Biomedical Research Education & Training
Faculty Member

Massion, Pierre Pascal, M.D.
Professor of Medicine
Professor of Cancer Biology
Ingram Professor of Cancer Research

Lab Url: N/A

Phone Number: 615-936-2256

Email Address: pierre.massion@vanderbilt.edu

Massion, Pierre's picture
Academic history
B.S., Univ Catholique de Louvain, Belgium
M.D., Univ Catholique de Louvain, Belgium
Research fellowship, Univ California San Francisco
Residency in Internal Medicine, Univ California San Francisco
Fellowship in Pulmonary and Critical Care Medicine , Univ California San Francisco

Office Address   Mailing Address

2200 Pierce Ave 640 PRB

640 PRB 6838


Research Keywords
Early detection, lung cancer, preinvasive lesions, array comparative genomic hybridization, proteomics, chemoprevention.,Cancer,Chromosome,Genomics,Mass spectroscopy,Proteomics,Pulmonary,Translation

Clinical Research Keywords
Lung cancer, biomarkers, early detection, tobacco, chemoprevention

Patient Care Specialty
Lung diseases including lung cancer, critical illnesses

Research Specialty
The laboratory of Dr. Massion emphasis is on lung tumorigenesis and on using genomic and proteomic approaches to identify molecular markers of lung neoplasia and to test those in multidisciplinary early detection strategies.

Research Description
1. Role of chromosome 3q in lung cancer. Selection of candidate genes driving a genomic amplicon on Chromosome 3q. Focus on functional genomics for candidate driver genes on chromosome 3q such as p63 and PIK3CA. RO1 funded.

2. Proteomic approach to preinvasive lung cancer. Protein profiling of preinvasive lesions in bronchial biopsy and invasive lung cancer by MALDI MS; Identification of discriminatory proteins by LC-MSMS proteomics; Image analysis. funded by RO1 and SPORE in lung cancer.

3. Lung cancer biomarker discovery and validation. Identification of discriminatory proteins between lung cancer and controls after multidimensional mass spectrometry analysis of biological specimen and Phage-display recombinant antibody library (serum, plasma or pleural fluid). Funded by Vanderbilt SPORE in lung cancer, VA Merit review grant, ASCO research award and EDRN Clinical Validation Center (U01).

4. Inflammation and cancer. We are working on 3 proteins. PPAR delta in lung tumorigenesis (Pedchenko, 2008), Role of serum amyloid A in regulating apoptosis in lung cancer cells, and pIgR as a potential tumor suppressor gene in lung cancer (Polosukhin, 2007). Work supported by Damon Runyon Foundation and a Vanderbilt Discovery Grant.

Clinical Research Description
Active Clinical Trials:
Iloprost in Preventing Lung Cancer in Patients at High Risk for This Disease --This study is currently recruiting patients. http://clinicaltrials.gov/ct/gui/show/NCT00084409?order=2

Publications
Hassanein, M, Hoeksema, MD, Shiota, M, Qian, J, Harris, BK, Chen, H, Clark, JE, Alborn, WE, Eisenberg, R, Massion, PP. SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival. Clin Cancer Res, 19(3), 560-70, 2013

Hassanein, M, Callison, JC, Callaway-Lane, C, Aldrich, MC, Grogan, EL, Massion, PP. The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev Res (Phila), 5(8), 992-1006, 2012

Kikuchi, T, Hassanein, M, Amann, JM, Liu, Q, Slebos, RJ, Rahman, SM, Kaufman, JM, Zhang, X, Hoeksema, MD, Harris, BK, Li, M, Shyr, Y, Gonzalez, AL, Zimmerman, LJ, Liebler, DC, Massion, PP, Carbone, DP. In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. Mol Cell Proteomics, 11(10), 916-32, 2012

Ocak, S, Chen, H, Callison, C, Gonzalez, AL, Massion, PP. Expression of focal adhesion kinase in small-cell lung carcinoma. Cancer, 118(5), 1293-301, 2012

Ocak, S, Pedchenko, TV, Chen, H, Harris, FT, Qian, J, Polosukhin, V, Pilette, C, Sibille, Y, Gonzalez, AL, Massion, PP. Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis. Eur Respir J, 39(5), 1171-80, 2012

