Biomedical Research Education & Training
Faculty Member

Inagami, Tadashi, Ph.D.
Professor of Biochemistry, Emeritus

Lab Url: N/A

Phone Number: 615-322-4347

Email Address: tadashi.inagami@vanderbilt.edu

Inagami, Tadashi's picture
Academic history
B.S., Kyoto University, Kyoto, Japan
M.S., Yale University, New Haven, CT
Ph.D., Yale University, New Haven, CT
D.Sc., Kyoto University, Kyoto, Japan

Office Address   Mailing Address

663 Light Hall Vanderbilt University
Nashville, TN 37232-0146

663 Light Hall 0146


Research Keywords
Angiotensin receptor cloning, targeted gene deletion, cross talk of G-protein coupled receptor with tyrosine-kinases and ? phosphatases, cellular messenger, cardiac hypertrophy mechanism, receptor binding proteins.

Research Specialty
Molecular biology of cardiovascular regulation and vasoactive substances

Research Description
Tadashi Inagami's research is focused on molecular and cellular mechanisms involved in pathobiology of vascular, cardiac and renal tissues and cells. Studies encompass the mechanism of generation and release of vasoactive substance, their receptors, and signal transduction pathways. The vasoactive substances include; angiotensin, PDGF, endothelin and Na, K-ATPase inhibitors. The search for hypertensinogenic genes in genetically hypertensive rats is actively conducted using recombinant techniques.
Angiotensin II receptors have been cloned, several different receptor subtypes are being cloned, and different and possible hitherto unknown signaling mechanisms are being looked for. Unique signaling mechanisms in vascular and renal cells from genetically hypertensive rats are investigated focusing on the abnormalities in plasma membrane lipid metabolism.

Studies on the mechanism of crosstalk between the G-protein coupled angiotensin II receptors and tyrosine kinase receptors revealed that the former borrows epidermal growth factor receptor in the activation of mitogen activated protein kinase.

Publications
Wang, N, Li, Z, Ding, R, Frank, GD, Senbonmatsu, T, Landon, EJ, Inagami, T, Zhao, ZJ. Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem, 281(31), 21878-83, 2006 PMCID:2377019

Zhang, MZ, Yao, B, Cheng, HF, Wang, SW, Inagami, T, Harris, RC. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A, 103(43), 16045-50, 2006 PMCID:1635124

Kagawa, N, Senbonmatsu, TA, Satoh, K, Ichihara, K, Yamagata, N, Hatano, O, Saito, T, Nguyen, VQ, Waterman, MR, Price, E, Atkinson, JB, Inagami, T. Tetracycline protects myocardium against ischemic injury. Front Biosci, 10, 608-19, 2005

Utsunomiya, H, Nakamura, M, Kakudo, K, Inagami, T, Tamura, M. Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice. Regul Pept, 126(3), 155-61, 2005

Eguchi, S, Frank, G D, Mifune, M, Inagami, T. Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling. Biochem Soc Trans, 31(Pt 6), 1198-202, 2003

Frank, Gerald D, Mifune, Mizuo, Inagami, Tadashi, Ohba, Motoi, Sasaki, Terukatsu, Higashiyama, Shigeki, Dempsey, Peter J, Eguchi, Satoru. Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. Mol Cell Biol, 23(5), 1581-9, 2003 PMCID:151697

Senbonmatsu, Takaaki, Saito, Takako, Landon, Erwin J, Watanabe, Otsu, Price, Edward, Roberts, Richard L, Imboden, Hans, Fitzgerald, Trinita G, Gaffney, F Andrew, Inagami, Tadashi. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J, 22(24), 6471-82, 2003 PMCID:291832

Frank, Gerald D, Saito, Shuichi, Motley, Evangeline D, Sasaki, Terukatsu, Ohba, Motoi, Kuroki, Toshio, Inagami, Tadashi, Eguchi, Satoru. Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Mol Endocrinol, 16(2), 367-77, 2002

Ichihara, Sahoko, Senbonmatsu, Takaaki, Price, Edward, Ichiki, Toshihiro, Gaffney, F Andrew, Inagami, Tadashi. Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation, 106(17), 2244-9, 2002

Saito, Shuichi, Frank, Gerald D, Mifune, Mizuo, Ohba, Motoi, Utsunomiya, Hirotoshi, Motley, Evangeline D, Inagami, Tadashi, Eguchi, Satoru. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem, 277(47), 44695-700, 2002

Saito, Shuichi, Frank, Gerald D, Motley, Evangeline D, Dempsey, Peter J, Utsunomiya, Hirotoshi, Inagami, Tadashi, Eguchi, Satoru. Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation. Biochem Biophys Res Commun, 294(5), 1023-9, 2002

Saito, Shuichi, Frank, Gerald D, Motley, Evangeline D, Utsunomiya, Hirotoshi, Inagami, Tadashi, Eguchi, Satoru. Cyclosporin A inhibits angiotensin II-induced c-Jun NH(2)-terminal kinase activation but not protein synthesis in vascular smooth muscle cells. Eur J Pharmacol, 443(1-3), 47-50, 2002

Takagi, Tetsuo, Nakano, Yuichiro, Takekoshi, Susumu, Inagami, Tadashi, Tamura, Masaaki. Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis. Carcinogenesis, 23(7), 1235-41, 2002

Xin, Hong-Bo, Senbonmatsu, Takaaki, Cheng, Dong-Sheng, Wang, Yong-Xiao, Copello, Julio A, Ji, Guang-Ju, Collier, Mei Lin, Deng, Ke-Yu, Jeyakumar, Loice H, Magnuson, Mark A, Inagami, Tadashi, Kotlikoff, Michael I, Fleischer, Sidney. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature, 416(6878), 334-8, 2002

Eguchi, S, Dempsey, P J, Frank, G D, Motley, E D, Inagami, T. Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK. J Biol Chem, 276(11), 7957-62, 2001

Frank, G D, Eguchi, S, Motley, E D, Sasaki, T, Inagami, T. Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells. Biochem Biophys Res Commun, 286(4), 692-6, 2001

Guo DF, Sun YL, Hamet P, Inagami T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Res, 11(3), 165-80, 2001

Ichihara, S, Senbonmatsu, T, Price, E, Ichiki, T, Gaffney, F A, Inagami, T. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation, 104(3), 346-51, 2001

Inagami, T, Senbonmatsu, T. Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. Trends Cardiovasc Med, 11(8), 324-8, 2001

K. Satoh, K. Ichihara, E.J. Landon, T. Inagami, H. Tang. HMG-CoA Reductase Inhibitors Block Calcium-dependent Tyrosine Kinase Pyk2 Activation by Angiotensin II in Vascular Endothelial Cells. Involvement of Geranylgerany-lation of small G protein Rap 1. J. Biol. Chem., 276, 15761-67, 2001

