Biomedical Research Education & Training
Faculty Member

Harris, Thomas R., M.D., Ph.D.
Professor of Medicine, Emeritus
Orrin Henry Ingram Distinguished Professor of Engineering, Emeritus; Professor of Biomedical Engineering, Emeritus; Professor of Chemical Engineering, Emeritus

Lab Url: N/A

Phone Number: 615-322-3521

Email Address: trh@vuse.vanderbilt.edu

Harris, Thomas's picture
Academic history
B.S., Texas A & M University, College Station, TX
M.S., Texas A & M University, College Station, TX
Ph.D., Tulane University, New Orleans, LA
M.D., Vanderbilt University, Nashville, TN

Office Address   Mailing Address

1225 Stevenson Center

BOX 351631 Station B


Research Specialty
Transport of fluid and solutes in the lung microcirculation

Research Description
This research is concentrated on the quantitative physiology of the exchange of fluids and solutes in the capillaries of the lung. We seek to understand the basic biophysical mechanisms by which the exchange functions of the lung are regulated, how injury affects these functions and how diseases which lead to lung vascular injury should be treated. Our scientific goals are the establishment of a precise mathematical description of lung vascular fluid mechanics, diffusion and exchange in normal and abnormal situations. Our medical goals are to improve the diagnosis and treatment of lung vascular diseases especially Adult Respiratory Distress Syndrome. Our engineering goals are the development of minimally invasive instruments and methods to evaluate lung vascular function and fluid balance in patients. We perform experiments on isolated endothelial cell systems, isolated perfused lungs and intact animals. In addition, there is collaboration with clinical investigators in studies on patients. Lung vascular transport is measured with radioisotopes, the surgical cannulation and collection of lung lymph, infrared spectroscopy, gamma scanning and magnetic resonance imaging. The computer is prominent in our work, and we are engaged in several studies involving mathematical simulation of lung function and the use of scientific visualization methods to guide advanced computer analysis of the lung.

Current Projects Include:

(1) The control of functioning capillary surface area in the lung.

(2) The analysis of heterogeneous perfusion in the lung.

(3) Optical densitometry as an instrument for on-line evaluation of indicator dilution curves in animals and patients.

(4) Development of a computerized system for the simulation of lung fluid balance and solute exchange.

(5) Development of minimally invasive instrumentation for measuring lung vascular function.

Publications
Harris, T. R., Bransford, J. D., Brophy, S. P. Roles for learning sciences and learning technologies in biomedical engineering education: A review of recent advances. Annual Reviews: Biomedical Engineering, in press, 2002.

Harris, Thomas R, Bransford, John D, Brophy, Sean P. Roles for learning sciences and learning technologies in biomedical engineering education: a review of recent advances. Annu Rev Biomed Eng, 4, 29-48, 2002

Seale, Kevin T, Pou, N A, Krivitski, N, Harris, Thomas R. Quantification of lung microvascular injury with ultrasound. Ann Biomed Eng, 30(5), 671-82, 2002

Seale, K T, Harris, T R. A three-compartment model of osmotic water exchange in the lung microvasculature. Ann Biomed Eng, 28(8), 1019-27, 2000

Seale, Kevin T. and Harris, T. R. A three-compartment model of osmotic water exchange in the lung microvasculature. 28, Ann Biomedical Engr.g, 1019-1027, 2000

Caruthers, S D, Paschal, C B, Pou, N A, Roselli, R J, Harris, T R. Regional measurements of pulmonary edema by using magnetic resonance imaging. J Appl Physiol, 84(6), 2143-53, 1998

Caruthers, S.D., Paschal, C.B., Pou, N.A., Roselli, R. J., Harris, T. R. Regional measurement of pulmonary edema using magnetic resonance imaging. J. Applied Physiol, 84, 2143-2153, 1998

DeMarino, S., Olson, L.E., Galloway, R.L., Pou, A., Harris, T.R. Optical and radioisotope measures of capillary transport in isolated dog lungs during increased vascular pressure and increased vascular permeability. Ann. Biomed. Engrg., 26, 417-430, 1998

Bosan, S, Harris, T R. Visualization-based analysis of multiparameter models using environment for N-dimensional model analysis. Comput Biomed Res, 30(3), 171-87, 1997

Bosan, S. and Harris, T.R. Visualization based analysis of multi-parameter models using EN-DIMAN (Environment for N-Dimensional Model Analysis. Computers and Biomedical Research, 30, 171-187, 1997