Pecot, CV, Li, M, Zhang, XJ, Rajanbabu, R, Calitri, C, Bungum, A, Jett, JR, Putnam, JB, Callaway-Lane, C, Deppen, S, Grogan, EL, Carbone, DP, Worrell, JA, Moons, KG, Shyr, Y, Massion, PP. Added value of a serum proteomic signature in the diagnostic evaluation of lung nodules. Cancer Epidemiol Biomarkers Prev, 21(5), 786-92, 2012

Deppen, S, Putnam, JB, Andrade, G, Speroff, T, Nesbitt, JC, Lambright, ES, Massion, PP, Walker, R, Grogan, EL. Accuracy of FDG-PET to diagnose lung cancer in a region of endemic granulomatous disease. Ann Thorac Surg, 92(2), 428-32; discussion 433, 2011

Grogan, EL, Weinstein, JJ, Deppen, SA, Putnam, JB, Nesbitt, JC, Lambright, ES, Walker, RC, Dittus, RS, Massion, PP. Thoracic operations for pulmonary nodules are frequently not futile in patients with benign disease. J Thorac Oncol, 6(10), 1720-5, 2011

Hassanein, M, Rahman, JS, Chaurand, P, Massion, PP. Advances in proteomic strategies toward the early detection of lung cancer. Proc Am Thorac Soc, 8(2), 183-8, 2011

Isbell, JM, Deppen, S, Putnam, JB, Nesbitt, JC, Lambright, ES, Dawes, A, Massion, PP, Speroff, T, Jones, DR, Grogan, EL. Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation. Ann Thorac Surg, 91(1), 227-33; discussion 233, 2011

Kashikar, ND, Zhang, W, Massion, PP, Gonzalez, AL, Datta, PK. Role of STRAP in regulating GSK3I? function and Notch3 stabilization. Cell Cycle, 10(10), 2011

Polosukhin, VV, Cates, JM, Lawson, WE, Milstone, AP, Matafonov, AG, Massion, PP, Lee, JW, Randell, SH, Blackwell, TS. Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J Pathol, 224(2), 203-11, 2011

Polosukhin, VV, Cates, JM, Lawson, WE, Zaynagetdinov, R, Milstone, AP, Massion, PP, Ocak, S, Ware, LB, Lee, JW, Bowler, RP, Kononov, AV, Randell, SH, Blackwell, TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 184(3), 317-27, 2011

Rahman, SM, Gonzalez, AL, Li, M, Seeley, EH, Zimmerman, LJ, Zhang, XJ, Manier, ML, Olson, SJ, Shah, RN, Miller, AN, Putnam, JB, Miller, YE, Franklin, WA, Blot, WJ, Carbone, DP, Shyr, Y, Caprioli, RM, Massion, PP. Lung Cancer Diagnosis from Proteomic Analysis of Preinvasive Lesions. Cancer Res, 71(8), 3009-3017, 2011

Su, Z, Dias-Santagata, D, Duke, M, Hutchinson, K, Lin, YL, Borger, DR, Chung, CH, Massion, PP, Vnencak-Jones, CL, Iafrate, AJ, Pao, W. A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. J Mol Diagn, 13(1), 74-84, 2011

Zhang, H, Liu, Q, Zimmerman, LJ, Ham, AJ, Slebos, RJ, Rahman, J, Kikuchi, T, Massion, PP, Carbone, DP, Billheimer, D, Liebler, DC. Methods for peptide and protein quantitation by liquid chromatography-multiple reaction monitoring mass spectrometry. Mol Cell Proteomics, 2011

Grogan, EL, Deppen, S, Pecot, CV, Putnam, JB, Nesbitt, JC, Shyr, Y, Rajanbabu, R, Ory, B, Lambright, ES, Massion, PP. Diagnostic characteristics of a serum biomarker in patients with positron emission tomography scans. Ann Thorac Surg, 89(6), 1724-8; discussion 1728-9, 2010 PMCID:3026702

