vanderbilt.edu

Grogan, Eric's picture
Academic history
BS, David Lipscomb University
MD, Vanderbilt University School of Medicine
, Vanderbilt University Medical Center
MPH, Vanderbilt University School of Medicine
, University of Virginia
, University of Virginia

Office Address   Mailing Address

609 Oxford House

609 Oxford House 37232-4682


Research Keywords
lung cancer,Cancer,Proteomics

Research Specialty
My interests are using proteomics, genomics, and epidemiology to develop personalized diagnostic and treatment options for patients with lung cancer. In addition we are evaluating the most effective new strategies for the diagnosis and treatment of lung cancer.

Research Description
A recently recruited member of the Department of Thoracic Surgery, Eric L. Grogan, M.D., M.P.H., has also been awarded the VPSD grant. His grant entitled ?Predicting Lung Cancer with a Serum Protein Test? is a translational research project that is using serum proteomics, epidemiology, and imaging techniques to predict lung cancer in patients with pulmonary nodules. ?With the increasing use of Computed Tomography (CT scan), we are finding more pulmonary nodules. Most of these nodules are benign, but some are malignant and determining which ones are cancerous is challenging. Currently we use a combination of the patient?s risk factors and imaging to decide which nodules are high risk for cancer and need surgical excision. However, 20 percent of our operations on these suspicious nodules result in a benign diagnosis. This puts our patients at risk and is costly to the medical system.?
?Using a multidisciplinary approach, we have a team of basic scientists, translational scientists pulmonologists, thoracic surgeons, epidemiologists, and health economists. We are working together to develop a cost-effective blood test for patients with suspected lung cancer. Dr. Pierre Massion?s laboratory (VICC Spore Grant) has developed a simple blood test that can predict patients who have all stages of lung cancer. Using MALDI ? MS techniques, they have identified a seven protein signature that is highly predictive of lung cancer. Together, we are determining the accuracy of this serum proteomic test in patients with lung nodules and are combining this serum proteomic test with the patient?s risk factors and imaging characteristics. A highly specific test will help reduce unnecessary surgery while not missing any cases of lung cancer. We are also evaluating the accuracy of this test in predicting lung cancer recurrence.?

Publications
Grogan, EL, Deppen, S, Pecot, CV, Putnam, JB, Nesbitt, JC, Shyr, Y, Rajanbabu, R, Ory, B, Lambright, ES, Massion, PP. Diagnostic characteristics of a serum biomarker in patients with positron emission tomography scans. Ann Thorac Surg, 89(6), 1724-8; discussion 1728-9, 2010

Hennessy, SA, Grogan, EL, Harthun, NL, Jones, DR, Kozower, BD, Ailawadi, G, Lau, CL. Transplant pneumonectomy in a patient with an acutely thrombosed allograft. Ann Thorac Surg, 89(3), 975-7, 2010

Grogan, EL, Jones, DR. VATS lobectomy is better than open thoracotomy: what is the evidence for short-term outcomes. Thorac Surg Clin, 18(3), 249-58, 2008

Grogan, EL, Jones, DR, Kozower, BD, Simmons, WD, Daniel, TM. Identification of small lung nodules: technique of radiotracer-guided thoracoscopic biopsy. Ann Thorac Surg, 85(2), S772-7, 2008

Grogan, EL, Stukenborg, GJ, Nagji, AS, Simmons, W, Kozower, BD, Jones, DR, Daniel, TM. Radiotracer-guided thoracoscopic resection is a cost-effective technique for the evaluation of subcentimeter pulmonary nodules. Ann Thorac Surg, 86(3), 934-40; discussion 934-40, 2008

Murff, HJ, France, DJ, Blackford, J, Grogan, EL, Yu, C, Speroff, T, Pichert, JW, Hickson, GB. Relationship between patient complaints and surgical complications. Qual Saf Health Care, 15(1), 13-6, 2006 PMCID:2564001