Miyata, I, Shiota, C, Chaki, S, Okuyama, S, Inagami, T. Localization and characterization of a short isoform of the corticotropin-releasing factor receptor type 2alpha (CRF(2)alpha-tr) in the rat brain. Biochem Biophys Res Commun, 280(2), 553-7, 2001

S. Eguchi, P.J. Dempsey, G. D. Frank, E.D. Motley, T. Inagami. Activation of MAPKs by Angiotensin II in vascular smooth muscle cells: Metalloprotease-dependent EG receptor activation is required for activation of ERK and p58 MAPK but not for JNK. J. Biol. Chem, 276, 7957-7962, 2001

S. Ichihara, T. Senbonmatsu, E. Price, Jr., T. Ichiki, F. A. Gaffney, T. Inagami. Angiotensin II Type 2 Receptor is essential for left ventricular hypertrophy and cardiac fibrosis. Circulation, 104, 346-351, 2001

Satoh, K, Ichihara, K, Landon, E J, Inagami, T, Tang, H. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1. J Biol Chem, 276(19), 15761-7, 2001

T. Inagami and T. Senbonmatsu. Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. Trends in Cardiovascular Medicine. , 11, 324-328, 2001

Eguchi, S, Inagami, T. Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept, 91(1-3), 13-20, 2000

F Suzuki, T Nakagawa, H Kakidachi, K Murakami, T Inagami, Y Nakamura. The dominant role of the prosegment of proreinin in determining the rate of trypsin: studies with molecular chimeras. Biochem Biophys Res Commun, 267, 577-580, 2000

Frank, G D, Motley, E D, Inagami, T, Eguchi, S. PYK2/CAKbeta represents a redox-sensitive tyrosine kinase in vascular smooth muscle cells. Biochem Biophys Res Commun, 270(3), 761-5, 2000

Fujinaka, H, Miyazaki, Y, Matsusaka, T, Yoshida, H, Fogo, A B, Inagami, T, Ichikawa, I. Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int, 58(5), 2018-27, 2000

H Tang, ZJ Zhao, EJ Landon, T Inagami. Regulation of calcium-sensitive tyrosine kinase PYK2 by angiotensin II in ER of YES tyrosine kinase and tyrosine phosphatase SHP-2. J Biol Chem, 275, 8389-8396, 2000

Hunley, T E, Tamura, M, Stoneking, B J, Nishimura, H, Ichiki, T, Inagami, T, Kon, V. The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice. Kidney Int, 57(2), 570-7, 2000

Inagami, T, Eguchi, S. Angiotensin II-mediated vascular smooth muscle cell growth signaling. Braz J Med Biol Res, 33(6), 619-24, 2000

K Ohnaka, K Numaguchi, T Inagami. Induction of cyclooxygenase-2 by angiotensin II in cultured rat vascular smooth vascular cells. Hypertension, 35, 68-75, 2000

Ohnaka, K, Numaguchi, K, Yamakawa, T, Inagami, T. Induction of cyclooxygenase-2 by angiotensin II in cultured rat vascular smooth muscle cells. Hypertension, 35(1 Pt 1), 68-75, 2000

Senbonmatsu, , Ichihara, , Price, , Gaffney, , Inagami, . Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overloa. J Clin Invest, 106(2), R1-5, 2000

Senbonmatsu, , Ichihara, , Price, , Gaffney, , Inagami, . Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest, 106(3), R25-R29, 2000

Senbonmatsu, T, Ichihara, S, Price, E, Gaffney, F A, Inagami, T. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest, 106(3), R25-9, 2000 PMCID:314331

Senbonmatsu, T, Ichihara, S, Price, E, Gaffney, FA, Inagami, T. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overloa. J Clin Invest, 106(2), R1-5, 2000

T Yamakawa, S Tanaka, K Numaguchi, Y Yamakawa, ED Motley, S Ichihara, T Inagami. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat VAS cells. Hypertension, 35, 313-318, 2000

T. Senbonmatsu, S. Ichihara, E. Price, Jr., F. A. Gaffney, T. Inagami. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J. Clin. Invest., 105, R9-14, 2000

TE Hunley, M Tamura, B Stoneking, H Nishimura, T Ichiki, T Inagami, V Kon. The angiotensin type 2 receptor tonically inhibits the Ang converting enzyme in AT2 null mutant mice. Kid Intl, 57, 570-577, 2000

Tang, H, Nishishita, T, Fitzgerald, T, Landon, E J, Inagami, T. Inhibition of AT1 receptor internalization by concanavalin A blocks angiotensin II-induced ERK activation in vascular smooth muscle cells. Involvement of epidermal growth factor receptor proteolysis but not AT1 receptor internalization. J Biol Chem, 275(18), 13420-6, 2000

Tang, H, Zhao, Z J, Landon, E J, Inagami, T. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. J Biol Chem, 275(12), 8389-96, 2000

V Gross, WH Schunck, H Honeck, AF Milia, E Kargel, T Walther, M Bader, T Inagami, FC Luft. Inhibition of pressure natriuresis in mice lacking the AT2 receptor. Kidney Int, 57, 191-202, 2000

Yamakawa, T, Tanaka, S, Numaguchi, K, Yamakawa, Y, Motley, E D, Ichihara, S, Inagami, T. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension, 35(1 Pt 2), 313-8, 2000

H.M. Siragy, T. Ichiki, T. Inagami, R.M. Carey.. Sustained hypersensitivity to Angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) ang, receptor. Proc. Natl. Acad. Sci. USA, 96, 6506-10, 1999

Eguchi, S, Iwasaki, H, Hirata, Y, Frank, G D, Motley, E D, Yamakawa, T, Numaguchi, K, Inagami, T. Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II. Eur J Pharmacol, 376(1-2), 203-6, 1999

Eguchi, S, Iwasaki, H, Ueno, H, Frank, G D, Motley, E D, Eguchi, K, Marumo, F, Hirata, Y, Inagami, T. Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. J Biol Chem, 274(52), 36843-51, 1999

H Nishimura, E Yerkes, K Hohenfellner, Y Miyazaki, J Ma, TE Hunley, H Yoshida, T Ichiki, D Threadgill, JA Phillips III, BML Hogan, A Fogo, JW Brock III, T Inagami, and I Ichikawa. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell, 3, 1-10, 1999

H Tang, Z Zhao, X-Y Huang, EJ Landon, T Inagami. Fyn Kinase-directed activation of SH2 domain-containing protein tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. J Biol Chem, 274, 12401-12407, 1999

