Biomedical Research Education & Training
Faculty Member

Chakravarthy, Anuradha, M.D.
Professor of Radiation Oncology

Lab Url: N/A

Phone Number: 322 2555

Email Address: bapsi.chak@Vanderbilt.Edu

Chakravarthy, Anuradha's picture
Academic history
B.S., Johns Hopkins
M.D., George Washington

Office Address   Mailing Address

B-1003 PRB 5671

Clinical Research Description
Dr. Chak's primary clinical interests are in Breast and Gastrointestinal Malignancies. Her research interests include the development of novel ways to combine radiation with radiosensitizing chemotherapy. Patients interested in participating in studies looking at better ways to combine Chemotherapy and Radiation should contact: Ms. Teresa Knoop 1-800-811-8480 .

Atuegwu, NC, Li, X, Arlinghaus, LR, Abramson, RG, Williams, JM, Chakravarthy, AB, Abramson, VG, Yankeelov, TE. Longitudinal, intermodality registration of quantitative breast PET and MRI data acquired before and during neoadjuvant chemotherapy: preliminary results. Med Phys, 41(5), 052302, 2014

FitzHenry, F, Wells, N, Slater, V, Dietrich, MS, Wisawatapnimit, P, Chakravarthy, AB. A randomized placebo-controlled pilot study of the impact of healing touch on fatigue in breast cancer patients undergoing radiation therapy. Integr Cancer Ther, 13(2), 105-13, 2014

Li, X, Arlinghaus, LR, Ayers, GD, Chakravarthy, AB, Abramson, RG, Abramson, VG, Atuegwu, N, Farley, J, Mayer, IA, Kelley, MC, Meszoely, IM, Means-Powell, J, Grau, AM, Sanders, M, Bhave, SR, Yankeelov, TE. DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: pilot study findings. Magn Reson Med, 71(4), 1592-602, 2014

Li, X, Kang, H, Arlinghaus, LR, Abramson, RG, Chakravarthy, AB, Abramson, VG, Farley, J, Sanders, M, Yankeelov, TE. Analyzing Spatial Heterogeneity in DCE- and DW-MRI Parametric Maps to Optimize Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer. Transl Oncol, 7(1), 14-22, 2014

Abramson, RG, Li, X, Hoyt, TL, Su, PF, Arlinghaus, LR, Wilson, KJ, Abramson, VG, Chakravarthy, AB, Yankeelov, TE. Early assessment of breast cancer response to neoadjuvant chemotherapy by semi-quantitative analysis of high-temporal resolution DCE-MRI: preliminary results. Magn Reson Imaging, 31(9), 1457-64, 2013

Al-Greene, NT, Means, AL, Lu, P, Jiang, A, Schmidt, CR, Chakravarthy, AB, Merchant, NB, Washington, MK, Zhang, B, Shyr, Y, Deane, NG, Beauchamp, RD. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. PLoS One, 8(7), e69660, 2013

Atuegwu, NC, Arlinghaus, LR, Li, X, Chakravarthy, AB, Abramson, VG, Sanders, ME, Yankeelov, TE. Parameterizing the Logistic Model of Tumor Growth by DW-MRI and DCE-MRI Data to Predict Treatment Response and Changes in Breast Cancer Cellularity during Neoadjuvant Chemotherapy. Transl Oncol, 6(3), 256-64, 2013

Castel, LD, Hartmann, KE, Mayer, IA, Saville, BR, Alvarez, J, Boomershine, CS, Abramson, VG, Chakravarthy, AB, Friedman, DL, Cella, DF. Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort. Cancer, 119(13), 2375-82, 2013

Wang, T, Wentz, SC, Ausborn, NL, Washington, MK, Merchant, N, Zhao, Z, Shyr, Y, Chakravarthy, AB, Xia, F. Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma. Pancreas, 42(6), 977-82, 2013

Weis, JA, Miga, MI, Arlinghaus, LR, Li, X, Chakravarthy, AB, Abramson, V, Farley, J, Yankeelov, TE. A mechanically coupled reaction-diffusion model for predicting the response of breast tumors to neoadjuvant chemotherapy. Phys Med Biol, 58(17), 5851-66, 2013

Chakravarthy, AB, Catalano, PJ, Mondschein, JK, Rosenthal, DI, Haller, DG, Whittington, R, Spitz, FR, Wagner, H, Sigurdson, ER, Tschetter, LK, Bayer, GK, Mulcahy, MF, Benson, AB. Phase II Trial of Paclitaxel/Cisplatin Followed by Surgery and Adjuvant Radiation Therapy and 5-Fluorouracil/Leucovorin for Gastric Cancer (ECOG E7296). Gastrointest Cancer Res, 5(6), 191-7, 2012

