Biomedical Research Education & Training
Faculty Member

Peebles, R. Stokes, M.D.
Professor of Medicine
Elizabeth and John Murray Chair in Medicine

Lab Url: N/A

Phone Number: 615-322-3412

Email Address: stokes.peebles@vanderbilt.edu

Peebles, R.'s picture
Academic history
B.S., Davidson College
M.D., Vanderbilt

Office Address   Mailing Address

B-1227 MCN

T-1218 MCN Vanderbilt University Medical Center 37232-2650


Research Keywords
eicosanoid prostaglandin leukotriene lung allergy virus immunology

Research Specialty
Our lab is interested in allergically-mediated and virally-induced lung inflammation. Presently funded projects include how IL-17 and PGI2 mediate inflammatory responses.

Publications
Claar, D, Hartert, TV, Peebles, RS. The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med, 9(1), 55-72, 2015

Hotard, AL, Lee, S, Currier, MG, Crowe, JE, Sakamoto, K, Newcomb, DC, Peebles, RS, Plemper, RK, Moore, ML. Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. J Virol, 89(1), 512-22, 2015

Karlin, E, Gebretsadik, T, Peebles, RS, Hartert, TV, Langley, EW, Arnold, DH. Fractional exhaled nitric oxide change in pediatric patients after emergency department care of asthma exacerbations. Ann Allergy Asthma Immunol, 114(2), 149-51, 2015

Larkin, EK, Gebretsadik, T, Moore, ML, Anderson, LJ, Dupont, WD, Chappell, JD, Minton, PA, Peebles, RS, Moore, PE, Valet, RS, Arnold, DH, Rosas-Salazar, C, Das, SR, Polack, FP, Hartert, TV, , . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med, 15, 45, 2015

Newcomb, DC, Cephus, JY, Boswell, MG, Fahrenholz, JM, Langley, EW, Feldman, AS, Zhou, W, Dulek, DE, Goleniewska, K, Woodward, KB, Sevin, CM, Hamilton, RG, Kolls, JK, Peebles, RS. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. J Allergy Clin Immunol, 2015

Peebles, RS. At the bedside: the emergence of group 2 innate lymphoid cells in human disease. J Leukoc Biol, 97(3), 469-75, 2015

Zaynagetdinov, R, Sherrill, TP, Gleaves, LA, McLoed, AG, Saxon, JA, Habermann, AC, Connelly, L, Dulek, D, Peebles, RS, Fingleton, B, Yull, FE, Stathopoulos, GT, Blackwell, TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res, 75(8), 1624-34, 2015

Dulek, DE, Newcomb, DC, Goleniewska, K, Cephus, J, Zhou, W, Reiss, S, Toki, S, Ye, F, Zaynagetdinov, R, Sherrill, TP, Blackwell, TS, Moore, ML, Boyd, KL, Kolls, JK, Peebles, RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 82(9), 3723-39, 2014

Dulek, DE, Newcomb, DC, Toki, S, Goliniewska, K, Cephus, J, Reiss, S, Bates, JT, Crowe, JE, Boyd, KL, Moore, ML, Zhou, W, Peebles, RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol, 88(17), 9655-72, 2014

Miller, EK, Avila, PC, Khan, YW, Word, CR, Pelz, BJ, Papadopoulos, NG, Peebles, RS, Heymann, PW, , . Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma. J Allergy Clin Immunol Pract, 2(5), 537-43, 2014

Patel, DA, You, Y, Huang, G, Byers, DE, Kim, HJ, Agapov, E, Moore, ML, Peebles, RS, Castro, M, Sumino, K, Shifren, A, Brody, SL, Holtzman, MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J Allergy Clin Immunol, 134(6), 1402-1412.e7, 2014

Zhou, W, Goleniewska, K, Zhang, J, Dulek, DE, Toki, S, Lotz, MT, Newcomb, DC, Boswell, MG, Polosukhin, VV, Milne, GL, Wu, P, Moore, ML, FitzGerald, GA, Peebles, RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol, 134(3), 698-705.e5, 2014

Langley, EW, Gebretsadik, T, Hartert, TV, Peebles, RS, Arnold, DH. Exhaled nitric oxide is associated with severity of pediatric acute asthma exacerbations. J Allergy Clin Immunol Pract, 2(5), 618-20.e1, 2013

Lotz, MT, Moore, ML, Peebles, RS. Respiratory syncytial virus and reactive airway disease. Curr Top Microbiol Immunol, 372, 105-18, 2013

