Biomedical Research Education & Training
Faculty Member

Haase, Volker H., M.D. (Dr. med.)
Professor of Medicine
Professor of Molecular Physiology and Biophysics
Professor of Cancer Biology
Krick-Brooks Chair in Nephrology

Lab Url: N/A

Phone Number: 615-343-7254

Email Address:

Haase, Volker's picture
Academic history
Abitur, Gymnasiale Oberstufenschule Dieburg, Germany
Artz/MD, Johann Wolfgang Goethe University
Dr. Med, Johann Wolfgang Goethe University

Office Address   Mailing Address

C-3119A MCN

Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C-3119A MCN 37232-2372

Research Keywords
Molecular oxygen-sensing; the pVHL/HIF pathway; erythropoiesis; EPO; iron metabolism; glucose and fat metabolism; ischemic cell injury and regeneration; progression of chronic renal disease; von Hippel-Lindau disease (VHL); kidney cancer and renal cystogenesis; hepatic steatosis; conditional gene targeting technology and transgenesis; embryonic stem (ES) cells; mouse model systems.,Developmental biology,Gene regulation,Kidney,Malignancy,Mass spectroscopy,Molecular medicine,Mouse,Physiology

Patient Care Specialty
Internal Medicine and General Nephrology

Research Specialty
Cellular and molecular mechanisms of oxygen sensing in health and disease.

Research Description
The Haase laboratory studies the VHL/HIF oxygen-sensing pathway and uses conditional gene targeting technology and transgenesis, as well as biochemical and functional genomics approaches to define the specific roles of the von Hippel-Lindau (VHL) tumor suppressor and individual HIF transcription factors in tumorigenesis, acute ischemia and chronic hypoxic injury, as well as erythropoiesis and iron metabolism. Hypoxia-Inducible Factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and cellular adaptation to oxygen deprivation. HIFs consist of an oxygen-sensitive alpha-subunit, HIF-alpha and a constitutively expressed beta-subunit, HIF-beta, and regulate the expression of genes that are involved in energy metabolism, angiogenesis, erythropoiesis and iron metabolism, cell proliferation, apoptosis and other biological processes. Under conditions of normal oxygen tension HIF-alpha is hydroxylated and targeted for rapid proteasomal degradation by the VHL/E3-ubiquitin ligase. When cells experience hypoxia, HIF-alpha is stabilized and either dimerizes with HIF-beta in the nucleus to form transcriptionally active HIF executing the canonical hypoxia response, or it physically interacts with other non-HIF proteins, enabling convergence of HIF oxygen sensing with other signaling pathways. Since HIF increases the expression of cytoprotective factors and erythropoietin, pharmacologic inhibition of HIF-alpha degradation offers significant potential for the treatment of acute hypoxic injuries and anemia.

Clinical Interests
General Nephrology, Renal Anemia and Renal Metabolism.

Haase, VH. Inflammation and hypoxia in the kidney: friends or foes. Kidney Int, 88(2), 213-215, 2015

Haase, VH. A breath of fresh air for diabetic nephropathy. J Am Soc Nephrol, 26(2), 239-41, 2015

Kapitsinou, PP, Haase, VH. Molecular Mechanisms of Ischemic Preconditioning in the Kidney. Am J Physiol Renal Physiol, ajprenal.00224.2015, 2015

Koury, MJ, Haase, VH. Anaemia in kidney disease: harnessing hypoxia responses for therapy. Nat Rev Nephrol, 2015

Pastor-Soler, NM, Sutton, TA, Mang, HE, Kinlough, CL, Gendler, SJ, Madsen, CS, Bastacky, SI, Ho, J, Al-Bataineh, MM, Hallows, KR, Singh, S, Monga, SP, Kobayashi, H, Haase, VH, Hughey, RP. Muc1 is Protective during Kidney Ischemia-Reperfusion Injury. Am J Physiol Renal Physiol, ajprenal.00066.2015, 2015

