Biomedical Research Education & Training
Faculty Member

Alcendor, Donald J, Ph.D.
Assistant Professor of Cancer Biology at Meharry Medical College
Adjunct Assistant Professor of Cancer Biology at Vanderbilt University School of Medicine

Lab Url: N/A

Phone Number: 615-327-6449

Email Address: dalcendor@mmc.edu

Alcendor, Donald's picture
Academic history
PhD, University of Californina, Davis
BSc, Southern University
MS, Louisiana

Office Address   Mailing Address

1005 Dr. D.B. Todd Jr. Blvd

Room 5025 5th Floor Hubbard Hospital 37208-3599


Research Keywords
Cancer, Kaposi's sarcoma, Fibulins, Galectins, Tissue microarrays, Extracellular matrix , Infectious disease, Vascular Biology, Transcription, HIV malignancies

Research Specialty
Dysregulation of genes induced by Kaposi's sarcoma virus for novel therapeutic.

Research Description
Research Description

Antiretroviral therapy (ART) has reduced the incidence of Kaposi?s sarcoma (KS) in developed western countries. However, 95% of the estimated 40 to 60 million people infected with HIV have no access to these drugs. HIV/AIDS-associated KS is still a significant problem in the U.S. among individuals who are noncompliant due to toxicities and those who progress to AIDS without receiving drug therapy. KS is cause by Kaposi?s sarcoma-associated herpesvirus (KSHV) and is characterized as an angioproliferative tumor of vascular endothelial cells and produces rare B cell lymphoproliferative diseases in the form of pleural effusion lymphomas (PEL) and some forms of Multicentric Castleman?s Disease (MCD). Only 1-5% of cells in KS lesions actively support lytic replication of KSHV, and it is clear that cellular factors must interact with viral factors in the process of oncogenesis and tumor progression. Identifying novel host-factor determinants that contribute to KS pathology is essential for developing prognostic markers for tumor progression and metastasis as well as novel therapeutics for the treatment of KS.
Our studies thus far have shown that galectin-3, fibulin-2 and fibulin-5 are dysregulated genes in KSHV infected dermal microvascular endothelial cells (DMVEC). All of these genes are implicated in malignancy and most likely contribute to KS pathogenesis. Thus, we are interested in evaluating galectin-3, fibulin-2, and fibulin-5 in order to determine their usefulness as diagnostic markers for KS tumor progression/metastasis, and whether they would serve as a target(s) for a novel treatment strategy.
Our hypothesis is that downregulation of galectin-3, fibulin-2 and fibulin-5 contributes to KS pathogenesis and tumorigenesis, and that modulation of their expression in the tumor microenvironment could serve to either alter virus replication and/or reduce tumor angiogenesis, progression and metastasis. Thus reconstitution or over-expression of these genes in KS tissue and AIDS-associated pleural effusion lymphomas (PELs) could alter and/or reduce viral pathogenesis associated with KS and hence serve as molecular targets for therapeutic interventions.

Publications
Ahsen R. Chaudhry, Knobel S.M., Ladson G. and Alcendor DJ.. Expression of fibulins in vaginal epithelium from women of diverse ethnicity: Implication for racial disparities in stress urinary incontinence ( to be submitted ).. , 2010

Alcendor D.J., Charest A. M, Knobel S.M., and Zhu WQ.. Infection and upregulation of proinflammatory cytokines in brain vascular by human cytomegalovirus ( in revision ). , 2010

Alcendor D.J., Knobel S. Desai P, Zhu W.Q., Vigil H.E., and Hayward G.S.. KSHV downregulation of galectin-3 in kaposi's sarcoma.. Glycobiology, 20, 521-532, 2010

Alcendor D.J., Zhu W.Q., and Desai P.. KSHV Downregulation of Fibulins in Kaposi's sarcoma: Implications for tumorigenesis ( to be submitted).. , 2010

Hayward, G.S, Alcendor DJ., and Boger RA. In Viral Oncology: Basic Science and Clinical Applications (Book). The Role of KSHV in Pathogenesis of Kaposis Sarcoma: Jeang KT and K.Kalili eds, Ver, 377-407, 2010

Marrs C.N., Zhu W.Q, Sweet S., Alcendor D.J.. Evidence for Gardnerella Vaginalis uptake and internalization by squamous vaginal epithelial cells: Implications for the phathogenesis of bacterial vaginosis ( in revision ). , 2010

. Dual labeled Immunohistochemistry in Kaposi's Sarcoma.. J. Vis. Exp ( in press ), 2010

Alcendor D.J., Zong J.C., Dolan A., Davidson A., and Hayward G.S.. Patterns of divergence in the rapidly evolving vCXC and vGPCR gene clusters in primate cytomegalovirus genomes. Virology, 365, 21-32, 2009

Hildreth J.E.K., and Alcendor, D.. Mayo Clinic HIV eCurriculum Series: In Essentials of HIV medicine.. Mayo Clinic Foundation for Medical Education and Research, 1 - 20, 2009

Alcendor, D. J, and Hayward G. S.. "Cytomegalovirus (Herpesviridae) Simian Cytomegaloviruses " . In Encyclopedia of Virology, 3rd ed., 2008