Ocak, S, Yamashita, H, Udyavar, AR, Miller, AN, Gonzalez, AL, Zou, Y, Jiang, A, Yi, Y, Shyr, Y, Estrada, L, Quaranta, V, Massion, PP. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene, 29(48), 6331-42, 2010

Massion, PP, Zou, Y, Uner, H, Kiatsimkul, P, Wolf, HJ, Baron, AE, Byers, T, Jonsson, S, Lam, S, Hirsch, FR, Miller, YE, Franklin, WA, Varella-Garcia, M. Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS One, 4(6), e5611, 2009 PMCID:2699220

Ocak, S, Chaurand, P, Massion, PP. Mass spectrometry-based proteomic profiling of lung cancer. Proc Am Thorac Soc, 6(2), 159-70, 2009 PMCID:2674226

Ocak, S, Sos, ML, Thomas, RK, Massion, PP. High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications. Eur Respir J, 34(2), 489-506, 2009 PMCID:3026702

Qian, J, Zou, Y, Rahman, JS, Lu, B, Massion, PP. Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung. Mol Cancer Ther, 8(1), 101-9, 2009 PMCID:2674226

Wehbe, FH, Brown, SH, Massion, PP, Gadd, CS, Masys, DR, Aliferis, CF. A novel information retrieval model for high-throughput molecular medicine modalities. Cancer Inform, 8, 1-17, 2009 PMCID:2664697

DeBusk, LM, Massion, PP, Lin, PC. IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis. Cancer Res, 68(24), 10223-8, 2008 PMCID:2674226

Groseclose, MR, Massion, PP, Chaurand, P, Caprioli, RM. High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics, 8(18), 3715-24, 2008 PMCID:2927989

Massion, PP, Zou, Y, Chen, H, Jiang, A, Coulson, P, Amos, CI, Wu, X, Wistuba, I, Wei, Q, Shyr, Y, Spitz, MR. Smoking-related genomic signatures in non-small cell lung cancer. Am J Respir Crit Care Med, 178(11), 1164-72, 2008 PMCID:2720147

Pedchenko, TV, Gonzalez, AL, Wang, D, Dubois, RN, Massion, PP. Peroxisome Proliferator-Activated Receptor {beta}/{delta} Expression and Activation in Lung Cancer. Am J Respir Cell Mol Biol, 2008

Qian, J, Massion, PP. Role of chromosome 3q amplification in lung cancer. J Thorac Oncol, 3(3), 212-5, 2008

Xu, BJ, Gonzalez, AL, Kikuchi, T, Yanagisawa, K, Massion, PP, Wu, H, Mason, SE, Olson, SJ, Shyr, Y, Carbone, DP, Caprioli, RM. MALDI-MS derived prognostic protein markers for resected non-small cell lung cancer. Proteomics Clin Appl, 2(10-11), 1508-17, 2008 PMCID:2674226

Albert, JM, Gonzalez, A, Massion, PP, Chen, H, Olson, SJ, Shyr, Y, Diaz, R, Lambright, ES, Sandler, A, Carbone, DP, Putnam, JB, Johnson, DH, Lu, B. Cytoplasmic clusterin expression is associated with longer survival in patients with resected non small cell lung cancer. Cancer Epidemiol Biomarkers Prev, 16(9), 1845-51, 2007

Polosukhin, VV, Lawson, WE, Milstone, AP, Egunova, SM, Kulipanov, AG, Tchuvakin, SG, Massion, PP, Blackwell, TS. Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch, 451(4), 793-803, 2007

Taguchi, F, Solomon, B, Gregorc, V, Roder, H, Gray, R, Kasahara, K, Nishio, M, Brahmer, J, Spreafico, A, Ludovini, V, Massion, PP, Dziadziuszko, R, Schiller, J, Grigorieva, J, Tsypin, M, Hunsucker, SW, Caprioli, R, Duncan, MW, Hirsch, FR, Bunn, PA, Carbone, DP. Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study. J Natl Cancer Inst, 99(11), 838-46, 2007