Kapitsinou, PP, Sano, H, Michael, M, Kobayashi, H, Davidoff, O, Bian, A, Yao, B, Zhang, MZ, Harris, RC, Duffy, KJ, Erickson-Miller, CL, Sutton, TA, Haase, VH. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest, 124(6), 2396-2409, 2014

Tak, E, Ridyard, D, Kim, JH, Zimmerman, M, Werner, T, Wang, XX, Shabeka, U, Seo, SW, Christians, U, Klawitter, J, Moldovan, R, Garcia, G, Levi, M, Haase, V, Ravid, K, Eltzschig, HK, Grenz, A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol, 25(3), 547-63, 2014

Haase, VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev, 27(1), 41-53, 2013

Haase, VH. Mechanisms of hypoxia responses in renal tissue. J Am Soc Nephrol, 24(4), 537-41, 2013

Lin, Q, Huang, Y, Booth, CJ, Haase, VH, Johnson, RS, Celeste Simon, M, Giordano, FJ, Yun, Z. Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc, 2(6), e000548, 2013

Grenz, A, Bauerle, JD, Dalton, JH, Ridyard, D, Badulak, A, Tak, E, McNamee, EN, Clambey, E, Moldovan, R, Reyes, G, Klawitter, J, Ambler, K, Magee, K, Christians, U, Brodsky, KS, Ravid, K, Choi, DS, Wen, J, Lukashev, D, Blackburn, MR, Osswald, H, Coe, IR, N??rnberg, B, Haase, VH, Xia, Y, Sitkovsky, M, Eltzschig, HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest, 122(2), 693-710, 2012

Haase, VH. Hypoxia-inducible factor signaling in the development of kidney fibrosis. Fibrogenesis Tissue Repair, 5 Suppl 1, S16, 2012

Haase, VH. Renal cancer: oxygen meets metabolism. Exp Cell Res, 318(9), 1057-67, 2012

Kapitsinou, PP, Jaffe, J, Michael, M, Swan, CE, Duffy, KJ, Erickson-Miller, CL, Haase, VH. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. Am J Physiol Renal Physiol, 302(9), F1172-9, 2012

Kobayashi, H, Gilbert, V, Liu, Q, Kapitsinou, PP, Unger, TL, Rha, J, Rivella, S, Schl??ndorff, D, Haase, VH. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol, 188(10), 5106-15, 2012

Liu, Q, Davidoff, O, Niss, K, Haase, VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest, 122(12), 4635-44, 2012

Park, SW, Kim, M, Kim, JY, Brown, KM, Haase, VH, D''Agati, VD, Lee, HT. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int, 82(8), 878-91, 2012

Gurley, SB, Riquier-Brison, AD, Schnermann, J, Sparks, MA, Allen, AM, Haase, VH, Snouwaert, JN, Le, TH, McDonough, AA, Koller, BH, Coffman, TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab, 13(4), 469-75, 2011

Haase, VH. Angiotensin II: breathtaking in the renal medulla. Kidney Int, 79(3), 269-71, 2011

Kapitsinou, PP, Liu, Q, Unger, TL, Rha, J, Davidoff, O, Keith, B, Epstein, JA, Moores, SL, Erickson-Miller, CL, Haase, VH. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood, 116(16), 3039-48, 2010 (see commentary by Terry Lappin in the same issue of Blood, see commentary in Kidney International - Journal Club: 78 (8), 717a??718, 2010. doi:10.1038/ki.2010.34)

Bajwa, A, Jo, SK, Ye, H, Huang, L, Dondeti, KR, Rosin, DL, Haase, VH, Macdonald, TL, Lynch, KR, Okusa, MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol, 21(6), 955-65, 2010

Bielesz, B, Sirin, Y, Si, H, Niranjan, T, Gruenwald, A, Ahn, S, Kato, H, Pullman, J, Gessler, M, Haase, VH, Susztak, K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest, 120(11), 4040-54, 2010 PMCID:2964979

Haase, VH. The sweet side of HIF. Kidney Int, 78(1), 10-3, 2010

Haase, VH. Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol, 299(1), F1-13, 2010

