Biomedical Research Education & Training
Faculty Member

Carpenter, Graham F., Ph.D.
Professor of Biochemistry, Emeritus

Lab Url: N/A

Phone Number: 615-322-6678

Email Address: graham.carpenter@vanderbilt.edu

Carpenter, Graham's picture
Academic history
B.S., University of Rhode Island,Kingston, RI
M.S., University of Rhode Island, Kingston, RI
Ph.D., University of Tennessee, Memphis, TN
Postdoc, Vanderbilt University, Nashville, TN

Office Address   Mailing Address

647 Light Hall Vanderbilt University
Nashville, TN 37232-0146

647 Light Hall 0146


Research Keywords
growth factors, receptors, cell proliferation,Biochemistry,Cancer,Membrane,Mouse,Receptor,Signal transduction,Tyrosine phosphorylation

Research Specialty
Growth Factor Signal Transduction/Trafficking of Growth Factor Receptors

Research Description
The focus of research in this laboratory is understanding the mechanisms by which growth factors regulate the proliferation of mammalian cells. In particular, we utilize the polypeptide mitogen epidermal growth factor (EGF) and cultures of mammalian cells as a model system. Specific research interests at the present time involve two interrelated aspects of the mechanism of action of EGF. The first area centers on the generation of second messenger molecules or intracellular signals in response to the binding of EGF to its receptor on the surface of target cells. The receptor, a transmembrane protein, contains an intrinsic tyrosine kinase activity in the cytoplasmic domain. Recently, this laboratory identified a particular phospholipase C isozyme (PLC-gamma 1) as an important phosphorylation substrate of the EGF receptor. Also, we have shown that tyrosine phosphorylation of PLC-gamma 1 increases its catalytic activity to generate the second messenger molecules IP3 and diacylglycerol. Various approaches are now being used to understand the biology and biochemistry of this protein. This includes targeted disruption of the PLC-gamma 1 gene in mice, analysis of the biological properties of PLC-gamma 1 null cells derived from such mice, and mutagenesis of the PLC-gamma 1 molecule.
The second focus of research involves receptor tyrosine kinases, known as ErbB receptors, that bind the EGF/heregulin growth factors and mediate cell proliferation/differentiation. In particular, the laboratory is focused on the proteolytic processing as a mechanism for nuclear translocation and signal transduction for the ErbB-4 receptor. Also, a project focused on the trafficking of ErbB-1 to the nucleus without proteolytic processing is underway.

Publications
Liao, HJ, Carpenter, G. Role of the sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell, 18(3), 1064-72, 2007 PMCID:1805100

Liao, HJ, de Los Santos, J, Carpenter, G. Contrasting role of phospholipase C-gamma1 in the expression of immediate early genes induced by epidermal or platelet-derived growth factors. Exp Cell Res, 312(6), 807-16, 2006

Linggi, B, Carpenter, G. ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol, 16(12), 649-56, 2006

Linggi, B, Carpenter, G. ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression. J Biol Chem, 281(35), 25373-80, 2006

Linggi, B, Cheng, QC, Rao, AR, Carpenter, G. The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase. Oncogene, 25(1), 160-3, 2006

Thiel, KW, Carpenter, G. ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains. Biochem Biophys Res Commun, 350(3), 629-33, 2006 PMCID:1637093

Wang, SE, Narasanna, A, Perez-Torres, M, Xiang, B, Wu, FY, Yang, S, Carpenter, G, Gazdar, AF, Muthuswamy, SK, Arteaga, CL. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10(1), 25-38, 2006

Arasada, RR, Carpenter, G. Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment. J Biol Chem, 280(35), 30783-7, 2005

Tikhomirov, O, Carpenter, G. Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci, 118(Pt 24), 5681-90, 2005

Tikhomirov, O, Dikov, M, Carpenter, G. Identification of proteolytic fragments from ErbB-2 that induce apoptosis. Oncogene, 24(24), 3906-13, 2005

Tvorogov, D, Wang, XJ, Zent, R, Carpenter, G. Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci, 118(Pt 3), 601-10, 2005

Tikhomirov, O, Carpenter, G. Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. J Biol Chem, 279(13), 12988-96, 2004

Carpenter, G. ErbB-4: mechanism of action and biology. Exp Cell Res, 284(1), 66-77, 2003

Carpenter, G. Nuclear localization and possible functions of receptor tyrosine kinases. Curr Opin Cell Biol, 15(2), 143-8, 2003

