Biomedical Research Education & Training
Faculty Member

Abumrad, Naji, M.D.
Chair of the Department of Surgery
Professor of Surgery
John L. Sawyers Chair in Surgical Sciences

Lab Url: N/A

Phone Number: 343-2735

Email Address: naji.abumrad@vanderbilt.edu

Abumrad, Naji's picture
Academic history
B.S., American Univ of Beirut, Lebanon
M.D., American Univ of Beirut, Lebanon

Office Address   Mailing Address

D-4313 MCN

D-4316 MCN 2736


Research Keywords
Obesity; metabolic syndrome; morbid obesity; metabolism; insulin resistance; ,Diabetes,Endocrinology,Physiology

Patient Care Specialty
General and endocrine surgery

Clinical Research Description
Surgical Oncology

Clinical Interests
All aspects of general and endocrine surgery, including surgeries of the thyroid, parathyroid, pancreas and adrenals.

Publications
Youssef, Y, Richards, WO, Sekhar, N, Kaiser, J, Spagnoli, A, Abumrad, N, Torquati, A. Risk of secondary hyperparathyroidism after laparoscopic gastric bypass surgery in obese women. Surg Endosc, 2007

Cotton, BA, Guy, JS, Morris, JA, Abumrad, NN. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock, 26(2), 115-21, 2006

Hansen, E, Hajri, T, Abumrad, NN. Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus. Surgery, 139(6), 711-6, 2006

Hansen, EN, Torquati, A, Abumrad, NN. Results of bariatric surgery. Annu Rev Nutr, 26, 481-511, 2006

Poulose, BK, Ray, WA, Arbogast, PG, Needleman, J, Buerhaus, PI, Griffin, MR, Abumrad, NN, Beauchamp, RD, Holzman, MD. Resident work hour limits and patient safety. Ann Surg, 241(6), 847-56; discussion 856-60, 2005 PMCID:1357165

Torquati, A, Lutfi, R, Abumrad, N, Richards, WO. Is Roux-en-Y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients. J Gastrointest Surg, 9(8), 1112-6; discussion 1117-8, 2005

Shipman, Jason, Guy, Jeffrey, Abumrad, Naji N. Repair of metabolic processes. Crit Care Med, 31(8 Suppl), S512-7, 2003

Goldstein, R E, O'Neill, J A, Holcomb, G W, Morgan, W M, Neblett, W W, Oates, J A, Brown, N, Nadeau, J, Smith, B, Page, D L, Abumrad, N N, Scott, H W. Clinical experience over 48 years with pheochromocytoma. Ann Surg, 229(6), 755-64; discussion 764-6, 1999 PMCID:1420821

Ghishan, F K, Dykes, W, Acra, S, Pietsch, J, Abumrad, N. Effect of burn injury on intestinal Na+/H+ exchangers. J Surg Res, 58(2), 137-42, 1995

Goldstein, R E, Abumrad, N N, Lacy, D B, Wasserman, D H, Cherrington, A D. Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Diabetes, 44(6), 672-81, 1995

Flakoll, P J, Borel, M J, Wentzel, L S, Williams, P E, Lacy, D B, Abumrad, N N. The role of glucagon in the control of protein and amino acid metabolism in vivo. Metabolism, 43(12), 1509-16, 1994

Goldstein, R E, Cherrington, A D, Reed, G W, Lacy, D B, Wasserman, D H, Abumrad, N N. Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency. Am J Physiol, 266(4 Pt 1), E618-27, 1994

Goldstein, R E, Wasserman, D H, Reed, G W, Lacy, D B, Abumrad, N N, Cherrington, A D. The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency. Horm Metab Res, 26(1), 9-13, 1994

Molina, P E, Jabbour, K, Williams, P, Abumrad, N N. Effect of acute ethanol intoxication on glucoregulation during prolonged insulin-induced hypoglycemia. Am J Physiol, 267(5 Pt 2), R1280-7, 1994

