Biomedical Research Education & Training
Faculty Member

Dermody, Terence S., M.D.
Director, Medical Scientist Training Program
Director, Pediatric Infectious Diseases
Professor of Pediatrics
Professor of Pathology, Microbiology and Immunology
Dorothy Overall Wells Chair in Pediatrics

Lab Url: N/A

Phone Number: 615-343-9943

Email Address: terry.dermody@vanderbilt.edu

Dermody, Terence's picture
Academic history
B.S., Cornell University, Ithaca, NY
M.D., Columbia University, New York, NY
Residency, Presbyterian Hospital, New York, NY
Fellowship, Brigham and Women's Hospital, Boston MA
Fellowship, Harvard Medical School, Boston, MA

Office Address   Mailing Address

D-6227-A Medical Center North

D-6227 MCN Lamb Center for Pediatric Research 2581


Research Keywords
Apoptosis, Biochemistry, Genetics, Immunology, Infectious Disease, Microbiology, Mouse, Receptors, Reovirus, Viral Pathogenesis, Virology

Patient Care Specialty
Pediatric Infectious Diseases

Research Specialty
Viral pathogenesis and vaccine development

Research Description
Our lab studies the molecular pathogenesis of mammalian reovirus and Chikungunya virus infections. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, but disease is restricted to the very young. Chikungunya virus is an emerging arthropod-borne alphavirus that causes epidemics of febrile arthritis in humans. Research in my laboratory encompasses several interrelated themes to better understand viral and cellular mediators of disease. These include the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. We also are developing viral vectors for oncolytic and vaccine applications.

(1) Reovirus receptors and pathogenesis. Following peroral inoculation of newborn mice, reovirus disseminates systemically to target the heart, liver, and central nervous system. The reovirus attachment protein, sigma 1, plays a key role in target cell selection in the infected host. We are conducting experiments to investigate the role of reovirus receptors, sialic acid and junctional adhesion molecule A (JAM-A), in reovirus dissemination and tropism. These studies employ polarized cells and mice lacking reovirus receptors. This work will be interpreted in the context of ongoing structural studies of sigma 1 in complex with its receptors with the goal of determining how sigma 1 structure relates to its function in receptor binding. Additional research focuses on the identification of receptors in host tissues that do not require JAM-A for productive infection.

(2) Reovirus entry into cells. Reovirus enters cells by clathrin-dependent endocytosis and undergoes proteolytic disassembly in endosomes. Studies are in progress to define mechanisms of reovirus uptake and transport within the endocytic pathway. Viral disassembly in most cell types is catalyzed by cathepsins B, L, or S. We are using molecular genetics, biochemical analyses, and electron cryomicroscopy to study domains in reovirus outer-capsid proteins that regulate proteolytic cleavage. A final series of experiments seeks to define mechanisms underlying the roles of individual cathepsins in reovirus disease. This research will reveal fundamental mechanisms by which viral and cellular factors cooperate to facilitate viral entry and illuminate new targets for therapy against viruses that use the endocytic pathway to enter cells.

(3) Reovirus-induced apoptosis. Reovirus induces apoptosis in cultured cells and in the murine central nervous system and heart. Our studies indicate that apoptosis is triggered by innate immune response signal transducers initiated by the viral mu 1 protein following reovirus disassembly and penetration of endosomal membranes. Experiments are in progress to identify components of the cell-signaling apparatus required for apoptosis induction by reovirus and to determine the relationship between apoptosis and virulence. These studies will establish new ideas about how RNA-containing viruses interact with innate immune response signaling circuits and lead to a better understanding of how viruses injure their host cells.

(4) Chikungunya virus (CHIKV) attachment and cell entry. CHIKV has produced explosive outbreaks in East Africa, several islands in the Indian Ocean, India, and Southeast Asia. We have found that attenuated CHIKV vaccine strain 181/25 engages heparan sulfate proteoglycans to initiate infection. Ongoing work is focused on identification of host cell proteins that contribute to CHIKV attachment and internalization and definition of CHIKV virulence determinants. This research will fill major gaps in an understanding of CHIKV pathogenesis and illuminate new targets for antiviral therapies and vaccines.