Yildiz, PB, Shyr, Y, Rahman, JS, Wardwell, NR, Zimmerman, LJ, Shakhtour, B, Gray, WH, Chen, S, Li, M, Roder, H, Liebler, DC, Bigbee, WL, Siegfried, JM, Weissfeld, JL, Gonzalez, AL, Ninan, M, Johnson, DH, Carbone, DP, Caprioli, RM, Massion, PP. Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. J Thorac Oncol, 2(10), 893-901, 2007

Amann, JM, Chaurand, P, Gonzalez, A, Mobley, JA, Massion, PP, Carbone, DP, Caprioli, RM. Selective profiling of proteins in lung cancer cells from fine-needle aspirates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Cancer Res, 12(17), 5142-50, 2006

Massion, PP, Caprioli, RM. Proteomic strategies for the characterization and the early detection of lung cancer. J Thorac Oncol, 1(9), 1027-39, 2006

Stacy, DR, Ely, K, Massion, PP, Yarbrough, WG, Hallahan, DE, Sekhar, KR, Freeman, ML. Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck, 28(9), 813-8, 2006

Amann, J, Kalyankrishna, S, Massion, PP, Ohm, JE, Girard, L, Shigematsu, H, Peyton, M, Juroske, D, Huang, Y, Stuart Salmon, J, Kim, YH, Pollack, JR, Yanagisawa, K, Gazdar, A, Minna, JD, Kurie, JM, Carbone, DP. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res, 65(1), 226-35, 2005

Anumanthan, G, Halder, SK, Osada, H, Takahashi, T, Massion, PP, Carbone, DP, Datta, PK. Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells. Br J Cancer, 93(10), 1157-67, 2005 PMCID:2361493

Haruki, N, Kawaguchi, KS, Eichenberger, S, Massion, PP, Olson, S, Gonzalez, A, Carbone, DP, Dang, TP. Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res, 65(9), 3555-61, 2005

Rahman, SM, Shyr, Y, Yildiz, PB, Gonzalez, AL, Li, H, Zhang, X, Chaurand, P, Yanagisawa, K, Slovis, BS, Miller, RF, Ninan, M, Miller, YE, Franklin, WA, Caprioli, RM, Carbone, DP, Massion, PP. Proteomic patterns of preinvasive bronchial lesions. Am J Respir Crit Care Med, 172(12), 1556-62, 2005 PMCID:2718455

Shinohara, ET, Gonzalez, A, Massion, PP, Chen, H, Li, M, Freyer, AS, Olson, SJ, Andersen, JJ, Shyr, Y, Carbone, DP, Johnson, DH, Hallahan, DE, Lu, B. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma. Cancer, 103(8), 1685-92, 2005

Wardwell, NR, Massion, PP. Novel strategies for the early detection and prevention of lung cancer. Semin Oncol, 32(3), 259-68, 2005

Gonzalez, Adriana L, Roberts, Richard L, Massion, Pierre P, Olson, Sandra J, Shyr, Yu, Shappell, Scott B. 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation. Hum Pathol, 35(7), 840-9, 2004

Lu, B, Gonzalez, A, Massion, P P, Shyr, Y, Shaktour, B, Carbone, D P, Hallahan, D E. Nuclear survivin as a biomarker for non-small-cell lung cancer. Br J Cancer, 91(3), 537-40, 2004 PMCID:2409840

Massion, Pierre P, Taflan, Peter M, Rahman, S M Jamshedur, Yildiz, Pinar, Shyr, Yu, Carbone, David P, Gonzalez, Adriana L. Role of p63 amplification and overexpression in lung cancer development. Chest, 125(5 Suppl), 102S, 2004

Massion, Pierre P, Taflan, Peter M, Shyr, Yu, Rahman, S M Jamshedur, Yildiz, Pinar, Shakthour, Bashar, Edgerton, Mary E, Ninan, Matthew, Andersen, Jeremiah J, Gonzalez, Adriana L. Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression. Am J Respir Crit Care Med, 170(10), 1088-94, 2004

Massion, Pierre P, Carbone, David P. From clinical and pathologic to molecular staging of lung cancer. Am J Respir Crit Care Med, 167(12), 1587-8, 2003

Massion, Pierre P, Carbone, David P. The molecular basis of lung cancer: molecular abnormalities and therapeutic implications. Respir Res, 4(1), 12, 2003 PMCID:314397