Cheng, QC, Tikhomirov, O, Zhou, W, Carpenter, G. Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. J Biol Chem, 278(40), 38421-7, 2003

Ni, CY, Yuan, H, Carpenter, G. Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage. J Biol Chem, 278(7), 4561-5, 2003

Tikhomirov, O, Carpenter, G. Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. Cancer Res, 63(1), 39-43, 2003

Chattopadhyay, A, Carpenter, G. PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion. J Cell Sci, 115(Pt 10), 2233-9, 2002

Liao, HJ, Kume, T, McKay, C, Xu, MJ, Ihle, JN, Carpenter, G. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem, 277(11), 9335-41, 2002

Tvorogov, D, Carpenter, G. EGF-dependent association of phospholipase C-gamma1 with c-Cbl. Exp Cell Res, 277(1), 86-94, 2002

Zhou, W, Carpenter, G. ErbB-4: a receptor tyrosine kinase. Inflamm Res, 51(2), 91-101, 2002

Liao, HJ, Ji, QS, Carpenter, G. Phospholipase C-gamma1 is required for the induction of immediate early genes by platelet-derived growth factor. J Biol Chem, 276(12), 8627-30, 2001

Ni, CY, Murphy, MP, Golde, TE, Carpenter, G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science, 294(5549), 2179-81, 2001

Tikhomirov, O, Carpenter, G. Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin. J Biol Chem, 276(36), 33675-80, 2001

Wang, XJ, Liao, HJ, Chattopadhyay, A, Carpenter, G. EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes. Exp Cell Res, 267(1), 28-36, 2001

Zhou, W, Carpenter, G. Heregulin-dependent translocation and hyperphosphorylation of ErbB-2. Oncogene, 20(29), 3918-20, 2001

Carpenter, G. The EGF receptor: a nexus for trafficking and signaling. Bioessays, 22(8), 697-707, 2000

Carpenter, G. EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. Sci STKE, 2000(15), PE1, 2000

Ji, QS, Carpenter, G. Role of basal calcium in the EGF activation of MAP kinases. Oncogene, 19(14), 1853-6, 2000

Tikhomirov, O, Carpenter, G. Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation. J Biol Chem, 275(34), 26625-31, 2000

Zhou, W, Carpenter, G. Heregulin-dependent trafficking and cleavage of ErbB-4. J Biol Chem, 275(44), 34737-43, 2000

Carpenter, G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol, 146(4), 697-702, 1999 PMCID:2156131

Carpenter, G, Ji, Q. Phospholipase C-gamma as a signal-transducing element. Exp Cell Res, 253(1), 15-24, 1999

Chattopadhyay, A, Vecchi, M, Ji, Q, Mernaugh, R, Carpenter, G. The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor. J Biol Chem, 274(37), 26091-7, 1999

Horstman, DA, Chattopadhyay, A, Carpenter, G. The influence of deletion mutations on phospholipase C-gamma 1 activity. Arch Biochem Biophys, 361(1), 149-55, 1999

Ji, QS, Chattopadhyay, A, Vecchi, M, Carpenter, G. Physiological requirement for both SH2 domains for phospholipase C-gamma1 function and interaction with platelet-derived growth factor receptors. Mol Cell Biol, 19(7), 4961-70, 1999 PMCID:84312

Xu, Y, Carpenter, G. Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association. J Cell Biochem, 75(2), 264-71, 1999

Zhang, X, Chattopadhyay, A, Ji, QS, Owen, JD, Ruest, PJ, Carpenter, G, Hanks, SK. Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A, 96(16), 9021-6, 1999 PMCID:17725

Hess, JA, Ji, QS, Carpenter, G, Exton, JH. Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1. J Biol Chem, 273(32), 20517-24, 1998

Ji, QS, Ermini, S, Baulida, J, Sun, FL, Carpenter, G. Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts. Mol Biol Cell, 9(4), 749-57, 1998 PMCID:25303

Sun, L, Carpenter, G. Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium. Oncogene, 16(16), 2095-102, 1998

Vecchi, M, Rudolph-Owen, LA, Brown, CL, Dempsey, PJ, Carpenter, G. Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. J Biol Chem, 273(32), 20589-95, 1998

Baulida, J, Carpenter, G. Heregulin degradation in the absence of rapid receptor-mediated internalization. Exp Cell Res, 232(1), 167-72, 1997

Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997 PMCID:20311

Kamat, A, Carpenter, G. Phospholipase C-gamma1: regulation of enzyme function and role in growth factor-dependent signal transduction. Cytokine Growth Factor Rev, 8(2), 109-17, 1997

