Biomedical Research Education & Training
Faculty Member

Bernard, Gordon R., M.D.
Senior Associate Dean for Clinical Sciences
Associate Vice Chancellor for Clinical and Translational Research
Professor of Medicine
Melinda Owen Bass Chair in Medicine

Lab Url: N/A

Phone Number: 615-343-0077

Email Address:

Bernard, Gordon's picture
Academic history
B.S., Southern Illinois
M.D., Louisiana State

Office Address   Mailing Address

T-1208 MCN Vanderbilt University Medical Center 37232-2650

Research Specialty
Sepsis and Acute Respiratory Distress Syndrome

Byrne, DW, Biaggioni, I, Bernard, GR, Helmer, TT, Boone, LR, Pulley, JM, Edwards, T, Dittus, RS. Clinical and translational research studios: a multidisciplinary internal support program. Acad Med, 87(8), 1052-9, 2012

Girard, TD, Ware, LB, Bernard, GR, Pandharipande, PP, Thompson, JL, Shintani, AK, Jackson, JC, Dittus, RS, Ely, EW. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med, 38(12), 1965-73, 2012

Pulley, JM, Denny, JC, Peterson, JF, Bernard, GR, Vnencak-Jones, CL, Ramirez, AH, Delaney, JT, Bowton, E, Brothers, K, Johnson, K, Crawford, DC, Schildcrout, J, Masys, DR, Dilks, HH, Wilke, RA, Clayton, EW, Shultz, E, Laposata, M, McPherson, J, Jirjis, JN, Roden, DM. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther, 92(1), 87-95, 2012

Rice, TW, Rubinson, L, Uyeki, TM, Vaughn, FL, John, BB, Miller, RR, Higgs, E, Randolph, AG, Smoot, BE, Thompson, BT, , . Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med, 40(5), 1487-98, 2012

Harris, PA, Swafford, JA, Edwards, TL, Zhang, M, Nigavekar, SS, Yarbrough, TR, Lane, LD, Helmer, T, Lebo, LA, Mayo, G, Masys, DR, Bernard, GR, Pulley, JM. StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portal. J Biomed Inform, 44(4), 655-62, 2011

Rice, TW, Mogan, S, Hays, MA, Bernard, GR, Jensen, GL, Wheeler, AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med, 39(5), 967-74, 2011

Rice, TW, Ware, LB, Haponik, EF, Chiles, C, Wheeler, AP, Bernard, GR, Steingrub, JS, Hite, RD, Matthay, MA, Wright, P, Ely, EW, , . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care, 15(2), R86, 2011

Rice, TW, Wheeler, AP, Thompson, BT, deBoisblanc, BP, Steingrub, J, Rock, P, , , , . Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA, 306(14), 1574-81, 2011

Ware, LB, Koyama, T, Billheimer, D, Landeck, M, Johnson, E, Brady, S, Bernard, GR, Matthay, MA, , . Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care, 1(1), 20, 2011

Bernard, GR. Statins for acutely hospitalized patients: randomized controlled trials are long overdue. Crit Care, 14(2), 141, 2010

Fremont, RD, Koyama, T, Calfee, CS, Wu, W, Dossett, LA, Bossert, FR, Mitchell, D, Wickersham, N, Bernard, GR, Matthay, MA, May, AK, Ware, LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma, 68(5), 1121-7, 2010

Girard, TD, Jackson, JC, Pandharipande, PP, Pun, BT, Thompson, JL, Shintani, AK, Gordon, SM, Canonico, AE, Dittus, RS, Bernard, GR, Ely, EW. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med, 38(7), 1513-20, 2010

Girard, TD, Pandharipande, PP, Carson, SS, Schmidt, GA, Wright, PE, Canonico, AE, Pun, BT, Thompson, JL, Shintani, AK, Meltzer, HY, Bernard, GR, Dittus, RS, Ely, EW, , . Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med, 38(2), 428-37, 2010

Jackson, JC, Girard, TD, Gordon, SM, Thompson, JL, Shintani, AK, Thomason, JW, Pun, BT, Canonico, AE, Dunn, JG, Bernard, GR, Dittus, RS, Ely, EW. Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med, 182(2), 183-91, 2010

Pulley, J, Clayton, E, Bernard, GR, Roden, DM, Masys, DR. Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci, 3(1), 42-8, 2010

Pulley, J, Hassan, NN, Bernard, GR, Jirjis, JN, Schildcrout, J, Robertson, D, Masys, DR, Harris, P. Identifying unpredicted drug benefit through query of patient experiential knowledge: a proof of concept web-based system. Clin Transl Sci, 3(3), 98-103, 2010