Newcomb, DC, Boswell, MG, Reiss, S, Zhou, W, Goleniewska, K, Toki, S, Harintho, MT, Lukacs, NW, Kolls, JK, Peebles, RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax, 2013

Newcomb, DC, Boswell, MG, Sherrill, TP, Polosukhin, VV, Boyd, KL, Goleniewska, K, Brody, SL, Kolls, JK, Adler, KB, Peebles, RS. IL-17A Induces STAT6-Independent Airway Mucous Cell Metaplasia. Am J Respir Cell Mol Biol, 2013

Newcomb, DC, Peebles, RS. Th17-mediated inflammation in asthma. Curr Opin Immunol, 25(6), 755-60, 2013

Peebles, RS. A new horizon in asthma: inhibiting ILC function. Sci Transl Med, 5(174), 174fs7, 2013

Rosen, MJ, Chaturvedi, R, Washington, MK, Kuhnhein, LA, Moore, PD, Coggeshall, SS, McDonough, EM, Weitkamp, JH, Singh, AB, Coburn, LA, Williams, CS, Yan, F, Van Kaer, L, Peebles, RS, Wilson, KT. STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines. J Immunol, 190(4), 1849-58, 2013

Sevin, CM, Newcomb, DC, Toki, S, Han, W, Sherrill, TP, Boswell, MG, Zhu, Z, Collins, RD, Boyd, KL, Goleniewska, K, Huckabee, MM, Blackwell, TS, Peebles, RS. Deficiency of gp91phox inhibits allergic airway inflammation. Am J Respir Cell Mol Biol, 49(3), 396-402, 2013

Toki, S, Goleniewska, K, Huckabee, MM, Zhou, W, Newcomb, DC, Fitzgerald, GA, Lawson, WE, Peebles, RS. PGI??? signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol, 94(1), 77-88, 2013

Toki, S, Omary, RA, Wilson, K, Gore, JC, Peebles, RS, Pham, W. A comprehensive analysis of transfection-assisted delivery of iron oxide nanoparticles to dendritic cells. Nanomedicine, 9(8), 1235-44, 2013

Dorris, SL, Peebles, RS. PGI2 as a regulator of inflammatory diseases. Mediators Inflamm, 2012, 926968, 2012

James, KM, Peebles, RS, Hartert, TV. Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility. J Allergy Clin Immunol, 130(2), 343-51, 2012

Lotz, MT, Peebles, RS. Mechanisms of respiratory syncytial virus modulation of airway immune responses. Curr Allergy Asthma Rep, 12(5), 380-7, 2012

Newcomb, DC, Boswell, MG, Huckabee, MM, Goleniewska, K, Dulek, DE, Reiss, S, Lukacs, NW, Kolls, JK, Peebles, RS. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol, 188(3), 1027-35, 2012 PMCID:3349674

Zhou, W, Dowell, DR, Huckabee, MM, Newcomb, DC, Boswell, MG, Goleniewska, K, Lotz, MT, Toki, S, Yin, H, Yao, S, Natarajan, C, Wu, P, Sriram, S, Breyer, RM, Fitzgerald, GA, Peebles, RS. Prostaglandin i(2) signaling drives th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS One, 7(5), e33518, 2012 PMCID:3349674

Boswell, MG, Zhou, W, Newcomb, DC, Peebles, RS. PGI2 as a regulator of CD4+ subset differentiation and function. Prostaglandins Other Lipid Mediat, 96(1-4), 21-6, 2011 PMCID:3349674

Dulek, DE, Peebles, RS. Bacteria and asthma: more there than we thought. Expert Rev Respir Med, 5(3), 329-32, 2011 PMCID:3349674

Dulek, DE, Peebles, RS. Viruses and asthma. Biochim Biophys Acta, 1810(11), 1080-90, 2011 PMCID:3349674

Newcomb, DC, Boswell, MG, Zhou, W, Huckabee, MM, Goleniewska, K, Sevin, CM, Hershey, GK, Kolls, JK, Peebles, RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J Allergy Clin Immunol, 127(4), 1006-13.e1-4, 2011 PMCID:3349674

Zaynagetdinov, R, Stathopoulos, GT, Sherrill, TP, Cheng, DS, McLoed, AG, Ausborn, JA, Polosukhin, VV, Connelly, L, Zhou, W, Fingleton, B, Peebles, RS, Prince, LS, Yull, FE, Blackwell, TS. Epithelial nuclear factor-I?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene, 2011 PMCID:3349674

