Biomedical Research Education & Training
Faculty Member

Page-McCaw, Andrea, PhD
Associate Professor of Cell and Developmental Biology
Associate Professor of Cancer Biology

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Phone Number: 615-875-5841

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Page-McCaw, Andrea's picture
Academic history
AB Magna Cum Laude, Harvard University, Cambridge MA
PhD, MIT, Cambridge, MA
post-doctoral, Univ. California Berkeley

Office Address   Mailing Address

Learned Lab/MRB-III, rm U-4213A

PMB 407935 37240-7935

Research Keywords
Developmental biology, cell signaling, signal transduction, stem cells, tissue remodeling, wound healing, basement membrane, MMPs (matrix metalloproteinases), optogenetics, genetics, Drosophila.

Research Specialty
Cell-extracellular interactions: cell signaling, extracellular matrix, and mechanical signaling.

Research Description
Animals modify existing tissues to meet the demands of continuing growth and development or environmental challenge. This is known as tissue remodeling. Tissue remodeling is also required for tissue repair after insult or injury, and it goes awry during cancer when tumors usurp tissue remodeling functions to promote metastasis. My lab is especially interested in how cells interact with the extracellular environment during remodeling, both in terms of signaling and extracellular matrix. Matrix can be cleaved and removed by proteases, strengthened by cross linking, or repaired by unknown mechanisms, and we are investigating all these processes.

Drosophila melanogaster (the common fruitfly) has been an important model organism for understanding cell and developmental biology because of its advanced genetics and beautiful cytology. The extracellular environment is highly conserved in the fly, but much simpler, with less redundancy. Genetic experiments can be done rapidly and with great precision. We exploit this genomic simplicity and genetic precision to address fundamental questions about how cells interact with their extracellular environment.

McCall, AS, Cummings, CF, Bhave, G, Vanacore, R, Page-McCaw, A, Hudson, BG. Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture. Cell, 157(6), 1380-92, 2014

Wang, X, Page-McCaw, A. A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation. J Cell Biol, 206(7), 923-36, 2014

Saito-Diaz, K, Chen, TW, Wang, X, Thorne, CA, Wallace, HA, Page-McCaw, A, Lee, E. The way Wnt works: components and mechanism. Growth Factors, 31(1), 1-31, 2013

Broderick, S, Wang, X, Simms, N, Page-McCaw, A. Drosophila Ninjurin A induces nonapoptotic cell death. PLoS One, 7(9), e44567, 2012

Stevens, LJ, Page-McCaw, A. A secreted MMP is required for reepithelialization during wound healing. Mol Biol Cell, 23(6), 1068-79, 2012

Miller, CM, Liu, N, Page-McCaw, A, Broihier, HT. Drosophila mmp2 regulates the matrix molecule faulty attraction (frac) to promote motor axon targeting in Drosophila. J Neurosci, 31(14), 5335-47, 2011

Glasheen, BM, Robbins, RM, Piette, C, Beitel, GJ, Page-McCaw, A. A matrix metalloproteinase mediates airway remodeling in Drosophila. Dev Biol, 344(2), 772-83, 2010

Glasheen, BM, Kabra, AT, Page-McCaw, A. Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase. Proc Natl Acad Sci U S A, 106(8), 2659-64, 2009 PMCID:2636737

Miller, CM, Page-McCaw, A, Broihier, HT. Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo. Development, 135(1), 95-109, 2008 PMCID:2636737

Page-McCaw, A. Remodeling the model organism: matrix metalloproteinase functions in invertebrates. Semin Cell Dev Biol, 19(1), 14-23, 2008 PMCID:2248213

Beaucher, M, Hersperger, E, Page-McCaw, A, Shearn, A. Metastatic ability of Drosophila tumors depends on MMP activity. Dev Biol, 303(2), 625-34, 2007 PMCID:2760082

Page-McCaw, A, Ewald, AJ, Werb, Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol, 8(3), 221-33, 2007 PMCID:2760082

Zhang, S, Dailey, GM, Kwan, E, Glasheen, BM, Sroga, GE, Page-McCaw, A. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Genes Dev, 20(14), 1899-910, 2006 PMCID:1522090

Myllykangas, L, Tyynel, J, Page-McCaw, A, Rubin, GM, Haltia, MJ, Feany, MB. Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses. Neurobiol Dis, 19(1-2), 194-9, 2004

Page-McCaw, A, Serano, J, Sante, JM, Rubin, GM. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Dev Cell, 4(1), 95-106, 2003 PMCID:1522090

Postdoctoral Position Available

Postdoctoral Position Details

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