Rice, D E, Flakoll, P J, May, M M, Hill, J O, Abumrad, N N. The opposing effects of insulin and hyperglycemia in modulating amino acid metabolism during a glucose tolerance test in lean and obese subjects. Metabolism, 43(2), 211-6, 1994

Wasserman, D H, Ruzumna, P A, Bracy, D P, Lacy, D B, Boothe, H W, Williams, P E, Abumrad, N N. Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism. Metabolism, 43(10), 1266-74, 1994

Flakoll, P J, Hill, J O, Abumrad, N N. Acute hyperglycemia enhances proteolysis in normal man. Am J Physiol, 265(5 Pt 1), E715-21, 1993

Goldstein, R E, Wasserman, D H, McGuinness, O P, Lacy, D B, Cherrington, A D, Abumrad, N N. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am J Physiol, 264(1 Pt 1), E119-27, 1993

Harmon, C M, Abumrad, N A. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J Membr Biol, 133(1), 43-9, 1993

Melki, S A, Abumrad, N A. Expression of the adipocyte fatty acid-binding protein in streptozotocin-diabetes: effects of insulin deficiency and supplementation. J Lipid Res, 34(9), 1527-34, 1993

Molina, P E, Eltayeb, K, Hourani, H, Okamura, K, Nanney, L B, Williams, P, Abumrad, N N. Hormonal and metabolic effects of neuroglucopenia. Brain Res, 614(1-2), 99-108, 1993

Whitesell, R R, Aboumrad, M K, Powers, A C, Regen, D M, Le, C, Beechem, J M, May, J M, Abumrad, N A. Coupling of glucose transport and phosphorylation in Xenopus oocytes and cultured cells: determination of the rate-limiting step. J Cell Physiol, 157(3), 509-18, 1993

Bennett, C, Reed, G W, Peters, J C, Abumrad, N N, Sun, M, Hill, J O. Short-term effects of dietary-fat ingestion on energy expenditure and nutrient balance. Am J Clin Nutr, 55(6), 1071-7, 1992

Flakoll, P J, Wentzel, L S, Rice, D E, Hill, J O, Abumrad, N N. Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability. Diabetologia, 35(4), 357-66, 1992

Frexes-Steed, M, Lacy, D B, Collins, J, Abumrad, N N. Role of leucine and other amino acids in regulating protein metabolism in vivo. Am J Physiol, 262(6 Pt 1), E925-35, 1992

Ghishan, F K, Shewayhat, W, Dykes, W, Abumrad, N. Ontogeny of glutamine transport by rat liver plasma membrane vesicles. J Dev Physiol, 18(1), 1-7, 1992

Goldstein, R E, Reed, G W, Wasserman, D H, Williams, P E, Lacy, D B, Buckspan, R, Abumrad, N N, Cherrington, A D. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metabolism, 41(12), 1295-303, 1992

Grimaldi, P A, Knobel, S M, Whitesell, R R, Abumrad, N A. Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proc Natl Acad Sci U S A, 89(22), 10930-4, 1992 PMCID:50456

Harmon, C M, Luce, P, Abumrad, N A. Labelling of an 88 kDa adipocyte membrane protein by sulpho-N-succinimidyl long-chain fatty acids: inhibition of fatty acid transport. Biochem Soc Trans, 20(4), 811-3, 1992

Melki, S A, Abumrad, N A. Glycerolipid synthesis in isolated adipocytes: substrate dependence and influence of norepinephrine. J Lipid Res, 33(5), 669-78, 1992

Sharp, T A, Reed, G W, Sun, M, Abumrad, N N, Hill, J O. Relationship between aerobic fitness level and daily energy expenditure in weight-stable humans. Am J Physiol, 263(1 Pt 1), E121-8, 1992

Thomas, C D, Peters, J C, Reed, G W, Abumrad, N N, Sun, M, Hill, J O. Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am J Clin Nutr, 55(5), 934-42, 1992

