Biomedical Research Education & Training
Faculty Member

Boutaud, Olivier G., Ph.D.
Research Associate Professor of Pharmacology

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Phone Number: 615-343-7398

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Boutaud, Olivier's picture
Academic history
Ph.D., Louis Pasteur University, France
D.E.A., Louis Pasteur University, France
M.S., Louis Pasteur University, France

Office Address   Mailing Address

514 RRB

514 RRB 37232-6602

Smith, JP, Haddad, EV, Taylor, MB, Oram, D, Blakemore, D, Chen, Q, Boutaud, O, Oates, JA. Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Hypertension, 59(3), 719-25, 2012

Yin, H, Vergeade, A, Shi, Q, Zackert, WE, Gruenberg, KC, Bokiej, M, Amin, T, Ying, W, Masterson, TS, Zinkel, SS, Oates, JA, Boutaud, O, Roberts, LJ. Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation. Biochem Biophys Res Commun, 423(2), 224-8, 2012

Chacon, A, Zagol-Ikapitte, I, Amarnath, V, Reyzer, ML, Oates, JA, Caprioli, RM, Boutaud, O. On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry. J Mass Spectrom, 46(8), 840-6, 2011

Holinstat, M, Boutaud, O, Apopa, PL, Vesci, J, Bala, M, Oates, JA, Hamm, HE. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2I? differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol, 31(2), 435-42, 2011 PMCID:3035574

Reed, KA, Tucker, DE, Aloulou, A, Adler, D, Ghomashchi, F, Gelb, MH, Leslie, CC, Oates, JA, Boutaud, O. Functional characterization of mutations in inherited human cPLAa?? deficiency. Biochemistry, 50(10), 1731-8, 2011

Zagol-Ikapitte, I, Amarnath, V, Jadhav, S, Oates, JA, Boutaud, O. Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: Application to in vivo pharmacokinetics studies. J Chromatogr B Analyt Technol Biomed Life Sci, 879(15-16), 1098-104, 2011

Boutaud, O, Moore, KP, Reeder, BJ, Harry, D, Howie, AJ, Wang, S, Carney, CK, Masterson, TS, Amin, T, Wright, DW, Wilson, MT, Oates, JA, Roberts, LJ. Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc Natl Acad Sci U S A, 107(6), 2699-704, 2010

Boutaud, O, Oates, JA. Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes. Methods Mol Biol, 644, 67-90, 2010 PMCID:3035574

Boutaud, O, Roberts, LJ. Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radic Biol Med, 2010 PMCID:3035574

Plunkett, J, Doniger, S, Morgan, T, Haataja, R, Hallman, M, Puttonen, H, Menon, R, Kuczynski, E, Norwitz, E, Snegovskikh, V, Palotie, A, Peltonen, L, Fellman, V, DeFranco, EA, Chaudhari, BP, Oates, J, Boutaud, O, McGregor, TL, McElroy, JJ, Teramo, K, Borecki, I, Fay, JC, Muglia, LJ. Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. BMC Med Genomics, 3, 62, 2010 PMCID:3017005

Smith, JP, Haddad, EV, Downey, JD, Breyer, RM, Boutaud, O. PGE2 decreases reactivity of human platelets by activating EP2 and EP4. Thromb Res, 126(1), e23-9, 2010 PMCID:3035574

Zagol-Ikapitte, I, Amarnath, V, Bala, M, Roberts, LJ, Oates, JA, Boutaud, O. Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis. Chem Res Toxicol, 23(1), 240-50, 2010

Zagol-Ikapitte, IA, Matafonova, E, Amarnath, V, Bodine, CL, Boutaud, O, Tirona, RG, Oates, JA, Roberts, LJ, Davies, SS. Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent ??-Ketoaldehyde Scavenger, by LC/MS/MS. Pharmaceutics, 2(1), 18-29, 2010

Adler, DH, Phillips, JA, Cogan, JD, Iverson, TM, Schnetz-Boutaud, N, Stein, JA, Brenner, DA, Milne, GL, Morrow, JD, Boutaud, O, Oates, JA. The enteropathy of prostaglandin deficiency. J Gastroenterol, 44 Suppl 19, 1-7, 2009 PMCID:2799331

Carrier, EJ, Amarnath, V, Oates, JA, Boutaud, O. Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. Biochemistry, 48(45), 10775-81, 2009

Mosoni, L, Balage, M, Vazeille, E, Combaret, L, Morand, C, Zagol-Ikapitte, I, Boutaud, O, Marzani, B, Papet, I, Dardevet, D. Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs. Nutrition, 26(11-12), 1157-62, 2009 PMCID:2823910

Nam, TG, Nara, SJ, Zagol-Ikapitte, I, Cooper, T, Valgimigli, L, Oates, JA, Porter, NA, Boutaud, O, Pratt, DA. Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Org Biomol Chem, 7(24), 5103-12, 2009

Potet, F, Petersen, CI, Boutaud, O, Shuai, W, Stepanovic, SZ, Balser, JR, Kupershmidt, S. Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator. J Mol Cell Cardiol, 46(2), 257-67, 2009 PMCID:2708093

Adler, DH, Cogan, JD, Phillips, JA, Schnetz-Boutaud, N, Milne, GL, Iverson, T, Stein, JA, Brenner, DA, Morrow, JD, Boutaud, O, Oates, JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest, 118(6), 2121-31, 2008 PMCID:2350426

Bala, M, Chin, CN, Logan, AT, Amin, T, Marnett, LJ, Boutaud, O, Oates, JA. Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem Pharmacol, 75(7), 1472-81, 2008 PMCID:2693035

