Biomedical Research Education & Training
Faculty Member

Davidson, Jeffrey M., Ph.D.
Professor of Pathology, Microbiology and Immunology

Lab Url: http://medschool.mc.vanderbilt.edu/pathology/php_file/show_partpathology.php?id3=754

Phone Number: 615-327-4751 ext. 5488

Email Address: jeff.davidson@vanderbilt.edu

Davidson, Jeffrey's picture
Academic history
B.S., Tufts University
M.S., Stanford University
Ph.D., Stanford University

Office Address   Mailing Address

F527 ACRE, VA Medical Center

C-3321A MCN 37232-2562


Research Specialty
Connective tissue research; Wound healing; Gene therapy

Research Description
Elastin is a highly insoluble matrix protein with very low turnover. We study elastin gene expression in several biological systems. cDNA and antibody probes are used, respectively, to study regulation of elastin mRNA and protein synthesis, particularly related to modulation of elastin metabolism in diseases of human connective tissues such as blood vessels, lung and skin. Transcriptional and post-transcriptional regulation of matrix synthesis is evident in this system The role of mRNA stability, cis-acting mutations, and trans-acting factors are being evaluated in the context of elastic tissue diseases and growth factor responses. Cytokine effects are tested on cells from vascular smooth muscle, skin, and vocal fold. Several human diseases involve loss or excessive accumulation of elastic tissue, including an unusual aging syndrome, Hutchinson-Gilford progeria, and recessive and acquired forms of cutis laxa.. The consequences of elastin mutations that we discovered in cutis laxa is under intense examination

Connective tissue production and remodeling are also critical to proper wound repair. We have been examining the mechanisms of collagen and elastin turnover in pulmonary fibrosis and related diseases. We also use animal models to explore how addition or local inactivation of growth factors such as basic fibroblast growth factor, keratinocyte growth factor, transforming growth factor-? superfamily members, platelet derived growth factor and connective tissue growth affect the process and outcome of wound healing. Defective wound healing is an important clinical problem that is under study in fibrotic, aging and diabetic animal populations. Cellular and tissue-equivalent models are used where they appear to accurately reflect tissue behavior. Evaluation of gene expression by in situ and filter hybridization reveals diverse mechanisms, including the influence of metalloproteinases involved in reorganization of fibrous connective tissue.

We have used a novel form of gene therapy to express various factors in wounds with clear effects on the rate of healing. This technique offers the possibility of manipulating the healing process in a new and precise way, since recombinant expression vectors can be readily modified to understand structure-function relationships in an authentic biological context. Gene therapy of wounds also offers a rapid way to screen for wound healing functions of newly discovered cDNAs.

The laboratory is also part of the Vanderbilt Free-Electron Laser Center. This is a multidisciplinary program in which this laboratory is examining how tissues respond and heal after irradiation from the most powerful source of pulsed, infrared light energy in the country. .

Publications
Caldwell, RL, Opalenik, SR, Davidson, JM, Caprioli, RM, Nanney, LB. Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds. Wound Repair Regen, 16(3), 442-9, 2008

Davidson, JM. First-class delivery: getting growth factors to their destination. J Invest Dermatol, 128(6), 1360-2, 2008

Hafeman, AE, Li, B, Yoshii, T, Zienkiewicz, K, Davidson, JM, Guelcher, SA. Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration. Pharm Res, 2008

Prokop, A, Davidson, JM. Nanovehicular intracellular delivery systems. J Pharm Sci, 97(9), 3518-90, 2008

Wilmink, GJ, Opalenik, SR, Beckham, JT, Abraham, AA, Nanney, LB, Mahadevan-Jansen, A, Davidson, JM, Jansen, ED. Molecular Imaging-Assisted Optimization of Hsp70 Expression during Laser-Induced Thermal Preconditioning for Wound Repair Enhancement. J Invest Dermatol, 2008

Caldwell, RL, Opalenik, SR, Davidson, JM, Caprioli, RM, Nanney, LB. Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds. Wound Repair Regen, 2007

Hartig, SM, Carlesso, G, Davidson, JM, Prokop, A. Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights. Biomacromolecules, 8(1), 265-72, 2007

Hartig, SM, Greene, RR, Carlesso, G, Higginbotham, JN, Khan, WN, Prokop, A, Davidson, JM. Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells. Biomaterials, 28(26), 3843-55, 2007 PMCID:2000344