Zhou, W, Dowell, DR, Geraci, MW, Blackwell, TS, Collins, RD, Polosukhin, VV, Lawson, WE, Wu, P, Sussan, T, Biswal, S, Goleniewska, K, O''Neal, J, Newcomb, DC, Toki, S, Morrow, JD, Peebles, RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am J Physiol Lung Cell Mol Physiol, 301(4), L615-22, 2011 PMCID:3349674

Hartert, TV, Carroll, K, Gebretsadik, T, Woodward, K, Minton, P, , . The Tennessee Children''s Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases. Respirology, 15(4), 691-9, 2010 PMCID:2992986

Sevin, CM, Peebles, RS. Infections and asthma: new insights into old ideas. Clin Exp Allergy, 40(8), 1142-54, 2010 PMCID:2966842

Stathopoulos, GT, Sherrill, TP, Karabela, SP, Goleniewska, K, Kalomenidis, I, Roussos, C, Fingleton, B, Yull, FE, Peebles, RS, Blackwell, TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am J Respir Crit Care Med, 182(10), 1273-81, 2010 PMCID:3001265

Westerly, BD, Peebles, RS. Respiratory syncytial virus infections in the adult asthmatic--mechanisms of host susceptibility and viral subversion. Immunol Allergy Clin North Am, 30(4), 523-39, vi-vii, 2010 PMCID:2966842

Zaynagetdinov, R, Ryzhov, S, Goldstein, AE, Yin, H, Novitskiy, SV, Goleniewska, K, Polosukhin, VV, Newcomb, DC, Mitchell, D, Morschl, E, Zhou, Y, Blackburn, MR, Peebles, RS, Biaggioni, I, Feoktistov, I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am J Respir Cell Mol Biol, 42(5), 564-71, 2010 PMCID:2874442

Huckabee, MM, Peebles, RS. Novel concepts in virally induced asthma. Clin Mol Allergy, 7, 2, 2009 PMCID:2651109

Moore, ML, Chi, MH, Luongo, C, Lukacs, NW, Polosukhin, VV, Huckabee, MM, Newcomb, DC, Buchholz, UJ, Crowe, JE, Goleniewska, K, Williams, JV, Collins, PL, Peebles, RS. A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J Virol, 83(9), 4185-94, 2009 PMCID:2668460

Moore, ML, Newcomb, DC, Parekh, VV, Van Kaer, L, Collins, RD, Zhou, W, Goleniewska, K, Chi, MH, Mitchell, D, Boyce, JA, Durbin, JE, Sturkie, C, Peebles, RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol, 183(3), 2016-26, 2009 PMCID:2992986

Newcomb, DC, Peebles, RS. Bugs and asthma: a different disease. Proc Am Thorac Soc, 6(3), 266-71, 2009 PMCID:2677401

Newcomb, DC, Zhou, W, Moore, ML, Goleniewska, K, Hershey, GK, Kolls, JK, Peebles, RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol, 182(9), 5317-21, 2009

Sheller, JR, Polosukhin, VV, Mitchell, D, Cheng, DS, Peebles, RS, Blackwell, TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res, 35(10), 883-95, 2009 PMCID:2992986

Yin, H, Liu, W, Goleniewsk, K, Porter, NA, Morrow, JD, Peebles, RS. Dietary Supplementation of omega-3 Fatty Acid - Containing Fish Oil Suppresses F(2)-Isoprostanes But Enhances Inflammatory Cytokine Response in a Mouse Model of Ovalbumin-Induced Allergic Lung Inflammation. Free Radic Biol Med, 2009 PMCID:2716436

Hashimoto, K, Ishibashi, K, Gebretsadik, T, Hartert, TV, Yamamoto, A, Nakayama, T, Ohashi, K, Sakata, H, Kawasaki, Y, Katayose, M, Sakuma, H, Suzuki, H, Hosoya, M, Peebles, RS, Suzutani, T. Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children. J Med Virol, 80(11), 2015-22, 2008

Moore, ML, Chi, MH, Goleniewska, K, Durbin, JE, Peebles, RS. Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. Viral Immunol, 21(3), 327-39, 2008

Temi??o, VM, Peebles, RS. The spectrum and treatment of angioedema. Am J Med, 121(4), 282-6, 2008

Zhou, W, Newcomb, DC, Moore, ML, Goleniewska, K, O''Neal, JF, Peebles, RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J Immunol, 181(8), 5360-7, 2008