Publications
Boehme, KW, Lai, CM, Dermody, TS. Mechanisms of reovirus bloodstream dissemination. Adv Virus Res, 87, 1-35, 2013

Lai, CM, Mainou, BA, Kim, KS, Dermody, TS. Directional release of reovirus from the apical surface of polarized endothelial cells. MBio, 4(2), e00049-13, 2013

Bokiej, M, Ogden, KM, Ikizler, M, Reiter, DM, Stehle, T, Dermody, TS. Optimum length and flexibility of reovirus attachment protein ??1 are required for efficient viral infection. J Virol, 86(19), 10270-80, 2012

Doyle, JD, Danthi, P, Kendall, EA, Ooms, LS, Wetzel, JD, Dermody, TS. Molecular determinants of proteolytic disassembly of the reovirus outer capsid. J Biol Chem, 287(11), 8029-38, 2012

Frierson, JM, Pruijssers, AJ, Konopka, JL, Reiter, DM, Abel, TW, Stehle, T, Dermody, TS. Utilization of sialylated glycans as coreceptors enhances the neurovirulence of serotype 3 reovirus. J Virol, 86(24), 13164-73, 2012

Iskarpatyoti, JA, Morse, EA, McClung, RP, Ikizler, M, Wetzel, JD, Contractor, N, Dermody, TS. Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein sigma1. Virology, 433(2), 489-97, 2012

Mainou, BA, Dermody, TS. Transport to late endosomes is required for efficient reovirus infection. J Virol, 86(16), 8346-58, 2012

Ooms, LS, Jerome, WG, Dermody, TS, Chappell, JD. Reovirus replication protein mu2 influences cell tropism by promoting particle assembly within viral inclusions. J Virol, 86(20), 10979-87, 2012

Boehme, KW, Frierson, JM, Konopka, JL, Kobayashi, T, Dermody, TS. The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. J Virol, 85(22), 11781-90, 2011 PMCID:3209282

Boehme, KW, Ikizler, M, Kobayashi, T, Dermody, TS. Reverse genetics for mammalian reovirus. Methods, 55(2), 109-13, 2011 PMCID:3154680

Mainou, BA, Dermody, TS. Src kinase mediates productive endocytic sorting of reovirus during cell entry. J Virol, 85(7), 3203-13, 2011

Danthi, P, Guglielmi, KM, Kirchner, E, Mainou, B, Stehle, T, Dermody, TS. From touchdown to transcription: the reovirus cell entry pathway. Curr Top Microbiol Immunol, 343, 91-119, 2010 PMCID:2898218

Danthi, P, Pruijssers, AJ, Berger, AK, Holm, GH, Zinkel, SS, Dermody, TS. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog, 6, e1000980, 2010 PMCID:2895667

Holm, GH, Pruijssers, AJ, Li, L, Danthi, P, Sherry, B, Dermody, TS. Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. J Virol, 84(14), 6900-8, 2010

Kobayashi, T, Ooms, LS, Ikizler, M, Chappell, JD, Dermody, TS. An improved reverse genetics system for mammalian orthoreoviruses. Virology, 398(2), 194-200, 2010

Ooms, LS, Kobayashi, T, Dermody, TS, Chappell, JD. A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism. J Biol Chem, 285(53), 41604-13, 2010

Trask, SD, Taraporewala, ZF, Boehme, KW, Dermody, TS, Patton, JT. Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Proc Natl Acad Sci U S A, 107(43), 18652-7, 2010 PMCID:2972929

Antar, AA, Konopka, JL, Campbell, JA, Henry, RA, Perdigoto, AL, Carter, BD, Pozzi, A, Abel, TW, Dermody, TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe, 5(1), 59-71, 2009 PMCID:2642927

Boehme, KW, Guglielmi, KM, Dermody, TS. Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Proc Natl Acad Sci U S A, 106(47), 19986-91, 2009 PMCID:2774258

Cseke, G, Maginnis, MS, Cox, RG, Tollefson, SJ, Podsiad, AB, Wright, DW, Dermody, TS, Williams, JV. Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc Natl Acad Sci U S A, 106(5), 1566-71, 2009 PMCID:2629439

Dermody, TS, Kirchner, E, Guglielmi, KM, Stehle, T. Immunoglobulin superfamily virus receptors and the evolution of adaptive immunity. PLoS Pathog, 5(11), e1000481, 2009 PMCID:2777377

Johnson, EM, Doyle, JD, Wetzel, JD, McClung, RP, Katunuma, N, Chappell, JD, Washington, MK, Dermody, TS. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol, 83(19), 9630-40, 2009 PMCID:2748054

Kobayashi, T, Ooms, LS, Chappell, JD, Dermody, TS. Identification of functional domains in reovirus replication proteins muNS and mu2. J Virol, 83(7), 2892-906, 2009 PMCID:2655549