Rauth, TP, Poulose, BK, Davidson, JM, Nanney, LB, Holzman, MD. Mechanical abrasion improves early incorporation of small intestinal submucosa. Am Surg, 73(7), 647-51; discussion 651, 2007

Davidson, JM, Giro, M. Healing slack skin. J Invest Dermatol, 126(12), 2563-4, 2006

Nanney, LB, Caldwell, RL, Pollins, AC, Cardwell, NL, Opalenik, SR, Davidson, JM. Novel approaches for understanding the mechanisms of wound repair. J Investig Dermatol Symp Proc, 11(1), 132-9, 2006

Nanney, LB, Caldwell, RL, Pollins, AC, Cardwell, NL, Opalenik, SR, Davidson, JM. Novel approaches for understanding the mechanisms of wound repair. J Invest Dermatol, 126 Suppl, 132-9, 2006

Samaras, SE, Shi, Y, Davidson, JM. CARP: Fishing for Novel Mechanisms of Neovascularization. J Invest Dermatol, 126 Suppl, 124-31, 2006

Samaras, SE, Shi, Y, Davidson, JM. CARP: fishing for novel mechanisms of neovascularization. J Investig Dermatol Symp Proc, 11(1), 124-31, 2006

Spindler, KP, Murray, MM, Devin, C, Nanney, LB, Davidson, JM. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res, 24(3), 401-406, 2006

Tang, T, Shi, Y, Opalenik, SR, Brantley-Sieders, DM, Chen, J, Davidson, JM, Brandt, SJ. Expression of the TAL1/SCL transcription factor in physiological and pathological vascular processes. J Pathol, 210(1), 121-9, 2006

Wilmink, GJ, Opalenik, SR, Beckham, JT, Davidson, JM, Jansen, ED. Assessing laser-tissue damage with bioluminescent imaging. J Biomed Opt, 11(4), 041114, 2006

Carlesso, G, Kozlov, E, Prokop, A, Unutmaz, D, Davidson, JM. Nanoparticulate system for efficient gene transfer into refractory cell targets. Biomacromolecules, 6(3), 1185-92, 2005

Opalenik, SR, Davidson, JM. Fibroblast differentiation of bone marrow-derived cells during wound repair. FASEB J, 19(11), 1561-3, 2005

Shi, Y, Reitmaier, B, Regenbogen, J, Slowey, RM, Opalenik, SR, Wolf, E, Goppelt, A, Davidson, JM. CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. Am J Pathol, 166(1), 303-12, 2005 PMCID:1602297

Wu, N, Davidson, JM. Migration inhibitory factor-related protein (MRP)8 and MRP14 are differentially expressed in free-electron laser and scalpel incisions. Wound Repair Regen, 12(3), 327-36, 2004

Davidson, Jeffrey M, Breyer, Matthew D. Inflammatory modulation and wound repair. J Invest Dermatol, 120(5), xi-xii, 2003

Davidson, Jeffrey M, Eming, Sabine A, Dasgupta, Jayasri. Particle-mediated gene therapy of wounds. Methods Mol Med, 78, 433-52, 2003

Ma, Li-Jun, Yang, Haichun, Gaspert, Ariana, Carlesso, Gianluca, Barty, Melissa M, Davidson, Jeffrey M, Sheppard, Dean, Fogo, Agnes B. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol, 163(4), 1261-73, 2003 PMCID:1868298

Riordan, Colin L, McDonough, Mark, Davidson, Jeffrey M, Corley, Randall, Perlov, Cathy, Barton, Ronald, Guy, Jeffrey, Nanney, Lillian B. Noncontact laser Doppler imaging in burn depth analysis of the extremities. J Burn Care Rehabil, 24(4), 177-86, 2003

Spindler, Kurt P, Murray, Martha M, Detwiler, Kenneth B, Tarter, Jeremy T, Dawson, John M, Nanney, Lillian B, Davidson, Jeffrey M. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res, 21(2), 245-9, 2003

Wu, Nanjun, Jansen, E Duco, Davidson, Jeffrey M. Comparison of mouse matrix metalloproteinase 13 expression in free-electron laser and scalpel incisions during wound healing. J Invest Dermatol, 121(4), 926-32, 2003

Prokop, A., Kozlov, E., Moore, W. Davidson , J.M. Maximizing the in vivo efficiency of gene transfer by means of non-viral polymeric gene delivery vehicles. J Pharmaceut Sci, in press

Davidson, Jeffrey M. Smad about elastin regulation. Am J Respir Cell Mol Biol, 26(2), 164-6, 2002

Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B, Davidson, Jeffrey M, Linton, MacRae F, Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni. Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J Clin Invest, 110(12), 1859-68, 2002 PMCID:151648

Prokop, Ales, Kozlov, Evgenii, Moore, William, Davidson, Jeffrey M. Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles. J Pharm Sci, 91(1), 67-76, 2002

Spindler, K P, Dawson, J M, Stahlman, G C, Davidson, J M, Nanney, L B. Collagen expression and biomechanical response to human recombinant transforming growth factor beta (rhTGF-beta2) in the healing rabbit MCL. J Orthop Res, 20(2), 318-24, 2002

Wu, Nanjun, Opalenik, Susan, Liu, Jinhua, Jansen, E Duco, Giro, Maria Gabriella, Davidson, Jeffrey M. Real-time visualization of MMP-13 promoter activity in transgenic mice. Matrix Biol, 21(2), 149-61, 2002

Ballas, C B, Davidson, J M. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Repair Regen, 9(3), 223-37, 2001

Ballas, C.B., Davidson, J.M. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Rep. Regen, 9, 223-227, 2001

Bennett, L L, Rosenblum, R S, Perlov, C, Davidson, J M, Barton, R M, Nanney, L B. An in vivo comparison of topical agents on wound repair. Plast Reconstr Surg, 108(3), 675-87, 2001

Davidson, J M, Krieg, T, Eming, S A. Particle-mediated gene therapy of wounds. Wound Repair Regen, 8(6), 452-9, 2001

Davidson, J.M. Experimental animal wound models. Wounds, 13, 9-23, 2001

Drew, A.F., Liu, H., Davidson, J.M., Daugherty, C.C., Degen, J.L. Wound healing defects in mice lacking fibrinogen. Blood, 97, 3691-98, 2001

Nanney LB, Wamil BD, Whitsitt J, Cardwell JL, Davidson JM, Yan, H.P., Hellerqvist CG. CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis, 4, 61-70, 2001

Nanney, L B, Wamil, B D, Whitsitt, J, Cardwell, N L, Davidson, J M, Yan, H P, Hellerqvist, C G. CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis, 4(1), 61-70, 2001

Prokop, A, Kozlov, E, Nun Non, S, Dikov, M M, Sephel, G C, Whitsitt, J S, Davidson, J M. Towards retrievable vascularized bioartificial pancreas: induction and long-lasting stability of polymeric mesh implant vascularized with the help of acidic and basic fibroblast growth factors and hydrogel coating. Diabetes Technol Ther, 3(2), 245-61, 2001

Prokop, A., Kozlov, E., Nun Non, Shuhaida, Dikov, M.M., Sephel, G.C., Davidson, J.M. Towards retrievable vascularized bioartificial pancreas (vbap): induction and long-lasting stability of polymeric mesh implant vascularized with help of acidic and basic fibroblast growth factors and hydrogel coating. Diab Technol Therap, 3, 245-261, 2001

Light, R.W., Cheng, D-S., Lee, Y.C., Rogers, J., Davidson, J.M., Lane, K.B. A single intrapleural injection of transforming growth factor ?2 produces an excellent pleurodesis in rats. Am J Respir Crit Care Med., 162, 98-104, 2000

Ma, L J, Nakamura, S, Whitsitt, J S, Marcantoni, C, Davidson, J M, Fogo, A B. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int, 58(6), 2425-36, 2000

Ma, L.-J., Nakamura, S., Whitsitt, J.S., Marcantoni, C., Davidson, J.M., Fogo, A.B. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int., 56, 2425-2436, 2000

Nanney, L B, Paulsen, S, Davidson, M K, Cardwell, N L, Whitsitt, J S, Davidson, J M. Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen, 8(2), 117-27, 2000

Nanney, L.B., Paulsen, S., Davidson, M.K., Cardwell, N.L., Whitsitt, J.S., Davidson, J.M. Boosting EGF receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Rep. Reg, 8, 117-127, 2000

Davidson, J M, Aquino, A M, Woodward, S C, Wilfinger, W W. Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. FASEB J, 13(2), 325-9, 1999

Davidson, J M, Whitsitt, J S, Pennington, B, Ballas, C B, Eming, S, Benn, S I. Gene therapy of wounds with growth factors. Curr Top Pathol, 93, 111-21, 1999

Davidson, J.M., Aquino, A.M., Woodward, S.C., Wilfinger, W.W. Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. FASEB J, 13, 325-329, 1999

