Biomedical Research Education & Training
Faculty Member

Exton, John H., M.D., Ph.D.
Professor of Molecular Physiology and Biophysics
Professor of Pharmacology

Lab Url: N/A

Phone Number: 615-322-6494

Email Address: john.exton@vanderbilt.edu

Exton, John's picture
Academic history
B.Med.Sc., Univ. New Zealand, Dunedin, New Zealand
M.B.Ch.B., Univ. New Zealand, Dunedin, New Zealand
Ph.D., Univ. Otago, Dunedin, New Zealand
M.D. with distinction, Univ. Otago, Dunedin, New Zealand

Office Address   Mailing Address

831B Light Hall

831B Light Hall 0295


Research Keywords
Phospholipase, Hormones, Growth Factors, Signal Transduction, G Proteins

Research Specialty
Mechanisms of cell signaling

Research Description
Many hormones, neurotransmitters and growth factors produce their physiological actions by stimulating the breakdown of certain phospholipids in their target cells. This leads to an increase in the concentration of Ca2+ ions and changes in lipid messenger molecules that are responsible for the physiological effects observed. We are studying the phospholipase isozymes that are specifically involved in agonist-stimulated phospholipid breakdown and also the G proteins, protein kinases and other factors involved in their regulation. The structural elements required for catalysis and the domains and mechanisms of interaction of the phopholipases and their regulatory proteins are being defined. We are also exploring the molecular mechanisms by which hormones and growth factors stimulate phospholipid breakdown in intact cells, in particular, those mechanisms involving large and small G proteins and protein tyrosine and serine-threonine kinases. We are also examining the roles played by some of the products of phospholipid breakdown (phosphatidic acid and diacylglycerol) in generating physiological responses. The approaches involve the generation of mutant forms of the enzymes and regulatory proteins that are constitutively active or function as dominant negative forms, and the use of cells and animals in which the proteins are selectively depleted. This information is aimed at helping us understand how some of the important physiological reponses to hormones, neurotransmitters and growth factors are generated.


Publications
Couvillon, AD, Exton, JH. Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells. Cell Signal, 18(5), 715-28, 2006

Henage, LG, Exton, JH, Brown, HA. Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. J Biol Chem, 281(6), 3408-17, 2006

Hu, P, Han, Z, Couvillon, AD, Kaufman, RJ, Exton, JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol, 26(8), 3071-84, 2006 PMCID:1446932

Buchanan, FG, McReynolds, M, Couvillon, A, Kam, Y, Holla, VR, Dubois, RN, Exton, JH. Requirement of phospholipase D1 activity in H-RasV12-induced transformation. Proc Natl Acad Sci U S A, 102(5), 1638-42, 2005 PMCID:547811

Chen, JS, Exton, JH. Sites on phospholipase D2 phosphorylated by PKCalpha. Biochem Biophys Res Commun, 333(4), 1322-6, 2005

Hiroyama, M, Exton, JH. Studies of the roles of ADP-ribosylation factors and phospholipase D in phorbol ester-induced membrane ruffling. J Cell Physiol, 202(2), 608-22, 2005

Hiroyama, M, Exton, JH. Localization and regulation of phospholipase D2 by ARF6. J Cell Biochem, 95(1), 149-64, 2005

Ho, WT, Xie, Z, Zhao, ZJ, Exton, JH. Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation. Cell Signal, 17(6), 691-9, 2005

Hu, T, Exton, JH. A point mutation at phenylalanine 663 abolishes protein kinase C alpha''s ability to translocate to the perinuclear region and activate phospholipase D1. Biochem Biophys Res Commun, 333(3), 750-3, 2005

Hu, T, Exton, JH. 1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity. Biochem Biophys Res Commun, 327(4), 1047-51, 2005

Kook, S, Exton, JH. Identification of interaction sites of protein kinase Calpha on phospholipase D1. Cell Signal, 17(11), 1423-32, 2005

Chen, JS, Exton, JH. Regulation of phospholipase D2 activity by protein kinase C alpha. J Biol Chem, 279(21), 22076-83, 2004

Hu, T, Exton, JH. Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1. J Biol Chem, 279(34), 35702-8, 2004