Hao, CM, Haase, VH. Sirtuins and their relevance to the kidney. J Am Soc Nephrol, 21(10), 1620-7, 2010

Kapitsinou, PP, Haase, VH. HO-1 in control of a self-eating kidney. J Am Soc Nephrol, 21(10), 1600-2, 2010

Lee, JJ, Natsuizaka, M, Ohashi, S, Wong, GS, Takaoka, M, Michaylira, CZ, Budo, D, Tobias, JW, Kanai, M, Shirakawa, Y, Naomoto, Y, Klein-Szanto, AJ, Haase, VH, Nakagawa, H. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis, 31(3), 427-34, 2010

Seagroves, TN, Peacock, DL, Liao, D, Schwab, LP, Krueger, R, Handorf, CR, Haase, VH, Johnson, RS. VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol, 176(5), 2269-82, 2010

Wei, Q, Bhatt, K, He, HZ, Mi, QS, Haase, VH, Dong, Z. Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol, 21(5), 756-61, 2010

Weidemann, A, Krohne, TU, Aguilar, E, Kurihara, T, Takeda, N, Dorrell, MI, Simon, MC, Haase, VH, Friedlander, M, Johnson, RS. Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia, 58(10), 1177-85, 2010

Welford, SM, Dorie, MJ, Li, X, Haase, VH, Giaccia, AJ. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol Cell Biol, 30(19), 4595-603, 2010

Rankin, EB, Rha, J, Selak, MA, Unger, TL, Keith, B, Liu, Q, Haase, VH. Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol, 29(16), 4527-38, 2009 (cover page feature) PMCID:2725738

Haase, VH. The VHL tumor suppressor: master regulator of HIF. Curr Pharm Des, 15(33), 3895-903, 2009 PMCID:2769183

Haase, VH. Pathophysiological Consequences of HIF Activation. Ann N Y Acad Sci, 1177, 57-65, 2009

Haase, VH. Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int, 76(5), 492-9, 2009

Weidemann, A, Kerdiles, YM, Knaup, KX, Rafie, CA, Boutin, AT, Stockmann, C, Takeda, N, Scadeng, M, Shih, AY, Haase, VH, Simon, MC, Kleinfeld, D, Johnson, RS. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest, 119(11), 3373-83, 2009 PMCID:2769183

Boutin, AT, Weidemann, A, Fu, Z, Mesropian, L, Gradin, K, Jamora, C, Wiesener, M, Eckardt, KU, Koch, CJ, Ellies, LG, Haddad, G, Haase, VH, Simon, MC, Poellinger, L, Powell, FL, Johnson, RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell, 133(2), 223-34, 2008 PMCID:2849644

Haase, VH. Hemoglobin in the kidney: breaking with traditional dogma. J Am Soc Nephrol, 19(8), 1440-1, 2008

Higgins, DF, Kimura, K, Iwano, M, Haase, VH. Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle, 7(9), 1128-32, 2008 PMCID:2849644

Kapitsinou, PP, Haase, VH. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ, 15(4), 650-9, 2008 PMCID:2849644

Kimura, K, Iwano, M, Higgins, DF, Yamaguchi, Y, Nakatani, K, Harada, K, Kubo, A, Akai, Y, Rankin, EB, Neilson, EG, Haase, VH, Saito, Y. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol, 295(4), F1023-9, 2008 PMCID:2725738

Maltzman, JS, Haase, VH. Low oxygen stimulates the immune system. Kidney Int, 73(7), 797-9, 2008

Peng, M, Falk, MJ, Haase, VH, King, R, Polyak, E, Selak, M, Yudkoff, M, Hancock, WW, Meade, R, Saiki, R, Lunceford, AL, Clarke, CF, Gasser, DL. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet, 4(4), e1000061, 2008 PMCID:2291193

Rankin, EB, Rha, J, Unger, TL, Wu, CH, Shutt, HP, Johnson, RS, Simon, MC, Keith, B, Haase, VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene, 27(40), 5354-8, 2008 PMCID:2575082