D.J., Zong R. Arav-Boger, Alcendor, D.J, and Hayward G.S., . Reflections on the interpretations of heterogeneity and strain differences based on very limited PCR sequence data from Kaposii??s sarcoma associated herpesvirus. . A review. J. Clin., 40:, 1-8, 2007

Davison, A.J., Dolan, A., Akter, P., Addison, C., Dargan, D.J., Alcendor, D.J, McGeoch, D.J., and Hayward, G.S. . The Human Cytomegalovirus Genome Revisited: Comparison with the chimpanzee cytomegalovirus genome. . J Gen Virol, 84:, 17-28, 2003

Arav-Boger, R., Willoughby, R.F., Pass, R.F., Zong, J-C., Jang, W.J., Alcendor, D.J, and Hayward, G.S. . Polymorphisms of the cytomegalovirus-encoded TNFI? and I?-chemokine receptors in congenital CMV disease. J. Inf. Dis, 186, 1057-1064, 2002

Chiou, C.J., Poole, L.J., Kim, P.S., Ciufo, D.M., Cannon, J.S., ap Rhys, C.J., Zong, J.-C., Alcendor, D.J, Ambinder, R.F., and Hayward, G.S. . Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposii??s sarcoma-associated herpesvirus. J. Virol, 76, 3421-3439, 2002

Alcendor, D. J, and Hayward G. S.. Index of Viruses: "Cytomegalovirus Betaherpesviridae" . In Springer Verlag, 1st ed., 156-162, 2001

Wu, F., Ahn, J-H., Alcendor, D.J, Jang W-J., Xiao, J., Hayward, S.D., Hayward, G.S.. Origin independent assembly of sarcoma-associated herpesvirus (KSHV) DNA replication compartments in transient co-transfection assays and association with the ORF-K8 protein and cellular PML (PODs). J. Virol, 75, 1487-1506, 2001

Alcendor, D. J, and Hayward G. S.. Animal Cytomegalovirus (Herpesviridae). In Encyclopedia of Virology, 2nd ed., 357-363, 1999

Poole, L., Zong, J-C., Ciufo, D.M., Alcendor, D.J, Cannon, J.S. Ambinder, R.F., Orenstein, J.M., Reitz, M.S. and Hayward, G.S. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposis sarcoma associated herpesvirus (HHV8) reveals evidence for recombinant and for two distinct types of ORF-K15 alleles at the right hand end.. J. Virol, 73:, 6646-6660, 1999

Richman K.L., Montali R. J., Garber R. L., Kennedy M.L., Lehnhardt, J., Hildebrandt T., Schmitt D., Alcendor, D.J, and Hayward G. S.. Novel endotheliotropic herpesviruses fatal for asian and african elephants. Science, 5405:, 1171-1176, 1999

Zong, JC, Ciufo DM, Alcendor, D.J, Wan X, Nicholas J, Browning P, Rady P, Orenstein JM, Rabkin C, Su IJ and GS Hayward. High level variability in the ORF-K1 membrane protein gene at the left end of the kaposis sarcoma associated herpesvirus genome defines four major virus subtypes and multiple variant or clades in different human populations. J. Virol, 73:, 4156-4170, 1999

Nicholas, J.Zong, Alcendor, D.J, Ciufo, D, Poole, L. J, Sarisky, R.T, Chiou, C. J, Zhang, X, Wan, X, Guo, H., G., Reitz, and Hayward G.S . Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8. JNCI, 23:, 79-88, 1998

Micheals, MG, Alcendor, D.J, St. George, K, Rinaldo, Jr., Ehrlich, G.D, Becich, M.J, and Hayward G. S.. Distinguishing baboon cytomegalovirus from human cytomegalovirus: Importance for xenotransplantation. J. Inf. Dis, 176:, 1476-1483, 1997

Barry, PA, Alcendor, D.J, Power, MD, kerr, H, and Luciw PA. Nucleotide sequence and molecular analysis of the rhesus cytomegalovirus immediate-early gene and the UL121-117 open reading frame. Virology, 215:, 61-72, 1996

Alcendor, D.J., Chapman GD, Beaman BL. Isolation, sequencing and expression of the superoxide dismutase-encoding gene (sod) of Nocardia asteroides strain GUH-2. Gene, 164:, 143-145, 1995

Alcendor, D.J., Barry P.A, Pratt-Lowe E, Luciw PA. Analysis of the rhesus cytomegalovirus immediate early gene promoter. Virology, 194:, 815-21, 1993

Alcendor, D.J.. Structure and function of the rhesus cytomegalovirus immediate early gene. Dissertation(University of California, Davis), 1992

Barry, P.A., Pratt-Lowe, E., Alcendor, D.J., E. Unger, and Paul Luciw. Molecular interactions between human immunodeficiency virus type I and human cytomegalovirus Ann. New York Acad, 616:, 54-63, 1990

Barry, P.A., Pratt-Lowe, E., Unger, R.E., Marthas, M., Acendor, D.J., and Luciw, P.A.. Molecularinteractions of rhesus cytomegalovirus and the human and simian immunodeficiency viruses. J.Med. Primatol, 19:, 327-337, 1990


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
06/30/2010