Biomedical Research Education & Training
Faculty Member

Dohn, Michael R, Ph.D.
Research Assistant Professor of Pharmacology

Lab Url: N/A

Phone Number: 615-875-7619

Email Address:

Dohn, Michael's picture
Academic history
B.S., Florida Institute of Technology
Ph.D., Medical College of Georgia
, Medical College of Georgia
, Vanderbilt University

Office Address   Mailing Address

461 Preston Research Building

2220 Pierce Avenue 37232

Research Keywords
pharmacology, neuroscience, cell-ECM adhesion, cell-cell adhesion, cancer biology

Research Description
Autism, depression, and anxiety disorders are associated with an imbalance in the serotonin system, which often involves changes in the function of the serotonin transporter (SERT). SERT interacts with and is regulated by integrins, transmembrane proteins that link the extracellular matrix to the intracellular cytoskeleton. My research focuses on the physical and functional interactions between SERT and the integrin beta3 subunit in the brain. Using mouse models that alter integrin beta3 function, we 1) analyze the signaling pathways involved in beta3-mediated regulation of SERT activity and 2) evaluate the role of these signaling mechanisms in mouse behaviors linked to SERT function. These studies highlight the complex regulation of serotonin homeostasis and social behaviors by integrin beta3 and reveal an important role for integrins in modulating risk for neuropsychiatric disorders.

Dohn, MR, Kooker, CG, Bastarache, L, Jessen, T, Rinaldi, C, Varney, S, Mazalouskas, MD, Oliver, KH, Pan, H, Sutcliffe, JS, Valez Edwards, DR, Denny, JC, and Carneiro, AMD. Integrin beta3 Pro33 Gain-of-Function Variant Reduces Serotonin Transporter Activity and Alters Social and Emotional Behaviors. , Submitted

Yu, HH, Dohn, MR, Markham, NO, Coffey, RJ, and Reynolds, AB. p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. J Cell Sci., In Press

Markham, NO, Doll, CA, Dohn, MR, Miller, RK, Yu, H, Coffey, RJ, McCrea, PD, Gamse, JT, Reynolds, AB. DIPA family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. Mol Biol Cell, 25(17), 2592-603, 2014

Dohn, MR, Mundell, NA, Sawyer, LM, Dunlap, JA, Jessen, JR. Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev Biol, 383(1), 39-51, 2013

Naydenov, NG, Brown, B, Harris, G, Dohn, MR, Morales, VM, Baranwal, S, Reynolds, AB, Ivanov, AI. A membrane fusion protein alphaSNAP is a novel regulator of epithelial apical junctions. PLoS One, 7(4), e34320, 2012 PMCID:3317505

Periyasamy-Thandavan, S, Takhar, S, Singer, A, Dohn, MR, Jackson, WH, Welborn, AE, Leroith, D, Marrero, M, Thangaraju, M, Huang, S, Schoenlein, PV. Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim. Breast Cancer Res, 14(2), R52, 2012

Smith, AL, Dohn, MR, Brown, MV, Reynolds, AB. Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell, 23(1), 99-110, 2012 PMCID:3248908

Dohn, MR, Brown, MV, Reynolds, AB. An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth. J Cell Biol, 184(3), 437-50, 2009 PMCID:2646551

Wildenberg, GA, Dohn, MR, Carnahan, RH, Davis, MA, Lobdell, NA, Settleman, J, Reynolds, AB. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell, 127(5), 1027-39, 2006 PMCID:2646551

Dohn, M, Nozell, S, Willis, A, Chen, X. Tumor suppressor gene-inducible cell lines. Methods Mol Biol, 223, 221-35, 2003

Schoenlein, PV, Barrett, JT, Kulharya, A, Dohn, MR, Sanchez, A, Hou, DY, McCoy, J. Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. Int J Radiat Oncol Biol Phys, 55(4), 1051-65, 2003

Dohn, M, Jiang, J, Chen, X. Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis. Oncogene, 20(45), 6503-15, 2001

Dohn, M, Zhang, S, Chen, X. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene, 20(25), 3193-205, 2001

Postdoctoral Position Available

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