Zurney, J, Kobayashi, T, Holm, GH, Dermody, TS, Sherry, B. Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9. J Virol, 83(5), 2178-87, 2009 PMCID:2643726

Danthi, P, Coffey, CM, Parker, JS, Abel, TW, Dermody, TS. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain. PLoS Pathog, 4(12), e1000248, 2008 PMCID:2600812

Danthi, P, Kobayashi, T, Holm, GH, Hansberger, MW, Abel, TW, Dermody, TS. Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. J Virol, 82(1), 161-72, 2008 PMCID:2224352

Excoffon, KJ, Guglielmi, KM, Wetzel, JD, Gansemer, ND, Campbell, JA, Dermody, TS, Zabner, J. Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. J Infect Dis, 197(8), 1189-97, 2008 PMCID:2736797

Kirchner, E, Guglielmi, KM, Strauss, HM, Dermody, TS, Stehle, T. Structure of reovirus sigma1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog, 4(12), e1000235, 2008 PMCID:2588538

Maginnis, MS, Mainou, BA, Derdowski, A, Johnson, EM, Zent, R, Dermody, TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol, 82(7), 3181-91, 2008 PMCID:2268482

Guglielmi, KM, Kirchner, E, Holm, GH, Stehle, T, Dermody, TS. Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem, 282(24), 17930-40, 2007

Hansberger, MW, Campbell, JA, Danthi, P, Arrate, P, Pennington, KN, Marcu, KB, Ballard, DW, Dermody, TS. I{kappa}B kinase subunits {alpha} and {gamma} are required for activation of NF-{kappa}B and induction of apoptosis by mammalian reovirus. J Virol, 81(3), 1360-71, 2007 PMCID:1797491

Holm, GH, Zurney, J, Tumilasci, V, Leveille, S, Danthi, P, Hiscott, J, Sherry, B, Dermody, TS. RIG-I and IPS-1 augment proapoptotic responses following mammalian reovirus infection via IRF-3. J Biol Chem, 282(30), 21953-61, 2007

Johansson, C, Wetzel, JD, He, J, Mikacenic, C, Dermody, TS, Kelsall, BL. Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. J Exp Med, 204(6), 1349-58, 2007 PMCID:2118611

Kobayashi, T, Antar, AA, Boehme, KW, Danthi, P, Eby, EA, Guglielmi, KM, Holm, GH, Johnson, EM, Maginnis, MS, Naik, S, Skelton, WB, Wetzel, JD, Wilson, GJ, Chappell, JD, Dermody, TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe, 1(2), 147-57, 2007 PMCID:2034303

Laukoetter, MG, Nava, P, Lee, WY, Severson, EA, Capaldo, CT, Babbin, BA, Williams, IR, Koval, M, Peatman, E, Campbell, JA, Dermody, TS, Nusrat, A, Parkos, CA. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med, 204(13), 3067-76, 2007 PMCID:2150975

Schelling, P, Guglielmi, KM, Kirchner, E, Paetzold, B, Dermody, TS, Stehle, T. The reovirus sigma 1 aspartic acid sandwich: A trimerization motif poised for conformational change. J Biol Chem, 282(15), 17930-40, 2007

Clark, KM, Wetzel, JD, Gu, Y, Ebert, DH, McAbee, SA, Stoneman, EK, Baer, GS, Zhu, Y, Wilson, GJ, Prasad, BV, Dermody, TS. Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3. J Virol, 80(2), 671-81, 2006 PMCID:1346852

Danthi, P, Hansberger, MW, Campbell, JA, Forrest, JC, Dermody, TS. JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. J Virol, 80(3), 1261-70, 2006 PMCID:1346953

Guglielmi, KM, Johnson, EM, Stehle, T, Dermody, TS. Attachment and cell entry of mammalian orthoreovirus. Curr Top Microbiol Immunol, 309, 1-38, 2006

Huang, IC, Bosch, BJ, Li, F, Li, W, Lee, KH, Ghiran, S, Vasilieva, N, Dermody, TS, Harrison, SC, Dormitzer, PR, Farzan, M, Rottier, PJ, Choe, H. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem, 281(6), 3198-203, 2006

Kobayashi, T, Chappell, JD, Danthi, P, Dermody, TS. Gene-specific inhibition of reovirus replication by RNA interference. J Virol, 80(18), 9053-63, 2006 PMCID:1563907

