Biomedical Research Education & Training
Faculty Member

Linton, MacRae F., M.D.
Professor of Medicine
Dr. Stephen J. Schillig, Jr. and Mary Schillig Chair in Medicine
Professor of Pharmacology

Lab Url: http://www.vanderbilthealth.com/cardiovascular/22999

Phone Number: 615-936-1656

Email Address: macrae.linton@vanderbilt.edu

Linton, MacRae's picture
Academic history
B.S., Tulane University, New Orleans, LA
M.D., University of Tennessee, Memphis, TN

Office Address   Mailing Address

312 Preston Research Building

383 PRB, Cardiovascular Medicine 6300


Research Specialty
The Macrophage in Artherosclerosis; Gene Therapy

Research Description
Research in Dr. Linton's laboratory focuses on the areas of lipoprotein metabolism and atherosclerosis. A major focus is the investigation of the role of the macrophage in atherosclerosis. The first recognizable lesion of atherosclerosis is the fatty streak which consists primarily of cholesterol loaded macrophages or foam cells. The macrophage expresses genes for a number of lipoprotein receptors, apoproteins, enzymes, and cytokines that may influence foam cell formation and atherogenesis. Since tissue macrophages are derived from monocytes, bone marrow transplantation in gene targeted mice is being used to deliver genetically altered macrophages to the atherosclerotic lesion, providing an in vivo model in which to examine the role of expression of various candidate genes by the macrophage in atherogenesis. Recent studies have focused on the role of apolipoprotein (apo) E secretion by the macrophage in the pathogenesis of atherosclerosis. ApoE is a ligand for receptor mediated lipoprotein clearance, and studies in Dr. Linton's laboratory have demonstrated that expression of apoE by the macrophage in the artery wall is a protective mechanism that retards foam cell formation and atherosclerosis. Gene transfer studies are in progress to investigate the potential of the macrophage as a vehicle for cellular gene therapy of atherosclerotic lesions.

Publications
Ormseth, MJ, Swift, LL, Fazio, S, Linton, MF, Raggi, P, Solus, JF, Oeser, A, Bian, A, Gebretsadik, T, Shintani, A, Stein, CM. Free fatty acids are associated with metabolic syndrome and insulin resistance but not inflammation in systemic lupus erythematosus. Lupus, 22(1), 26-33, 2013

Tavori, H, Fan, D, Blakemore, JL, Yancey, PG, Ding, L, Linton, MF, Fazio, S. Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation. Circulation, 127(24), 2403-13, 2013

Fazio, S, Linton, MF. When it looks like familial hypercholesterolemia...but is not. Circ Cardiovasc Genet, 5(6), 599-601, 2012

Fazio, S, Linton, MF. Proprotein convertase subtilisin/kexin type 9 as transducer of physiologic influences on cellular cholesterol: a case for resistin. J Am Coll Cardiol, 59(19), 1706-8, 2012

Fazio, S, Linton, MF. Inhibition of apolipoprotein(a) synthesis by farnesoid X receptor and fibroblast growth factor 15/19: a step toward selective lipoprotein(a) therapeutics. Arterioscler Thromb Vasc Biol, 32(5), 1060-2, 2012

Levin, MC, Lidberg, U, Jirholt, P, Adiels, M, Wramstedt, A, Gustafsson, K, Greaves, DR, Li, S, Fazio, S, Linton, MF, Olofsson, SO, Boren, J, Gjertsson, I. Evaluation of macrophage-specific promoters using lentiviral delivery in mice. Gene Ther, 19(11), 1041-7, 2012

Lilley, JS, Linton, MF, Fazio, S. Dyslipidemias in children. Pediatr Ann, 41(2), e1-7, 2012

Prins, PA, Perati, PR, Kon, V, Guo, Z, Ramesh, A, Linton, MF, Fazio, S, Sampson, UK. Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice. Cell Physiol Biochem, 29(1-2), 121-30, 2012

Sampson, UK, Fazio, S, Linton, MF. Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges. Curr Atheroscler Rep, 14(1), 1-10, 2012