Pulley, JM, Harris, PA, Yarbrough, T, Swafford, J, Edwards, T, Bernard, GR. An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan. Acad Med, 85(1), 164-8, 2010

Rice, TW, Wheeler, AP, Bernard, GR, Vincent, JL, Angus, DC, Aikawa, N, Demeyer, I, Sainati, S, Amlot, N, Cao, C, Ii, M, Matsuda, H, Mouri, K, Cohen, J. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med, 38(8), 1685-94, 2010

Ware, LB, Koyama, T, Billheimer, DD, Wu, W, Bernard, GR, Thompson, BT, Brower, RG, Standiford, TJ, Martin, TR, Matthay, MA, , . Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest, 137(2), 288-96, 2010

Pulley, JM, Bernard, GR. Proven processes: The Vanderbilt Institute for clinical and translational research . Clin Transl Sci, 2(3), 180-2, 2009

Ely, E Wesley, Stephens, Rasheeda K, Jackson, James C, Thomason, Jason W W, Truman, Brenda, Gordon, Sharon, Dittus, Robert S, Bernard, Gordon R. Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med, 32(1), 106-12, 2004

Bernard, Gordon R. Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis. Crit Care Med, 31(1 Suppl), S85-93, 2003

Bernard, Gordon R, Macias, William L, Joyce, David E, Williams, Mark D, Bailey, Joan, Vincent, Jean-Louis. Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care, 7(2), 155-63, 2003 PMCID:270661

Ely, E Wesley, Angus, Derek C, Williams, Mark D, Bates, Becky, Qualy, Rebecca, Bernard, Gordon R. Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis, 37(2), 187-95, 2003

Ely, E Wesley, Laterre, Pierre-Fran??ois, Angus, Derek C, Helterbrand, Jeffrey D, Levy, Howard, Dhainaut, Jean-Fran??ois, Vincent, Jean-Louis, Macias, William L, Bernard, Gordon R, , . Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med, 31(1), 12-9, 2003

Ely, E Wesley, Truman, Brenda, Shintani, Ayumi, Thomason, Jason W W, Wheeler, Arthur P, Gordon, Sharon, Francis, Joseph, Speroff, Theodore, Gautam, Shiva, Margolin, Richard, Sessler, Curtis N, Dittus, Robert S, Bernard, Gordon R. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA, 289(22), 2983-91, 2003

Jiang, Keyuan, Higgins, Stanley B, Swindell, Bridget B, Bernard, Gordon R. CommLog: a communication log system for clinical trials. IEEE Trans Inf Technol Biomed, 7(4), 378-83, 2003

Ely, E Wesley, Wheeler, Arthur P, Thompson, B Taylor, Ancukiewicz, Marek, Steinberg, Kenneth P, Bernard, Gordon R. Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med, 136(1), 25-36, 2002

Bernard, G R, Ely, E W, Wright, T J, Fraiz, J, Stasek, J E, Russell, J A, Mayers, I, Rosenfeld, B A, Morris, P E, Yan, S B, Helterbrand, J D. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med, 29(11), 2051-9, 2001

Bernard, G R, Vincent, J L, Laterre, P F, LaRosa, S P, Dhainaut, J F, Lopez-Rodriguez, A, Steingrub, J S, Garber, G E, Helterbrand, J D, Ely, E W, Fisher, C J, , . Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med, 344(10), 699-709, 2001

Ely, E W, Inouye, S K, Bernard, G R, Gordon, S, Francis, J, May, L, Truman, B, Speroff, T, Gautam, S, Margolin, R, Hart, R P, Dittus, R. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA, 286(21), 2703-10, 2001

Ely, E W, Margolin, R, Francis, J, May, L, Truman, B, Dittus, R, Speroff, T, Gautam, S, Bernard, G R, Inouye , S K. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med, 29(7), 1370-9, 2001

Martin, G S, Bernard, G R, , . Airway and lung in sepsis. Intensive Care Med, 27 Suppl 1, S63-79, 2001

Bernard, G R, Sopko, G, Cerra, F, Demling, R, Edmunds, H, Kaplan, S, Kessler, L, Masur, H, Parsons, P, Shure, D, Webb, C, Weidemann, H, Weinmann, G, Williams, D. Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement. JAMA, 283(19), 2568-72, 2000

Conner, B D, Bernard, G R. Acute respiratory distress syndrome. Potential pharmacologic interventions. Clin Chest Med, 21(3), 563-87, 2000