Kam, Yoonseok, Exton, John H. Role of phospholipase D in the activation of protein kinase D by lysophosphatidic acid. Biochem Biophys Res Commun, 315(1), 139-43, 2004

Kam, Yoonseok, Exton, John H. Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid. FASEB J, 18(2), 311-9, 2004

Ho, Wan-Ting, Exton, John H, Williger, Ben-Tsion. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. FEBS Lett, 537(1-3), 91-5, 2003

Hu, Tianhui, Exton, John H. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. J Biol Chem, 278(4), 2348-55, 2003

Exton, J H. Phospholipase D-structure, regulation and function. Rev Physiol Biochem Pharmacol, 144, 1-94, 2002

Exton, John H. Regulation of phospholipase D. FEBS Lett, 531(1), 58-61, 2002

Kam, Yoonseok, Exton, John H. Dimerization of phospholipase d isozymes. Biochem Biophys Res Commun, 290(1), 375-80, 2002

Xie, Z., Ho, W.-T., Spellmlan, R., Cai, S. and Exton, J.H. Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G(13) and G(q). J. Biol. Chem., 277, 11979-11986, 2002

Xie, Zhi, Ho, Wan-Ting, Exton, John H. Functional implications of post-translational modifications of phospholipases D1 and D2. Biochim Biophys Acta, 1580(1), 9-21, 2002

Xie, Zhi, Ho, Wan-Ting, Spellman, Rachel, Cai, Songmin, Exton, John H. Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq. J Biol Chem, 277(14), 11979-86, 2002

Xie, Zhi, Kim, Ha Kun, Exton, John H. Expression and characterization of rat brain phospholipase D. Methods Enzymol, 345, 255-64, 2002

Cai, S, Exton, J H. Determination of interaction sites of phospholipase D1 for RhoA. Biochem J, 355(Pt 3), 779-85, 2001 PMCID:1221795

Kam, Y, Exton, J H. Phospholipase D activity is required for actin stress fiber formation in fibroblasts. Mol Cell Biol, 21(12), 4055-66, 2001 PMCID:87067

Kam, Y. and Exton, J.H. Phospholipase D activity as required for actin stress fiber formation in fibroblasts. Mol. Cell. Biol., 21, 4055-4066, 2001

Shin, O H, Couvillon, A D, Exton, J H. Arfophilin is a common target of both class II and class III ADP-ribosylation factors. Biochemistry, 40(36), 10846-52, 2001

Shin, O H, Exton, J H. Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1. Biochem Biophys Res Commun, 285(5), 1267-73, 2001

Xie, Z, Ho, W T, Exton, J H. Requirements and effects of palmitoylation of rat PLD1. J Biol Chem, 276(12), 9383-91, 2001

Xie, Z., Ho, W.-T. and Exton, J.H. Requirements and effects of palmitoylation of rat PLD1. J. Biol. Chem, 276, 9383-9391, 2001

Buchanan, F G, Elliot, C M, Gibbs, M, Exton, J H. Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid. J Biol Chem, 275(13), 9742-8, 2000

Buchanan, F.G., Elliott, C.M., Gibbs M. and Exton, J.H. Translocation of the Rac1 guanine nucleotide exchange factor and lysophosphatidic acid. J. Biol. Chem, 275, 9742-9748, 2000

Exton, J H. Phospholipase D. Ann N Y Acad Sci, 905, 61-8, 2000

Hess, J A, Buchanan, F G, Ryder, S, Exton, J H. Altered activation of phospholipase D by lysophosphatidic acid and endothelin-1 in mouse embryo fibroblasts lacking phospholipase C-gamma1. Cell Signal, 12(1), 37-45, 2000

Jin, S, Exton, J H. Activation of RhoA by association of Galpha(13) with Dbl. Biochem Biophys Res Commun, 277(3), 718-21, 2000

Xie, Z, Ho, W T, Exton, J H. Conserved amino acids at the C-terminus of rat phospholipase D1 are essential for enzymatic activity. Eur J Biochem, 267(24), 7138-46, 2000