Villegas, R, Xiang, YB, Cai, H, Elasy, T, Cai, Q, Zhang, X, Fazio, S, Linton, MF, Li, H, Xu, WH, Yang, G, Zheng, W, Shu, XO. Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men. Nutr Metab Cardiovasc Dis, 22(3), 223-30, 2012

Villegas, R, Xiang, YB, Elasy, T, Xu, WH, Cai, H, Cai, Q, Linton, MF, Fazio, S, Zheng, W, Shu, XO. Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men''s Health Study. Nutr Metab Cardiovasc Dis, 22(5), 409-16, 2012

Yamamoto, S, Yancey, PG, Ikizler, TA, Jerome, WG, Kaseda, R, Cox, B, Bian, A, Shintani, A, Fogo, AB, Linton, MF, Fazio, S, Kon, V. Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J Am Coll Cardiol, 60(23), 2372-9, 2012

Babaev, VR, Runner, RP, Fan, D, Ding, L, Zhang, Y, Tao, H, Erbay, E, Gorgen, CZ, Fazio, S, Hotamisligil, GS, Linton, MF. Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-gamma-regulated genes. Arterioscler Thromb Vasc Biol, 31(6), 1283-90, 2011

Du, F, Hui, Y, Zhang, M, Linton, MF, Fazio, S, Fan, D. Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein. J Biol Chem, 286(50), 43054-61, 2011

Fazio, S, Linton, MF. Low levels of high-density lipoprotein cholesterol due to lecithin:cholesterol acyltransferase mutations increase carotid atherosclerosis. J Am Coll Cardiol, 58(24), 2488-90, 2011

Kon, V, Linton, MF, Fazio, S. Atherosclerosis in chronic kidney disease: the role of macrophages. Nat Rev Nephrol, 7(1), 45-54, 2011

Ma, LJ, Corsa, BA, Zhou, J, Yang, H, Li, H, Tang, YW, Babaev, VR, Major, AS, Linton, MF, Fazio, S, Hunley, TE, Kon, V, Fogo, AB. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Am J Physiol Renal Physiol, 300(5), F1203-13, 2011

Ormseth, MJ, Swift, LL, Fazio, S, Linton, MF, Chung, CP, Raggi, P, Rho, YH, Solus, J, Oeser, A, Bian, A, Gebretsadik, T, Shintani, A, Stein, CM. Free fatty acids are associated with insulin resistance but not coronary artery atherosclerosis in rheumatoid arthritis. Atherosclerosis, 219(2), 869-74, 2011

Sampson, UK, Linton, MF, Fazio, S. Are statins diabetogenic. Curr Opin Cardiol, 26(4), 342-7, 2011

Sampson, UK, Perati, PR, Prins, PA, Pham, W, Liu, Z, Harrell, FE, Linton, MF, Gore, JC, Kon, V, Fazio, S. Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases. J Ultrasound Med, 30(6), 773-84, 2011

Villegas, R, Xiang, YB, Elasy, T, Cai, Q, Xu, W, Li, H, Fazio, S, Linton, MF, Raiford, D, Zheng, W, Shu, XO. Liver enzymes, type 2 diabetes, and metabolic syndrome in middle-aged, urban Chinese men. Metab Syndr Relat Disord, 9(4), 305-11, 2011

Woo, KV, Qu, X, Babaev, VR, Linton, MF, Guzman, RJ, Fazio, S, Baldwin, HS. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J Clin Invest, 121(4), 1624-35, 2011

Yamamoto, S, Yancey, PG, Zuo, Y, Ma, LJ, Kaseda, R, Fogo, AB, Ichikawa, I, Linton, MF, Fazio, S, Kon, V. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arterioscler Thromb Vasc Biol, 31(12), 2856-64, 2011

Yamamoto, S, Zuo, Y, Ma, J, Yancey, PG, Hunley, TE, Motojima, M, Fogo, AB, Linton, MF, Fazio, S, Ichikawa, I, Kon, V. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice. Nephrol Dial Transplant, 26(8), 2491-7, 2011

Yancey, PG, Ding, Y, Fan, D, Blakemore, JL, Zhang, Y, Ding, L, Zhang, J, Linton, MF, Fazio, S. Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Circulation, 124(4), 454-64, 2011

