Biomedical Research Education & Training
Faculty Member

Ihrie, Rebecca, PhD
Assistant Professor of Cancer Biology
Assistant Professor of Neurological Surgery

Lab Url: https://my.vanderbilt.edu/ihrielab

Phone Number: 6-2951

Email Address: rebecca.ihrie@vanderbilt.edu

Ihrie, Rebecca's picture
Academic history
B.S. Honors, University of Michigan
Ph.D., Stanford University School of Medicine
Postdoctoral Fellow, University of California, San Francisco

Office Address   Mailing Address

761 PRB

771 PRB 2220 Pierce Avenue 37232-6840


Research Keywords
Glioma, brain tumors, neural stem cells, Sonic hedgehog, growth factors,Cancer,Developmental biology,Mouse,Neuroscience,Receptor,Signal transduction,Stem cells,Transcription factor

Research Specialty
We study the biology of brain tumors and the properties of stem cells in normal brain.

Research Description
My research background is in cancer biology, neurobiology, and stem cell biology. I am interested in how extracellular signals are integrated within stem cells to direct self-renewal, proliferation, and the generation of committed progeny. Rapidly dividing progenitor cells share many molecular features with cancer cells, and the pathways regulating neural stem cells are frequently disrupted or altered in tumorigenesis. My laboratory focuses on a germinal niche in the brain: the subventricular zone (SVZ). In the mouse, this region generates thousands of young neurons every week - a remarkable process in a largely quiescent tissue. Understanding how long-lived neural stem cells survive, proliferate and differentiate will provide insight into the etiology and treatment of brain tumors.

My lab combines in vitro and in vivo approaches to address two major questions in the field: How are the many extracellular signals acting on neural progenitors integrated to maintain the adult germinal zone? What are the consequences of disrupting these signaling pathways in specific neural progenitor populations? In addition to their functions in normal homeostasis, mutations in proliferative pathways - in particular, the growth factors PDGF and EGF and the downstream effector BRaf - are common in pediatric and adult forebrain tumors. Ectopic stimulation of these pathways in murine neural progenitors results in hyperplastic growth and invasion into surrounding tissue, suggesting that aberrant signaling in progenitors may be the initiating event(s) in gliomas. Research in my laboratory focuses on the fundamental biology of neural stem cells and progenitor-like tumor cells: how signals from the niche environment combine to affect self-renewal, neurogenesis, and identity, and how mutations in these signaling pathways affect the survival, invasion, and proliferation of tumor cells.

Publications
Huillard, E, Hashizume, R, Phillips, JJ, Griveau, A, Ihrie, RA, Aoki, Y, Nicolaides, T, Perry, A, Waldman, T, McMahon, M, Weiss, WA, Petritsch, C, James, CD, Rowitch, DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A, 109(22), 8710-5, 2012 PMCID:3365162

Ihrie, RA, Alvarez-Buylla, A. Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. Neuron, 70(4), 674-86, 2011

Ihrie, RA, Shah, JK, Harwell, CC, Levine, JH, Guinto, CD, Lezameta, M, Kriegstein, AR, Alvarez-Buylla, A. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Neuron, 71(2), 250-62, 2011

Sanai, N, Nguyen, T, Ihrie, RA, Mirzadeh, Z, Tsai, HH, Wong, M, Gupta, N, Berger, MS, Huang, E, Garcia-Verdugo, JM, Rowitch, DH, Alvarez-Buylla, A. Corridors of migrating neurons in the human brain and their decline during infancy. Nature, 478(7369), 382-6, 2011

Beaudry, VG, Ihrie, RA, Jacobs, SB, Nguyen, B, Pathak, N, Park, E, Attardi, LD. Loss of the desmosomal component perp impairs wound healing in vivo. Dermatol Res Pract, 2010, 759731, 2010 PMCID:2902749

Ihrie, RA, Alvarez-Buylla, A. Cells in the astroglial lineage are neural stem cells. Cell Tissue Res, 331(1), 179-91, 2008 PMCID:2902749

Ihrie, RA, Bronson, RT, Attardi, LD. Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes. Cell Death Differ, 13(9), 1614-8, 2006 PMCID:2902749

Marques, MR, Ihrie, RA, Horner, JS, Attardi, LD. The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. J Invest Dermatol, 126(1), 69-73, 2006 PMCID:2879258

Ihrie, RA, Attardi, LD. A new Perp in the lineup: linking p63 and desmosomal adhesion. Cell Cycle, 4(7), 873-6, 2005 PMCID:2879258

Ihrie, RA, Marques, MR, Nguyen, BT, Horner, JS, Papazoglu, C, Bronson, RT, Mills, AA, Attardi, LD. Perp is a p63-regulated gene essential for epithelial integrity. Cell, 120(6), 843-56, 2005 PMCID:2879258

Marques, MR, Horner, JS, Ihrie, RA, Bronson, RT, Attardi, LD. Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. Cancer Res, 65(15), 6551-6, 2005 PMCID:2879258

Beer, S, Zetterberg, A, Ihrie, RA, McTaggart, RA, Yang, Q, Bradon, N, Arvanitis, C, Attardi, LD, Feng, S, Ruebner, B, Cardiff, RD, Felsher, DW. Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol, 2(11), e332, 2004 PMCID:519000

Ihrie, RA, Attardi, LD. Perp-etrating p53-dependent apoptosis. Cell Cycle, 3(3), 267-9, 2004 PMCID:519000

Ihrie, RA, Reczek, E, Horner, JS, Khachatrian, L, Sage, J, Jacks, T, Attardi, LD. Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol, 13(22), 1985-90, 2003 PMCID:519000


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
03/17/2013