Eming, S.A., Whitsitt, J.S., He, L., Krieg, T., Morgan, J.R., Davidson, J.M. Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J. Invest. Dermatol, 112, 297-302, 1999

Garrard, C L, Clements, R H, Nanney, L, Davidson, J M, Richards, W O. Adhesion formation is reduced after laparoscopic surgery. Surg Endosc, 13(1), 10-3, 1999

Hoff, C R, Perkins, D R, Davidson, J M. Elastin gene expression is upregulated during pulmonary fibrosis. Connect Tissue Res, 40(2), 145-53, 1999

Hoff, C.R. and Davidson, J.M. Elastin expression in murine pulmonary fibrosis. Connect. Tiss. Res, 40, 145-153, 1999

Zhang, M C, He, L, Giro, M, Yong, S L, Tiller, G E, Davidson, J M. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). J Biol Chem, 274(2), 981-6, 1999

Zhang, M.C., He L., Giro M, Yong S-L, Tiller G.E., and Davidson J.M . Cutis laxa arising from frame shift mutations in the elastin gene (ELN). J. Biol. Chem, 274, 981-986, 1999

Bryant, G L, Davidson, J M, Ossoff, R H, Garrett, C G, Reinisch, L. Histologic study of oral mucosa wound healing: a comparison of a 6.0- to 6.8-micrometer pulsed laser and a carbon dioxide laser. Laryngoscope, 108(1 Pt 1), 13-7, 1998

Bryant, G.L., Davidson, J.M., Ossoff, R.H., Garrett, G. and Reinisch, L. Histologic study of oral mucosa wound healing: A comparison of a 6.0- to 6.8-?m pulsed laser and a carbon dioxide laser. Laryngoscope, 108, 13-17, 1998

Davidson, J M. Animal models for wound repair. Arch Dermatol Res, 290 Suppl, S1-11, 1998

Davidson, J M. Wound repair. J Hand Ther, 11(2), 80-94, 1998

Davidson, J.M. Animal models for wound repair. Arch. Dermatol Res, 290, S1-S11, 1998

Liaw, L, Birk, D E, Ballas, C B, Whitsitt, J S, Davidson, J M, Hogan, B L. Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest, 101(7), 1468-78, 1998 PMCID:508725

Liaw, L., Birk, D.E., Whitsitt, J.S., Ballas, C.B., Davidson, J.M., Hogan, B.L.M. Altered wound healing in mice lacking a functional osteopontin gene (spp1). J. Clin. Invest., 101, 1468-1478, 1998

Davidson, J M, LuValle, P A, Zoia, O, Quaglino, D, Giro, M. Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. J Biol Chem, 272(1), 345-52, 1997

Davidson, J.M., Broadley, K.N., Quaglino Jr., D. Reversal of the wound healing deficit in diabetic rats by combined basic fibroblast growth factor and transforming growth factor-? therapy. Wound Rep. Regen, 5, 77-88, 1997

Davidson, J.M., LuValle, P.A., Zoia, O., Quaglino, Jr., D., Giro, M.G. Ascorbate down regulates collagen and elastin biosynthesis in vascular smooth muscle cells and skin fibroblasts by a pretranslational mechanism. J. Biol. Chem, 272, 345-352, 1997

Benn, S I, Whitsitt, J S, Broadley, K N, Nanney, L B, Perkins, D, He, L, Patel, M, Morgan, J R, Swain, W F, Davidson, J M. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. J Clin Invest, 98(12), 2894-902, 1996 PMCID:507757

Benn, S.I., Whitsitt, J.S., Broadley, K.N., He, L.,Nanney, L.B., Perkins, D, Patel, M., Swain, W.F.,Davidson, J.M. Particle mediated gene transfer with TGF-?1 cDNAs enhances wound repair in rat skin. J. Clin. Invest., 98(12), 2894-2902, 1996

Charous, S.J., Ossoff, R.H., Davidson, J.M. Canine subglottic stenosis as a model for hypertrophic scarring: histological and immunochemical analysis. Wound Repair Regen, 4, 444-453, 1996

Charous, SJ, Ossoff, RH, Reinisch, L, Davidson, JM. Canine subglottic stenosis as a model for excessive fibrosis: a pilot histologic and immunohistochemical analysis. Wound Repair Regen, 4(4), 444-53, 1996