Fazio, S, Linton, MF. High-density lipoprotein therapeutics and cardiovascular prevention. J Clin Lipidol, 4(5), 411-9, 2010

Ali, YS, Linton, MF, Fazio, S. Targeting cardiovascular risk in patients with diabetes: management of dyslipidemia. Curr Opin Endocrinol Diabetes Obes, 15(2), 142-6, 2008

Babaev, VR, Porro, F, Linton, MF, Fazio, S, Baralle, FE, Muro, AF. Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice. Atherosclerosis, 197(2), 534-40, 2008 PMCID:2358924

Chung, CP, Oeser, A, Raggi, P, Solus, JF, Avalos, I, Linton, MF, Fazio, S, Michael Stein, C. Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus. Clin Rheumatol, 2008

Fan, D, Yancey, PG, Qiu, S, Ding, L, Weeber, EJ, Linton, MF, Fazio, S. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry, 47(6), 1631-9, 2008 PMCID:2732112

Lee, SA, Wen, W, Xiang, YB, Fazio, S, Linton, MF, Cai, Q, Liu, D, Zheng, W, Shu, XO. Stability and reliability of plasma level of lipid biomarkers and their correlation with dietary fat intake. Dis Markers, 24(2), 73-9, 2008

Mathew, RP, Byrne, DW, Linton, MF, Vaughan, DE, Fazio, S, Russell, WE. Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis. Metabolism, 57(6), 733-40, 2008

Su, YR, Blakemore, JL, Zhang, Y, Linton, MF, Fazio, S. Lentiviral transduction of apoAI into hematopoietic progenitor cells and macrophages: applications to cell therapy of atherosclerosis. Arterioscler Thromb Vasc Biol, 28(8), 1439-46, 2008 PMCID:2744493

Zhang, X, Shu, XO, Signorello, LB, Hargreaves, MK, Cai, Q, Linton, MF, Fazio, S, Zheng, W, Blot, WJ. Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged population. Dis Markers, 24(6), 351-9, 2008

Babaev, VR, Ishiguro, H, Ding, L, Yancey, PG, Dove, DE, Kovacs, WJ, Semenkovich, CF, Fazio, S, Linton, MF. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation, 116(12), 1404-12, 2007

Chung, CP, Oeser, A, Solus, J, Avalos, I, Gebretsadik, T, Shintani, A, Linton, MF, Fazio, S, Stein, CM. Inflammatory mechanisms affecting the lipid profile in patients with systemic lupus erythematosus. J Rheumatol, 34(9), 1849-54, 2007

Fan, D, Qiu, S, Overton, CD, Yancey, PG, Swift, LL, Jerome, WG, Linton, MF, Fazio, S. Impaired secretion of apolipoprotein E2 from macrophages. J Biol Chem, 282(18), 13746-53, 2007

Lee, SA, Kallianpur, A, Xiang, YB, Wen, W, Cai, Q, Liu, D, Fazio, S, Linton, MF, Zheng, W, Shu, XO. Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies. Cancer Epidemiol Biomarkers Prev, 16(11), 2464-70, 2007

Overton, CD, Yancey, PG, Major, AS, Linton, MF, Fazio, S. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res, 100(5), 670-7, 2007

Roberts, LJ, Oates, JA, Linton, MF, Fazio, S, Meador, BP, Gross, MD, Shyr, Y, Morrow, JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med, 43(10), 1388-93, 2007 PMCID:2072864

Suganuma, E, Babaev, VR, Motojima, M, Zuo, Y, Ayabe, N, Fogo, AB, Ichikawa, I, Linton, MF, Fazio, S, Kon, V. Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques. J Am Soc Nephrol, 18(8), 2311-9, 2007

Yancey, PG, Jerome, WG, Yu, H, Griffin, EE, Cox, BE, Babaev, VR, Fazio, S, Linton, MF. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res, 48(5), 1140-9, 2007

Yancey, PG, Yu, H, Linton, MF, Fazio, S. A pathway-dependent on apoE, ApoAI, and ABCA1 determines formation of buoyant high-density lipoprotein by macrophage foam cells. Arterioscler Thromb Vasc Biol, 27(5), 1123-31, 2007