Shah, YM, Ito, S, Morimura, K, Chen, C, Yim, SH, Haase, VH, Gonzalez, FJ. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology, 134(7), 2036-48, 2048.e1-3, 2008 PMCID:2533811

Blouw, B, Haase, VH, Song, H, Bergers, G, Johnson, RS. Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene, 26(31), 4531-40, 2007

Brukamp, K, Jim, B, Moeller, MJ, Haase, VH. Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. Am J Physiol Renal Physiol, 293(4), F1397-407, 2007

Higgins, DF, Kimura, K, Bernhardt, WM, Shrimanker, N, Akai, Y, Hohenstein, B, Saito, Y, Johnson, RS, Kretzler, M, Cohen, CD, Eckardt, KU, Iwano, M, Haase, VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest, 117(12), 3810-20, 2007 PMCID:2082142

Park, SK, Haase, VH, Johnson, RS. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol, 30(2), 341-8, 2007

Peyssonnaux, C, Zinkernagel, AS, Schuepbach, RA, Rankin, E, Vaulont, S, Haase, VH, Nizet, V, Johnson, RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest, 117(7), 1926-32, 2007 PMCID:1884690

Rankin, EB, Biju, MP, Liu, Q, Unger, TL, Rha, J, Johnson, RS, Simon, MC, Keith, B, Haase, VH. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest, 117(4), 1068-77, 2007 PMCID:1838939

Wang, Y, Wan, C, Deng, L, Liu, X, Cao, X, Gilbert, SR, Bouxsein, ML, Faugere, MC, Guldberg, RE, Gerstenfeld, LC, Haase, VH, Johnson, RS, Schipani, E, Clemens, TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest, 117(6), 1616-26, 2007 PMCID:1878533

Ding, M, Cui, S, Li, C, Jothy, S, Haase, V, Steer, BM, Marsden, PA, Pippin, J, Shankland, S, Rastaldi, MP, Cohen, CD, Kretzler, M, Quaggin, SE. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat Med, 12(9), 1081-7, 2006

Haase, VH. The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease. Kidney Int, 69(8), 1302-7, 2006

Haase, VH. Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol, 291(2), F271-81, 2006

Liu, Y, Pop, R, Sadegh, C, Brugnara, C, Haase, VH, Socolovsky, M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood, 108(1), 123-33, 2006 PMCID:1895827

Rankin, EB, Tomaszewski, JE, Haase, VH. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res, 66(5), 2576-83, 2006

Tang, N, Mack, F, Haase, VH, Simon, MC, Johnson, RS. pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol, 26(7), 2519-30, 2006 PMCID:1430327

Wang, J, Biju, MP, Wang, MH, Haase, VH, Dong, Z. Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol, 17(7), 1875-85, 2006

Biju, MP, Akai, Y, Shrimanker, N, Haase, VH. Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent. Am J Physiol Renal Physiol, 289(6), F1217-26, 2005

Haase, VH. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin Cell Dev Biol, 16(4-5), 564-74, 2005

Karhausen, J, Haase, VH, Colgan, SP. Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle, 4(2), 256-8, 2005

Mack, FA, Patel, JH, Biju, MP, Haase, VH, Simon, MC. Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol, 25(11), 4565-78, 2005 PMCID:1140627

Neumann, AK, Yang, J, Biju, MP, Joseph, SK, Johnson, RS, Haase, VH, Freedman, BD, Turka, LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A, 102(47), 17071-6, 2005 PMCID:1287984

Rankin, EB, Higgins, DF, Walisser, JA, Johnson, RS, Bradfield, CA, Haase, VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol, 25(8), 3163-72, 2005 PMCID:1069599

Biju, MP, Neumann, AK, Bensinger, SJ, Johnson, RS, Turka, LA, Haase, VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol, 24(20), 9038-47, 2004 PMCID:517905