Clymer, M A, Schwaber, M K, Davidson, J M. The effects of keratinocyte growth factor on healing of tympanic membrane perforations. Laryngoscope, 106(3 Pt 1), 280-5, 1996

Clymer, M., Reinisch, L., Ossoff, R., Davidson, J.M. Effects of keratinocyte growth factor on healing of tympanic membrane perforations. Laryngoscope, 106, 280-285, 1996

McCarthy, M.J., Davidson, J.M., Cardone, J.S., Anderson, L.L. Cutis laxa aquisita associated with multiple myeloma: A case report and review of the literature. Cutis, 57(4), 267-270, 1996

Speyer, M, Joe, J, Davidson, J M, Ossoff, R H, Reinisch, L. Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions. Laryngoscope, 106(7), 845-50, 1996

Speyer, M., Joe, J., Davidson, J.M., Ossoff, R.H., Reinisch, L. Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions . Laryngoscope, 106, 845-850, 1996

Spindler, K P, Clark, S W, Nanney, L B, Davidson, J M. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J Orthop Res, 14(6), 857-61, 1996

Spindler, K P, Imro, A K, Mayes, C E, Davidson, J M. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta. J Orthop Res, 14(4), 542-6, 1996

Spindler, K.P., Clark, S.W., Nanney, L.B., Davidson, J.M. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J. Orth. Res., 14, 857-861, 1996

Spindler, K.P., Imro, A.K., Mayes, C.E., Davidson, J.M. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor ?. J. Orth. Res., 14, 542-6, 1996

Broadley, C, Broadley, KN, Disimone, G, Riensch, L, Davidson, JM. Low-energy helium-neon laser irradiation and the tensile strength of incisional wounds in the rat. Wound Repair Regen, 3(4), 512-7, 1995

Broadley, C, Gonzalez, D A, Nair, R, Koriwchak, M J, Ossoff, R H, Davidson, J M. A tissue-culture model for the study of canine vocal fold fibroblasts. Laryngoscope, 105(1), 23-7, 1995

Davidson, J M, Zang, M C, Zoia, O, Giro, M G. Regulation of elastin synthesis in pathological states. Ciba Found Symp, 192, 81-94; discussion 94-9, 1995

Gossage, J R, Perkett, E A, Davidson, J M, Starcher, B C, Carmichael, D, Brigham, K L, Meyrick, B. Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep. J Appl Physiol, 79(4), 1163-72, 1995

Spindler, K P, Mayes, C E, Miller, R R, Imro, A K, Davidson, J M. Regional mitogenic response of the meniscus to platelet-derived growth factor (PDGF-AB). J Orthop Res, 13(2), 201-7, 1995

Spindler, KP, Nanney, LB, Davidson, JM. Proliferative responses to platelet-derived growth factor in young and old rat patellar tendon. Connect Tissue Res, 31(2), 171-7, 1995

TGF-? reverses a post-transcriptional defect of elastin synthesis in two cutis laxa skin fibroblast strains. Zhang, M.C., Giro, M.G., Quaglino, D., Jr., Davidson, J.M. J. Clin. Invest, 95, 986-994, 1995

Zhang, M C, Giro, M, Quaglino, D, Davidson, J M. Transforming growth factor-beta reverses a posttranscriptional defect in elastin synthesis in a cutis laxa skin fibroblast strain. J Clin Invest, 95(3), 986-94, 1995 PMCID:441431

Tissue ablation by a free-electron laser tuned to the amide II band. Edwards, G., Logan, R., Copeland, M., Reinisch, L., Davidson, J.M., Johnson, B., Maciunas, R., Mendenhall, M., Ossoff, R., Tribble, J., Werkhaven, J., O'Day, D. Nature, 371, 416-419, 1994

Vrabec, J T, Schwaber, M K, Davidson, J M, Clymer, M A. Evaluation of basic fibroblast growth factor in tympanic membrane repair. Laryngoscope, 104(9), 1059-64, 1994

Giro, M, Davidson, J M. Familial co-segregation of the elastin phenotype in skin fibroblasts from Hutchinson-Gilford progeria. Mech Ageing Dev, 70(3), 163-36, 1993

Gossage, J R, Kuratomi, Y, Davidson, J M, Lefferts, P L, Snapper, J R. Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. Am Rev Respir Dis, 147(6 Pt 1), 1371-9, 1993

Kyzer, M D, Aly, A S, Davidson, J M, Reinisch, L, Ossoff, R H. Sub ablation effects of the KTP laser on wound healing. Lasers Surg Med, 13(1), 62-71, 1993

