Biomedical Research Education & Training
Faculty Member

Bruner-Tran, Kaylon L., Ph.D.
Associate Professor of Obstetrics and Gynecology

Lab Url: N/A

Phone Number: 615-322-6152

Email Address: kaylon.bruner-tran@vanderbilt.edu

Bruner-Tran, Kaylon's picture
Academic history
B.S., Delta State Univ
Ph.D., Vanderbilt

Office Address   Mailing Address

B-1100 MCN 2519


Research Keywords
reproductive medicine, human endometium, endometrial dysfunction, endometriosis, progesterone action, environmental endocrine disruptors, developmental exposure, pregnancy failure, preterm birth, epigenetics

Research Specialty
Normal and abnormal cell-cell communication within the female reproductive tract; paternal contribution to preterm birth, nutritional intervention and pregnancy outcomes

Publications
Bruner-Tran, KL, Ding, T, Yeoman, KB, Archibong, A, Arosh, JA, Osteen, KG. Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners. PLoS One, 9(8), e105084, 2014

Bruner-Tran, KL, Herington, JL, Duleba, AJ, Taylor, HS, Osteen, KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Ginecol, 65(2), 199-213, 2013

Herington, JL, Glore, DR, Lucas, JA, Osteen, KG, Bruner-Tran, KL. Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model. Fertil Steril, 99(2), 543-50, 2013

Sokalska, A, Anderson, M, Villanueva, J, Ortega, I, Bruner-Tran, KL, Osteen, KG, Duleba, AJ. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J Clin Endocrinol Metab, 98(3), E463-71, 2013

Villanueva, JA, Sokalska, A, Cress, AB, Ortega, I, Bruner-Tran, KL, Osteen, KG, Duleba, AJ. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab, 98(3), E455-62, 2013

Bruner-Tran, KL, Resuehr, D, Ding, T, Lucas, JA, Osteen, KG. The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans. Curr Obstet Gynecol Rep, 1(3), 116-123, 2012

Resuehr, D, Glore, DR, Taylor, HS, Bruner-Tran, KL, Osteen, KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertil Steril, 98(4), 948-56.e1, 2012

Sokalska, A, Cress, A, Bruner-Tran, KL, Osteen, KG, Taylor, HS, Ortega, I, Duleba, AJ. Simvastatin decreases invasiveness of human endometrial stromal cells. Biol Reprod, 87(1), 2, 1-6, 2012

Herington, JL, Bruner-Tran, KL, Lucas, JA, Osteen, KG. Immune interactions in endometriosis. Expert Rev Clin Immunol, 7(5), 611-26, 2011

McConaha, ME, Ding, T, Lucas, JA, Arosh, JA, Osteen, KG, Bruner-Tran, KL. Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) exposure prevents preterm birth in unexposed female partners. Reproduction, 2011

Taylor, HS, Osteen, KG, Bruner-Tran, KL, Krikun, G, Sokalska, A, Duleba, AJ. Novel Therapies Targeting Endometriosis. Reprod Sci, 2011

Bruner-Tran, K, Osteen, KG, Taylor, HS, Sokalska, A, Haines, K, Duleba, AJ. Resveratrol Inhibits Development of Experimental Endometriosis In Vivo and Reduces Endometrial Stromal Cell Invasiveness In Vitro. Biol Reprod, 2010

Bruner-Tran, KL, Ding, T, Osteen, KG. Dioxin and endometrial progesterone resistance. Semin Reprod Med, 28(1), 59-68, 2010 PMCID:2875884

Bruner-Tran, KL, Osteen, KG. Dioxin-like PCBs and endometriosis. Syst Biol Reprod Med, 56(2), 132-46, 2010 PMCID:2867352

Bruner-Tran, KL, Osteen, KG. Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod Toxicol, 2010

Ding, T, McConaha, M, Boyd, KL, Osteen, KG, Bruner-Tran, KL. Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice. Reprod Toxicol, 2010

Herington, JL, Crispens, MA, Carvalho-Macedo, AC, Camargos, AF, Lebovic, DI, Bruner-Tran, KL, Osteen, KG. Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Fertil Steril, 2010

Krikun, G, Hu, Z, Osteen, K, Bruner-Tran, KL, Schatz, F, Taylor, HS, Toti, P, Arcuri, F, Konigsberg, W, Garen, A, Booth, CJ, Lockwood, CJ. The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. Am J Pathol, 176(2), 1050-6, 2010 PMCID:2875884

Bruner-Tran, KL, Carvalho-Macedo, AC, Duleba, AJ, Crispens, MA, Osteen, KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil Steril, 2009

Bruner-Tran, KL, Osteen, KG, Duleba, AJ. Simvastatin protects against the development of endometriosis in a nude mouse model. J Clin Endocrinol Metab, 94(7), 2489-94, 2009

