Biomedical Research Education & Training
Faculty Member

Tyson, Darren R, PhD
Research Assistant Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-936-1534

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Tyson, Darren's picture
Academic history
PhD, St Louis University
MS, St Louis University
BS, Illinois Urbana-Champaign

Office Address   Mailing Address


Cancer Biology - PRB 771 37232-6840

Research Keywords
Cell biology, prostate, 3D culture,Cancer,Proteomics,Signal transduction,Tyrosine phosphorylation

Shukla, D, Box, GN, Edwards, RA, Tyson, DR. Bone marrow stem cells for urologic tissue engineering. World J Urol, 26(4), 341-9, 2008

Tyson, DR, Ornstein, DK. Proteomics of cancer of hormone-dependent tissues. Adv Exp Med Biol, 630, 133-47, 2008

Tyson, DR, Inokuchi, J, Tsunoda, T, Lau, A, Ornstein, DK. Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium. Prostate, 67(15), 1601-13, 2007

Hsiang, CH, Tunoda, T, Whang, YE, Tyson, DR, Ornstein, DK. The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. Prostate, 66(13), 1413-24, 2006

Ornstein, DK, Tyson, DR. Proteomics for the identification of new prostate cancer biomarkers. Urol Oncol, 24(3), 231-6, 2006

Jimenez, JC, Tyson, DR, Dhar, S, Nguyen, T, Hamai, Y, Bradshaw, RA, Evans, GR. Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration. Plast Reconstr Surg, 113(2), 605-10, 2004

Medzihradszky, KF, Darula, Z, Perlson, E, Fainzilber, M, Chalkley, RJ, Ball, H, Greenbaum, D, Bogyo, M, Tyson, DR, Bradshaw, RA, Burlingame, AL. O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes. Mol Cell Proteomics, 3(5), 429-40, 2004

Tyson, DR, Larkin, S, Hamai, Y, Bradshaw, RA. PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites. Int J Dev Neurosci, 21(2), 63-74, 2003

Swarthout, JT, Tyson, DR, Jefcoat, SC, Partridge, NC, Efcoat, SC. Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells. J Bone Miner Res, 17(8), 1401-7, 2002

Tyson, DR, Swarthout, JT, Jefcoat, SC, Partridge, NC. PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Endocrinology, 143(2), 674-82, 2002

Bajaj, MS, Tyson, DR, Steer, SA, Kuppuswamy, MN. Role of GATA motifs in tissue factor pathway inhibitor gene expression in malignant cells. Thromb Res, 101(3), 203-11, 2001

Selvamurugan, N, Pulumati, MR, Tyson, DR, Partridge, NC. Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. J Biol Chem, 275(7), 5037-42, 2000

Tyson, DR, Swarthout, JT, Partridge, NC. Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3'',5''-monophosphate response element-binding protein at serine 133. Endocrinology, 140(3), 1255-61, 1999

Koe, RC, Clohisy, JC, Tyson, DR, Pulumati, MR, Cook, TF, Partridge, NC. Parathyroid hormone versus phorbol ester stimulation of activator protein-1 gene family members in rat osteosarcoma cells. Calcif Tissue Int, 61(1), 52-8, 1997

Postdoctoral Position Available

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