Biomedical Research Education & Training
Faculty Member

Zhang, Ming-Zhi, M.D.
Assistant Professor of Medicine
Assistant Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-343-1548

Email Address: ming-zhi.zhang@Vanderbilt.Edu

Zhang, Ming-Zhi's picture
Academic history
M.S., Xuzhou Medical College
M.D., Xuzhou Medical College

Office Address   Mailing Address

S-3206A MCN 2175

S-3206 MCN 2175


Research Keywords
kidney, diabetes, dopamine, colorectal cancer, 11betaHSD2, COX-2, LOX

Research Description
My research focuses on three main areas:

1) Hormonal regulation of renal physiological and pathophysiologic functions. Specifically, we have investigated the regulation of renal cortical and medullary cyclooxygenase-2 (COX-2) expression by different hormones including elements of the renin-angiotensin system, dopaminergic system, adrenal corticosteroids, vasopressin, and others. We have also investigated the regulation of renal COX-2 by type II 11? hydroxysteroid dehydrogenase (11?HSD2) elevation of intracellular glucocorticoids. We are now intensively investigating the interaction between the intrarenal dopaminergic system and the intrarenal renin-angiotensin system using genetically manipulated mice with either elevated or reduced intrarenal dopaminergic activity.

2) 11?HSD2 and colorectal tumorigenesis. COX-2 expression increases in colorectal tumors. Inhibition of COX-2 activity suppresses colorectal tumorigenesis. Both COX-2 and 11?HSD2 expression are elevated in colorectal adenomas. Glucocorticoids are potent endogenous 11?HSD2 inhibitors. Inhibition of 11?HSD2 activity elevates levels of intracellular glucocorticoids in tumor cells, leading to inhibition of both COX-2 and tumorigenesis.

3) Immunohistochemistry in the kidney, application of image analysis and tissue microarray (TMA) in kidney research.

Publications
Zhang, MZ, Yao, B, Wang, S, Fan, X, Wu, G, Yang, H, Yin, H, Yang, S, Harris, RC. Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J Clin Invest, 121(7), 2845-54, 2011

Chen, X, Whiting, C, Borza, C, Hu, W, Mont, S, Bulus, N, Zhang, MZ, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol, 30(12), 3048-58, 2010 PMCID:2876688

He, W, Wang, Y, Zhang, MZ, You, L, Davis, LS, Fan, H, Yang, HC, Fogo, AB, Zent, R, Harris, RC, Breyer, MD, Hao, CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest, 120(4), 1056-68, 2010 PMCID:2846063

Zhang, MZ, Su, Y, Yao, B, Zheng, W, Decaestecker, M, Harris, RC. Assessing the application of tissue microarray technology to kidney research. J Histochem Cytochem, 58(5), 413-20, 2010 PMCID:2857813

Yao, B, Harris, RC, Zhang, MZ. Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. Hypertension, 54(5), 1077-83, 2009 PMCID:2782522

Zhang, MZ, Xu, J, Yao, B, Yin, H, Cai, Q, Shrubsole, MJ, Chen, X, Kon, V, Zheng, W, Pozzi, A, Harris, RC. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest, 119(4), 876-85, 2009 PMCID:2662561

Zhang, MZ, Yao, B, Fang, X, Wang, S, Smith, JP, Harris, RC. Intrarenal dopaminergic system regulates renin expression. Hypertension, 53(3), 564-70, 2009 PMCID:2680004

Yao, B, Xu, J, Harris, RC, Zhang, MZ. Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase. Am J Physiol Renal Physiol, 294(2), F433-9, 2008

Cheng, H, Wang, S, Jo, YI, Hao, CM, Zhang, M, Fan, X, Kennedy, C, Breyer, MD, Moeckel, GW, Harris, RC. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol, 18(2), 551-9, 2007

Xu, J, Yao, B, Fan, X, Langworthy, MM, Zhang, MZ, Harris, RC. Characterization of a putative intrarenal serotonergic system. Am J Physiol Renal Physiol, 293(5), F1468-75, 2007

Zeng, F, Zhang, MZ, Singh, AB, Zent, R, Harris, RC. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell, 18(11), 4446-56, 2007 PMCID:2043549

Yao, B, Xu, J, Qi, Z, Harris, RC, Zhang, MZ. Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake. Am J Physiol Renal Physiol, 291(2), F368-74, 2006

Zhang, MZ, Yao, B, Cheng, HF, Wang, SW, Inagami, T, Harris, RC. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A, 103(43), 16045-50, 2006 PMCID:1635124

Zhao, HJ, Wang, S, Cheng, H, Zhang, MZ, Takahashi, T, Fogo, AB, Breyer, MD, Harris, RC. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol, 17(10), 2664-9, 2006

Cheng, H, Zhang, M, Moeckel, GW, Zhao, Y, Wang, S, Qi, Z, Breyer, MD, Harris, RC. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron Exp Nephrol, 101(3), e75-85, 2005

Cheng, HF, Zhang, MZ, Harris, RC. NITRIC OXIDE STIMULATES CYCLOOXYGENASE-2 IN CULTURED CTAL CELLS THROUGH A P38-DEPENDENT PATHWAY. Am J Physiol Renal Physiol, 2005