Penta, K, Carpenter, G. Interaction of phospholipase C-gamma with activated growth factor receptor tyrosine kinases. Adv Exp Med Biol, 400B, 971-81, 1997

Vecchi, M, Carpenter, G. Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism. J Cell Biol, 139(4), 995-1003, 1997 PMCID:2139967

Xu, Y, Guo, DF, Davidson, M, Inagami, T, Carpenter, G. Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J Biol Chem, 272(21), 13463-6, 1997

Baulida, J, Kraus, MH, Alimandi, M, Di Fiore, PP, Carpenter, G. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem, 271(9), 5251-7, 1996

Horstman, DA, DeStefano, K, Carpenter, G. Enhanced phospholipase C-gamma1 activity produced by association of independently expressed X and Y domain polypeptides. Proc Natl Acad Sci U S A, 93(15), 7518-21, 1996 PMCID:38777

Vecchi, M, Baulida, J, Carpenter, G. Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation. J Biol Chem, 271(31), 18989-95, 1996

Carpenter, G, Soler, C, Baulida, J, Beguinot, L, Sorkin, A. Interaction of signaling and trafficking proteins with the carboxyterminus of the epidermal growth factor receptor. Ann N Y Acad Sci, 766, 44-51, 1995

Horstman, DA, Ball, R, Carpenter, G. Baculovirus expression and purification of the second messenger enzyme phospholipase C-gamma 1, a tyrosine kinase substrate. Protein Expr Purif, 6(3), 278-83, 1995

Polk, DB, McCollum, GW, Carpenter, G. Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6). J Cell Physiol, 162(3), 427-33, 1995

Sorkin, A, McKinsey, T, Shih, W, Kirchhausen, T, Carpenter, G. Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem, 270(2), 619-25, 1995

Fernald, AW, Jones, GA, Carpenter, G. Limited proteolysis of phospholipase C-gamma 1 indicates stable association of X and Y domains with enhanced catalytic activity. Biochem J, 302 ( Pt 2), 503-9, 1994 PMCID:1137256

Soler, C, Alvarez, CV, Beguinot, L, Carpenter, G. Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites. Oncogene, 9(8), 2207-15, 1994

Soler, C, Beguinot, L, Carpenter, G. Individual epidermal growth factor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins. J Biol Chem, 269(16), 12320-4, 1994

Soler, C, Felipe, A, Carpenter, G. Epidermal growth factor increases protein and messenger RNA expression levels of Ras GTPase activating protein. Cell Growth Differ, 5(5), 519-26, 1994

Carpenter, G. EGF: new tricks for an old growth factor. Curr Opin Cell Biol, 5(2), 261-4, 1993

Carpenter, G, Hern?!ndez-Sotomayor, T, Jones, G. Tyrosine phosphorylation of phospholipase C-gamma 1. Adv Second Messenger Phosphoprotein Res, 28, 179-85, 1993

Hern?!ndez-Sotomayor, SM, Arteaga, CL, Soler, C, Carpenter, G. Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity. Proc Natl Acad Sci U S A, 90(16), 7691-5, 1993 PMCID:47208

Hern?!ndez-Sotomayor, SM, Carpenter, G. Non-catalytic activation of phospholipase C-gamma 1 in vitro by epidermal growth factor receptor. Biochem J, 293 ( Pt 2), 507-11, 1993 PMCID:1134390

Jones, GA, Carpenter, G. The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters. J Biol Chem, 268(28), 20845-50, 1993

Liu, SM, Carpenter, G. Differential heat stress stability of epidermal growth factor receptor and erbB-2 receptor tyrosine kinase activities. J Cell Physiol, 157(2), 237-42, 1993

Soler, C, Beguinot, L, Sorkin, A, Carpenter, G. Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal growth factor receptor. J Biol Chem, 268(29), 22010-9, 1993

Sorkin, A, Carpenter, G. Interaction of activated EGF receptors with coated pit adaptins. Science, 261(5121), 612-5, 1993

Sorkin, A, Di Fiore, PP, Carpenter, G. The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired. Oncogene, 8(11), 3021-8, 1993

Carpenter, G. Receptor tyrosine kinase substrates: src homology domains and signal transduction. FASEB J, 6(14), 3283-9, 1992

Carpenter, G, Hern?!ndez-Sotomayor, SM, Nishibe, S, Todderud, G, Mumby, M, Wahl, M. Growth factor phosphorylation of PLC-gamma 1. Ciba Found Symp, 164, 223-33; discussion 233-9, 1992