Ayabe, N, Babaev, VR, Tang, Y, Tanizawa, T, Fogo, AB, Linton, MF, Ichikawa, I, Fazio, S, Kon, V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis, 184(2), 312-21, 2006

Babaev, VR, Ding, L, Reese, J, Morrow, JD, Breyer, MD, Dey, SK, Fazio, S, Linton, MF. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation, 113(1), 108-17, 2006

Braun, NA, Mohler, PJ, Weisgraber, KH, Hasty, AH, Linton, MF, Yancey, PG, Su, YR, Fazio, S, Swift, LL. Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. J Lipid Res, 47(6), 1176-86, 2006

Stanic, AK, Stein, CM, Morgan, AC, Fazio, S, Linton, MF, Wakeland, EK, Olsen, NJ, Major, AS. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A, 103(18), 7018-23, 2006 PMCID:1459011

Suganuma, E, Zuo, Y, Ayabe, N, Ma, J, Babaev, VR, Linton, MF, Fazio, S, Ichikawa, I, Fogo, AB, Kon, V. Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction. J Am Soc Nephrol, 17(2), 433-41, 2006

Yu, H, Zhang, W, Yancey, PG, Koury, MJ, Zhang, Y, Fazio, S, Linton, MF. Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice. Arterioscler Thromb Vasc Biol, 26(1), 150-6, 2006

Babaev, VR, Yancey, PG, Ryzhov, SV, Kon, V, Breyer, MD, Magnuson, MA, Fazio, S, Linton, MF. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol, 25(8), 1647-53, 2005

Burleigh, ME, Babaev, VR, Patel, MB, Crews, BC, Remmel, RP, Morrow, JD, Oates, JA, Marnett, LJ, Fazio, S, Linton, MF. Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice. Biochem Pharmacol, 70(3), 334-42, 2005

Burleigh, ME, Babaev, VR, Yancey, PG, Major, AS, McCaleb, JL, Oates, JA, Morrow, JD, Fazio, S, Linton, MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J Mol Cell Cardiol, 39(3), 443-52, 2005

Dove, DE, Linton, MF, Fazio, S. ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects. Am J Physiol Cell Physiol, 288(3), C586-92, 2005

Dove, DE, Su, YR, Swift, LL, Linton, MF, Fazio, S. ACAT1 deficiency increases cholesterol synthesis in mouse peritoneal macrophages. Atherosclerosis, 2005

Dove, DE, Su, YR, Zhang, W, Jerome, WG, Swift, LL, Linton, MF, Fazio, S. ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler Thromb Vasc Biol, 25(1), 128-34, 2005

Gruen, ML, Plummer, MR, Zhang, W, Posey, KA, Linton, MF, Fazio, S, Hasty, AH. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res, 46(9), 2007-14, 2005

Hasty, AH, Plummer, MR, Weisgraber, KH, Linton, MF, Fazio, S, Swift, LL. The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. J Lipid Res, 46(7), 1433-9, 2005

Su, YR, Dove, DE, Major, AS, Hasty, AH, Boone, B, Linton, MF, Fazio, S. Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation, 111(18), 2373-81, 2005

Zhu, MY, Hasty, AH, Harris, C, Linton, MF, Fazio, S, Swift, LL. Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes. Metabolism, 54(10), 1309-15, 2005

Farkas, MH, Weisgraber, KH, Shepherd, VL, Linton, MF, Fazio, S, Swift, LL. The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways. J Lipid Res, 45(8), 1546-54, 2004

Fazio, Sergio, Linton, MacRae F. The role of fibrates in managing hyperlipidemia: mechanisms of action and clinical efficacy. Curr Atheroscler Rep, 6(2), 148-57, 2004

Linton, MF, Fazio, S. Cyclooxygenase-2 and inflammation in atherosclerosis. Curr Opin Pharmacol, 4(2), 116-23, 2004

Major, AS, Wilson, MT, McCaleb, JL, Ru Su, Y, Stanic, AK, Joyce, S, Van Kaer, L, Fazio, S, Linton, MF. Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol, 24(12), 2351-7, 2004