Caruthers, S D, Paschal, C B, Pou, N A, Harris, T R. Relative quantification of pulmonary edema with noncontrast-enhanced MRI. J Magn Reson Imaging, 7(3), 544-50, 1997

Caruthers, S.D., Paschal, C.P., Pou, N.A., Harris, T.R. Relative quantification of pulmonary edema with non- contrast enhanced MRI. Jo. Magnetic Res. Imag, 7, 544-550, 1997

Roselli, R J, Tack, G, Harris, T R. A model of fluid, erythrocyte, and solute transport in the lung. Ann Biomed Eng, 25(1), 46-61, 1997

Roselli, R.J., Tack, G., Harris, T.R. A model of fluid, erythrocyte, and solute transport in the lung. Ann. Biomed. Engr, 25, 46-61, 1997

Bosan, S, Harris, T R. A visualization-based analysis method for multiparameter models of capillary tissue-exchange. Ann Biomed Eng, 24(1), 124-38, 1996

Bosan, S, Harris, T R. Graphical lung analysis and simulation environment. Comput Methods Programs Biomed, 49(3), 211-28, 1996

Bosan, S., Harris, T.R. Graphical Lung Analysis and Simulation Environment, Comp. Methods and Programs in Biomedicine, 49, 211-228, 1996

Bosan, S., and Harris, T.R. A visualization-based analysis method for multiparameter models of capillary- tissue exchange. Ann. Biomed. Engrg, 24, 124-138., 1996

Stead, W W, Borden, R, Bourne, J, Giuse, D, Giuse, N, Harris, T R, Miller, R A, Olsen, A J. The Vanderbilt University fast track to IAIMS: transition from planning to implementation. J Am Med Inform Assoc, 3(5), 308-17, 1996 PMCID:116315

Stead, W. W., Borden, R., Bourne, J., Guise, D., Guise, N., Harris, T. R., Miller, R.A., Olsen, A. . The Vanderbilt University fast track to IAIMS: Transition from planning to operations. J. Am. Med. Inf. Assoc, 3, 308-317, 1996

Caruthers, S D, Harris, T R, Overholser, K A, Pou, N A, Parker, R E. Effects of flow heterogeneity on the measurement of capillary exchange in the lung. J Appl Physiol, 79(5), 1449-60, 1995

Caruthers, S.D., Harris, T.R, Overholser, K.A., Pou, N.A., Parker, R.E. The effects of flow heterogenity on the measurement of capillary exchange in the lung. J. Appl. Physiol., 79, 1449-1460, 1995

Olson, L.E., Harris, T.R., Pou, A., Syed-Ahmed, M.N., Galloway, R.L. An optical multiple indicator dilution technique to measure lung permeability surface area: Calibration and baseline measurement. IEEE Trans. BME , 42, 451-463, 1995

Tack, G, Roselli, R J, Overholser, K A, Harris, T R. The use of microsoft excel as a user interface for biological simulations. Comput Biomed Res, 28(1), 24-37, 1995

Caruthers, S D, Harris, T R. Effects of pulmonary blood flow on the fractal nature of flow heterogeneity in sheep lungs. J Appl Physiol, 77(3), 1474-9, 1994

Caruthers, S.D., Harris, T.R. The effects of pulmonary blood flow on the fractal nature of flow heterogeneity in sheep lungs. J. Appl. Physiol, 77, 1474-1479, 1994

Harris, P A, Bosan, S, Harris, T R, Laughlin, M H, Overholser, K A. Parameter identification in coronary pressure flow models: a graphical approach. Ann Biomed Eng, 22(6), 622-37, 1994

Harris, T R, Waters, C M, Haselton, F R. Use of scaling theory to relate measurements of lung endothelial barrier permeability. J Appl Physiol, 77(5), 2496-505, 1994

Olson, L E, Staton, D J, Young, M, Galloway, R L, Harris, T R. Sulfhemoglobinated erythrocytes as an optical intravascular tracer in the lung. Ann Biomed Eng, 22(3), 319-27, 1994

Olson, L.E., Staton, D.J., Young, M., Galloway, R.L., Harris, T.R. Sulfhemoglobinated erythrocytes as an optical intravascular tracer in the lung. Ann. Biomed. Engrg, 22, 323-331, 1994

