Biomedical Research Education & Training
Faculty Member

Wells, K. Sam, Ph.D.
Research Professor of Molecular Physiology and Biophysics

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Phone Number: 322-6687

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Wells, K.'s picture
Academic history
B.S., University of Utah
M.S., University of New Mexico
Ph.D., University of New Mexico
Post-Doc, Cornell University, Ithaca, NY

Office Address   Mailing Address

710 Light Hall

702 Light Hall 37232-0615

Sidorova TN, Yermalitskaya LV, Wells KS, Mace LC, Boutaud O, Prinsen JK, Davies SS, Roberts JL, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Reactive gamma-Ketoaldehydes Promote Protein Misfolding and Preamyloid Oligomer Formation in Rapidly-Activated Atrial Cells. Journal of Molecular and Cellular Cardiology, in press

Exil, V, Ping, L, Yu, Y, Chakraborty, S, Caito, SW, Wells, KS, Karki, P, Lee, E, Aschner, M. Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One, 9(5), e94753, 2014

Sidorova, TN, Mace, LC, Wells, KS, Yermalitskaya, LV, Su, PF, Shyr, Y, Byrne, JG, Petracek, MR, Greelish, JP, Hoff, SJ, Ball, SK, Glabe, CG, Brown, NJ, Barnett, JV, Murray, KT. Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples. J Histochem Cytochem, 62(7), 479-487, 2014

Sobolik, T, Su, YJ, Wells, S, Ayers, GD, Cook, RS, Richmond, A. CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways. Mol Biol Cell, 25(5), 566-82, 2014

Kendall, PL, Case, JB, Sullivan, AM, Holderness, JS, Wells, KS, Liu, E, Thomas, JW. Tolerant anti-insulin B cells are effective APCs. J Immunol, 190(6), 2519-26, 2013

Schietinger, A, Arina, A, Liu, RB, Wells, S, Huang, J, Engels, B, Bindokas, V, Bartkowiak, T, Lee, D, Herrmann, A, Piston, DW, Pittet, MJ, Lin, PC, Zal, T, Schreiber, H. Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer. Oncoimmunology, 2(11), e26677, 2013

Hallaq, H, Wang, DW, Kunic, JD, George, AL, Wells, KS, Murray, KT. Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels. Am J Physiol Heart Circ Physiol, 302(3), H782-9, 2012

Chopra, SS, Stroud, DM, Watanabe, H, Bennett, JS, Burns, CG, Wells, KS, Yang, T, Zhong, TP, Roden, DM. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res, 106(8), 1342-50, 2010

Zhuang, G, Brantley-Sieders, DM, Vaught, D, Yu, J, Xie, L, Wells, S, Jackson, D, Muraoka-Cook, R, Arteaga, C, Chen, J. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res, 70(1), 299-308, 2010

Martin, MD, Fingleton, B, Lynch, CC, Wells, S, McIntyre, JO, Piston, DW, Matrisian, LM. Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin Exp Metastasis, 25(8), 877-85, 2008 PMCID:2588650

Nyman, LR, Wells, KS, Head, WS, McCaughey, M, Ford, E, Brissova, M, Piston, DW, Powers, AC. Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. J Clin Invest, 118(11), 3790-7, 2008 PMCID:2564611

Jia, H, King, IN, Chopra, SS, Wan, H, Ni, TT, Jiang, C, Guan, X, Wells, S, Srivastava, D, Zhong, TP. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A, 104(35), 14008-13, 2007 PMCID:1955785

Hallaq, H, Yang, Z, Viswanathan, PC, Fukuda, K, Shen, W, Wang, DW, Wells, KS, Zhou, J, Yi, J, Murray, KT. Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cells. Cardiovasc Res, 72(2), 250-61, 2006

Xu, M, Wells, KS, Emeson, RB. Substrate-dependent contribution of double-stranded RNA-binding motifs to ADAR2 function. Mol Biol Cell, 17(7), 3211-20, 2006 PMCID:1552048

Boczko, EM, Cooper, TG, Gedeon, T, Mischaikow, K, Murdock, DG, Pratap, S, Wells, KS. Structure theorems and the dynamics of nitrogen catabolite repression in yeast. Proc Natl Acad Sci U S A, 102(16), 5647-52, 2005 PMCID:556013

Bundy, L, Wells, S, Sealy, L. C/EBPbeta-2 confers EGF-independent growth and disrupts the normal acinar architecture of human mammary epithelial cells. Mol Cancer, 4, 43, 2005 PMCID:1360092

Kanki, H, Kupershmidt, S, Yang, T, Wells, S, Roden, DM. A structural requirement for processing the cardiac K+ channel KCNQ1. J Biol Chem, 279(32), 33976-83, 2004

Manza LL, Codreanu SG, Stamer SL, Smith DL, Wells KS, Roberts RL, Liebler DC.. Global shifts in protein sumoylation in response to electrophile and oxidative stress.. Chem Res Toxicol., 12(Dec; 17), 1706-15, 2004

McIntyre, J Oliver, Fingleton, Barbara, Wells, K Sam, Piston, David W, Lynch, Conor C, Gautam, Shiva, Matrisian, Lynn M. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J, 377(Pt 3), 617-28, 2004 PMCID:1223892

Sheng, J, Organ, EL, Hao, C, Wells, KS, Ruley, HE, Rubin, DH. Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection. BMC Cell Biol, 5(1), 32, 2004 PMCID:517494

Campbell, M, Qu, S, Wells, S, Sugandha, H, Jensen, RA. An adenoviral vector containing an arg-gly-asp (RGD) motif in the fiber knob enhances protein product levels from transgenes refractory to expression. Cancer Gene Ther, 10(7), 559-70, 2003