Xie, Z, Ho, W T, Exton, J H. Association of the N- and C-terminal domains of phospholipase D. Contribution of the conserved HKD motifs to the interaction and the requirement of the association for Ser/Thr phosphorylation of the enzyme. J Biol Chem, 275(32), 24962-9, 2000

Exton, J H. Regulation of phospholipase D. Biochim Biophys Acta, 1439(2), 121-33, 1999

Fleming, I N, Elliott, C M, Buchanan, F G, Downes, C P, Exton, J H. Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J Biol Chem, 274(18), 12753-8, 1999

Fleming, I.N., Elliott, C.M., Buchanan, F.G. and Exton, J.H. Ca2+calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J. Biol. Chem, 274, 12753-12758, 1999

Shin, O H, Ross, A H, Mihai, I, Exton, J H. Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors. J Biol Chem, 274(51), 36609-15, 1999

Williger, B T, Ho, W T, Exton, J H. Phospholipase D mediates matrix metalloproteinase-9 secretion in phorbol ester-stimulated human fibrosarcoma cells. J Biol Chem, 274(2), 735-8, 1999

Williger, B T, Ostermann, J, Exton, J H. Arfaptin 1, an ARF-binding protein, inhibits phospholipase D and endoplasmic reticulum/Golgi protein transport. FEBS Lett, 443(2), 197-200, 1999

Williger, B T, Provost, J J, Ho, W T, Milstine, J, Exton, J H. Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D. FEBS Lett, 454(1-2), 85-9, 1999

Bae, C D, Min, D S, Fleming, I N, Exton, J H. Determination of interaction sites on the small G protein RhoA for phospholipase D. J Biol Chem, 273(19), 11596-604, 1998

Bae, C.D., Min, D.S., Fleming, I.N. and Exton, J.H. Determination of interaction sites on the small G protein RhoA for phospholipase D. J. Biol. Chem, 273, 11596-11604, 1998

Exton, J H. Phospholipase D. Biochim Biophys Acta, 1436(1-2), 105-15, 1998

Exton, J H. Small GTPases minireview series. J Biol Chem, 273(32), 19923, 1998

Fleming, I N, Elliott, C M, Exton, J H. Phospholipase C-gamma, protein kinase C and Ca2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1. FEBS Lett, 429(3), 229-33, 1998

Guillemain, I, Exton, J H. Role of rho proteins in agonist regulation of phospholipase D in HL-60 cells. Biochim Biophys Acta, 1405(1-3), 161-70, 1998

Hess, J A, Ji, Q S, Carpenter, G, Exton, J H. Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1. J Biol Chem, 273(32), 20517-24, 1998

Min, D S, Exton, J H. Phospholipase D is associated in a phorbol ester-dependent manner with protein kinase C-alpha and with a 220-kDa protein which is phosphorylated on serine and threonine. Biochem Biophys Res Commun, 248(3), 533-7, 1998

Min, D S, Kim, E G, Exton, J H. Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts. J Biol Chem, 273(45), 29986-94, 1998

Min, D S, Park, S K, Exton, J H. Characterization of a rat brain phospholipase D isozyme. J Biol Chem, 273(12), 7044-51, 1998

Min, D.S., Kim, E.-G. and Exton, J.H. Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts. J. Biol. Chem, 273, 29986-29994, 1998

Min, D.S., Park, S.-K. and Exton, J.H. Characterization of a rat brain phospholipase D isozyme. J. Biol. Chem, 273, 7044-7051, 1998

Park, S K, Min, D S, Exton, J H. Definition of the protein kinase C interaction site of phospholipase D. Biochem Biophys Res Commun, 244(2), 364-7, 1998

Plonk, S G, Park, S K, Exton, J H. The alpha-subunit of the heterotrimeric G protein G13 activates a phospholipase D isozyme by a pathway requiring Rho family GTPases. J Biol Chem, 273(9), 4823-6, 1998

Plonk, S. G., Park, S. -K. and Exton, J. H. The a-subunit of the heterotrimeric G protein G13 activates a phospholipase D isozyme by a pathway requiring Rho-family GTPases. J. Biol. Chem., 273, 4823-4836, 1998