Massion, Pierre P, Taflan, Peter M, Jamshedur Rahman, S M, Yildiz, Pinar, Shyr, Yu, Edgerton, Mary E, Westfall, Matthew D, Roberts, John R, Pietenpol, Jennifer A, Carbone, David P, Gonzalez, Adriana L. Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res, 63(21), 7113-21, 2003

Yanagisawa, Kiyoshi, Shyr, Yu, Xu, Baogang J, Massion, Pierre P, Larsen, Paul H, White, Bill C, Roberts, John R, Edgerton, Mary, Gonzalez, Adriana, Nadaf, Sorena, Moore, Jason H, Caprioli, Richard M, Carbone, David P. Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet, 362(9382), 433-9, 2003

Aliferis, C F, Hardin, D, Massion, P P. Machine learning models for lung cancer classification using array comparative genomic hybridization. Proc AMIA Symp, 7-11, 2002 PMCID:2244172

Massion, Pierre P, Kuo, Wen-Lin, Stokoe, David, Olshen, Adam B, Treseler, Patrick A, Chin, Koei, Chen, Chira, Polikoff, Daniel, Jain, Ajay N, Pinkel, Daniel, Albertson, Donna G, Jablons, David M, Gray, Joe W. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. Cancer Res, 62(13), 3636-40, 2002

Godding, V, Sibille, Y, Massion, P P, Delos, M, Sibille, C, Thurion, P, Giffroy, D, Langendries, A, Vaerman, J P. Secretory component production by human bronchial epithelial cells is upregulated by interferon gamma. Eur Respir J, 11(5), 1043-52, 1998

Massion, P P, Lind??n, A, Inoue, H, Mathy, M, Grattan, K M, Nadel, J A. Dimethyl sulfoxide decreases interleukin-8-mediated neutrophil recruitment in the airways. Am J Physiol, 271(5 Pt 1), L838-43, 1996

Inoue, H, Hara, M, Massion, P P, Grattan, K M, Lausier, J A, Chan, B, Kaneko, T, Isono, K, Jorens, P G, Ueki, I F. Role of recruited neutrophils in interleukin-8 production in dog trachea after stimulation with Pseudomonas in vivo. Am J Respir Cell Mol Biol, 13(5), 570-7, 1995

Massion, P P, H??bert, C A, Leong, S, Chan, B, Inoue, H, Grattan, K, Sheppard, D, Nadel, J A. Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea. Am J Physiol, 268(1 Pt 1), L85-94, 1995

Yoshihara, S, Chan, B, Yamawaki, I, Geppetti, P, Ricciardolo, F L, Massion, P P, Nadel, J A. Plasma extravasation in the rat trachea induced by cold air is mediated by tachykinin release from sensory nerves. Am J Respir Crit Care Med, 151(4), 1011-7, 1995

Inoue, H, Massion, P P, Ueki, I F, Grattan, K M, Hara, M, Dohrman, A F, Chan, B, Lausier, J A, Golden, J A, Nadel, J A. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am J Respir Cell Mol Biol, 11(6), 651-63, 1994

Jorens, P G, Richman-Eisenstat, J B, Housset, B P, Massion, P P, Ueki, I, Nadel, J A. Pseudomonas-induced neutrophil recruitment in the dog airway in vivo is mediated in part by IL-8 and inhibited by a leumedin. Eur Respir J, 7(11), 1925-31, 1994

Massion, P P, Inoue, H, Richman-Eisenstat, J, Grunberger, D, Jorens, P G, Housset, B, Pittet, J F, Wiener-Kronish, J P, Nadel, J A. Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. J Clin Invest, 93(1), 26-32, 1994 PMCID:293717

Massion, P P, Funari, C C, Ueki, I, Ikeda, S, McDonald, D M, Nadel, J A. Parainfluenza (Sendai) virus infects ciliated cells and secretory cells but not basal cells of rat tracheal epithelium. Am J Respir Cell Mol Biol, 9(4), 361-70, 1993


Postdoctoral Position Available
No

Postdoctoral Position Details
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Updated Date
04/22/2011