Inagami, T. Molecular biology and signaling of angiotensin receptors: an overview. J Am Soc Nephrol, 10 Suppl 11, S2-7, 1999

Inagami, T, Eguchi, S, Numaguchi, K, Motley, E D, Tang, H, Matsumoto, T, Yamakawa, T. Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases. J Am Soc Nephrol, 10 Suppl 11, S57-61, 1999

Inagami, T, Kambayashi, Y, Ichiki, T, Tsuzuki, S, Eguchi, S, Yamakawa, T. Angiotensin receptors: molecular biology and signalling. Clin Exp Pharmacol Physiol, 26(7), 544-9, 1999

K Numaguchi, S Eguchi, T Yamakawa, ED Motley, T Inagami. Mechano-transduction of rat aortic VSMC requires RhoA and intact actin filaments. Circ Res, 85, 5-11, 1999

Matsusaka, T, Katori, H, Inagami, T, Fogo, A, Ichikawa, I. Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest, 103(10), 1451-8, 1999 PMCID:408452

Miyata, I, Shiota, C, Ikeda, Y, Oshida, Y, Chaki, S, Okuyama, S, Inagami, T. Cloning and characterization of a short variant of the corticotropin-releasing factor receptor subtype from rat amygdala. Biochem Biophys Res Commun, 256(3), 692-6, 1999

Nishimura, H, Yerkes, E, Hohenfellner, K, Miyazaki, Y, Ma, J, Hunley, T E, Yoshida, H, Ichiki, T, Threadgill, D, Phillips, J A, Hogan, B M, Fogo, A, Brock, J W, Inagami, T, Ichikawa, I. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell, 3(1), 1-10, 1999

Numaguchi, K, Eguchi, S, Yamakawa, T, Motley, E D, Inagami, T. Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments. Circ Res, 85(1), 5-11, 1999

S Okuyama, T Sakagawa, S Chaki, Y Imagawa, T Ichiki, T Inagami. Anxiety-like behavior in mice lacking the ang II type-2 receptor. Brain Resch, 821, 150-159, 1999

S. Eguchi, H. Iwasaki, H. Ueno, G.D. Frank, E.D. Motley, K. Eguchi, F. Marumo, Y. Hirata, & T. Inagami. Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser411 in vascular smooth muscle cells. J. Biol. Chem, 274, 36843-51, 1999

S. Eguchi, H. Iwasaki, Y. Hirata, G.D. Frank, E. D. Motley, T. Yamakawa, K. Numaguchi, T. Inagami. Epidermal growth factor receptor is indispensable for c-Fos expresion and protein synthesis by angiotensin II. E. J. Pharm., 376, 203-06, 1999

T Yamakawa, S Eguchi, T Matsumoto, Y Yamakawa, K Numaguchi, I Miyata, C M Reynolds, ED Motley, T Inagami. Intracellular signaling in rat cultured vascular smooth muscle cells: Role of NF-? B and p38 MAP kinase on tumor necrosis factor-alpha production. Endocrinology, 3562-3573, 140, 1999

Tamura, M, Wanaka, Y, Landon, E J, Inagami, T. Intracellular sodium modulates the expression of angiotensin II subtype 2 receptor in PC12W cells. Hypertension, 33(2), 626-32, 1999

Tang, H, Zhao, Z J, Huang, X Y, Landon, E J, Inagami, T. Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. J Biol Chem, 274(18), 12401-7, 1999

Tsuchida, S, Miyazaki, Y, Matsusaka, T, Hunley, T E, Inagami, T, Fogo, A, Ichikawa, I. Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. Kidney Int, 56(2), 509-16, 1999

Y Kitami, D Li-Zhi, T Fukuoka, K Hiwada and T Inagami. A high level of CCAAT-enhancer binding protein-? expression is a major determinant for markedly elevated differential gene expression of the platelet derived growth factor receptor ? in the vascular smooth muscle cells of genetically hypertensive rats. Circ Res, 64-73, 84, 1999

Yamakawa, T, Eguchi, S, Matsumoto, T, Yamakawa, Y, Numaguchi, K, Miyata, I, Reynolds, C M, Motley, E D, Inagami, T. Intracellular signaling in rat cultured vascular smooth muscle cells: roles of nuclear factor-kappaB and p38 mitogen-activated protein kinase on tumor necrosis factor-alpha production. Endocrinology, 140(8), 3562-72, 1999

A. Ishihata, S. Uno, D.-F. Guo, Y. Katano, T. Inagami. Inhibition of the expression of the gene for the angiotensin AT1 receptor by angiotensin II in the rat adreanl gland. E. J. of Pharm, 350, 129-139, 1998

Eguchi, S, Numaguchi, K, Iwasaki, H, Matsumoto, T, Yamakawa, T, Utsunomiya, H, Motley, E D, Kawakatsu, H, Owada, K M, Hirata, Y, Marumo, F, Inagami, T. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem, 273(15), 8890-6, 1998

H. Tang, D.-F. Guo, J.P. Porter, Y. Wanaka, and T. Inagami. Role of cytoplasmic tail of the type-1A angiotensin II receptor in agonist-and phorbol ester-induced desensitization. Circulation Res, 81, 523-531, 1998

H. Tang, D.M. Kerins, Q. Hao, T. Inagami, D.E. Vaughan. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J. Biol. Chem., 273, 18268-18272, 1998

Inagami, T. A memorial to Robert Tiegerstedt: the centennial of renin discovery. Hypertension, 32(6), 953-7, 1998

Ishihata, A, Uno, S, Guo, D F, Katano, Y, Inagami, T. Inhibition of the expression of the gene for the angiotensin AT1 receptor by angiotensin II in the rat adrenal gland. Eur J Pharmacol, 350(1), 129-39, 1998

Ma, J, Nishimura, H, Fogo, A, Kon, V, Inagami, T, Ichikawa, I. Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int, 53(4), 937-44, 1998

Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, J C, Harris, R C, McKanna, J M, Inagami, T, Hogan, B L, Fogo, A, Ichikawa, I. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102(8), 1489-97, 1998 PMCID:508998

S Tsuchida, T Matsusaka, X Chen, S Okubo, F Niimura, H Nishimura, A Fogo, H Utsunomiya, T Inagami and I Ichikawa. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J. Clin. Invest, 101, 755-760, 1998

Stoneking, B J, Hunley, T E, Nishimura, H, Ma, J, Fogo, A, Inagami, T, Tamura, M, Adams, M C, Brock, J W, Kon, V. Renal angiotensin converting enzyme promotes renal damage during ureteral obstruction. J Urol, 160(3 Pt 2), 1070-4, 1998