Chan, E, Wise, PE, Chakravarthy, AB. Controversies in radiation for upper rectal cancers. J Natl Compr Canc Netw, 10(12), 1567-72, 2012

Li, X, Abramson, RG, Arlinghaus, LR, Chakravarthy, AB, Abramson, V, Mayer, I, Farley, J, Delbeke, D, Yankeelov, TE. An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary results. EJNMMI Res, 2(1), 62, 2012

Li, X, Welch, EB, Chakravarthy, AB, Xu, L, Arlinghaus, LR, Farley, J, Mayer, IA, Kelley, MC, Meszoely, IM, Means-Powell, J, Abramson, VG, Grau, AM, Gore, JC, Yankeelov, TE. Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer. Magn Reson Med, 68(1), 261-71, 2012

Snyder, RA, Castaldo, ET, Bailey, CE, Phillips, SE, Chakravarthy, AB, Merchant, NB. Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy. Int J Surg Oncol, 2012, 307670, 2012

Atuegwu, NC, Arlinghaus, LR, Li, X, Welch, EB, Chakravarthy, BA, Gore, JC, Yankeelov, TE. Integration of diffusion-weighted MRI data and a simple mathematical model to predict breast tumor cellularity during neoadjuvant chemotherapy. Magn Reson Med, 66(6), 1689-96, 2011

Chakravarthy, AB, Catalano, PJ, Martenson, JA, Mondschein, JK, Wagner, H, Mansour, EG, Talamonti, MS, Benson, AB. Long-term follow-up of a Phase II trial of high-dose radiation with concurrent 5-fluorouracil and cisplatin in patients with anal cancer (ECOG E4292). Int J Radiat Oncol Biol Phys, 81(4), e607-13, 2011

Jiang, J, Yang, ES, Jiang, G, Nowsheen, S, Wang, H, Wang, T, Wang, Y, Billheimer, D, Chakravarthy, AB, Brown, M, Haffty, B, Xia, F. p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage. Cancer Res, 71(16), 5546-57, 2011

Lehmann, BD, Bauer, JA, Chen, X, Sanders, ME, Chakravarthy, AB, Shyr, Y, Pietenpol, JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest, 121(7), 2750-67, 2011

Li, X, Welch, EB, Arlinghaus, LR, Chakravarthy, AB, Xu, L, Farley, J, Loveless, ME, Mayer, IA, Kelley, MC, Meszoely, IM, Means-Powell, JA, Abramson, VG, Grau, AM, Gore, JC, Yankeelov, TE. A novel AIF tracking method and comparison of DCE-MRI parameters using individual and population-based AIFs in human breast cancer. Phys Med Biol, 56(17), 5753-69, 2011

Mani, S, Chen, Y, Arlinghaus, LR, Li, X, Chakravarthy, AB, Bhave, SR, Welch, EB, Levy, MA, Yankeelov, TE. Early prediction of the response of breast tumors to neoadjuvant chemotherapy using quantitative MRI and machine learning. AMIA Annu Symp Proc, 2011, 868-77, 2011

Li, X, Dawant, BM, Welch, EB, Chakravarthy, AB, Freehardt, D, Mayer, I, Kelley, M, Meszoely, I, Gore, JC, Yankeelov, TE. A nonrigid registration algorithm for longitudinal breast MR images and the analysis of breast tumor response. Magn Reson Imaging, 2009

Cuneo, KC, Geng, L, Fu, A, Orton, D, Hallahan, DE, Chakravarthy, AB. SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. Int J Radiat Oncol Biol Phys, 71(3), 873-9, 2008

Kim, DW, Blanke, CD, Wu, H, Shyr, Y, Berlin, J, Beauchamp, RD, Chakravarthy, B. Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer. Int J Radiat Oncol Biol Phys, 67(2), 397-404, 2007

Yankeelov, TE, Lepage, M, Chakravarthy, A, Broome, EE, Niermann, KJ, Kelley, MC, Meszoely, I, Mayer, IA, Herman, CR, McManus, K, Price, RR, Gore, JC. Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results. Magn Reson Imaging, 25(1), 1-13, 2007 PMCID:2634832

Chakravarthy, AB, Kelley, MC, McLaren, B, Truica, CI, Billheimer, D, Mayer, IA, Grau, AM, Johnson, DH, Simpson, JF, Beauchamp, RD, Jones, C, Pietenpol, JA. Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer. Clin Cancer Res, 12(5), 1570-6, 2006