Maginnis, MS, Forrest, JC, Kopecky-Bromberg, SA, Dickeson, SK, Santoro, SA, Zutter, MM, Nemerow, GR, Bergelson, JM, Dermody, TS. Beta 1 Integrin Mediates Internalization of Mammalian Reovirus. J Virol, 80(6), 2760-70, 2006 PMCID:1395463

ODonnell, SM, Holm, GH, Pierce, JM, Tian, B, Watson, MJ, Chari, RS, Ballard, DW, Brasier, AR, Dermody, TS. Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J Virol, 80(3), 1077-86, 2006 PMCID:1346919

Wetzel, JD, Barton, ES, Chappell, JD, Baer, GS, Mochow-Grundy, M, Rodgers, SE, Shyr, Y, Powers, AC, Thomas, JW, Dermody, TS. Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. J Virol, 80(6), 3078-82, 2006 PMCID:1395416

Campbell, JA, Schelling, P, Wetzel, JD, Johnson, EM, Wilson, GAR, Forrest, JC, Aurrand-Lions, M, Imhof, BA, Stehle, T, Dermody, TS. Junctional adhesion molecule A serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J Virol, 79(13), 7967-78, 2005 PMCID:1143703

Dong, X, Li, H, Derdowski, A, Ding, L, Burnett, A, Chen, X, Peters, TR, Dermody, TS, Woodruff, E, Wang, JJ, Spearman, P. AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell, 120(5), 663-74, 2005

O'Donnell, SM, Connolly, JL, Hansberger, MW, Chappell, JD, Watson, MJ, Han, W, Barton, ES, Forrest, Valyi-Nagy, T, JC, Pierce, JM, Yull, FE, Blackwell, TS, Rottman, JN, Sherry, B, Dermody, TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest, 115(9), 2341-50, 2005 PMCID:1184036

Tai, JH, Williams, JV, Edwards, KM, Wright, PF, Crowe, JE, Dermody, TS. Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. J Infect Dis, 191(8), 1221-4, 2005

Valyi-Nagy, T, Dermody, TS. Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol Histopathol, 20(3), 957-67, 2005

Ebert, D H, Kopecky-Bromberg, S A, Dermody, T S. Cathepsin B is inhibited in mutant cells selected during persistent reovirus infection. J Biol Chem, 279(5), 3837-51, 2004

Fleeton, M N, Contractor, N, Leon, F, Wetzel, J D, Dermody, T S, Kelsall, B L. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J Exp Med, 200(2), 235-45, 2004 PMCID:2212021

Mercier, G T, Campbell, J A, Chappell, J D, Stehle, T, Dermody, T S, Barry, M A. A chimeric adenovirus vector encoding reovirus attachment protein sigma 1 targets cells expressing junctional adhesion molecule 1. Proc Natl Acad Sci U S A, 101(16), 6188-93, 2004 PMCID:395944

Stehle, T, Dermody, T S. Structural similarities in the cellular receptors used by adenovirus and reovirus. Viral Immunol, 17(2), 129-43, 2004

Tyler, K L, Barton, E S, Ibach, M L, Robinson, C, Campbell, J A, O'Donnell, S M, Valyi-Nagy, T, Clarke, P, Wetzel, J D, Dermody, T S. Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis, 189(9), 1664-75, 2004

Barton, E S, Youree, B E, Ebert, D H, Forrest, J C, Connolly, J L, Valyi-Nagy, T, Washington, K, Wetzel, J D, Dermody, T S. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J Clin Invest, 111(12), 1823-33, 2003 PMCID:161418

Becker, M M, Peters, T R, Dermody, T S. Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection. J Virol, 77(10), 5948-63, 2003 PMCID:154006

Forrest, J C, Campbell, J A, Schelling, P, Stehle, T, Dermody, T S. Structure-function analysis of reovirus binding to junctional adhesion molecule 1: Implications for the mechanism of reovirus attachment. J Biol Chem, 278(48), 48434-44, 2003

Forrest, J C, Dermody, T S. Reovirus receptors and pathogenesis. J Virol, 77(17), 9109-15, 2003 PMCID:187431

Prota, A E, Campbell, J A, Schelling, P, Forrest, J C, Watson, M J, Peters, T R, Aurrand-Lions, M, Imhof, B A, Dermody, T S, Stehle, T. Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding. Proc Natl Acad Sci U S A, 100(9), 5366-71, 2003 PMCID:404559

Stehle, T, Dermody, T S. Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins. Rev Med Virol, 13(2), 123-32, 2003