Tsai, S-C., Adamik, R., Hong, J-X., Moss, J., Vaughan, M., Kanoh, H. and Exton, J.H. Effects of arfaptin 1 on guanine nucleotide-dependent activation of phospholipase D and cholera toxin by ARF. J. Biol. Chem, 273, 20697-20701, 1998

Xie, Z, Ho, W T, Exton, J H. Association of N- and C-terminal domains of phospholipase D is required for catalytic activity. J Biol Chem, 273(52), 34679-82, 1998

Xie, Z., Ho, W.-T. and Exton, J.H. Association of N- and C-terminal domains of phospholipase D is required for catalytic activity. J. Biol. Chem., 273, 34679-34682, 1998

Exton, J H. New developments in phospholipase D. J Biol Chem, 272(25), 15579-82, 1997

Exton, J H. Phospholipase D: enzymology, mechanisms of regulation, and function. Physiol Rev, 77(2), 303-20, 1997

Exton, J H. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. Eur J Biochem, 243(1-2), 10-20, 1997

Fleming, I N, Elliott, C M, Collard, J G, Exton, J H. Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C. J Biol Chem, 272(52), 33105-10, 1997

Fleming, I.N., Elliott, C.M., Collard, J.G. and Exton, J.H. Lysophosphatidic acid induces phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C. J. Biol. Chem, 272, 33105-33110, 1997

Guillemain, I, Exton, J H. Effects of brefeldin A on phosphatidylcholine phospholipase D and inositolphospholipid metabolism in HL-60 cells. Eur J Biochem, 249(3), 812-9, 1997

Hess, J A, Ross, A H, Qiu, R G, Symons, M, Exton, J H. Role of Rho family proteins in phospholipase D activation by growth factors. J Biol Chem, 272(3), 1615-20, 1997

Hess, J.A., Ross, A.H., Qui, R.-G., Symons, M. and Exton, J.H. Role of Rho family proteins in phospholipase D activation by growth factors. J. Biol. Chem., 272, 1615-1620, 1997

Kanoh, H, Williger, B T, Exton, J H. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. J Biol Chem, 272(9), 5421-9, 1997

Kanoh, H. and Exton, J.H. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. J. Biol. Chem., 272, 5421-5429, 1997

Kanoh, H. and Exton, J.H. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. 272, 5421-5429, J. Biol. Chem, 1997

Park, S K, Provost, J J, Bae, C D, Ho, W T, Exton, J H. Cloning and characterization of phospholipase D from rat brain. J Biol Chem, 272(46), 29263-71, 1997

Park, S.-K., Provost, J.J., Bae, C.D., Ho, W.-T. and Exton, J.H. Cloning and characterization of phospholipase D from rat brain. J. Biol. Chem, 272, 29263-29271, 1997

Yeo, E J, Provost, J J, Exton, J H. Dissociation of tyrosine phosphorylation and activation of phosphoinositide phospholipase C induced by the protein kinase C inhibitor Ro-31-8220 in Swiss 3T3 cells treated with platelet-derived growth factor. Biochim Biophys Acta, 1356(3), 308-20, 1997

Fleming, I N, Elliott, C M, Exton, J H. Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor. J Biol Chem, 271(51), 33067-73, 1996

Fleming, I.N. and Exton, J.H. Differential translocation of Rho-family GTPases by lysophosphatidic acid, endothelin-1 and platelet-derived growth factor. J. Biol. Chem., 271, 33067-33073, 1996

Malcolm, K C, Elliott, C M, Exton, J H. Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme. J Biol Chem, 271(22), 13135-9, 1996

Malcolm, K C, Sable, C L, Elliott, C M, Exton, J H. Enhanced phospholipase D activity and altered morphology in RhoA-overexpressing RAT1 fibroblasts. Biochem Biophys Res Commun, 225(2), 514-9, 1996

Malcolm, K.C., Elliott, C.M. and Exton, J.H. Evidence for Rho-mediated agonist stimulation of phospholipase D in Rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme. J. Biol. Chem, 271, 13135-13139, 1996