Abumrad, N A, Forest, C C, Regen, D M, Sanders, S. Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation. Proc Natl Acad Sci U S A, 88(14), 6008-12, 1991 PMCID:52011

Abumrad, N A, Forest, C, Regen, D M, Barnella, U S, Melki, S A. Metabolism of oleic acid in differentiating BFC-1 preadipose cells. Am J Physiol, 261(1 Pt 1), E76-86, 1991

Donahue, E P, Brown, L L, Flakoll, P J, Abumrad, N N. Rapid measurement of leucine-specific activity in biological fluids by ion-exchange chromatography and post-column ninhydrin detection. J Chromatogr, 571(1-2), 29-36, 1991

Flakoll, P J, Brown, L L, Frexes-Steed, M, Abumrad, N N. Use of amino acid clamps to investigate the role of insulin in regulating protein breakdown in vivo. JPEN J Parenter Enteral Nutr, 15(3), 81S-85S, 1991

Flakoll, P J, Kulaylat, M, Frexes-Steed, M, Hill, J O, Abumrad, N N. Amino acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans. JPEN J Parenter Enteral Nutr, 15(2), 123-7, 1991

Harmon, C M, Luce, P, Beth, A H, Abumrad, N A. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport. J Membr Biol, 121(3), 261-8, 1991

Moore, J M, Earnest, M A, DiSimone, A G, Abumrad, N N, Fletcher, J R. A PAF receptor antagonist, BN 52021, attenuates thromboxane release and improves survival in lethal canine endotoxemia. Circ Shock, 35(1), 53-9, 1991

Nammour, T M, Williams, P E, Badr, K F, Abumrad, N N, Jacobson, H R. The amino acid-induced alteration in renal hemodynamics is glucagon independent. J Am Soc Nephrol, 2(2), 164-71, 1991

Wasserman, D H, Geer, R J, Rice, D E, Bracy, D, Flakoll, P J, Brown, L L, Hill, J O, Abumrad, N N. Interaction of exercise and insulin action in humans. Am J Physiol, 260(1 Pt 1), E37-45, 1991

Wasserman, D H, Geer, R J, Williams, P E, Becker, T, Lacy, D B, Abumrad, N N. Interaction of gut and liver in nitrogen metabolism during exercise. Metabolism, 40(3), 307-14, 1991

Whitesell, R R, Powers, A C, Regen, D M, Abumrad, N A. Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1. Biochemistry, 30(49), 11560-6, 1991

Abumrad, N A, Melki, S A, Harmon, C M. Transport of fatty acid in the isolated rat adipocyte and in differentiating preadipose cells. Biochem Soc Trans, 18(6), 1130-2, 1990

Abumrad, N N, Frexes-Steed, M. What getting sick means. JPEN J Parenter Enteral Nutr, 14(5 Suppl), 157S-163S, 1990

Abumrad, N N, Yazigi, N, Cersosimo, E, Hourani, H, Gedde, S, Bulus, N, Williams, P. Glutamine metabolism during starvation. JPEN J Parenter Enteral Nutr, 14(4 Suppl), 71S-76S, 1990

Frexes-Steed, M, Warner, M L, Bulus, N, Flakoll, P, Abumrad, N N. Role of insulin and branched-chain amino acids in regulating protein metabolism during fasting. Am J Physiol, 258(6 Pt 1), E907-17, 1990

Geer, R J, Richards, W O, O'Dorisio, T M, Woltering, E O, Williams, S, Rice, D, Abumrad, N N. Efficacy of octreotide acetate in treatment of severe postgastrectomy dumping syndrome. Ann Surg, 212(6), 678-87, 1990 PMCID:1358252

Ghishan, F K, Arab, N, Bulus, N, Said, H, Pietsch, J, Abumrad, N. Glutamine transport by human intestinal basolateral membrane vesicle. Am J Clin Nutr, 51(4), 612-6, 1990