Nobuhiko, A, Suganuma, E, Babaev, VR, Fogo, A, Swift, LL, Linton, MF, Fazio, S, Ichikawa, I, Kon, V. Angiotensin II amplifies macrophage-driven atherosclerosis. Arterioscler Thromb Vasc Biol, 24(11), 2143-8, 2004

Asanuma, Yu, Oeser, Annette, Shintani, Ayumi K, Turner, Elizabeth, Olsen, Nancy, Fazio, Sergio, Linton, MacRae F, Raggi, Paolo, Stein, C Michael. Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med, 349(25), 2407-15, 2003

Farkas, Monica H, Swift, Larry L, Hasty, Alyssa H, Linton, MacRae F, Fazio, Sergio. The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism. J Biol Chem, 278(11), 9412-7, 2003

Fazio, Sergio, Linton, MacRae F. Apolipoprotein AI as Therapy for Atherosclerosis: Does the Future of Preventive Cardiology Include Weekly Injections of the HDL Protein. Mol Intervent, 3(8), 436-40, 2003

Linton, MacRae F, Fazio, Sergio. Macrophages, inflammation, and atherosclerosis. Int J Obes Relat Metab Disord, 27 Suppl 3, S35-40, 2003

Linton, MacRae F, Fazio, Sergio, , . A practical approach to risk assessment to prevent coronary artery disease and its complications. Am J Cardiol, 92(1A), 19i-26i, 2003

Su, Yan Ru, Ishiguro, Hiroyuki, Major, Amy S, Dove, Dwayne E, Zhang, Wenwu, Hasty, Alyssa H, Babaev, Vladimir R, Linton, MacRae F, Fazio, Sergio. Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters. Mol Ther, 8(4), 576-83, 2003

Zhang, Wenwu, Yancey, Patricia G, Su, Yan Ru, Babaev, Vladimir R, Zhang, Yuomin, Fazio, Sergio, Linton, MacRae F. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation, 108(18), 2258-63, 2003

Fazio S, Hasty AH, Linton MF, Swift L. (2001) A Recycling Pathway for Resecretion of Internalized Apolipoprotein E in Liver Cells. J. Biol. Chem. J. Biol. Chem. 276: 22965-22970

Boord JB, Fazio S, Linton MF. Cytoplasmic Fatty Acid Binding Proteins: Emerging Rols in Metabolism and Atherosclerosis. Curr. Opin. in Lipidol., 13(2), 141-147, 2002

Boord, Jeffrey B, Fazio, Sergio, Linton, MacRae F. Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis. Curr Opin Lipidol, 13(2), 141-7, 2002

Boord, Jeffrey B, Maeda, Kazuhisa, Makowski, Liza, Babaev, Vladimir R, Fazio, Sergio, Linton, MacRae F, Hotamisligil, G??khan S. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol, 22(10), 1686-91, 2002

Burleigh ME, Babaev VR, Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LF, Morrow JD, Fazio S, Linton MF. Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDLR Deficient Mice. Circulation, 105, 1816-1823 (Rapid Tract), 2002

Burleigh, Michael E, Babaev, Vladimir R, Oates, John A, Harris, Raymond C, Gautam, Shiva, Riendeau, Denis, Marnett, Lawrence J, Morrow, Jason D, Fazio, Sergio, Linton, MacRae F. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation, 105(15), 1816-23, 2002

Doggett, Kevin L, Briggs, Judith A, Linton, MacRae F, Fazio, Sergio, Head, David R, Xie, Jingping, Hashimoto, Yuko, Laborda, Jorge, Briggs, Robert C. Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression. J Cell Biochem, 86(1), 56-66, 2002

Fazio, Sergio, Babaev, Vladimir R, Burleigh, Michael E, Major, Amy S, Hasty, Alyssa H, Linton, MacRae F. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res, 43(10), 1602-9, 2002

Linton, MacRae F, Fazio, Sergio. Cyclooxygenase-2 and atherosclerosis. Curr Opin Lipidol, 13(5), 497-504, 2002

Major, Amy S, Fazio, Sergio, Linton, MacRae F. B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol, 22(11), 1892-8, 2002

Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B, Davidson, Jeffrey M, Linton, MacRae F, Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni. Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J Clin Invest, 110(12), 1859-68, 2002 PMCID:151648