Stewart, Phoebe L, Dermody, Terence S, Nemerow, Glen R. Structural basis of nonenveloped virus cell entry. Adv Protein Chem, 64, 455-91, 2003

Chappell, J D, Prota, A E, Dermody, T S, Stehle, T. Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J, 21(1-2), 1-11, 2002 PMCID:125343

Connolly, J L, Dermody, T S. Virion disassembly is required for apoptosis induced by reovirus. J Virol, 76(4), 1632-41, 2002 PMCID:135877

Ebert, D H, Deussing, J, Peters, C, Dermody, T S. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem, 277(27), 24609-17, 2002

Leary, T P, Erker, J C, Chalmers, M L, Cruz, A T, Wetzel, J D, Desai, S M, Mushahwar, I K, Dermody, T S. Detection of mammalian reovirus RNA by using reverse transcription-PCR: Sequence diversity within the lambda3-encoding L1 gene. J Clin Microbiol, 40(4), 1368-75, 2002 PMCID:140344

Milatovic, Dejan, Zhang, Yueli, Olson, Sandra J, Montine, Kathleen S, Roberts, L Jackson, Morrow, Jason D, Montine, Thomas J, Dermody, Terence S, Valyi-Nagy, Tibor. Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes. J Neurovirol, 8(4), 295-305, 2002

Wilson, G J, Nason, E L, Hardy, C S, Ebert, D H, Wetzel, J D, Prasad, B V, Dermody, T S. A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure. J Virol, 76(19), 9832-43, 2002 PMCID:136532

Barton, E S, Connolly, J L, Forrest, J C, Chappell, J D, Dermody, T S. Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J Biol Chem, 276, 2200-11, 2001

Barton, E S, Forrest, J C, Connolly, J L, Chappell, J D, Liu, Y, Schnell, F J, Nusrat, A, Parkos, C A, Dermody, T S. Junction adhesion molecule is a receptor for reovirus. Cell, 104, 441-51, 2001

Becker, M M, Goral, M I, Hazelton, P R, Baer, G S, Rodgers, S E, Brown, E G, Coombs, K M, Dermody, T S. Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions. J Virol, 75, 1459-75, 2001 PMCID:114052

Chandran, K, Zhang, X, Olson, N H, Walker, S B, Chappell, J D, Dermody, T S, Baker, T S, Nibert, M L. Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J Virol, 75, 5335-42, 2001 PMCID:114938

Connolly, J L, Barton, E S, Dermody, T S. Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis. J Virol, 75, 4029-39, 2001 PMCID:114148

Ebert, D H, Wetzel, J D, Brumbaugh, D E, Chance, S R, Stobie, L E, Baer, G S, Dermody, T S. Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. J Virol, 75, 3197-206, 2001 PMCID:114113

Mochow-Grundy, M, Dermody, T S. The reovirus S4 gene 3' nontranslated region contains a translational operator sequence. J Virol, 75(14), 6517-26, 2001 PMCID:114375

Nason, E L, Wetzel, J D, Mukherjee, S K, Barton, E S, Prasad, B V, Dermody, T S. A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance. J Virol, 75, 6625-34, 2001 PMCID:114386

Poggioli, G J, Dermody, T S, Tyler, K L. Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2). J Virol, 75, 7429-34, 2001 PMCID:114978

Chappell, J D, Duong, J L, Wright, B W, Dermody, T S. Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. J Virol, 74, 8472-9, 2000 PMCID:116358

Connolly, J L, Rodgers, S E, Clarke, P, Ballard, D W, Kerr, L D, Tyler, K L, Dermody, T S. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J Virol, 74, 2981-9, 2000 PMCID:111796

Mbisa, J L, Becker, M M, Zou, S, Dermody, T S, Brown, E G. Reovirus mu2 protein determines strain-specific differences in the rate of viral inclusion formation in L929 cells. Virology, 272(1), 16-26, 2000

Poggioli, G J, Keefer, C, Connolly, J L, Dermody, T S, Tyler, K L. Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis. J Virol, 74, 9562-70, 2000 PMCID:112387

Valyi-Nagy, T, Olson, S J, Valyi-Nagy, K, Montine, T J, Dermody, T S. Herpes simplex virus type 1 latency in the murine nervous system is associated with oxidative damage to neurons. Virology, 278, 309-21, 2000

Baer, G S, Ebert, D H, Chung, C J, Erickson, A H, Dermody, T S. Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly. J Virol, 73, 9532-43, 1999 PMCID:112988