Tedesco, KL, Berlin, J, Blanke, CD, Teng, M, Choy, H, Roberts, J, Beauchamp, RD, Leach, S, Wyman, K, Tarpley, J, Shyr, Y, Caillouette, C, Chakravarthy, B. Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer. Int J Radiat Oncol Biol Phys, 61(5), 1364-70, 2005

Tedesco, KL, Berlin, J, Rothenberg, M, Choy, H, Wyman, K, Scott Pearson, A, Daniel Beauchamp, R, Merchant, N, Lockhart, AC, Shyr, Y, Caillouette, C, Chakravarthy, B. A phase I study of concurrent 9-nitro-20(s)-camptothecin (9NC/Orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas. Radiother Oncol, 76(1), 54-8, 2005

Chakravarthy, B, Pietenpol, JA. Combined modality management of breast cancer: development of predictive markers through proteomics. Semin Oncol, 30(4 Suppl 9), 23-36, 2003

Choy, H, Chakravarthy, A, Kim, JS. Radiation therapy for non-small cell lung cancer (NSCLC). Cancer Treat Res, 105, 121-48, 2001

Hallahan, DE, Geng, L, Cmelak, AJ, Chakravarthy, AB, Martin, W, Scarfone, C, Gonzalez, A. Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature. J Control Release, 74(1-3), 183-91, 2001

Hallahan, DE, Qu, S, Geng, L, Cmelak, A, Chakravarthy, A, Martin, W, Scarfone, C, Giorgio, T. Radiation-mediated control of drug delivery. Am J Clin Oncol, 24(5), 473-80, 2001

Chakravarthy, A, Choy H. A Phase I Trial of outpatient Weekly irinotecan/carboplatin and concurrent radiation for Stage III unresectable non-small-cell lung cancer. Vanderbilt-Ingram Cancer Center Affiliate Network Trial, Brief communication, Clinical Lung Cancer , 1(4), 310-311, 2000

Chakravarthy, A, Choy, H. A phase I trial of outpatient weekly irinotecan/carboplatin and concurrent radiation for stage III unresectable non small-cell lung cancer: a Vanderbilt-Ingram Cancer Center Affiliate Network Trial. Clin Lung Cancer, 1(4), 310-1, 2000

Chakravarthy, A, Nicholson B, Kelley M, Beauchamp D, Johnson D, Frexes-Steed M, Simpson J, Shyr Y, Pietenpol J. A pilot study of neoadjuvant paclitaxel and radiation therapy with correlative molecular studies in Stage II/III breast cancer. Clinical Breast Cancer , 1(1), 68-71, 2000

Chakravarthy, A, Nicholson, B, Kelley, M, Beauchamp, D, Johnson, D, Frexes-Steed, M, Simpson, J, Shyr, Y, Pietenpol, J. A pilot study of neoadjuvant paclitaxel and radiation with correlative molecular studies in stage II/III breast cancer. Clin Breast Cancer, 1(1), 68-71, 2000

Choy, H, Chakravarthy, A, Devore, RF, Jagasia, M, Hande, KR, Roberts, JR, Johnson, DH, Yunus, F. Weekly irinotecan and concurrent radiation therapy for stage III unresectable NSCLC. Oncology (Williston Park), 14(7 Suppl 5), 43-6, 2000

Abrams RA, Grochow LB, Chakravarthy A, Sohn TA, Zahurek ML, Haulk TL, Ord S, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL, Yeo CJ. Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy and CA 19-9 levels. Int J Radiat Oncol Biol Phys., 44(5), 151039-46, 1999

Chakravarthy, A, Johnson, D, Choy, H. The role of radiation, with or without chemotherapy, in the management of NSCLC. Oncology (Williston Park), 13(10 Suppl 5), 93-100, 1999

Chakravarthy, A., Johnson, D., Choy, H. The Role of Radiation with or without Chemotherapy in the management of NSCLC. Oncology, 13: 10 (supp 5), 93-100, 1999

Choy, H, Chakravarthy, A. Phase I trial of Irinotecan and concurrent radiation therapy for stage III non-small cell lung cancer. Cancer Conference Highlights, 4(6-7), 12, 1999

Mignano, J.E., Zahurak, M.L., Chakravarthy, A., Piantadosi, S., Dooley, W.C., Gage,I. Significance of axillary nodal extranodal soft tissue extension and indications for post-mastectomy irradiation. Cancer, 86(7), 1258-62, 1999

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