Mangialardi, R J, Martin, G S, Bernard, G R, Wheeler, A P, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 28(9), 3137-45, 2000

Arons, M M, Wheeler, A P, Bernard, G R, Christman, B W, Russell, J A, Schein, R, Summer, W R, Steinberg, K P, Fulkerson, W, Wright, P, Dupont, W D, Swindell, B B. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 27(4), 699-707, 1999

Bernard, G R. Research in sepsis and acute respiratory distress syndrome: are we changing course. Crit Care Med, 27(2), 434-6, 1999

Wheeler, A P, Bernard, G R. Treating patients with severe sepsis. N Engl J Med, 340(3), 207-14, 1999

Price, B J, Bernard, G R, Drew, K, Foss, J, Wheeler, A P. Impact of a critical care pathway for unstable mechanically ventilated patients. Crit Care Nurs Clin North Am, 10(1), 75-85, 1998

Bernard, G R, Wheeler, A P, Arons, M M, Morris, P E, Paz, H L, Russell, J A, Wright, P E. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest, 112(1), 164-72, 1997

Bernard, G R, Wheeler, A P, Russell, J A, Schein, R, Summer, W R, Steinberg, K P, Fulkerson, W J, Wright, P E, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med, 336(13), 912-8, 1997

Carmichael, L C, Dorinsky, P M, Higgins, S B, Bernard, G R, Dupont, W D, Swindell, B, Wheeler, A P. Diagnosis and therapy of acute respiratory distress syndrome in adults: an international survey. J Crit Care, 11(1), 9-18, 1996

Weikert, L F, Bernard, G R. Pharmacotherapy of sepsis. Clin Chest Med, 17(2), 289-305, 1996

Wheeler, A P, Bernard, G R. Applications of molecular biology and biotechnology: antibody therapy of sepsis. J Crit Care, 11(2), 77-94, 1996

Bernard, G R. Sepsis trials. Intersection of investigation, regulation, funding, and practice. Am J Respir Crit Care Med, 152(1), 4-10, 1995

Bernard, G R, Pou, N A, Coggeshall, J W, Carroll, F E, Snapper, J R. Comparison of the pulmonary dysfunction caused by cardiogenic and noncardiogenic pulmonary edema. Chest, 108(3), 798-803, 1995

Higgins, S B, Jiang, K, Plummer, W D, Edens, T R, Stroud, M J, Swindell, B B, Wheeler, A P, Bernard, G R. Pivot/Remote: a distributed database for remote data entry in multi-center clinical trials. Medinfo, 8 Pt 2, 1097, 1995

Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, LeGall, J R, Morris, A, Spragg, R. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med, 20(3), 225-32, 1994

Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, Legall, J R, Morris, A, Spragg, R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med, 149(3 Pt 1), 818-24, 1994

Morris, P E, Bernard, G R. Significance of glutathione in lung disease and implications for therapy. Am J Med Sci, 307(2), 119-27, 1994

Wright, P E, Carmichael, L C, Bernard, G R. Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS). Chest, 106(5), 1517-23, 1994

Christman, B W, Bernard, G R. Antilipid mediator and antioxidant therapy in adult respiratory distress syndrome. New Horiz, 1(4), 623-30, 1993

Wheeler, A P, Carroll, F E, Bernard, G R. Radiographic issues in adult respiratory distress syndrome. New Horiz, 1(4), 471-7, 1993

Christman, B W, McPherson, C D, Newman, J H, King, G A, Bernard, G R, Groves, B M, Loyd, J E. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med, 327(2), 70-5, 1992

Hardie, W D, Wheeler, A P, Wright, P W, Swindell, B B, Bernard, G R. Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep. J Infect Dis, 166(1), 134-8, 1992

Schriver, E E, Davidson, J M, Sutcliffe, M C, Swindell, B B, Bernard, G R. Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease. Am Rev Respir Dis, 145(4 Pt 1), 762-6, 1992

Wheeler, A P, Hardie, W D, Bernard, G R. The role of cyclooxygenase products in lung injury induced by tumor necrosis factor in sheep. Am Rev Respir Dis, 145(3), 632-9, 1992

Bernard, G R. N-acetylcysteine in experimental and clinical acute lung injury. Am J Med, 91(3C), 54S-59S, 1991

Bernard, G R, Korley, V, Chee, P, Swindell, B, Ford-Hutchinson, A W, Tagari, P. Persistent generation of peptido leukotrienes in patients with the adult respiratory distress syndrome. Am Rev Respir Dis, 144(2), 263-7, 1991