Bruner-Tran, KL, Yeaman, GR, Crispens, MA, Igarashi, TM, Osteen, KG. Dioxin may promote inflammation-related development of endometriosis. Fertil Steril, 89(5 Suppl), 1287-98, 2008 PMCID:2430157

Bruner-Tran, KL, Zhang, Z, Eisenberg, E, Winneker, RC, Osteen, KG. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrinol Metab, 91(4), 1554-60, 2006

Nayyar, T, Bruner-Tran, KL, Piestrzeniewicz-Ulanska, D, Osteen, KG. Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Reprod Toxicol, 2006 PMCID:1885235

Harris, HA, Bruner-Tran, KL, Zhang, X, Osteen, KG, Lyttle, CR. A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Hum Reprod, 20(4), 936-41, 2005 PMCID:1885235

Igarashi, TM, Bruner-Tran, KL, Yeaman, GR, Lessey, BA, Edwards, DP, Eisenberg, E, Osteen, KG. Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil Steril, 84(1), 67-74, 2005

Kurita, T, Medina, R, Schabel, AB, Young, P, Gama, P, Parekh, TV, Brody, J, Cunha, GR, Osteen, KG, Bruner-Tran, KL, Gold, LI. The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen. Differentiation, 73(6), 313-22, 2005 PMCID:1885235

Osteen, KG, Bruner-Tran, KL, Eisenberg, E. Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Fertil Steril, 83(3), 529-37, 2005

Osteen, KG, Bruner-Tran, KL, Eisenberg, E. Endometrial biology and the etiology of endometriosis. Fertil Steril, 84(1), 33-4; discussion 38-9, 2005

Osteen, KG, Igarashi, TM, Yeaman, GR, Bruner-Tran, KL. Steroid and cytokine regulation of matrix metalloproteinases and the pathophysiology of endometriosis. Gynecol Obstet Invest, 57(1), 53-4, 2004

Hull, ML, Charnock-Jones, DS, Chan, CL, Bruner-Tran, KL, Osteen, KG, Tom, BD, Fan, TP, Smith, SK. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab, 88(6), 2889-99, 2003 PMCID:1885235

Osteen, KG, Igarashi, TM, Bruner-Tran, KL. Progesterone action in the human endometrium: induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression. Front Biosci, 8, d78-86, 2003

Osteen, KG, Yeaman, GR, Bruner-Tran, KL. Matrix metalloproteinases and endometriosis. Semin Reprod Med, 21(2), 155-64, 2003

Bruner-Tran, KL, Eisenberg, E, Yeaman, GR, Anderson, TA, McBean, J, Osteen, KG. Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J Clin Endocrinol Metab, 87(10), 4782-91, 2002

Bruner-Tran, KL, Webster-Clair, D, Osteen, KG. Experimental endometriosis: the nude mouse as a xenographic host. Ann N Y Acad Sci, 955, 328-39; discussion 340-2, 396-406, 2002

Osteen, KG, Bruner-Tran, KL, Keller, NR, Eisenberg, E. Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosis. Ann N Y Acad Sci, 955, 37-47; discussion 86-8, 396-406, 2002

Osteen, KG, Bruner-Tran, KL, Ong, D, Eisenberg, E. Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis. Ann N Y Acad Sci, 955, 139-46; discussion 157-8, 396-406, 2002

Bruner, KL, Eisenberg, E, Gorstein, F, Osteen, KG. Progesterone and transforming growth factor-beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids, 64(9), 648-53, 1999

Bruner-Tran, KL, Rier, SE, Eisenberg, E, Osteen, KG. The potential role of environmental toxins in the pathophysiology of endometriosis. Gynecol Obstet Invest, 48 Suppl 1, 45-56, 1999

Bruner, KL, Matrisian, LM, Rodgers, WH, Gorstein, F, Osteen, KG. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest, 99(12), 2851-7, 1997 PMCID:508135

Osteen, KG, Bruner, KL, Sharpe-Timms, KL. Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis. Semin Reprod Endocrinol, 14(3), 247-55, 1996 PMCID:508135

Bruner, KL, Rodgers, WH, Gold, LI, Korc, M, Hargrove, JT, Matrisian, LM, Osteen, KG. Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Proc Natl Acad Sci U S A, 92(16), 7362-6, 1995 PMCID:41339

Cmarik, JL, Humphreys, WG, Bruner, KL, Lloyd, RS, Tibbetts, C, Guengerich, FP. Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide. J Biol Chem, 267(10), 6672-9, 1992 PMCID:41339

Bowling, JM, Bruner, KL, Cmarik, JL, Tibbetts, C. Neighboring nucleotide interactions during DNA sequencing gel electrophoresis. Nucleic Acids Res, 19(11), 3089-97, 1991 PMCID:328275


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
06/24/2015