Moore, ML, Chi, MH, Zhou, W, Goleniewska, K, O''Neal, JF, Higginbotham, JN, Peebles, RS. Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity. J Immunol, 178(5), 2651-4, 2007

Peebles, RS, Moore, ML. A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy. Am J Respir Cell Mol Biol, 37(4), 375-7, 2007

Rudd, BD, Luker, GD, Luker, KE, Peebles, RS, Lukacs, NW. Type I interferon regulates respiratory virus infected dendritic cell maturation and cytokine production. Viral Immunol, 20(4), 531-40, 2007

Sadikot, RT, Zeng, H, Azim, AC, Joo, M, Dey, SK, Breyer, RM, Peebles, RS, Blackwell, TS, Christman, JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur J Immunol, 37(4), 1001-9, 2007

Zhou, W, Blackwell, TS, Goleniewska, K, O'neal, JF, Fitzgerald, GA, Lucitt, M, Breyer, RM, Peebles, RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol, 81(3), 809-817, 2007

Zhou, W, Hashimoto, K, Goleniewska, K, O''Neal, JF, Ji, S, Blackwell, TS, Fitzgerald, GA, Egan, KM, Geraci, MW, Peebles, RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol, 178(2), 702-10, 2007

Lukacs, NW, Moore, ML, Rudd, BD, Berlin, AA, Collins, RD, Olson, SJ, Ho, SB, Peebles, RS. Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus. Am J Pathol, 169(3), 977-86, 2006 PMCID:1698832

Moore, ML, Peebles, RS. Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics. Pharmacol Ther, 112(2), 405-24, 2006

Moore, ML, Peebles, RS. Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think. J Allergy Clin Immunol, 117(5), 1036-9, 2006

Moore, PE, Cunningham, G, Calder, MM, DeMatteo, AD, Peeples, ME, Summar, ML, Peebles, RS. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am J Respir Cell Mol Biol, 35(5), 559-64, 2006 PMCID:2643275

Hashimoto, K, Durbin, JE, Zhou, W, Collins, RD, Ho, SB, Kolls, JK, Dubin, PJ, Sheller, JR, Goleniewska, K, O''Neal, JF, Olson, SJ, Mitchell, D, Graham, BS, Peebles, RS. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J Allergy Clin Immunol, 116(3), 550-7, 2005

Hashimoto, K, Sheller, JR, Morrow, JD, Collins, RD, Goleniewska, K, O''Neal, J, Zhou, W, Ji, S, Mitchell, DB, Graham, BS, Peebles, RS. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J Immunol, 174(1), 525-32, 2005

Kalomenidis, I, Guo, Y, Peebles, RS, Lane, KB, Papiris, S, Elias, J, Light, RW. Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent. Chest, 128(4), 2978-83, 2005

Peebles, RS, Hashimoto, K, Sheller, JR, Moore, ML, Morrow, JD, Ji, S, Elias, JA, Goleniewska, K, O''neal, J, Mitchell, DB, Graham, BS, Zhou, W. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J Immunol, 175(12), 8253-9, 2005

Zhou, W, Hashimoto, K, Moore, ML, Elias, JA, Zhu, Z, Durbin, J, Colasurdo, G, Rutigliano, JA, Chiappetta, CL, Goleniewska, K, O''Neal, JF, Graham, BS, Peebles, RS. IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect, 8(14-15), 2880-9, 2005 PMCID:1811125

Hashimoto, K, Graham, BS, Geraci, MW, FitzGerald, GA, Egan, K, Zhou, W, Goleniewska, K, O''Neal, JF, Morrow, JD, Durbin, RK, Wright, PF, Collins, RD, Suzutani, T, Peebles, RS. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. J Virol, 78(19), 10303-9, 2004 PMCID:516432

Hashimoto, K, Graham, BS, Ho, SB, Adler, KB, Collins, RD, Olson, SJ, Zhou, W, Suzutani, T, Jones, PW, Goleniewska, K, O''Neal, JF, Peebles, RS. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am J Respir Crit Care Med, 170(3), 306-12, 2004


Postdoctoral Position Available
Yes

Postdoctoral Position Details
Post-doctoral research fellow position will be open in Sepetmber 2009. Funding will be provided by the Peebles lab; however, the expectation is that the candidate will be eligible for an NIH F32 or T32 grant. Our lab has a strong track record in obtaining these grants for post-doctoral fellows.

Updated Date
03/05/2013