Pete, M J, Exton, J H. Purification of a lysophospholipase from bovine brain that selectively deacylates arachidonoyl-substituted lysophosphatidylcholine. J Biol Chem, 271(30), 18114-21, 1996

Pete, M J, Wu, D W, Exton, J H. Subcellular fractions of bovine brain degrade phosphatidylcholine by sequential deacylation of the sn-1 and sn-2 positions. Biochim Biophys Acta, 1299(3), 325-32, 1996

Provost, J J, Fudge, J, Israelit, S, Siddiqi, A R, Exton, J H. Tissue-specific distribution and subcellular distribution of phospholipase D in rat: evidence for distinct RhoA- and ADP-ribosylation factor (ARF)-regulated isoenzymes. Biochem J, 319 ( Pt 1), 285-91, 1996 PMCID:1217766

Venkatakrishnan, G, Exton, J H. Identification of determinants in the alpha-subunit of Gq required for phospholipase C activation. J Biol Chem, 271(9), 5066-72, 1996

Venkatakrishnan, G. and Exton, J.H. Identification of determinants in the alpha subunit of G(q) required for phospholipase C activation. J. Biol. Chem., 271, 5066-5072, 1996

Malcolm, K C, Trammell, S E, Exton, J H. Purinergic agonist and G protein stimulation of phospholipase D in rat liver plasma membranes. Independence from phospholipase C activation. Biochim Biophys Acta, 1268(2), 152-8, 1995

Pete, M J, Exton, J H. Phospholipid interactions affect substrate hydrolysis by bovine brain phospholipase A1. Biochim Biophys Acta, 1256(3), 367-73, 1995

Siddiqi, A R, Smith, J L, Ross, A H, Qiu, R G, Symons, M, Exton, J H. Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D. J Biol Chem, 270(15), 8466-73, 1995

Siddiqi, A.R., Smith, J.L., Ross, A.H., Qiu, R.-G., Symons, M. and Exton, J.H. Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D. J. Biol. Chem, 270, 8466-8473, 1995

Conricode, K M, Smith, J L, Burns, D J, Exton, J H. Phospholipase D activation in fibroblast membranes by the alpha and beta isoforms of protein kinase C. FEBS Lett, 342(2), 149-53, 1994

Exton, J H. Messenger molecules derived from membrane lipids. Curr Opin Cell Biol, 6(2), 226-9, 1994

Exton, J H. Phosphoinositide phospholipases and G proteins in hormone action. Annu Rev Physiol, 56, 349-69, 1994

Malcolm, K.C., Ross, A.H., Qiu, R.-G., Symons, M. and Exton, J.H. Activation of rat liver phospholipase D by the small GTP- binding protein rhoA. J. Biol. Chem., 269, 25951-25954, 1994

Pete, M J, Ross, A H, Exton, J H. Purification and properties of phospholipase A1 from bovine brain. J Biol Chem, 269(30), 19494-500, 1994

Pete, M.J., Ross, A.H. and Exton, J.H. Purification and properties of phospholipase A1 from bovine brain. J. Biol. Chem, 269, 19494-19500, 1994

Yeo, E J, Kazlauskas, A, Exton, J H. Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor. J Biol Chem, 269(45), 27823-6, 1994

Yeo, E.-J., Kazlauskas, A. and Exton, J.H. Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor. 27823-27826, 269, J. Biol. Chem., 1994

Allan, C J, Exton, J H. Quantification of inositol phospholipid breakdown in isolated rat hepatocytes. Biochem J, 290 ( Pt 3), 865-72, 1993 PMCID:1132361

Blank, J L, Shaw, K, Ross, A H, Exton, J H. Purification of a 110-kDa phosphoinositide phospholipase C that is activated by G-protein beta gamma-subunits. J Biol Chem, 268(33), 25184-91, 1993

Exton, J H. Role of G proteins in activation of phosphoinositide phospholipase C. Adv Second Messenger Phosphoprotein Res, 28, 65-72, 1993

Ha, K S, Exton, J H. Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J Cell Biol, 123(6 Pt 2), 1789-96, 1993 PMCID:2290890

Ha, K.-S. and Exton, J.H. Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. J. Biol. Chem, 268, 10534-10539, 1993