Hern?!ndez-Sotomayor, SM, Carpenter, G. Epidermal growth factor receptor: elements of intracellular communication. J Membr Biol, 128(2), 81-9, 1992

Jones, G, Carpenter, G. Regulation of phospholipase C isozymes. Prog Growth Factor Res, 4(2), 97-106, 1992

Liu, SM, Carpenter, G. Activity of the epidermal-growth-factor receptor and phospholipase C-gamma 1 in heat-stressed fibroblasts and A-431 cells. Biochem J, 286 ( Pt 2), 541-7, 1992 PMCID:1132931

Nanney, LB, Gates, RE, Todderud, G, King, LE, Carpenter, G. Altered distribution of phospholipase C-gamma 1 in benign hyperproliferative epidermal diseases. Cell Growth Differ, 3(4), 233-9, 1992

Soderquist, AM, Todderud, G, Carpenter, G. Elevated membrane association of phospholipase C-gamma 1 in MDA-468 mammary tumor cells. Cancer Res, 52(16), 4526-9, 1992

Sorkin, A, Helin, K, Waters, CM, Carpenter, G, Beguinot, L. Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors. J Biol Chem, 267(12), 8672-8, 1992

Wahl, MI, Jones, GA, Nishibe, S, Rhee, SG, Carpenter, G. Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes. J Biol Chem, 267(15), 10447-56, 1992

Waters, CM, Overholser, KA, Sorkin, A, Carpenter, G. Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism. J Cell Physiol, 152(2), 253-63, 1992

Arteaga, CL, Johnson, MD, Todderud, G, Coffey, RJ, Carpenter, G, Page, DL. Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci U S A, 88(23), 10435-9, 1991 PMCID:52943

Brown, AB, Carpenter, G. Acute regulation of the epidermal growth factor receptor in response to nerve growth factor. J Neurochem, 57(5), 1740-9, 1991

Hern?!ndez-Sotomayor, SM, Mumby, M, Carpenter, G. Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor. Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. J Biol Chem, 266(31), 21281-6, 1991

Oberg, KC, Carpenter, G. Dexamethasone and retinoic acid regulate the expression of epidermal growth factor receptor mRNA by distinct mechanisms. J Cell Physiol, 149(2), 244-51, 1991

Sorkin, A, Carpenter, G. Dimerization of internalized epidermal growth factor receptors. J Biol Chem, 266(34), 23453-60, 1991

Sorkin, A, Waters, C, Overholser, KA, Carpenter, G. Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis. J Biol Chem, 266(13), 8355-62, 1991

Wahl, M, Carpenter, G. Selective phospholipase C activation. Bioessays, 13(3), 107-13, 1991

Ball, RL, Tanner, KD, Carpenter, G. Epidermal growth factor potentiates cyclic AMP accumulation in A-431 cells. J Biol Chem, 265(22), 12836-45, 1990

Carpenter, G. Rocky Mountain kinase fever. Receptor-Mediated Second Messenger Pathways: A UCLA symposium sponsored by ICI Pharmaceuticals and Smith Kline and French, Keystone, CO, USA, January 27-February 3, 1990. New Biol, 2(5), 421-5, 1990

Carpenter, G. PLC and PKC: a tale of two messengers. Receptor-mediated stimulation of phosphoinositide metabolism and protein kinase C, Sixth International Symposium on Cellular Endocrinology sponsored by the W. Alton Jones Cell Science Center, Lake Placid, NY, USA, August 12-15, 1990. New Biol, 2(11), 965-9, 1990

Carpenter, G, Cohen, S. Epidermal growth factor. J Biol Chem, 265(14), 7709-12, 1990

Johnson, MD, Gray, ME, Carpenter, G, Pepinsky, RB, Stahlman, MT. Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs. Hum Pathol, 21(2), 182-91, 1990

Nishibe, S, Carpenter, G. Tyrosine phosphorylation and the regulation of cell growth: growth factor-stimulated tyrosine phosphorylation of phospholipase C. Semin Cancer Biol, 1(4), 285-92, 1990

Nishibe, S, Wahl, MI, Hern?!ndez-Sotomayor, SM, Tonks, NK, Rhee, SG, Carpenter, G. Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation. Science, 250(4985), 1253-6, 1990

Nishibe, S, Wahl, MI, Wedegaertner, PB, Kim, JW, Rhee, SG, Carpenter, G, Kim, JJ. Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proc Natl Acad Sci U S A, 87(1), 424-8, 1990 PMCID:53276