Higgins, DF, Biju, MP, Akai, Y, Wutz, A, Johnson, RS, Haase, VH. Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol, 287(6), F1223-32, 2004

Karhausen, J, Furuta, GT, Tomaszewski, JE, Johnson, RS, Colgan, SP, Haase, VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest, 114(8), 1098-106, 2004 PMCID:522241

Pfander, D, Kobayashi, T, Knight, MC, Zelzer, E, Chan, DA, Olsen, BR, Giaccia, AJ, Johnson, RS, Haase, VH, Schipani, E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development, 131(10), 2497-508, 2004 PMCID:517905

Cramer, T, Yamanishi, Y, Clausen, BE, F??rster, I, Pawlinski, R, Mackman, N, Haase, VH, Jaenisch, R, Corr, M, Nizet, V, Firestein, GS, Gerber, HP, Ferrara, N, Johnson, RS. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell, 112(5), 645-57, 2003 PMCID:162224

Higgins, DF, Lappin, DW, Kieran, NE, Anders, HJ, Watson, RW, Strutz, F, Schlondorff, D, Haase, VH, Fitzpatrick, JM, Godson, C, Brady, HR. DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Kidney Int, 64(6), 2079-91, 2003 PMCID:1069599

Park, SK, Dadak, AM, Haase, VH, Fontana, L, Giaccia, AJ, Johnson, RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol, 23(14), 4959-71, 2003 PMCID:162224

Haase, VH, Glickman, JN, Socolovsky, M, Jaenisch, R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A, 98(4), 1583-8, 2001 PMCID:29300

Socolovsky, M, Nam, H, Fleming, MD, Haase, VH, Brugnara, C, Lodish, HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood, 98(12), 3261-73, 2001

Snijders, AJ, Ho, SC, Haase, VH, Pillai, S, Bernards, A. A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin. J Biol Chem, 272(2), 1297-301, 1997

Haase VH, Schmidt EV, Wang T, Bernards A. Normal lymphopoiesis in transgenic mice overexpressing the ltk transmembrane tyrosine kinase. Transgenics(1), 487-95, 1995

Haase, VH, Trofatter, JA, MacCollin, M, Tarttelin, E, Gusella, JF, Ramesh, V. The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms. Hum Mol Genet, 3(3), 407-11, 1994

Snijders, AJ, Haase, VH, Bernards, A. Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment. Oncogene, 8(1), 27-35, 1993

Trofatter, JA, MacCollin, MM, Rutter, JL, Murrell, JR, Duyao, MP, Parry, DM, Eldridge, R, Kley, N, Menon, AG, Pulaski, K, Haase, VH, Ambrose, CM, Munroe, D, Bove, C, Haines, JL, Martuza, RL, MAcDonald, ME, Seizinger, BR, Short, MP, Buckler, A, Gusella JF. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell, 72(5), 791-800, 1993

Bernards, A, Haase, VH, Murthy, AE, Menon, A, Hannigan, GE, Gusella, JF. Complete human NF1 cDNA sequence: two alternatively spliced mRNAs and absence of expression in a neuroblastoma line. DNA Cell Biol, 11(10), 727-34, 1992

Haase, VH, Snijders, AJ, Cooke, SM, Teng, MN, Kaul, D, Le Beau, MM, Bruns, GA, Bernards, A. Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain. Oncogene, 6(12), 2319-25, 1991

Postdoctoral Position Available

Postdoctoral Position Details
NIH-funded postdoctoral position: We are looking for highly motivated applicants, who would like to pursue a career in biomedical science and would like to work in a competitive field. A successful applicant will have excellent communication skills.

Research projects include:
a) characterization of mouse models of disrupted oxygen sensing,
b) identification, functional and molecular characterization of HIF target genes involved in cellular metabolism and hypoxic injury responses,
c) in vitro and in vivo investigations of HIF signaling in acute and chronic hypoxic injury.

Rotation students will participate in ongoing projects and will be exposed to a broad spectrum of molecular techniques, as well as in vivo work.

Updated Date