Giro, M G, Duvic, M, Smith, L T, Kennedy, R, Rapini, R, Arnett, F C, Davidson, J M. Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. J Invest Dermatol, 99(2), 129-37, 1992

Lane, K B, Zoia, O, Davidson, J M. Semidry electrophoretic transfer of RNA to membranes. Biotechniques, 12(3), 340-2, 346, 1992

Schriver, E E, Davidson, J M, Sutcliffe, M C, Swindell, B B, Bernard, G R. Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease. Am Rev Respir Dis, 145(4 Pt 1), 762-6, 1992

Davidson, J M, Broadley, K N. Manipulation of the wound-healing process with basic fibroblast growth factor. Ann N Y Acad Sci, 638, 306-15, 1991

Davidson, J M, Nanney, L B, Broadley, K N, Whitsett, J S, Aquino, A M, Beccaro, M, Rastrelli, A. Hyaluronate derivatives and their application to wound healing: preliminary observations. Clin Mater, 8(1-2), 171-7, 1991

Fava, R A, Olsen, N J, Postlethwaite, A E, Broadley, K N, Davidson, J M, Nanney, L B, Lucas, C, Townes, A S. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. J Exp Med, 173(5), 1121-32, 1991 PMCID:2118851

Henderson, G S, Conary, J T, Davidson, J M, Stewart, S J, House, F S, McCurley, T L. A reliable method for northern blot analysis using synthetic oligonucleotide probes. Biotechniques, 10(2), 190-7, 1991

Perkett, E A, Davidson, J M, Meyrick, B. Sequence of structural changes and elastin peptide release during vascular remodelling in sheep with chronic pulmonary hypertension induced by air embolization. Am J Pathol, 139(6), 1319-32, 1991 PMCID:1886467

Quaglino, D, Nanney, L B, Ditesheim, J A, Davidson, J M. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: incisional wound model. J Invest Dermatol, 97(1), 34-42, 1991

Davidson, J M. Biochemistry and turnover of lung interstitium. Eur Respir J, 3(9), 1048-63, 1990

Garcia, F U, Wojta, J, Broadley, K N, Davidson, J M, Hoover, R L. Bartonella bacilliformis stimulates endothelial cells in vitro and is angiogenic in vivo. Am J Pathol, 136(5), 1125-35, 1990 PMCID:1877437

Quaglino, D, Nanney, L B, Kennedy, R, Davidson, J M. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model. Lab Invest, 63(3), 307-19, 1990

Broadley, K N, Aquino, A M, Hicks, B, Ditesheim, J A, McGee, G S, Demetriou, A A, Woodward, S C, Davidson, J M. The diabetic rat as an impaired wound healing model: stimulatory effects of transforming growth factor-beta and basic fibroblast growth factor. Biotechnol Ther, 1(1), 55-68, 1989

Broadley, K N, Aquino, A M, Woodward, S C, Buckley-Sturrock, A, Sato, Y, Rifkin, D B, Davidson, J M. Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab Invest, 61(5), 571-5, 1989

Buckley-Sturrock, A, Woodward, S C, Senior, R M, Griffin, G L, Klagsbrun, M, Davidson, J M. Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors. J Cell Physiol, 138(1), 70-8, 1989

Broadley, K N, Aquino, A M, Hicks, B, Ditesheim, J A, McGee, G S, Demetriou, A A, Woodward, S C, Davidson, J M. Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats. Int J Tissue React, 10(6), 345-53, 1988

Liu, J M, Davidson, J M. The elastogenic effect of recombinant transforming growth factor-beta on porcine aortic smooth muscle cells. Biochem Biophys Res Commun, 154(3), 895-901, 1988

McGee, G S, Davidson, J M, Buckley, A, Sommer, A, Woodward, S C, Aquino, A M, Barbour, R, Demetriou, A A. Recombinant basic fibroblast growth factor accelerates wound healing. J Surg Res, 45(1), 145-53, 1988

Sephel, G C, Sturrock, A, Giro, M G, Davidson, J M. Increased elastin production by progeria skin fibroblasts is controlled by the steady-state levels of elastin mRNA. J Invest Dermatol, 90(5), 643-7, 1988

Buckley, A, Davidson, J M, Kamerath, C D, Woodward, S C. Epidermal growth factor increases granulation tissue formation dose dependently. J Surg Res, 43(4), 322-8, 1987


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
01/06/2012