Overholser, K A, Lomangino, N A, Harris, T R, Bradley, J D, Bosan, S. Deduction of pulmonary microvascular hematocrit from indicator dilution curves. Bull Math Biol, 56(2), 225-47, 1994

Overholser, K A, Lomangino, N A, Parker, R E, Pou, N A, Harris, T R. Pulmonary vascular resistance distribution and recruitment of microvascular surface area. J Appl Physiol, 77(2), 845-55, 1994

Overholser, K.A., Lomangino, N.A., Parker, R.E., Pou, N.A., Harris, T.R. Pulmonary vascular resistance distribution and the recruitment of microvascular area. J. Appl. Physiol, 77, 845-855, 1994

Waters, C M, Alexander, J S, Harris, T R, Haselton, F R. Perilla ketone increases endothelial cell monolayer permeability in vitro. J Appl Physiol, 74(5), 2493-501, 1993

Waters, C.M., Alexander, J.S., Harris, T.R., Haselton, F.R. Perilla ketone increases endothelial cell monolayer permeability in vitro. J. Appl. Physiol, 74, 2493-2501, 1993

Stead, W W, Baker, W, Harris, T R, Hodges, T M, Sittig, D F. A fast track to IAIMS: the Vanderbilt University strategy. Proc Annu Symp Comput Appl Med Care, 527-31, 1992 PMCID:2248037

Olson, L E, Pou, A, Harris, T R. Surface area-independent assessment of lung microvascular permeability with an amphipathic tracer. J Appl Physiol, 70(3), 1085-96, 1991

Olson, L.E., Pou, A., Harris, T.R. Surface-area independent assessment of lung microvascular permeability using an amphipathic tracer. J. Appl. Physiol., 70, 1085-1096, 1991

Bradley, J D, Parker, R E, Harris, T R, Overholser, K A. Effects of ligation and embolization on Kf and multiple tracer measurements in dog lungs. J Appl Physiol, 69(4), 1460-6, 1990

Harris, T R, Bernard, G R, Brigham, K L, Higgins, S B, Rinaldo, J E, Borovetz, H S, Sibbald, W J, Kariman, K, Sprung, C L. Lung microvascular transport properties measured by multiple indicator dilution methods in patients with adult respiratory distress syndrome. A comparison between patients reversing respiratory failure and those failing to reverse. Am Rev Respir Dis, 141(2), 272-80, 1990

Harris, T.R., Bernard, G.R., Brigham, K.L., Higgins, S.B., Rinaldo, J.E., Borovetz, H.S., Sibbald, W.J., Kariman, K., Sprung, C.L. Lung microvascular transport properties measured by multiple indicator dilution methods in ARDS patients: A comparison between patients reversing respiratory failure and those failing to reverse. AM. Rev. Resp. Dis., 67, 280-292, 1990

Harris, T.R., Roselli, R.J. The exchange of small molecules in the normal and abnormal lung circulatory bed. Respiration Physiology: A Quantitative Approach, Chang and Paiva, editors, Dekker, New York, 737-798, 1989

Pou, N A, Roselli, R J, Parker, R E, Clanton, J A, Harris, T R. Measurement of lung fluid volumes and albumin exclusion in sheep. J Appl Physiol, 67(4), 1323-30, 1989

Roselli, R.J., Harris, T.R. Lung fluid and macromolecular transport. Chapter 16 in Respiration Physiology: A Quantitative Approach, Chang and Paiva, editors, Dekker, New York, 633-735, 1989

Bradley, J D, Roselli, R J, Parker, R E, Harris, T R. Effects of endotoxemia on the sheep lung microvascular membrane: a two-pore theory. J Appl Physiol, 64(6), 2675-83, 1988

Bradley, J.D., Roselli, R.J., Parker, R.E., Harris, T.R. Effects of endotoxemia on the sheep lung microvascular membrane: A two-pore theory. J. Appl. Physiol, 64, 2675-2683, 1988

Harris, T.R. The influence of endothelial volume on the kinetics of reacting indicators in the lung. J. Appl. Physiol, 57, 1528-1530, 1984

Haselton, F.R., Roselli, R.J., Parker, R.E., Harris, T.R. An effective-diffusivity model of pulmonary capillary exchange: General theory, limiting cases, and sensitivity analysis. Math. Biosciences, 70, 237-263, 1984


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
04/11/2001