Sansam, Christopher L, Wells, K Sam, Emeson, Ronald B. Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci U S A, 100(24), 14018-23, 2003 PMCID:283538

Kupershmidt, Sabina, Yang, Iris C-H, Sutherland, Margaret, Wells, K Sam, Yang, Tao, Yang, Ping, Balser, Jeffrey R, Roden, Dan M. Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system. Cardiovasc Res, 56, 93-103, 2002

Gurrieri, S, Wells, K S, Johnson, I D, Bustamante, C. Direct visualization of individual DNA molecules by fluorescence microscopy: characterization of the factors affecting signal/background and optimization of imaging conditions using YOYO. Anal Biochem, 249, 44-53, 1997

Gurrieri, S, Smith, S B, Wells, K S, Johnson, I D, Bustamante, C. Real-time imaging of the reorientation mechanisms of YOYO-labelled DNA molecules during 90 degrees and 120 degrees pulsed field gel electrophoresis. Nucleic Acids Res, 24, 4759-67, 1996 PMCID:146294

Poot, M, Zhang, Y Z, Kramer, J A, Wells, K S, Jones, L J, Hanzel, D K, Lugade, A G, Singer, V L, Haugland, R P. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains. J Histochem Cytochem, 44, 1363-72, 1996

Larison, K D, BreMiller, R, Wells, K S, Clements, I, Haugland, R P. Use of a new fluorogenic phosphatase substrate in immunohistochemical applications. J Histochem Cytochem, 43, 77-83, 1995

Haugland, R P, You, W, Paragas, V B, Wells, K S, DuBose, D A, . Simultaneous visualization of G- and F-actin in endothelial cells.. J Histochem Cytochem, 42, 345-50, 1994

Sandison DR, Williams RM, Wells KS, Strickler J, Webb WW. Quantitative Fluorescence Confocal Laser Scanning Microscopy (CLSM). Handbook of Confocal Microscopy, Pawley, J., Ed.(2nd Edition), Plenum, 1994

Singer, V L, Paragas, V B, Larison, K D, Wells, K S, Fox, C J, Haugland, R P, . Fluorescence-based signal amplification technology.. Am Biotechnol Lab, 12, 55-58, 1994

Wells, K.S. and Johnson, I.D.. Fluorescent Labels for Confocal Microscopy. In: Three Dimensional Confocal Microscopy: Volume Investigation of Biological Specimens, Stevens, J., Mills, L.R. and Trogadis, J., Eds,(Acadedmic Press), 101-129, 1994

Kwon YH, Wells KS, Hoch HC. Fluorescence Confocal Microscopy: Applications in Fungal Cytology. Mycologia, 85(5), 721-733, 1993

Webb WW, Wells KS, Sandison DR Strickler J. Criteria for Quantitative Dynamical Confocal Fluorescence Imaging. In: An International Conference on Digitized Video Microscopy, Alan R. Liss, Inc., 1990

Wells KS, Sandison DR, Strickler J, Webb, WW. Quantitative Fluorescence Imaging in Laser Scanning Confocal Microscopy. Handbook of Biological Confocal Microscopy, Pawley, J. Ed.(Plenum), 27-39, 1990

Beach, D A, Bustamante, C, Wells, K S, Foucar, K M, . Differential polarization imaging. III. Theory confirmation. Patterns of polymerization of hemoglobin S in red blood sickle cells.. Biophys J, 53, 449-56, 1988 PMCID:1330212

Garab G, Wells S, Finzi L, Bustamante C. Helically Organized Macroaggregates of Pigment Protein Complexes in Chloroplasts: Evidence from Circular Intensity Differential Scattering. Biochemistry, 27(16), 5839-43, 1988

Spada GP, Gotterelli G, Samori B, Bustamante CJ, Wells KS. A Study of some Lyotropic Cholesteric Mesophases by Circular and Linear Dichroism and by Circular Intensity Differential Scattering. Liquid Crystals 3, 3(1), 101-113, 1988

Beach DA, Wells KS, Husher F, Bustamante C. Differential Polarization Microscope Using an Image Dissector Camera and Phase Lock Detection. Rev. Sci. Instr., 58(Nov), 1987-1995, 1987

Beach, D A, Bustamante, C, Wells, K S, Foucar, K M, . Differential polarization imaging. III. Theory confirmation. Patterns of polymerization of hemoglobin S in red blood sickle cells.. Biophys J, 52, 947-54, 1987 PMCID:1330093

Bustamante, C, Maestre, M F, Wells, K S. Recent advances in polarization spectroscopy: perspectives of the extension to the soft X-ray region. Photochem Photobiol, 44(3), 331-41, 1986

Wells KS, Beach DA, Keller D, Bustamante C. An analysis of circular intensity differential scattering measurements: studies on the sperm cell of Eledone cirrhosa. Biopolymers, 25(11), 2043-64, 1986

Hall K, Wells KS, Keller D, Samori B, Maestre MF, Tinoco Jr. I, Bustamante C. Circular Intensity Differential Scattering of Planar and Focal Conic Orientations of Cholesteric Liquid Crystals. Applications of Circularly Polarized Radiation, Allen FS, Bustamante C, Eds.(Springer), 1985

Bustamante, C., Wells, K.S., Keller, D., Samori, B., Maestre, M.F. and Tinoco, I.,Jr. The Circular Intensity Differential Scattering (CIDS) of Cholesteric and Blue Mesophases. Molecular Crystals and Liquid Crystals, 111(1), 79-102, 1984

Katz JE, Wells S, Ussery D, Bustamante C, Maestre MF. Design and Construction of a Circular Intensity Differential Scattering Instrument. Rev. Sci. Instrum., 55(Oct), 1574-1579, 1984

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