T Yamakawa, S Eguchi, Y Yamakawa, ED Motley, K Numaguchi, H Utsunomiya, T Inagami. Isophosphatidyl-choline stimulates MAP kinase activity in rat vascular smooth muscle cells. Hypertension, 31, 248-254, 1998

Tamura, M, Landon, E J, Inagami, T. Na+,K+-ATPase inhibitors in rat urine: origins and physiological significance. Clin Exp Hypertens, 20(5-6), 543-50, 1998

Tang, H, Guo, D F, Porter, J P, Wanaka, Y, Inagami, T. Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization. Circ Res, 82(5), 523-31, 1998

Tang, H, Kerins, D M, Hao, Q, Inagami, T, Vaughan, D E. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem, 273(29), 18268-72, 1998

Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, Fogo, A, Utsunomiya, H, Inagami, T, Ichikawa, I. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest, 101(4), 755-60, 1998 PMCID:508622

Yamakawa, T, Eguchi, S, Yamakawa, Y, Motley, E D, Numaguchi, K, Utsunomiya, H, Inagami, T. Lysophosphatidylcholine stimulates MAP kinase activity in rat vascular smooth muscle cells. Hypertension, 31(1 Pt 2), 248-53, 1998

. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen- activated protein kinase activation in vascular smooth muscle cells. J. Biol. Chem, 273, 8890-8896, 1998

Inagami, T, Eguchi, S, Tsuzuki, S, Ichiki, T. Angiotensin II receptors AT1 and AT2--new mechanisms of signaling and antagonistic effects of AT1 and AT2. Jpn Circ J, 61(10), 807-13, 1997

Xu, Y, Guo, D F, Davidson, M, Inagami, T, Carpenter, G. Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J Biol Chem, 272(21), 13463-6, 1997

Eguchi, S, Matsumoto, T, Motley, E D, Utsunomiya, H, Inagami, T. Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated p21ras activation coupled to a Ca2+/calmodulin-sensitive tyrosine kinase. J Biol Chem, 271(24), 14169-75, 1996

Ichiki, T, Kambayashi, Y, Inagami, T. Molecular cloning and expression of angiotensin II type 2 receptor gene. Adv Exp Med Biol, 396, 145-52, 1996

Ichiki, T, Kambayashi, Y, Inagami, T. Differential inducibility of angiotensin II AT2 receptor between SHR and WKY vascular smooth muscle cells. Kidney Int Suppl, 55, S14-7, 1996

Ichiki, T, Kambayashi, Y, Inagami, T. Transcription of the rat angiotensin II type 2 receptor gene. Biochem Biophys Res Commun, 222(2), 566-71, 1996

Matsusaka, T, Nishimura, H, Utsunomiya, H, Kakuchi, J, Niimura, F, Inagami, T, Fogo, A, Ichikawa, I. Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest, 98(8), 1867-77, 1996 PMCID:507627

S Eguchi, T Matsumoto, E Motley,H Utsunomiya, T Inagami. Identification of an Essential Signaling cascade for mitogen-activated protein kinase activation by Ang II. J Biol Chem, 271, 14169-14175, 1996

S Tsuzuki, T Matoba, S Eguchi, T Inagami. Angiotensin II type 2 receptor inhibits cell proliferation and tyrosine phosphatase. Hypertension, 28, 916-918, 1996

Tamura, M, Piston, D W, Tani, M, Naruse, M, Landon, E J, Inagami, T. Ouabain increases aldosterone release from bovine adrenal glomerulosa cells: role of renin-angiotensin system. Am J Physiol, 270(1 Pt 1), E27-35, 1996

Tsuzuki, S, Eguchi, S, Inagami, T. Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT2) receptor in R3T3 cells. Biochem Biophys Res Commun, 228(3), 825-30, 1996

Tsuzuki, S, Matoba, T, Eguchi, S, Inagami, T. Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase. Hypertension, 28(5), 916-8, 1996

Y Yamano, K Ohyama, M Kikyo, T Sano, Y Nakagomi, Y Inoue, N Nakamura, I Morishima, D-F Guo, T Hamakubo and T Inagami: Mutagenesis and the molecular modeling of the rat angiotensin II receptor (AT 1). J Biol Chem 270:14024-14030, 1995

Guo, D F, Uno, S, Inagami, T. Steroid hormones upregulate rat angiotensin II type 1A receptor gene: role of glucocorticoid responsive elements in rat angiotensin II type 1A promoter. J Steroid Biochem Mol Biol, 53(1-6), 69-73, 1995

Guo, D F, Uno, S, Ishihata, A, Nakamura, N, Inagami, T. Identification of a cis-acting glucocorticoid responsive element in the rat angiotensin II type 1A promoter. Circ Res, 77(2), 249-57, 1995

Ichiki, T, Inagami, T. Transcriptional regulation of the mouse angiotensin II type 2 receptor gene. Hypertension, 25(4 Pt 2), 720-5, 1995

Ichiki, T, Inagami, T. Expression, genomic organization, and transcription of the mouse angiotensin II type 2 receptor gene. Circ Res, 76(5), 693-700, 1995

Ichiki, T, Kambayashi, Y, Inagami, T. Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells. Circ Res, 77(6), 1070-6, 1995

Ichiki, T, Labosky, P A, Shiota, C, Okuyama, S, Imagawa, Y, Fogo, A, Niimura, F, Ichikawa, I, Hogan, B L, Inagami, T. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature, 377(6551), 748-50, 1995

Ichiki,T., Labosky, P.A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B.L.M., Inagami, T. Effects on blood pressure and reduced exploratory behavior in mice lacking angiotensin II type 2 receptor. Nature, 377, 748-750, 1995

Inagami, T. Recent progress in molecular and cell biological studies of angiotensin receptors. Curr Opin Nephrol Hypertens, 4(1), 47-54, 1995

Inagami, T, Naruse, M, Hoover, R. Endothelium as an endocrine organ. Annu Rev Physiol, 57, 171-89, 1995

Inagami, T, Yamano, Y, Bardhan, S, Chaki, S, Guo, D F, Ohyama, K, Kambayashi, Y, Takahashi, K, Ichiki, T, Tsuzuki, S. Cloning, expression and regulation of angiotensin II receptors. Adv Exp Med Biol, 377, 311-7, 1995

Kakuchi, J, Ichiki, T, Kiyama, S, Hogan, B L, Fogo, A, Inagami, T, Ichikawa, I. Developmental expression of renal angiotensin II receptor genes in the mouse. Kidney Int, 47(1), 140-7, 1995

Kambayashi, Y, Takahashi, K, Bardhan, S, Inagami, T. Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line. Biochem J, 306 ( Pt 2), 331-5, 1995 PMCID:1136525