Todderud, G, Wahl, MI, Rhee, SG, Carpenter, G. Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor. Science, 249(4966), 296-8, 1990

Wahl, MI, Nishibe, S, Kim, JW, Kim, H, Rhee, SG, Carpenter, G. Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells. J Biol Chem, 265(7), 3944-8, 1990

Waters, CM, Oberg, KC, Carpenter, G, Overholser, KA. Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration. Biochemistry, 29(14), 3563-9, 1990

Johnson, MD, Gray, ME, Carpenter, G, Pepinsky, RB, Sundell, H, Stahlman, MT. Ontogeny of epidermal growth factor receptor/kinase and of lipocortin-1 in the ovine lung. Pediatr Res, 25(5), 535-41, 1989

Nishibe, S, Wahl, MI, Rhee, SG, Carpenter, G. Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. J Biol Chem, 264(18), 10335-8, 1989

N??tzli, HP, Swiontkowski, MF, Thaxter, ST, Carpenter, GK, Wyatt, R. Laser Doppler flowmetry for bone blood flow measurements: helium-neon laser light attenuation and depth of perfusion assessment. J Orthop Res, 7(3), 413-24, 1989

Oberg, KC, Carpenter, G. EGF-induced PGE2 release is synergistically enhanced in retinoic acid treated fetal rat lung cells. Biochem Biophys Res Commun, 162(3), 1515-21, 1989

Oberg, KC, Carpenter, G. Dexamethasone acts as a negative regulator of epidermal growth factor receptor synthesis in fetal rat lung cells. Mol Endocrinol, 3(6), 915-22, 1989

Seiler, JG, Milek, MA, Carpenter, GK, Swiontkowski, MF. Intraoperative assessment of median nerve blood flow during carpal tunnel release with laser Doppler flowmetry. J Hand Surg [Am], 14(6), 986-91, 1989

Todderud, G, Carpenter, G. Epidermal growth factor: the receptor and its function. Biofactors, 2(1), 11-5, 1989

Wahl, MI, Nishibe, S, Carpenter, G. Growth factor signaling pathways: phosphoinositide metabolism and phosphorylation of phospholipase C. Cancer Cells, 1(4), 101-7, 1989

Wahl, MI, Nishibe, S, Suh, PG, Rhee, SG, Carpenter, G. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium. Proc Natl Acad Sci U S A, 86(5), 1568-72, 1989 PMCID:286739

Wahl, MI, Olashaw, NE, Nishibe, S, Rhee, SG, Pledger, WJ, Carpenter, G. Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol, 9(7), 2934-43, 1989 PMCID:362761

Miller-Davis, S, McKeehan, W, Carpenter, G. Prostatropin and acidic FGF also support proliferation of an EGF-dependent keratinocyte cell line. Exp Cell Res, 179(2), 595-9, 1988

Mroczkowski, B, Carpenter, G. Epidermal growth factor. Prog Clin Biol Res, 262, 207-16, 1988

Oberg, KC, Soderquist, AM, Carpenter, G. Accumulation of epidermal growth factor receptors in retinoic acid-treated fetal rat lung cells is due to enhanced receptor synthesis. Mol Endocrinol, 2(10), 959-65, 1988

Soderquist, AM, Stoscheck, C, Carpenter, G. Similarities in glycosylation and transport between the secreted and plasma membrane forms of the epidermal growth factor receptor in A-431 cells. J Cell Physiol, 136(3), 447-54, 1988

Soderquist, AM, Todderud, G, Carpenter, G. The role of carbohydrate as a post-translational modification of the receptor for epidermal growth factor. Adv Exp Med Biol, 231, 569-82, 1988

Todderud, G, Carpenter, G. Presence of mannose phosphate on the epidermal growth factor receptor in A-431 cells. J Biol Chem, 263(34), 17893-6, 1988

Wahl, M, Carpenter, G. Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C. J Biol Chem, 263(16), 7581-90, 1988

Wahl, MI, Daniel, TO, Carpenter, G. Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells. Science, 241(4868), 968-70, 1988

Zendegui, JG, Inman, WH, Carpenter, G. Modulation of the mitogenic response of an epidermal growth factor-dependent keratinocyte cell line by dexamethasone, insulin, and transforming growth factor-beta. J Cell Physiol, 136(2), 257-65, 1988

Wahl, M, Carpenter, G. Characterization and control of EGF-stimulated formation of inositol phosphates in A-431 cells. Prog Clin Biol Res, 249, 87-98, 1987


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
10/21/2008