Rao, R, Zhang, MZ, Zhao, M, Cai, H, Harris, RC, Breyer, MD, Hao, CM. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol, 288(4), F642-9, 2005

Yao, B, Harris, RC, Zhang, MZ. Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Am J Physiol Regul Integr Comp Physiol, 288(6), R1767-73, 2005

Zhang, MZ, Yao, B, McKanna, JA, Harris, RC. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. Am J Physiol Renal Physiol, 288(4), F840-5, 2005

Harris, RC, Zhang, MZ, Cheng, HF. Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol Scand, 181(4), 543-7, 2004

Schneider, A, Zhang, Y, Zhang, M, Lu, WJ, Rao, R, Fan, X, Redha, R, Davis, L, Breyer, RM, Harris, R, Guan, Y, Breyer, MD. Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Kidney Int, 65(4), 1205-13, 2004

Zhang, MZ, Mai, W, Li, C, Cho, SY, Hao, C, Moeckel, G, Zhao, R, Kim, I, Wang, J, Xiong, H, Wang, H, Sato, Y, Wu, Y, Nakanuma, Y, Lilova, M, Pei, Y, Harris, RC, Li, S, Coffey, RJ, Sun, L, Wu, D, Chen, XZ, Breyer, MD, Zhao, ZJ, McKanna, JA, Wu, G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A, 101(8), 2311-6, 2004 PMCID:356947

Zhang, MZ, Sanchez Lopez, P, McKanna, JA, Harris, RC. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology, 145(3), 1402-9, 2004

Zhang, MZ, Wang, SW, Cheng, H, Zhang, Y, McKanna, JA, Harris, RC. Regulation of renal cortical cyclooxygenase-2 in young rats. Am J Physiol Renal Physiol, 285(5), F881-8, 2003

Cheng, HF, Wang, CJ, Moeckel, GW, Zhang, MZ, McKanna, JA, Harris, RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney Int, 62(3), 929-39, 2002

Cheng, HF, Wang, SW, Zhang, MZ, McKanna, JA, Breyer, R, Harris, RC. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Am J Physiol Regul Integr Comp Physiol, 283(3), R638-46, 2002

Zhang, MZ, Hao, CM, Breyer, MD, Harris, RC, McKanna, JA. Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla. Am J Physiol Renal Physiol, 283(3), F509-16, 2002

Cheng, HF, Wang, JL, Zhang, MZ, Wang, SW, McKanna, JA, Harris, RC. Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Am J Physiol Renal Physiol, 280(3), F449-56, 2001

Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. J Clin Invest, 106(5), 681-8, 2000 PMCID:381289

Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC. Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Am J Physiol Renal Physiol, 279(1), F122-9, 2000

Harris, RC, Cheng, H, Wang, J, Zhang, M, McKanna, JA. Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Acta Physiol Scand, 168(1), 47-51, 2000

Cheng, HF, Wang, JL, Zhang, MZ, Miyazaki, Y, Ichikawa, I, McKanna, JA, Harris, RC. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest, 103(7), 953-61, 1999 PMCID:408259

Zhang, MC, He, L, Giro, M, Yong, SL, Tiller, GE, Davidson, JM. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). J Biol Chem, 274(2), 981-6, 1999

Zhang, MZ, Harris, RC, McKanna, JA. Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Proc Natl Acad Sci U S A, 96(26), 15280-5, 1999 PMCID:24811

Harris, RC, Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA. Prostaglandins in macula densa function. Kidney Int Suppl, 67, S49-52, 1998

McKanna, JA, Zhang, MZ, Wang, JL, Cheng, H, Harris, RC. Constitutive expression of cyclooxygenase-2 in rat vas deferens. Am J Physiol, 275(1 Pt 2), R227-33, 1998

Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA, Harris, RC. Selective increase of cyclooxygenase-2 expression in a model of renal ablation. Am J Physiol, 275(4 Pt 2), F613-22, 1998

McKanna, JA, Zhang, MZ. Immunohistochemical localization of lipocortin 1 in rat brain is sensitive to pH, freezing, and dehydration. J Histochem Cytochem, 45(4), 527-38, 1997

Melzer, P, Zhang, MZ, McKanna, JA. Infraorbital nerve transection and whisker follicle removal in adult rats affect microglia and astrocytes in the trigeminal brainstem. A study with lipocortin1- and S100beta-immunohistochemistry. Neuroscience, 80(2), 459-72, 1997

Sakai, M, Zhang, M, Homma, T, Garrick, B, Abraham, JA, McKanna, JA, Harris, RC. Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest, 99(9), 2128-38, 1997 PMCID:508043

Zhang, MZ, McKanna, JA. Gliogenesis in postnatal rat optic nerve: LC1 + microglia and S100-beta + astrocytes. Brain Res Dev Brain Res, 101(1-2), 27-36, 1997

Zhang, MZ, Wang, JL, Cheng, HF, Harris, RC, McKanna, JA. Cyclooxygenase-2 in rat nephron development. Am J Physiol, 273(6 Pt 2), F994-1002, 1997


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
07/10/2011