Kitami, Y, Inui, H, Uno, S, Inagami, T. Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells. J Clin Invest, 96(1), 558-67, 1995 PMCID:185230

Mosqueda-Garcia, R, Yates, K, O'Leary, J, Inagami, T. Cardiovascular and respiratory effects of endothelin in the ventrolateral medulla of the normotensive rat. Hypertension, 26(2), 263-71, 1995

Niimura, F, Labosky, P A, Kakuchi, J, Okubo, S, Yoshida, H, Oikawa, T, Ichiki, T, Naftilan, A J, Fogo, A, Inagami, T. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest, 96(6), 2947-54, 1995 PMCID:186006

Shirai, H, Takahashi, K, Katada, T, Inagami, T. Mapping of G protein coupling sites of the angiotensin II type 1 receptor. Hypertension, 25(4 Pt 2), 726-30, 1995

Stein, C M, Nelson, R, Deegan, R, He, H, Inagami, T, Frazer, M, Badr, K F, Wood, M, Wood, A J. Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. Hypertension, 25(6), 1294-300, 1995

T Ichiki, T Inagami. Expression Genomic Organization, and Transcription of the Mouse Angiotensin II Type 2 Receptor Gene. Circ Res, 76, 693-700, 1995

T Ichiki, Y Kambayashi, and T Inagami. Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells. Circ Res, 77, 1070-1076, 1995

Tang, H, Shirai, H, Inagami, T. Inhibition of protein kinase C prevents rapid desensitization of type 1B angiotensin II receptor. Circ Res, 77(2), 239-48, 1995

Chaki, S, Guo, D F, Yamano, Y, Ohyama, K, Tani, M, Mizukoshi, M, Shirai, H, Inagami, T. Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor. Kidney Int, 46(6), 1492-5, 1994

Guo, D F, Furuta, H, Mizukoshi, M, Inagami, T. The genomic organization of human angiotensin II type 1 receptor. Biochem Biophys Res Commun, 200(1), 313-9, 1994

Guo, D F, Inagami, T. The genomic organization of the rat angiotensin II receptor AT1B. Biochim Biophys Acta, 1218(1), 91-4, 1994

Guo, D F, Inagami, T. Epidermal growth factor-enhanced human angiotensin II type 1 receptor. Hypertension, 23(6 Pt 2), 1032-5, 1994

Ichiki, T, Herold, C L, Kambayashi, Y, Bardhan, S, Inagami, T. Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor. Biochim Biophys Acta, 1189(2), 247-50, 1994

Inagami, T. The renin-angiotensin system. Essays Biochem, 28, 147-64, 1994

Inagami, T. Atrial natriuretic factor as a volume regulator. J Clin Pharmacol, 34(5), 424-6, 1994

Inagami, T, Guo, D F, Kitami, Y. Molecular biology of angiotensin II receptors: an overview. J Hypertens Suppl, 12(10), S83-94, 1994

Inagami, T, Iwai, N, Sasaki, K, Yamano, Y, Bardhan, S, Chaki, S, Guo, D F, Furuta, H, Ohyama, K, Kambayashi, Y. Cloning, expression and regulation of angiotensin II receptors. Eur Heart J, 15 Suppl D, 104-7, 1994

Inagami, T, Yamano, Y, Guo, D F, Furuta, H, Ohyama, K, Kambayashi, Y, Bardhan, S, Takahashi, K, Ichiki, T. Angiotensin II receptors: cloning and expression. Braz J Med Biol Res, 27(8), 1733-8, 1994

Inui, H, Kitami, Y, Tani, M, Kondo, T, Inagami, T. Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis. J Biol Chem, 269(48), 30546-52, 1994

Inui, H, Kondo, T, Konishi, F, Kitami, Y, Inagami, T. Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. Biochem Biophys Res Commun, 205(2), 1338-44, 1994

Kambayashi, Y, Takahashi, K, Bardhan, S, Inagami, T. Molecular structure and function of angiotensin type 2 receptor. Kidney Int, 46(6), 1502-4, 1994

Kondo, T, Inui, H, Konishi, F, Inagami, T. Enhanced phospholipase D activity in vascular smooth muscle cells derived from spontaneously hypertensive rats. Clin Exp Hypertens, 16(1), 17-28, 1994

Takahasi, K, Bardhan, S, Kambayashi, Y, Shirai, H, Inagami, T. Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2. Biochem Biophys Res Commun, 198(1), 60-6, 1994

Tamura, M, Harris, T M, Phillips, D, Blair, I A, Wang, Y F, Hellerqvist, C G, Lam, S K, Inagami, T. Identification of two cardiac glycosides as Na(+)-pump inhibitors in rat urine and diet. J Biol Chem, 269(16), 11972-9, 1994

Tsuzuki, S, Ichiki, T, Nakakubo, H, Kitami, Y, Guo, D F, Shirai, H, Inagami, T. Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun, 200(3), 1449-54, 1994

Velasco, C E, Turner, M, Inagami, T, Atkinson, J B, Virmani, R, Jackson, E K, Murray, J J, Forman, M B. Reperfusion enhances the local release of endothelin after regional myocardial ischemia. Am Heart J, 128(3), 441-51, 1994

Yoshida, H, Kakuchi, J, Yoshikawa, N, Saruta, T, Inagami, T, Phillips, J A, Ichikawa, I. Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome. Kidney Int, 46(6), 1505-9, 1994

Yoshida, M, Hamakubo, T, Inagami, T. Angiotensin II-mediated pressor effect of rat joining peptide. Am J Physiol, 266(3 Pt 2), R802-8, 1994

Biaggioni, I, Garcia, F, Inagami, T, Haile, V. Hyporeninemic normoaldosteronism in severe autonomic failure. J Clin Endocrinol Metab, 76(3), 580-6, 1993

Burns, K D, Inagami, T, Harris, R C. Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Am J Physiol, 264(4 Pt 2), F645-54, 1993

Chaki, S, Inagami, T. New signaling mechanism of angiotensin II in neuroblastoma neuro-2A cells: activation of soluble guanylyl cyclase via nitric oxide synthesis. Mol Pharmacol, 43(4), 603-8, 1993

H Inui, Y Kitami, T Kondo and T Inagami. Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF ? receptor without participation of PDGF receptor in vascular smooth muscle cells. J Biol Chem, 263, 17045-17050, 1993

Hamakubo, T, Yoshida, M, Nakajima, K, Watanabe, T X, Mosqueda-Garcia, R, Inagami, T. Central cardiovascular effects of joining peptide in genetically hypertensive rats. Am J Physiol, 265(5 Pt 2), R1184-90, 1993

