Biomedical Research Education & Training
Faculty Member

Gorden, David Lee , M.D.
Professor of Surgery
Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-936-2956

Email Address:

Gorden, David's picture
Academic history
B.A., Brown Univ
M.D., Vanderbilt
Residency, University of Minnesota
Fellowship, University of Toronto

Office Address   Mailing Address

738 PRB

801 Oxford House 37232-4753

Research Keywords

Patient Care Specialty
Hepatobiliary surgery and Liver Transplantation with special interest in primary and metastatic tumors of the liver including hepatocellular carcinoma and colorectal metastases.

Research Description
We are particularly interested in tumor- microenvironment interactions in primary and metastatic tumors of the liver.

Kappa, SF, Gorden, DL, Davidson, MA, Wright, JK, Guillamondegui, OD. Intraoperative blood loss predicts hemorrhage-related reoperation after orthotopic liver transplantation. Am Surg, 76(9), 969-73, 2010

Martin, MD, Kremers, GJ, Short, KW, Rocheleau, JV, Xu, L, Piston, DW, Matrisian, LM, Gorden, DL. Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. Mol Cancer Res, 8(10), 1319-27, 2010

Uddin, MJ, Crews, BC, Blobaum, AL, Kingsley, PJ, Gorden, DL, McIntyre, JO, Matrisian, LM, Subbaramaiah, K, Dannenberg, AJ, Piston, DW, Marnett, LJ. Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res, 70(9), 3618-27, 2010 PMCID:2864539

Zhang, B, Halder, SK, Kashikar, ND, Cho, YJ, Datta, A, Gorden, DL, Datta, PK. Antimetastatic role of Smad4 signaling in colorectal cancer. Gastroenterology, 138(3), 969-80.e1-3, 2010 PMCID:2831103

Earl, TM, Nicoud, IB, Pierce, JM, Wright, JP, Majoras, NE, Rubin, JE, Pierre, KP, Gorden, DL, Chari, RS. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis. Ann Surg Oncol, 16(4), 1043-50, 2009

VanSaun, MN, Lee, IK, Washington, MK, Matrisian, L, Gorden, DL. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol, 175(1), 355-64, 2009 PMCID:2708821

Castaldo, ET, Earl, TM, Chari, RS, Gorden, DL, Merchant, NB, Wright, JK, Feurer, ID, Pinson, CW. A clinical comparative analysis of crush/clamp, stapler, and dissecting sealer hepatic transection methods. HPB (Oxford), 10(5), 321-6, 2008 PMCID:2575677

Lee, IK, Jung, SE, Gorden, DL, Lee, YS, Jung, DY, Oh, ST, Kim, JG, Jeon, HM, Chang, SK. The diagnostic criteria for right colonic diverticulitis: prospective evaluation of 100 patients. Int J Colorectal Dis, 2008

Quarles, CC, Lepage, M, Gorden, DL, Fingleton, B, Yankeelov, TE, Price, RR, Matrisian, LM, Gore, JC, McIntyre, JO. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med, 60(3), 718-26, 2008 PMCID:2646120

Tessier, DJ, Iglesias, R, Chapman, WC, Kercher, K, Matthews, BD, Gorden, DL, Brunt, LM. Previously unreported high-grade complications of adrenalectomy. Surg Endosc, 2008

Castaldo, ET, Pinson, CW, Feurer, ID, Wright, JK, Gorden, DL, Kelly, BS, Chari, RS. Continuous versus interrupted suture for end-to-end biliary anastomosis during liver transplantation gives equal results. Liver Transpl, 13(2), 234-8, 2007

Gorden, DL, Fingleton, B, Crawford, HC, Jansen, DE, Lepage, M, Matrisian, LM. Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int J Cancer, 121(3), 495-500, 2007

Koller, FL, Geevarghese, SK, Gorden, DL. Liver transplantation for hepatocellular carcinoma: current role and future opportunities. Curr Pharm Des, 13(32), 3265-73, 2007

Lundquist, AL, Chari, RS, Wood, JH, Miller, GG, Schaefer, HM, Raiford, DS, Wright, KJ, Gorden, DL. Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and literature review. Liver Transpl, 13(5), 647-50, 2007

Nicoud, IB, Jones, CM, Pierce, JM, Earl, TM, Matrisian, LM, Chari, RS, Gorden, DL. Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer Res, 67(6), 2720-8, 2007

Acuff, HB, Carter, KJ, Fingleton, B, Gorden, DL, Matrisian, LM. Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res, 66(1), 259-66, 2006 PMCID:1360653

Buchanan, FG, Gorden, DL, Matta, P, Shi, Q, Matrisian, LM, DuBois, RN. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A, 103(5), 1492-7, 2006 PMCID:1360588

Schrager, JJ, Vnencak-Jones, CL, Graber, SE, Neff, AT, Chari, RS, Wright, KJ, Pinson, CW, Stewart, JH, Gorden, DL. Use of short tandem repeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation, 81(1), 21-5, 2006

Thomas, KT, Gorden, DL, Chari, RS, Wright, JK, Feurer, ID, Pinson, CW. Biliary reconstruction using non-penetrating, tissue everting clips versus conventional sewn biliary anastomosis in liver transplantation. HPB (Oxford), 8(2), 132-6, 2006 PMCID:2131420

Austin, MT, Feurer, ID, Chari, RS, Gorden, DL, Wright, JK, Pinson, CW. Survival after pediatric liver transplantation: why does living donation offer an advantage. Arch Surg, 140(5), 465-70; discussion 470-1, 2005

Moore, DE, Feurer, ID, Speroff, T, Gorden, DL, Wright, JK, Chari, RS, Pinson, CW. Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg, 140(3), 273-7, 2005

Thomas, KT, Welch, D, Trueblood, A, Sulur, P, Wise, P, Gorden, DL, Chari, RS, Wright, JK, Washington, K, Pinson, CW. Effective treatment of biliary cystadenoma. Ann Surg, 241(5), 769-73; discussion 773-5, 2005 PMCID:1357131

Anderson, CD, Meranze, S, Bream, P, Gorden, DL, Wright, JK, Pinson, CW, Chari, RS. Contralateral portal vein embolization for hepatectomy in the setting of hepatic steatosis. Am Surg, 70(7), 609-12, 2004

Moore, DE, Feurer, ID, Holzman, MD, Wudel, LJ, Strickland, C, Gorden, DL, Chari, R, Wright, JK, Pinson, CW. Long-term detrimental effect of bile duct injury on health-related quality of life. Arch Surg, 139(5), 476-81; discussion 481-2, 2004

Moore, DE, Feurer, ID, Rodgers, S, Shaffer, D, Nylander, W, Gorden, DL, Chari, RS, Wright, JK, Pinson, CW. Is there racial disparity in outcomes after solid organ transplantation. Am J Surg, 188(5), 571-4, 2004

Moore, D, Feurer, I, Speroff, T, Shaffer, D, Nylander, W, Kizilisik, T, Butler, J, Awad, J, Gorden, DL, Chari, R, Wright, JK, Pinson, CW. Survival and quality of life after organ transplantation in veterans and nonveterans. Am J Surg, 186(5), 476-80, 2003

Gorden, DL, Mandriota, SJ, Montesano, R, Orci, L, Pepper, MS. Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation, 63(3), 436-43, 1997

Gorden, DL, Robert, A, Moncada, VY, Taylor, SI, M??hlhauser, J, Carpentier, JL. Cell surface alteration in Epstein-Barr virus-transformed cells from patients with extreme insulin resistance. Diabetes, 39(8), 924-7, 1990

Postdoctoral Position Available

Postdoctoral Position Details

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