Su, Yan Ru, Linton, MacRae F, Fazio, Sergio. Rapid quantification of murine ABC mRNAs by real time reverse transcriptase-polymerase chain reaction. J Lipid Res, 43(12), 2180-7, 2002

Beed G, Migliori RJ, Goff CV, Mullins CD, Linton MF, Wright AT. Addressing the challenges of treating and managing the hyperlipidemic patient. Managed Care, 10(11Suppl), 19-24, 2001

Fazio S & Linton MF. Mouse Models of Hyperlipidemia and Atherosclerosis. Frontiers in Bioscience , 6, d515-525, 2001

Fazio S, Linton MF. "How Low Should Chilesterol be Lowered?". Curr. Control. Trials Cardiovasc. Med., 2, 8-11, 2001

Fazio S, Linton MF. The Inflammed Plaque: Cytokine Production and Cellular Cholesterol Balance in the Vessel Wall. Am J Cardiol, 88 (suppl), 12E-15E, 2001

Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV, Jr. Increased Atherosclerosis in LDL Receptor Null Mice Reconstituted with ACAT Negative Macrophages. 107, 613-171, J. Clin. Invest., 2001

Fazio, S, Linton, M F. Mouse models of hyperlipidemia and atherosclerosis. Front Biosci, 6, D515-25, 2001

Fazio, S, Linton, M F. The inflamed plaque: cytokine production and cellular cholesterol balance in the vessel wall. Am J Cardiol, 88(2A), 12E-15E, 2001

Fazio, S, Major, A S, Swift, L L, Gleaves, L A, Accad, M, Linton, M F, Farese, R V. Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. J Clin Invest, 107(2), 163-71, 2001 PMCID:198874

Fazio, Sergio, Linton, MacRae. Debate: 'How low should LDL cholesterol be lowered?' Viewpoint: 'It doesn't need to be very low. Curr Control Trials Cardiovasc Med, 2(1), 8-11, 2001 PMCID:59646

Ishiguro H, Yoshida H, Major AS, Zhu T, Babaev V, Linton MF, Fazio S. Retrovirus-mediated expression of apolipoprotein A-1 in the macrophage protects against atherosclerosis in vivo. J Biol Chem, 276, 36742-36748, 2001

Ishiguro, H, Yoshida, H, Major, A S, Zhu, T, Babaev, V R, Linton, M F, Fazio, S. Retrovirus-mediated expression of apolipoprotein A-I in the macrophage protects against atherosclerosis in vivo. J Biol Chem, 276(39), 36742-8, 2001

Linton MF, Burleigh ME, Fazio S. Class A Scavenger Receptors, Macrophages and Atherosclerosis. Curr. Opin. Lipidol., 12, 489-495, 2001

Linton, M F, Fazio, S. Class A scavenger receptors, macrophages, and atherosclerosis. Curr Opin Lipidol, 12(5), 489-95, 2001

Ma L, Marcantoni C, Linton MF, Fazio S, Fogo AB. Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Agonist Troglitazone Protects Against Non-Diabetic Glomerulsclerosis in Rats. Kidney International , 59, 1899-1910, 2001

Ma, L J, Marcantoni, C, Linton, M F, Fazio, S, Fogo, A B. Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int, 59(5), 1899-910, 2001

Major, A S, Dove, D E, Ishiguro, H, Su, Y R, Brown, A M, Liu, L, Carter, K J, Linton, M F, Fazio, S. Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice. Arterioscler Thromb Vasc Biol, 21(11), 1790-5, 2001

Makowski L, Boord JB, Maeda K, Babaev VR, Usyal KT, Morgan MA, Parker RA, Fazio S, Hotomisligil GS, Linton MF. Lack of Macrophage Fatty Acid Binding Protein aP2 Protects apoE Deficient Mice Against Atherosclerosis. Nature Medicine, 7, 699-705, 2001

Swift, L L, Farkas, M H, Major, A S, Valyi-Nagy, K, Linton, M F, Fazio, S. A recycling pathway for resecretion of internalized apolipoprotein E in liver cells. J Biol Chem, 276(25), 22965-70, 2001