Inagami, T, Iwai, N, Sasaki, K, Guo, D F, Furuta, H, Yamano, Y, Bardhan, S, Chaki, S, Makito, N, Badr, K. Angiotensin II receptors: cloning and regulation. Arzneimittelforschung, 43(2A), 226-8, 1993

Inagami, T, Yamano, Y, Bardhan, S, Iwai, N, Sasaki, K, Chaki, S, Ohyama, K, Makita, N, Badr, K F. Angiotensin II receptors: cloning, structure, function and regulation. Nippon Jinzo Gakkai Shi, 35(5), 421-3, 1993

Inui, H, Kitami, Y, Kondo, T, Inagami, T. Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF-beta receptor without participation of PDGF-alpha receptor in vascular smooth muscle cells. J Biol Chem, 268(23), 17045-50, 1993

Kakinuma, Y, Fogo, A, Inagami, T, Ichikawa, I. Intrarenal localization of angiotensin II type 1 receptor mRNA in the rat. Kidney Int, 43(6), 1229-35, 1993

Kambayashi, Y, Bardhan, S, Inagami, T. Peptide growth factors markedly decrease the ligand binding of angiotensin II type 2 receptor in rat cultured vascular smooth muscle cells. Biochem Biophys Res Commun, 194(1), 478-82, 1993

Kambayashi, Y, Bardhan, S, Takahashi, K, Tsuzuki, S, Inui, H, Hamakubo, T, Inagami, T. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem, 268(33), 24543-6, 1993

Kambayashi, Y., Bardhan, S., Takahashi, K., Inui, H., Hamakubo, T., Inagami, T. Molecular Cloning of a Novel Angiotensin II Receptor Isoform Involved in Phosphotyrosine Phosphatase Inhibition. J. Biol. Chem, 268, 24543-24546, 1993

Kato, H, Iwai, N, Inui, H, Kimoto, K, Uchiyama, Y, Inagami, T. Regulation of vascular angiotensin release. Hypertension, 21(4), 446-54, 1993

Kondo, T, Konishi, F, Inui, H, Inagami, T. Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells. J Biol Chem, 268(6), 4458-64, 1993

Mosqueda-Garcia, R, Inagami, T, Appalsamy, M, Sugiura, M, Robertson, R M. Endothelin as a neuropeptide. Cardiovascular effects in the brainstem of normotensive rats. Circ Res, 72(1), 20-35, 1993

Nakajo, S, Inagami, T. Atrial natriuretic factor stimulates phosphorylation of a 52-kDa calmodulin-binding protein in vascular smooth muscle cells. Arch Biochem Biophys, 301(2), 320-4, 1993

T Hamakubo, M Yoshida, K Nakajima, TX Watanabe, R Mosqueda-Garcia & T Inagami. Central cardiovascular effects of joining peptide in the genetically hypertensive rat. AJ Physiol, 265, R1184-1190, 1993

Tamura, M, Harris, T M, Konishi, F, Inagami, T. Isolation and characterization of an endogenous Na+,K(+)-ATPase-specific inhibitor from pig urine. Eur J Biochem, 211(1-2), 317-27, 1993

Tamura, M, Konishi, F, Inagami, T. A novel endogenous sodium-pump inhibitor in pig urine: purification and comparison with the inhibitor purified from bovine adrenal glands. J Cardiovasc Pharmacol, 22 Suppl 2, S47-50, 1993

Tamura, M, Naruse, M, Sakakibara, M, Inagami, T. Isolation of an endogenous Na-pump specific inhibitor from normal pig urine: characterization and comparison with the inhibitor purified from bovine adrenal glands. Biochim Biophys Acta, 1157(1), 15-22, 1993

Velasco, C E, Jackson, E K, Morrow, J A, Vitola, J V, Inagami, T, Forman, M B. Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischaemia and reperfusion. Cardiovasc Res, 27(1), 121-8, 1993

Chaki, S, Inagami, T. A newly found angiotensin II receptor subtype mediates cyclic GMP formation in differentiated Neuro-2A cells. Eur J Pharmacol, 225(4), 355-6, 1992

Chaki, S, Inagami, T. Identification and characterization of a new binding site for angiotensin II in mouse neuroblastoma neuro-2A cells. Biochem Biophys Res Commun, 182(1), 388-94, 1992

Fogo, A, Hellings, S E, Inagami, T, Kon, V. Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity. Kidney Int, 42(3), 770-4, 1992

Furuta, H, Guo, D F, Inagami, T. Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun, 183(1), 8-13, 1992

Hamakubo, T, Furuta, H, Ichimura, M, Appalsamy, M, Mosqueda-Garcia, R, Robertson, D, Inagami, T. A Na pump inhibitor from bovine posterior pituitary: purification, structure determination and its cardiovascular effect in rat. Biochem Biophys Res Commun, 189(2), 691-6, 1992

Inagami, T, Iwai, N, Sasaki, K, Yamamo, Y, Bardhan, S, Chaki, S, Guo, D F, Furuta, H. Cloning, expression and regulation of angiotensin II receptors. J Hypertens, 10(8), 713-6, 1992

Inagami, T, Mizuno, K, Kawamura, M, Okamura, T, Clemens, D L, Higashimori, K. Localization of components of the renin-angiotensin system within the kidney and sustained release of angiotensins from isolated and perfused kidney. Tohoku J Exp Med, 166(1), 17-26, 1992

Inui, H, Kondo, T, Inagami, T. Platelet-derived growth factor AA homodimer stimulates protein synthesis rather than DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats but not from normotensive rats. Biochem Biophys Res Commun, 188(2), 524-30, 1992

Iwai, N, Inagami, T. Regulation of the expression of the rat angiotensin II receptor mRNA. Biochem Biophys Res Commun, 182(3), 1094-9, 1992

Iwai, N, Inagami, T. Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method. J Hypertens, 10(8), 717-24, 1992

Iwai, N, Inagami, T. Identification of two subtypes in the rat type I angiotensin II receptor. FEBS Lett, 298(2-3), 257-60, 1992

Iwai, N, Inagami, T. Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats. J Hypertens, 10(10), 1155-7, 1992

Iwai, N, Kurtz, T W, Inagami, T. Further evidence of the SA gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat. Biochem Biophys Res Commun, 188(1), 64-9, 1992

Kondo, T, Inui, H, Konishi, F, Inagami, T. Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells. J Biol Chem, 267(33), 23609-16, 1992

Kondo, T, Konishi, F, Inui, H, Inagami, T. Diacylglycerol formation from phosphatidylcholine in angiotensin II-stimulated vascular smooth muscle cells. Biochem Biophys Res Commun, 187(3), 1460-5, 1992