Hill, J O, Peters, J C, Swift, L L, Yang, D, Sharp, T, Abumrad, N, Greene, H L. Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. J Lipid Res, 31(3), 407-16, 1990

Hourani, H, Lacy, D B, Nammour, T M, Abumrad, N N, Morris, J A. Differential effects of alpha and beta adrenergic blockade on glucose and lactate metabolism during acute stress. J Trauma, 30(9), 1116-23; discussion 1123-4, 1990

Hourani, H, Williams, P, Morris, J A, May, M E, Abumrad, N N. Effect of insulin-induced hypoglycemia on protein metabolism in vivo. Am J Physiol, 259(3 Pt 1), E342-50, 1990

Van Voorhis, K, Said, H M, Abumrad, N, Ghishan, F K. Effect of chemically induced diabetes mellitus on glutamine transport in rat intestine. Gastroenterology, 98(4), 862-6, 1990

Whitesell, R R, Regen, D M, Pelletier, D, Abumrad, N A. Evidence that downregulation of hexose transport limits intracellular glucose in 3T3-L1 fibroblasts. Diabetes, 39(10), 1228-34, 1990

al-Mahroos, F T, Abumrad, N, Ghishan, F K. Developmental changes in glutamine transport by rat jejunal basolateral membrane vesicles. Proc Soc Exp Biol Med, 194(3), 186-92, 1990

al-Mahroos, F T, Bulus, N, Abumrad, N, Said, H, Ghishan, F K. Maturational changes in glutamine transport by rat jejunal brush border membrane vesicles. Pediatr Res, 27(5), 519-24, 1990

Abumrad, N N, Morse, E L, Lochs, H, Williams, P E, Adibi, S A. Possible sources of glutamine for parenteral nutrition: impact on glutamine metabolism. Am J Physiol, 257(2 Pt 1), E228-34, 1989

Abumrad, N N, Williams, P, Frexes-Steed, M, Geer, R, Flakoll, P, Cersosimo, E, Brown, L L, Melki, I, Bulus, N, Hourani, H. Inter-organ metabolism of amino acids in vivo. Diabetes Metab Rev, 5(3), 213-26, 1989

Bulus, N M, Abumrad, N N, Ghishan, F K. Characteristics of glutamine transport in dog jejunal brush-border membrane vesicles. Am J Physiol, 257(1 Pt 1), G80-5, 1989

Bulus, N, Cersosimo, E, Ghishan, F, Abumrad, N N. Physiologic importance of glutamine. Metabolism, 38(8 Suppl 1), 1-5, 1989

Cersosimo, E, Williams, P, Geer, R, Lairmore, T, Ghishan, F, Abumrad, N N. Importance of ammonium ions in regulating hepatic glutamine synthesis during fasting. Am J Physiol, 257(4 Pt 1), E514-9, 1989

Flakoll, P J, Kulaylat, M, Frexes-Steed, M, Hourani, H, Brown, L L, Hill, J O, Abumrad, N N. Amino acids augment insulin's suppression of whole body proteolysis. Am J Physiol, 257(6 Pt 1), E839-47, 1989

Ghishan, F K, Sutter, W, Said, H, Leonard, D, Pietsch, J, Abumrad, N. Glutamine transport by rat basolateral membrane vesicles. Biochim Biophys Acta, 979(1), 77-81, 1989

Hill, J O, Peters, J C, Yang, D, Sharp, T, Kaler, M, Abumrad, N N, Greene, H L. Thermogenesis in humans during overfeeding with medium-chain triglycerides. Metabolism, 38(7), 641-8, 1989

Hubbard, M M, Husami, T W, Abumrad, N N. Nonfunctioning adrenal tumors. Dilemmas in management. Am Surg, 55(8), 516-22, 1989

Nash, J A, Radosevich, P M, Lacy, D B, Rizk, N, Hourani, H, Williams, P E, Abumrad, N N. Effects of naloxone on glucose homeostasis during insulin-induced hypoglycemia. Am J Physiol, 257(3 Pt 1), E367-73, 1989