Yoshida, H, Hasty, A H, Major, A S, Ishiguro, H, Su, Y R, Gleaves, L A, Babaev, V R, Linton, M F, Fazio, S. Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice. Circulation, 104(23), 2820-5, 2001

Accad MS, Smith DL, Newland DA, Sanan JL, King LE, Jr., Linton MF, Fazio S, Farese RV, Jr. Massive Xanthomatosis and Altered Composition of Atherosclerotic Lesions in Hyperlipidemic Mice Lacking ACAT1. J. Clin. Invest., 105, 711-719, 2000

Babaev VR, Gleaves LA, Carter KJ, Kodama T, Fazio S, Linton MF. ReducedAtherosclerosis in Mice Null for Macrophage Expression of Scavenger Receptor-A. Arterioscl. Thromb. Vasc. Biol., 20, 2593-2599, 2000

Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in LDL Receptor Deficient Mice. J. Biol. Chem, 275, 26293-26299, 2000

Babaev, V R, Gleaves, L A, Carter, K J, Suzuki, H, Kodama, T, Fazio, S, Linton, M F. Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A. Arterioscler Thromb Vasc Biol, 20(12), 2593-9, 2000

Babaev, V R, Patel, M B, Semenkovich, C F, Fazio, S, Linton, M F. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem, 275(34), 26293-9, 2000

Fazio, S, Linton, M F, Swift, L L. The cell biology and physiologic relevance of ApoE recycling. Trends Cardiovasc Med, 10(1), 23-30, 2000

Linton, M F, Fazio, S. Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk. Curr Atheroscler Rep, 2(1), 29-35, 2000

Maron, D J, Fazio, S, Linton, M F. Current perspectives on statins. Circulation, 101(2), 207-13, 2000

Babaev VR, Fazio S, Gleaves LA, Carter KJ, Semenkovich CF, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J. Clin. Invest., 103, 1697-1705, 1999

Babaev, V R, Fazio, S, Gleaves, L A, Carter, K J, Semenkovich, C F, Linton, M F. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J Clin Invest, 103(12), 1697-705, 1999 PMCID:408384

Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Funk CD. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apolipoprotein E-deficient mice. J. Clin. Invest., 103, 1597-1604, 1999

Fazio S, Hasty AH, Linton MF, Swift L. Recycling of apolipoprotein E in mouse liver. J. Biol. Chem., 274, 8247-8253, 1999

Fazio, S, Linton, M F, Hasty, A H, Swift, L L. Recycling of apolipoprotein E in mouse liver. J Biol Chem, 274(12), 8247-53, 1999

Hasty AH, Linton MF, Brandt SJ, Babaev VR, Gleaves LA, Fazio S. Retroviral Gene Therapy in ApoE Deficient Mice, ApoE Expression in the Artery Wall Reduces Early Foam Cell Lesion Formation. Circulation, 99, 2571-2576, 1999

Hasty AH, Linton MF, Swift L, Fazio S. Determination of the lower threshold of apoE resulting in remnant lipoprotein clearance. J. Lipid Res., 409, 1529-1538, 1999

Hasty, A H, Linton, M F, Brandt, S J, Babaev, V R, Gleaves, L A, Fazio, S. Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation. Circulation, 99(19), 2571-6, 1999

Hasty, A H, Linton, M F, Swift, L L, Fazio, S. Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance. J Lipid Res, 40(8), 1529-38, 1999

Linton MF, Babaev VR, Gleaves LA, Fazio S. A direct role for the macrophage LDL receptor in atherosclerotic lesion formation. J. Biol. Chem., 274, 19204-19210, 1999

Linton, M F, Babaev, V R, Gleaves, L A, Fazio, S. A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation. J Biol Chem, 274(27), 19204-10, 1999

Linton, M F, Fazio, S. Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies. Curr Opin Lipidol, 10(2), 97-105, 1999

Linton, MF, Fazio S. Macrophages, lipoprotein metabolism, and atherosclerosis: Insights from murine bone marrow transplantation studies. Curr. Opin. Lipidol., 10, 97-105, 1999

Maron DJ, Fazio S, Linton MF. Current perspectives on HMG-CoA reductase inhibitors. Circulation, 101, 207-213, 1999