Makita, N, Iwai, N, Inagami, T, Badr, K F. Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells. Biochem Biophys Res Commun, 185(1), 142-6, 1992

Ohyama, K, Yamano, Y, Chaki, S, Kondo, T, Inagami, T. Domains for G-protein coupling in angiotensin II receptor type I: studies by site-directed mutagenesis. Biochem Biophys Res Commun, 189(2), 677-83, 1992

T Kondo, H Inui, F Konishi and T Inagami. Phospholipase D mimics platelet-derived growth factor as a competence factor in VSMC. 267, J Biol Chem, 23609-23616, 1992

Takeda, M, Breyer, M D, Noland, T D, Homma, T, Hoover, R L, Inagami, T, Kon, V. Endothelin-1 receptor antagonist: effects on endothelin- and cyclosporine-treated mesangial cells. Kidney Int, 41(6), 1713-9, 1992

Yamano, Y, Ohyama, K, Chaki, S, Guo, D F, Inagami, T. Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. Biochem Biophys Res Commun, 187(3), 1426-31, 1992

Yoshida, H, Kakuchi, J, Guo, D F, Furuta, H, Iwai, N, van der Meer-de Jong, R, Inagami, T, Ichikawa, I. Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). Biochem Biophys Res Commun, 186(2), 1042-9, 1992

Awazu, M, Kon, V, Harris, R C, Imada, T, Inagami, T, Ichikawa, I. Renal sympathetic nerves modulate glomerular ANP receptors and filtration. Am J Physiol, 261(1 Pt 2), F29-35, 1991

Awazu, M, Sugiura, M, Inagami, T, Ichikawa, I, Kon, V. Cyclosporine promotes glomerular endothelin binding in vivo. J Am Soc Nephrol, 1(11), 1253-8, 1991

Higashimori, K, Gante, J, Holzemann, G, Inagami, T. Significance of vascular renin for local generation of angiotensins. Hypertension, 17(3), 270-7, 1991

Inagami, T. Purification of renin and prorenin. Hypertension, 18(3), 241-51, 1991

Inagami, T, Mizuno, K, Higashimori, K. Juxtaglomerular cells as a source of intrarenal angiotensin II production. Kidney Int Suppl, 32, S20-2, 1991

Inagami, T, Murakami, T, Higuchi, K, Nakajo, S. Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Lack of hypotensive effects of inhibition of renin, converting enzyme, and angiotensin II receptor blocker after bilateral nephrectomy. Am J Hypertens, 4(1 Pt 2), 15S-22S, 1991

Inagami, T, Murakami, T, Higuchi, K, Nakajo, S. Role of vascular wall renin: intracellular and extracellular mechanism. Blood Vessels, 28(1-3), 217-23, 1991

Iwai, N, Inagami, T. Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension, 17(2), 161-9, 1991

Iwai, N, Yamano, Y, Chaki, S, Konishi, F, Bardhan, S, Tibbetts, C, Sasaki, K, Hasegawa, M, Matsuda, Y, Inagami, T. Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression. Biochem Biophys Res Commun, 177(1), 299-304, 1991

Konishi, F, Kondo, T, Inagami, T. Phospholipase D in cultured rat vascular smooth muscle cells and its activation by phorbol ester. Biochem Biophys Res Commun, 179(2), 1070-6, 1991

Mizuno, K, Fukuchi, S, Inagami, T. Distinct localization of renin and angiotensins in separate subcellular fractions of the rat adrenal cortex. Endocrinol Jpn, 38(6), 655-60, 1991

Mizuno, K, Higashimori, K, Fukuchi, S, Inagami, T. Exaggerated response to electrical nerve stimulation of angiotensin II release in isolated perfused hind legs of spontaneously hypertensive rats. Clin Exp Hypertens A, 13(5), 839-47, 1991

Munger, K A, Sugiura, M, Takahashi, K, Inagami, T, Badr, K F. A role for atrial natriuretic peptide in endothelin-induced natriuresis. J Am Soc Nephrol, 1(12), 1278-83, 1991

Sasaki, K, Yamano, Y, Bardhan, S, Iwai, N, Murray, J J, Hasegawa, M, Matsuda, Y, Inagami, T. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature, 351(6323), 230-3, 1991

Sasaki, K., Yamano, Y., Bardhan, S., Iwai, N., Murray, J.J., Hasegawa, N., Inagami, T. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor gene from bovine adrenocortical cells. Nature, 351, 230-232, 1991

Fogo, A, Hakim, R C, Sugiura, M, Inagami, T, Kon, V. Severe endothelial injury in a renal transplant patient receiving cyclosporine. Transplantation, 49(6), 1190-2, 1990

Inagami, T, Mizuno, K, Naruse, K, Okamura, T, Kawamura, M. Intracellular formation and release of angiotensins from juxtaglomerular cells. Kidney Int Suppl, 30, S33-7, 1990

Iwai, N, Inagami, T. Molecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA. Kidney Int, 37(6), 1460-5, 1990

Jackson, E K, Inagami, T. Blockade of the pre- and postjunctional effects of angiotensin in vivo with a non-peptide angiotensin receptor antagonist. Life Sci, 46(13), 945-53, 1990

Kon, V, Sugiura, M, Inagami, T, Harvie, B R, Ichikawa, I, Hoover, R L. Role of endothelin in cyclosporine-induced glomerular dysfunction. Kidney Int, 37(6), 1487-91, 1990

Mizuno, K, Higashimori, K, Stone, W J, Shimamoto, K, Fukuchi, S, Inagami, T. Re-evaluation of the plasma renin-angiotensin system in anephric patients. Clin Exp Hypertens A, 12(7), 1135-57, 1990

Nakajo, S, Sugiura, M, Inagami, T. Native form of endothelin receptor in human placental membranes. Biochem Biophys Res Commun, 167(1), 280-6, 1990

Awazu, M, Imada, T, Kon, V, Inagami, T, Ichikawa, I. Role of endogenous atrial natriuretic peptide in congestive heart failure. Am J Physiol, 257(3 Pt 2), R641-6, 1989

Badr, K F, Munger, K A, Sugiura, M, Snajdar, R M, Schwartzberg, M, Inagami, T. High and low affinity binding sites for endothelin on cultured rat glomerular mesangial cells. Biochem Biophys Res Commun, 161(2), 776-81, 1989

Badr, K F, Murray, J J, Breyer, M D, Takahashi, K, Inagami, T, Harris, R C. Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. J Clin Invest, 83(1), 336-42, 1989 PMCID:303681