Bernard, G R, Reines, H D, Halushka, P V, Higgins, S B, Metz, C A, Swindell, B B, Wright, P E, Watts, F L, Vrbanac, J J. Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. Am Rev Respir Dis, 144(5), 1095-101, 1991

Hardie, W D, Wright, P E, Bernard, G R. Effects of intravenous amphotericin B infusion on hemodynamics and airway mechanics in awake sheep. Chest, 99(2), 457-62, 1991

Higgins, S B, Jiang, K, Swindell, B B, Bernard, G R. A graphical ICU workstation. Proc Annu Symp Comput Appl Med Care, 783-7, 1991 PMCID:2247637

Morris, P, Bernard, G R. Adult respiratory distress syndrome. Strategies to provide support and enhance oxygen delivery. Postgrad Med, 90(8), 163-6, 169-70, 172, 1991

Onrot, J, Bernard, G R, Biaggioni, I, Hollister, A S, Robertson, D. Direct vasodilator effect of hyperventilation-induced hypocarbia in autonomic failure patients. Am J Med Sci, 301(5), 305-9, 1991

Watts, F L, Bernard, G R. Effects of ritodrine infusion on hemodynamics and lung lymph in awake sheep. Pulm Pharmacol, 4(1), 32-6, 1991

Bernard, G R. Potential of N-acetylcysteine as treatment for the adult respiratory distress syndrome. Eur Respir J Suppl, 11, 496s-498s, 1990

Cowan, H B, Bernard, G R. The adult respiratory distress syndrome. Compr Ther, 16(10), 66-71, 1990

Harris, T R, Bernard, G R, Brigham, K L, Higgins, S B, Rinaldo, J E, Borovetz, H S, Sibbald, W J, Kariman, K, Sprung, C L. Lung microvascular transport properties measured by multiple indicator dilution methods in patients with adult respiratory distress syndrome. A comparison between patients reversing respiratory failure and those failing to reverse. Am Rev Respir Dis, 141(2), 272-80, 1990

Wheeler, A P, Bernard, G R. Minimal positive end expiratory pressure (PEEP): a safe, effective, defensible practice. Clin Intensive Care, 1(4), 175-9, 1990

Taylor, R F, Bernard, G R. Airway complications from free-basing cocaine. Chest, 95(2), 476-7, 1989

Wright, P E, Bernard, G R. The role of airflow resistance in patients with the adult respiratory distress syndrome. Am Rev Respir Dis, 139(5), 1169-74, 1989

Wright, P E, Bernard, G R. Mechanisms of late hemodynamic and airway dynamic responses to endotoxin in awake sheep. Am Rev Respir Dis, 140(3), 672-8, 1989

Wright, P E, Marini, J J, Bernard, G R. In vitro versus in vivo comparison of endotracheal tube airflow resistance. Am Rev Respir Dis, 140(1), 10-6, 1989

Lucht, W D, Bernard, G R, Butka, B, Brigham, K L. Corticosteroids inhibit endotoxin-induced lung lymph neutrophil stimulating activity in sheep. Am J Med Sci, 296(2), 98-102, 1988

Wright, P, Ishihara, Y, Bernard, G R. Effects of nitroprusside on lung mechanics and hemodynamics after endotoxemia in awake sheep. J Appl Physiol, 64(5), 2026-32, 1988

Bernard, G R, Luce, J M, Sprung, C L, Rinaldo, J E, Tate, R M, Sibbald, W J, Kariman, K, Higgins, S, Bradley, R, Metz, C A. High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med, 317(25), 1565-70, 1987

Coggeshall, J W, Lefferts, P L, Butterfield, M J, Bernard, G R, Carroll, F E, Pou, N A, Snapper, J R. Perilla ketone: a model of increased pulmonary microvascular permeability pulmonary edema in sheep. Am Rev Respir Dis, 136(6), 1453-8, 1987

Lucht, W D, English, D K, Bernard, G R, Serafin, W E, Brigham, K L. Prevention of release of granulocyte aggregants into sheep lung lymph following endotoxemia by N-acetylcysteine. Am J Med Sci, 294(3), 161-7, 1987

May, D G, Stratton, C W, Denney, W D, Watts, F L, Bernard, G R, Branch, R A. Vancomycin entry into lung lymph in sheep. Antimicrob Agents Chemother, 31(11), 1689-91, 1987 PMCID:175021

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