Valyi-Nagy, T, Sidell, K R, Marnett, L J, Roberts, L J, Dermody, T S, Morrow, J D, Montine, T J. Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. J Neuropathol Exp Neurol, 58(12), 1269-75, 1999

Chappell, J D, Barton, E S, Smith, T H, Baer, G S, Duong, D T, Nibert, M L, Dermody, T S. Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck. J Virol, 72, 8205-13, 1998 PMCID:110170

Rodgers, S E, Connolly, J L, Chappell, J D, Dermody, T S. Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant. J Virol, 72, 8597-604, 1998 PMCID:110270

Baer, G S, Dermody, T S. Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. J Virol, 71, 4921-8, 1997 PMCID:191722

Chappell, J D, Gunn, V L, Wetzel, J D, Baer, G S, Dermody, T S. Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1. J Virol, 71, 1834-41, 1997 PMCID:191253

Oberhaus, S M, Smith, R L, Clayton, G H, Dermody, T S, Tyler, K L. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol, 71, 2100-6, 1997 PMCID:191302

Rodgers, S E, Barton, E S, Oberhaus, S M, Pike, B, Gibson, C A, Tyler, K L, Dermody, T S. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol, 71, 2540-6, 1997 PMCID:191370

Wetzel, J D, Chappell, J D, Fogo, A B, Dermody, T S. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J Virol, 71, 299-306, 1997 PMCID:191051

Wetzel, J D, Wilson, G J, Baer, G S, Dunnigan, L R, Wright, J P, Tang, D S, Dermody, T S. Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. J Virol, 71, 1362-9, 1997 PMCID:191191

Goral, M I, Mochow-Grundy, M, Dermody, T S. Sequence diversity within the reovirus S3 gene: Reoviruses evolve independently of host species, geographic locale, and date of isolation. Virology, 216(1), 265-71, 1996

Tyler, K L, Squier, M K, Brown, A L, Pike, B, Willis, D, Oberhaus, S M, Dermody, T S, Cohen, J J. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol, 70(11), 7984-91, 1996 PMCID:190871

Wilson, G J, Wetzel, J D, Puryear, W, Bassel-Duby, R, Dermody, T S. Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability. J Virol, 70, 6598-606, 1996 PMCID:190700

Haller, B L, Barkon, M L, Li, X Y, Hu, W M, Wetzel, J D, Dermody, T S, Virgin, H W. Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice. J Virol, 69(6), 3933-7, 1995 PMCID:189121

Nibert, M L, Chappell, J D, Dermody, T S. Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. J Virol, 69(8), 5057-67, 1995 PMCID:189323

Tyler, K L, Squier, M K, Rodgers, S E, Schneider, B E, Oberhaus, S M, Grdina, T A, Cohen, J J, Dermody, T S. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1. J Virol, 69, 6972-9, 1995 PMCID:189616

Chapell, J D, Goral, M I, Rodgers, S E, dePamphilis, C W, Dermody, T S. Sequence diversity within the reovirus S2 gene: Reovirus genes reassort in nature, and their termini are predicted to form a panhandle motif. J Virol, 68(2), 750-6, 1994 PMCID:236511

Dermody, T S, Nibert, M L, Wetzel, J D, Tong, X, Fields, B N. Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J Virol, 67, 2055-63, 1993 PMCID:240279

Morrison, L A, Fields, B N, Dermody, T S. Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures. J Virol, 67(6), 3019-26, 1993 PMCID:237638

Rubin, D H, Wetzel, J D, Williams, W V, Cohen, J A, Dworkin, C, Dermody, T S. Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells. J Clin Invest, 90(6), 2536-42, 1992 PMCID:443412

Dermody, T S, Schiff, L A, Nibert, M L, Coombs, K M, Fields, B N. The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: Characterization of reovirus core protein sigma 2. J Virol, 65(11), 5721-31, 1991 PMCID:250232

Dermody, T S, Nibert, M L, Bassel-Duby, R, Fields, B N. Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. J Virol, 64(10), 4842-50, 1990 PMCID:247973

Dermody, T S, Nibert, M L, Bassel-Duby, R, Fields, B N. A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. J Virol, 64(10), 5173-6, 1990 PMCID:248012

Nibert, M L, Dermody, T S, Fields, B N. Structure of the reovirus cell-attachment protein: A model for the domain organization of sigma 1. J Virol, 64(6), 2976-89, 1990 PMCID:249482


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Updated Date
08/09/2013