Higashimori, K, Mizuno, K, Nakajo, S, Boehm, F H, Marcotte, P A, Egan, D A, Holleman, W H, Heusser, C, Poisner, A M, Inagami, T. Pure human inactive renin. Evidence that native inactive renin is prorenin. J Biol Chem, 264(25), 14662-7, 1989

Hollister, A S, Rodeheffer, R J, White, F J, Potts, J R, Imada, T, Inagami, T. Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog. J Clin Invest, 83(2), 623-8, 1989 PMCID:303723

Inagami, T. Atrial natriuretic factor. J Biol Chem, 264(6), 3043-6, 1989

Inagami, T. Structure and function of renin. J Hypertens Suppl, 7(2), S3-8, 1989

Inagami, T, Mizuno, K, Naruse, M, Nakamaru, M, Naruse, K, Hoffman, L H, McKenzie, J C. Active and inactive renin in the adrenal. Am J Hypertens, 2(4), 311-9, 1989

Inagami, T, Tanaka, I, McKenzie, J C, Nakamaru, M, Takayanagi, R, Imada, T, Pochet, R, Resibois, A, Naruse, M, Naruse, K. Discovery of atrial natriuretic factor in the brain: its characterization and cardiovascular implication. Cell Mol Neurobiol, 9(1), 75-85, 1989

Nakajo, S, Sugiura, M, Snajdar, R M, Boehm, F H, Inagami, T. Solubilization and identification of human placental endothelin receptor. Biochem Biophys Res Commun, 164(1), 205-11, 1989

Sugiura, M, Inagami, T, Hare, G M, Johns, J A. Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols. Biochem Biophys Res Commun, 158(1), 170-6, 1989

Sugiura, M, Inagami, T, Kon, V. Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. Biochem Biophys Res Commun, 161(3), 1220-7, 1989

Sugiura, M, Snajdar, R M, Schwartzberg, M, Badr, K F, Inagami, T. Identification of two types of specific endothelin receptors in rat mesangial cell. Biochem Biophys Res Commun, 162(3), 1396-401, 1989

Hagiwara, H, Hollister, A S, Carr, R K, Inagami, T. Norepinephrine and epinephrine in human erythrocyte plasma membranes. Biochem Biophys Res Commun, 154(3), 1003-9, 1988

Imada, T, Takayanagi, R, Inagami, T. Atrioactivase, a specific peptidase in bovine atria for the processing of pro-atrial natriuretic factor. Purification and characterization. J Biol Chem, 263(19), 9515-9, 1988

Imada, T, Takayanagi, R, Inagami, T. Purification of a specific peptidase in bovine atria for the processing of pro-atrial natriuretic factor. Biol Chem Hoppe Seyler, 369 Suppl, 113-20, 1988

Inagami, T, Mizuno, K, Nakamaru, M, Pandey, K N, Naruse, M, Naruse, K, Misono, K, Okamura, T, Kawamura, M, Higashimori, K. The renin-angiotensin system: an overview of its intracellular function. Cardiovasc Drugs Ther, 2(4), 453-8, 1988

Inagami, T, Nakamaru, M, Mizuno, K, Higashimori, K. Conceptual evolution of renin research. Clin Exp Hypertens A, 10(6), 1129-39, 1988

Inagami, T, Tamura, M. Purification and characterization of specific endogenous ouabainlike substance from bovine adrenal. Am J Med Sci, 295(4), 400-5, 1988

Kawamura, M, Parmentier, M, Inagami, T. Localization and secretion of newly synthesized and stored renin: two compartments and secretory mechanisms. Am J Physiol, 255(1 Pt 2), F100-7, 1988

Mizuno, K, Higashimori, K, Inagami, T. Suppression of angiotensin II release by prostaglandin synthesis inhibitors in hind legs. Hypertension, 12(1), 67-73, 1988

Mizuno, K, Higashimori, K, Inagami, T. Direct evidence for the local generation of vascular angiotensin II and its prostaglandin-mediated release from isolated hind legs in the rat. J Hypertens Suppl, 6(4), S435-7, 1988

Mizuno, K, Hoffman, L H, McKenzie, J C, Inagami, T. Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin II but not by adrenocorticotropin. J Clin Invest, 82(3), 1007-16, 1988 PMCID:303615

Mizuno, K, Nakamaru, M, Higashimori, K, Inagami, T. Local generation and release of angiotensin II in peripheral vascular tissue. Hypertension, 11(3), 223-9, 1988

Pandey, K N, Inagami, T. Kidney tubular epithelium cells and vascular smooth muscle cells contain different types of atrial natriuretic factor receptors. J Hypertens Suppl, 6(4), S292-4, 1988

Pandey, K N, Pavlou, S N, Inagami, T. Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis. J Biol Chem, 263(26), 13406-13, 1988

Tamura, M, Lam, T T, Inagami, T. Isolation and characterization of a specific endogenous Na+,K+-ATPase inhibitor from bovine adrenal. Biochemistry, 27(12), 4244-53, 1988

Inagami, T, Misono, K S, Fukumi, H, Maki, M, Tanaka, I, Takayanagi, R, Imada, T, Grammer, R T, Naruse, M, Naruse, K. Structure and physiological actions of rat atrial natriuretic factor. Hypertension, 10(5 Pt 2), I113-7, 1987

Inagami, T, Tamura, M. Identification of Na+,K+-ATPase inhibitors of volume-expanded hog plasma. Hypertension, 10(5 Pt 2), I108-12, 1987

Mizuno, K, Higashimori, K, Imada, T, Inagami, T. Direct release of angiotensins I and II from isolated rat kidney perfused with angiotensinogen-free medium. Biochem Biophys Res Commun, 149(2), 475-81, 1987

Pandey, K N, Inagami, T, Girard, P R, Kuo, J F, Misono, K S. New signal transduction mechanisms of atrial natriuretic factor: inhibition of phosphorylation of protein kinase C and A 240 kDa protein in adrenal cortical plasma membrane by cGMP dependent and independent mechanisms. Biochem Biophys Res Commun, 148(2), 589-95, 1987

Pandey, K N, Inagami, T, Misono, K S. Three distinct forms of atrial natriuretic factor receptors: kidney tubular epithelium cells and vascular smooth muscle cells contain different types of receptors. Biochem Biophys Res Commun, 147(3), 1146-52, 1987

Tamura, M, Lam, T T, Inagami, T. Specific endogenous Na, K-ATPase inhibitor purified from bovine adrenal. Biochem Biophys Res Commun, 149(2), 468-74, 1987

Maki, M., Takayanagi, R. Misono, K.S., Pandey, K.N., Tibbetts C. , Inagami, T. Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence. Nature, 309, 722-724, 1984


Postdoctoral Position Available
No

Postdoctoral Position Details
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Updated Date
05/04/2007