Pietsch, J B, Leonard, D, Neblett, W W, Abumrad, N N, Ghishan, F K. Burn injury alters intestinal glutamine transport. J Surg Res, 46(4), 296-9, 1989

Radosevich, P M, Lacy, D B, Brown, L L, Williams, P E, Abumrad, N N. Central effects of beta-endorphins on glucose homeostasis in the conscious dog. Am J Physiol, 256(2 Pt 1), E322-30, 1989

Radosevich, P M, Nash, J A, Lacy, D B, O'Donovan, C, Williams, P E, Abumrad, N N. Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid levels of ir-beta-endorphin, ACTH, cortisol, norepinephrine and glucose in the conscious dog. Brain Res, 498(1), 89-98, 1989

Van Voorhis, K, Said, H M, Ghishan, F K, Abumrad, N N. Transport of glutamine in rat intestinal brush-border membrane vesicles. Biochim Biophys Acta, 978(1), 51-5, 1989

Wasserman, D H, Abumrad, N N. Physiological bases for the treatment of the physically active individual with diabetes. Sports Med, 7(6), 376-92, 1989

Whitesell, R R, Regen, D M, Abumrad, N A. Evidence for functionally distinct glucose transporters in basal and insulin-stimulated adipocytes. Biochemistry, 28(17), 6937-43, 1989

Whitesell, R R, Regen, D M, Beth, A H, Pelletier, D K, Abumrad, N A. Activation energy of the slowest step in the glucose carrier cycle: break at 23 degrees C and correlation with membrane lipid fluidity. Biochemistry, 28(13), 5618-25, 1989

Abumrad, N A, Briscoe, P, Beth, A H, Whitesell, R R. Temperature dependence of glucose transport in erythrocytes from normal and alloxan-diabetic rats. Biochim Biophys Acta, 938(2), 222-30, 1988

Abumrad, N A, Harmon, C M, Barnela, U S, Whitesell, R R. Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Studies on its mechanism of action. J Biol Chem, 263(29), 14678-83, 1988

Brown, L L, Williams, P E, Becker, T A, Ensley, R J, May, M E, Abumrad, N N. Rapid high-performance liquid chromatographic method to measure plasma leucine: importance in the study of leucine kinetics in vivo. J Chromatogr, 426(2), 370-5, 1988

Kikuchi, K, Abumrad, N N, Ghishan, F K. Na+/H+ exchange by brush border membrane vesicles of human ileal small intestine. Gastroenterology, 95(2), 388-93, 1988

Kulaylat, M N, Frexes-Steed, M, Geer, R, Williams, P E, Abumrad, N N. The role of leucine in hepatic ketogenesis. Surgery, 103(3), 351-60, 1988

Lipman, J J, Colowick, S P, Lawrence, P L, Abumrad, N N. Aluminum induced encephalopathy in the rat. Life Sci, 42(8), 863-75, 1988

Radosevich, P M, Lacy, D B, Brown, L L, Williams, P E, Abumrad, N N. Effects of insulin-induced hypoglycemia on plasma and cerebrospinal fluid levels of ir-beta-endorphins, ACTH, cortisol, norepinephrine, insulin and glucose in the conscious dog. Brain Res, 458(2), 325-38, 1988

McGee, G S, Kulaylat, M M, Abumrad, N N. Defective glucose utilization in patients with functioning beta-cell tumors persists after tumor excision. Ann Surg, 206(4), 449-57, 1987 PMCID:1493209

Noland, T D, Abumrad, N A, Beth, A H, Garbers, D L. Protein phosphorylation in intact bovine epididymal spermatozoa: identification of the type II regulatory subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase as an endogenous phosphoprotein. Biol Reprod, 37(1), 171-80, 1987

Scott, H W, Abumrad, N N, Orth, D N. Tumors of the adrenal cortex and Cushing's syndrome. Ann Surg, 201(5), 586-94, 1985 PMCID:1250765


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
04/03/2007