Nakanishi, H, Brewer, K A, Exton, J H. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 268(1), 13-6, 1993

Berstein, G., Blank, J.L., Exton, J.H. and Ross, E.M. Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11 and phospholipase C-beta 1. J. Biol. Chem, 267, 8081-8088, 1992

Berstein, G., Blank, J.L., Jhon, D.-Y., Exton, J.H., Rhee, S.G. and Ross, E.M. Phospholipase C-1 is a GTPase activating protein (GAP) for Gq/11, its physiologic regulator. Cell, 70, 411-418, 1992

Blank, J L, Brattain, K A, Exton, J H. Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits. J Biol Chem, 267(32), 23069-75, 1992

Blank, J.L., Brattain, K.A. and Exton, J.H. Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits. J. Biol. Chem, 267, 23069-23075, 1992

Conricode, K.M. and Exton, J.H. Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation independent mechanism. J. Biol. Chem , 267, 7199-7202, 1992

Nakanishi, H. and Exton, J.H. Purification and characterization of the zeta isoform of protein kinase C from bovine kidney. J. Biol. Chem, 267, 16347-16354, 1992

Shaw, K, Exton, J H. Identification in bovine liver plasma membranes of a Gq-activatable phosphoinositide phospholipase C. Biochemistry, 31(27), 6347-54, 1992

Siddiqui, R A, Exton, J H. Phospholipid base exchange activity in rat liver plasma membranes. Evidence for regulation by G-protein and P2y-purinergic receptor. J Biol Chem, 267(9), 5755-61, 1992

Siddiqui, R A, Exton, J H. Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase. Eur J Biochem, 210(2), 601-7, 1992

Blank, J L, Ross, A H, Exton, J H. Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class. J Biol Chem, 266(27), 18206-16, 1991

Blank, J.L., Ross, A.H. and Exton, J.H. Purification and characterization of two G-proteins which activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the G(q) class. J. Biol. Chem., 266, 17206-18216, 1991

Bocckino, S B, Wilson, P B, Exton, J H. Phosphatidate-dependent protein phosphorylation. Proc Natl Acad Sci U S A, 88(14), 6210-3, 1991 PMCID:52052

Exton, J H. Some thoughts on the mechanism of action of insulin. Diabetes, 40(5), 521-6, 1991

Exton, J H, Taylor, S J, Augert, G, Bocckino, S B. Cell signalling through phospholipid breakdown. Mol Cell Biochem, 104(1-2), 81-6, 1991

Stewart, S J, Cunningham, G R, Strupp, J A, House, F S, Kelley, L L, Henderson, G S, Exton, J H, Bocckino, S B. Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex. Cell Regul, 2(10), 841-50, 1991 PMCID:361879

Taylor, S J, Chae, H Z, Rhee, S G, Exton, J H. Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins. Nature, 350(6318), 516-8, 1991

Taylor, S.J., Chae, H.Z., Rhee, S.G. and Exton, J.H. Activation of the Beta 1 isozyme of phospholipase C by purified a subunits of the G(q) class of G proteins. Nature, 350, 516-518, 1991

Wange, R L, Smrcka, A V, Sternweis, P C, Exton, J H. Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins. J Biol Chem, 266(18), 11409-12, 1991

Bouscarel, B, Augert, G, Taylor, S J, Exton, J H. Alterations in vasopressin and angiotensin II receptors and responses during culture of rat liver cells. Biochim Biophys Acta, 1055(3), 265-72, 1990

Exton, J H. Signaling through phosphatidylcholine breakdown. J Biol Chem, 265(1), 1-4, 1990

Exton, J H. Hormonal regulation of phosphatidylcholine breakdown. Adv Second Messenger Phosphoprotein Res, 24, 152-7, 1990

Georgoussi, Z, Taylor, S J, Bocckino, S B, Exton, J H. Purification of the hepatic vasopressin receptor using a novel affinity column. Biochim Biophys Acta, 1055(1), 69-74, 1990

Taylor, S J, Smith, J A, Exton, J H. Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit. J Biol Chem, 265(28), 17150-6, 1990