Montine, T J, Montine, K S, Olson, S J, Graham, D G, Roberts, L J, Morrow, J D, Linton, M F, Fazio, S, Swift, L L. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Exp Neurol, 158(1), 234-41, 1999

Linton, M F, Hasty, A H, Babaev, V R, Fazio, S. Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor. J Clin Invest, 101(8), 1726-36, 1998 PMCID:508755

Linton, M. F., Hasty, A. H., Babaev, V. R., Fazio, S. Hepatic apoE expression is required for remnant lipoprotein clearance. J. of Clin. Invest., 101, 1726-1736, 1998

Fazio S, Hasty AH, Carter KJ, Murray AB, Price JO, Linton MF. Reconstitution of leukocyte low density lipoprotein receptor (LDL-R) expression in mice lacking the LDL-R does not affect plasma cholesterol levels or LDL turnover. J. Lipid Res., 38, 391-400, 1997

Fazio, S, Babaev, V R, Murray, A B, Hasty, A H, Carter, K J, Gleaves, L A, Atkinson, J B, Linton, M F. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc Natl Acad Sci U S A, 94(9), 4647-52, 1997 PMCID:20778

Fazio, S, Hasty, A H, Carter, K J, Murray, A B, Price, J O, Linton, M F. Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse. J Lipid Res, 38(2), 391-400, 1997

Fazio, S., Babaev, V.R., Murray, A.B., Hasty, A.H., Carter, K.J., Gleaves, L.A., Atkinson, J.B., Linton, M.F. Increased atherosclerosis in mice reconstituted with apolipoprotein E null Macrophages. Proc. Natl. Acad. Sci. USA, 94, 4647-4652, 1997

Linton, M F, Raabe, M, Pierotti, V, Young, S G. Reading-frame restoration by transcriptional slippage at long stretches of adenine residues in mammalian cells. J Biol Chem, 272(22), 14127-32, 1997

Linton, M.F., Raabe, M., Pierotti, V., Young, S.G. Reading Frame Restoration in Mammalian Cells Caused by Transcriptional Slippage at Long Stretches of Adenine Residues. J. Biol. Chem., 272, 14127-14132, 1997

Young SG, Krul ES, McCormick S, Farese RV, Jr., Linton MF. Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia. Methods in Enz., 263, 120-145, 1996

Linton, M F, Atkinson, J B, Fazio, S. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science, 267(5200), 1034-7, 1995

Linton, M.F., Atkinson. J. B., Fazio, S. Prevention of atherosclerosis in apolipoprotein E deficient mice by bone marrow transplantation. Science, 267, 1034-1037, 1995

Purcell-Huynh DA, Farese RV, Jr., Flynn LM, Pierotti V, Newland DL, Fein H, Linton MF, Sanan DA, Young SG. Transgenic mice expressing high plasma levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J. of Clin. Invest., 95, 2246-2257, 1995

McCormick SA, Linton MF, Taylor S, Curtiss LK, Young SG. Expression of human apolipoprotein B90 in transgenic mice: Demonstration that apolipoprotein B90 lacks the structured requirements to form lipoprotein (a). J. Biol. Chem, 269, 24284-24289, 1994

Linton, M.F., Farese, R.V. Jr., Chiesa. G., Grass, D.S., Chin, P., Hammer, R.E., Hobbs, H.H., and Young, S.G. Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoprotein B100 and Lipoprotein(a). J. Clin. Invest, 92, 3029-3037, 1993

Linton MF, Pierotti V, Young SC. Reading-frame restoration with an apolipoprotein B gene frameshift mutation. Proc. Natl. Acad. Sci. USA , 89, 11431-11435, 1992

Linton MF, Gish R, Hubl S, Butler E, Esquivel C, Bry WI, Boyles JK, Wardell MR, Young SG. Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. J. Clin. Invest., 88, 270-281, 1991

Yao Z, Blackhart BD, Linton MF, Taylor SM, Young SG, McCarthy BJ. Expression of truncated forms of human apolipoprotein B in rat hepatoma cells: Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins. J. Biol. Chem., 266, 3300-3308, 1991


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
11/27/2013