Davies, SS, Amarnath, V, Brame, CJ, Boutaud, O, Roberts, LJ. Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc, 2(9), 2079-91, 2007

Aronoff, DM, Oates, JA, Boutaud, O. New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Clin Pharmacol Ther, 79(1), 9-19, 2006

Boutaud, O, Montine, TJ, Chang, L, Klein, WL, Oates, JA. PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J Neurochem, 96(4), 917-23, 2006 PMCID:1621054

Davies, SS, Brantley, EJ, Voziyan, PA, Amarnath, V, Zagol-Ikapitte, I, Boutaud, O, Hudson, BG, Oates, JA, Roberts, LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry, 45(51), 15756-67, 2006 PMCID:2597444

Boutaud, O, Andreasson, KI, Zagol-Ikapitte, I, Oates, JA. Cyclooxygenase-dependent lipid-modification of brain proteins. Brain Pathol, 15(2), 139-42, 2005

Zagol-Ikapitte, I, Masterson, TS, Amarnath, V, Montine, TJ, Andreasson, KI, Boutaud, O, Oates, JA. Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer''s disease severity. J Neurochem, 94(4), 1140-5, 2005

Brame, CJ, Boutaud, O, Davies, SS, Yang, T, Oates, JA, Roden, D, Roberts, LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem, 279(14), 13447-51, 2004

Zagol-Ikapitte, I, Bernoud-Hubac, N, Amarnath, V, Roberts, LJ, Boutaud, O, Oates, JA. Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry, 43(18), 5503-10, 2004

Aronoff, DM, Boutaud, O, Marnett, LJ, Oates, JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J Pharmacol Exp Ther, 304(2), 589-95, 2003

Aronoff, DM, Boutaud, O, Marnett, LJ, Oates, JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. Adv Exp Med Biol, 525, 125-8, 2003

Boutaud, O, Dixon, DA, Oates, JA, Sawaoka, H. Tristetraprolin binds to the COX-2 mRNA 3'' untranslated region in cancer cells. Adv Exp Med Biol, 525, 157-60, 2003

Boutaud, O, Li, J, Zagol, I, Shipp, EA, Davies, SS, Roberts, LJ, Oates, JA. Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J Biol Chem, 278(19), 16926-8, 2003

Kozak, W, Aronoff, DM, Boutaud, O, Kozak, A. 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide. Exp Biol Med (Maywood), 228(7), 786-94, 2003

Sawaoka, H, Dixon, DA, Oates, JA, Boutaud, O. Tristetraprolin binds to the 3''-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. J Biol Chem, 278(16), 13928-35, 2003

Boutaud, O, Aronoff, DM, Richardson, JH, Marnett, LJ, Oates, JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc Natl Acad Sci U S A, 99(10), 7130-5, 2002 PMCID:124540

Boutaud, O, Ou, JJ, Chaurand, P, Caprioli, RM, Montine, TJ, Oates, JA. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J Neurochem, 82(4), 1003-6, 2002

Cox, B, Murphey, LJ, Zackert, WE, Chinery, R, Graves-Deal, R, Boutaud, O, Oates, JA, Coffey, RJ, Morrow, JD. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. Biochim Biophys Acta, 1584(1), 37-45, 2002

Davies, SS, Amarnath, V, Montine, KS, Bernoud-Hubac, N, Boutaud, O, Montine, TJ, Roberts, LJ. Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J, 16(7), 715-7, 2002

Smith, LH, Boutaud, O, Breyer, M, Morrow, JD, Oates, JA, Vaughan, DE. Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro. Arterioscler Thromb Vasc Biol, 22(6), 983-8, 2002

Abraham, BD, Sono, M, Boutaud, O, Shriner, A, Dawson, JH, Brash, AR, Gaffney, BJ. Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron. Biochemistry, 40(7), 2251-9, 2001

Bernoud-Hubac, N, Davies, SS, Boutaud, O, Montine, TJ, Roberts, LJ. Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway. J Biol Chem, 276(33), 30964-70, 2001

Boutaud, O, Brame, CJ, Chaurand, P, Li, J, Rowlinson, SW, Crews, BC, Ji, C, Marnett, LJ, Caprioli, RM, Roberts, LJ, Oates, JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry, 40(23), 6948-55, 2001

Boutaud, O, Li, J, Chaurand, P, Brame, CJ, Marnett, LJ, Roberts, LJ, Oates, JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv Exp Med Biol, 500, 133-7, 2001

Benayoud, F., Abouabdellah, A., Richard, C., Bonnet-Delpon, D., B?gu?, J.-P, Levasseur, D., Boutaud, O. and Schuber, F. Trifluoromethyl ketones derived from squalene: inhibition of the cholesterol biosynthesis in HepG2 cells. Tetrahedron Lett., 41, 6367-6370, 2000

Boutaud, O, Brame, CJ, Salomon, RG, Roberts, LJ, Oates, JA. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry, 38(29), 9389-96, 1999

Boutaud, O, Brash, AR. Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. J Biol Chem, 274(47), 33764-70, 1999

Koljak, R, Boutaud, O, Shieh, BH, Samel, N, Brash, AR. Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. Science, 277(5334), 1994-6, 1997

Boutaud, O, Ceruti, M, Cattel, L, Schuber, F. Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. Biochem Biophys Res Commun, 208(1), 42-7, 1995

Viola, F, Brusa, P, Balliano, G, Ceruti, M, Boutaud, O, Schuber, F, Cattel, L. Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. Biochem Pharmacol, 50(6), 787-96, 1995

Boutaud, O, Dolis, D, Schuber, F. Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase. Biochem Biophys Res Commun, 188(2), 898-904, 1992

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