France, DJ, Stiles, R, Gaffney, EA, Seddon, MR, Grogan, EL, Nixon, WR, Speroff, T. Crew resource management training--clinicians'' reactions and attitudes. AORN J, 82(2), 213-24; quiz 225-8, 2005 PMCID:2564001

Grogan, EL. Should I lie about my work hours this week. J Am Coll Surg, 200(4), 635-6, 2005 PMCID:2564001

Grogan, EL, Morris, JA, Dittus, RS, Moore, DE, Poulose, BK, Diaz, JJ, Speroff, T. Cervical spine evaluation in urban trauma centers: lowering institutional costs and complications through helical CT scan. J Am Coll Surg, 200(2), 160-5, 2005 PMCID:2564001

Grogan, EL, Norris, PR, Speroff, T, Ozdas, A, France, DJ, Harris, PA, Jenkins, JM, Stiles, R, Dittus, RS, Morris, JA. Volatility: a new vital sign identified using a novel bedside monitoring strategy. J Trauma, 58(1), 7-12; discussion 12-4, 2005 PMCID:2564001

Norris, PR, Morris, JA, Ozdas, A, Grogan, EL, Williams, AE. Heart rate variability predicts trauma patient outcome as early as 12 h: implications for military and civilian triage. J Surg Res, 129(1), 122-8, 2005 PMCID:2564001

Poulose, BK, Holzman, MD, Lao, OB, Grogan, EL, Goldstein, RE. Laparoscopic adrenalectomy: 100 resections with clinical long-term follow-up. Surg Endosc, 19(3), 379-85, 2005 PMCID:2564001

Poulose, BK, Scholz, S, Moore, DE, Schmidt, CR, Grogan, EL, Lao, OB, Nanney, L, Davidson, J, Holzman, MD. Physiologic properties of small intestine submucosa. J Surg Res, 123(2), 262-7, 2005 PMCID:2564001

Diaz, JJ, Gray, BW, Dobson, JM, Grogan, EL, May, AK, Miller, R, Guy, J, O''Neill, P, Morris, JA. Repair of giant abdominal hernias: does the type of prosthesis matter. Am Surg, 70(5), 396-401; discussion 401-2, 2004 PMCID:1356445

Grogan, EL, Morris, JA, Norris, PR, France, DJ, Ozdas, A, Stiles, RA, Harris, PA, Dawant, BM, Speroff, T. Reduced heart rate volatility: an early predictor of death in trauma patients. Ann Surg, 240(3), 547-54; discussion 554-6, 2004 PMCID:1356445

Grogan, EL, Nylander, WA, Shaffer, D. Living-related transplantation of an ectopic pelvic kidney. Transplantation, 77(6), 953, 2004 PMCID:1356445

Grogan, EL, Speroff, T, Deppen, SA, Roumie, CL, Elasy, TA, Dittus, RS, Rosenbloom, ST, Holzman, MD. Improving documentation of patient acuity level using a progress note template. J Am Coll Surg, 199(3), 468-75, 2004 PMCID:2564001

Grogan, EL, Stiles, RA, France, DJ, Speroff, T, Morris, JA, Nixon, B, Gaffney, FA, Seddon, R, Pinson, CW. The impact of aviation-based teamwork training on the attitudes of health-care professionals. J Am Coll Surg, 199(6), 843-8, 2004 PMCID:2564001

Roumie, CL, Grogan, EL, Falbe, W, Awad, J, Speroff, T, Dittus, RS, Elasy, TA. A three-part intervention to change the use of hormone replacement therapy in response to new evidence. Ann Intern Med, 141(2), 118-25, 2004 PMCID:1356445

Grogan, EL, Wheeler, WG, Ross, CB. Management of incidentally discovered cervical paragangliomas: report of two cases and review of current issues. J Ky Med Assoc, 97(12), 559-65, 1999 PMCID:1356445


Postdoctoral Position Available
N/A

Postdoctoral Position Details
N/A

Updated Date
08/11/2010