Augert, G, Blackmore, P F, Exton, J H. Changes in the concentration and fatty acid composition of phosphoinositides induced by hormones in hepatocytes. J Biol Chem, 264(5), 2574-80, 1989

Augert, G, Bocckino, S B, Blackmore, P F, Exton, J H. Hormonal stimulation of diacylglycerol formation in hepatocytes. Evidence for phosphatidylcholine breakdown. J Biol Chem, 264(36), 21689-98, 1989

Augert, G., Blackmore, P.F. and Exton, J.H. Changes in the concentration and fatty acid composition of phosphoinositides induced by hormones in hepatocytes. J. Biol. Chem., 264, 2574-2580, 1989

Augert, G., Bocckino, S.B., Blackmore, P.F.and Exton, J.H. Hormonal stimulation of diacylglycerol formation in hepatocytes. Evidence for phosphatidylcholine breakdown. J. Biol. Chem., 264, 21689-21698, 1989

Bocckino, S B, Wilson, P B, Exton, J H. An early elevation of diacylglycerol and phosphatidate in regenerating liver. Biochem Biophys Res Commun, 164(1), 290-4, 1989

Lynch, C J, Blackmore, P F, Johnson, E H, Wange, R L, Krone, P K, Exton, J H. Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides. J Clin Invest, 83(6), 2050-62, 1989 PMCID:303930

Stewart, S J, Prpic, V, Johns, J A, Powers, F S, Graber, S E, Forbes, J T, Exton, J H. Bacterial toxins affect early events of T lymphocyte activation. J Clin Invest, 83(1), 234-42, 1989 PMCID:303667

Augert, G, Exton, J H. Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes. J Biol Chem, 263(8), 3600-9, 1988

Blackmore, P F, Lynch, C J, Uhing, R J, Fitzgerald, T, Bocckino, S B, Exton, J H. Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium. Adv Exp Med Biol, 232, 169-82, 1988

Bouscarel, B, Blackmore, P F, Exton, J H. Characterization of the angiotensin II receptor in primary cultures of rat hepatocytes. Evidence that a single population is coupled to two different responses. J Biol Chem, 263(29), 14913-9, 1988

Bouscarel, B, Meurer, K, Decker, C, Exton, J H. The role of protein kinase C in the inactivation of hepatic glycogen synthase by calcium-mobilizing agonists. Biochem J, 251(1), 47-53, 1988 PMCID:1148962

Bouscarel, B, Wilson, P B, Blackmore, P F, Lynch, C J, Exton, J H. Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes. J Biol Chem, 263(29), 14920-4, 1988

Exton, J H. Role of phosphoinositides in the regulation of liver function. Hepatology, 8(1), 152-66, 1988

Exton, J H. Mechanisms of action of calcium-mobilizing agonists: some variations on a young theme. FASEB J, 2(11), 2670-6, 1988

Lynch, C J, Taylor, S J, Smith, J A, Exton, J H. Formation of the high-affinity agonist state of the alpha 1-adrenergic receptor at cold temperatures does not require a G-protein. FEBS Lett, 229(1), 54-8, 1988

Bocckino, S B, Wilson, P B, Exton, J H. Ca2+-mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation. FEBS Lett, 225(1-2), 201-4, 1987

Bocckino, S.B., Blackmore, P.F., Wilson, P.B., and Exton, J.H. Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism. J. Biol. Chem., 262, 15309-15315, 1987

Exton, J H. Calcium signalling in cells--molecular mechanisms. Kidney Int Suppl, 23, S68-81, 1987

Irving, H. and Exton, J.H. Phosphatidylcholine breakdown in rat liver plasma membranes. J.Biol.Chem., 262, 3440-3443, 1987

Lynch, C J, Bocckino, S B, Blackmore, P F, Exton, J H. Calcium-mobilizing hormones and phorbol myristate acetate mediate heterologous desensitization of the hormone-sensitive hepatic Na+/K+ pump. Biochem J, 248(3), 807-13, 1987 PMCID:1148621

Taylor, S J, Exton, J H. Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements. Biochem J, 248(3), 791-9, 1987 PMCID:1148619


Postdoctoral Position Available
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Updated Date
04/25/2007