Biomedical Research Education & Training
Faculty Member

Magnuson, Mark A., M.D.
Professor of Molecular Physiology and Biophysics
Professor of Cell and Developmental Biology
Louise B. McGavock Chair
Professor of Medicine

Lab Url:

Phone Number: (615) 322-7006

Email Address:

Magnuson, Mark's picture
Academic history
B.A., Luther College, Decorah, IA
M.D., University of Iowa, Iowa City, IA
Resident, University of Rochester, Rochester, NY
Staff Fellow, NIADDK, NIH, Bethesda, MD
Clinical Fellow, Vanderbilt Univ. School of Medicine, Nashville, TN

Office Address   Mailing Address

9475 MRB IV

Center for Stem Cell Biology 9465 MRB IV 37232-0494

Research Keywords
pancreatic endocrine cell differentitation and dedifferentiation, reprogramming of pancreatic acinar cells into new beta cells, genetic and epigenetic regulation of cellular plasticity, mouse models, transcription factors, genomics, diabetes

Research Description
We are interested in developing new types of therapies for the treatment of diabetes. This requires a deep understanding of pancreatic beta cell function and development. My laboratory has a long history of developing novel mouse models using gene targeting and recombinase-mediated cassette exchange (RMCE) strategies, and using these mice to gain important new insights and understanding of the molecular physiology of diabetes. However, better models that more closely mimic the physiology and pathophysiology of human diseases, including type 1 and type 2 diabetes, are needed. Towards this end, we have been developing several novel strategies and methods that will enable us to generate better animal models that more closely model the human.

Seto, Y, Nakatani, T, Masuyama, N, Taya, S, Kumai, M, Minaki, Y, Hamaguchi, A, Inoue, YU, Inoue, T, Miyashita, S, Fujiyama, T, Yamada, M, Chapman, H, Campbell, K, Magnuson, MA, Wright, CV, Kawaguchi, Y, Ikenaka, K, Takebayashi, H, Ishiwata, S, Ono, Y, Hoshino, M. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nat Commun, 5, 3337, 2014

Tornovsky-Babeay, S, Dadon, D, Ziv, O, Tzipilevich, E, Kadosh, T, Schyr-Ben Haroush, R, Hija, A, Stolovich-Rain, M, Furth-Lavi, J, Granot, Z, Porat, S, Philipson, LH, Herold, KC, Bhatti, TR, Stanley, C, Ashcroft, FM, In''t Veld, P, Saada, A, Magnuson, MA, Glaser, B, Dor, Y. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ?? cells. Cell Metab, 19(1), 109-21, 2014

Worchel, HN, Magnuson, MA. Cytokine-driven beta-cell production in vivo. Nat Biotechnol, 32(1), 63-4, 2014

Magnuson, MA, Osipovich, AB. Pancreas-specific cre driver lines and considerations for their prudent use. Cell Metab, 18(1), 9-20, 2013

Pan, FC, Bankaitis, ED, Boyer, D, Xu, X, Van de Casteele, M, Magnuson, MA, Heimberg, H, Wright, CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development, 140(4), 751-64, 2013

Choi, E, Kraus, MR, Lemaire, LA, Yoshimoto, M, Vemula, S, Potter, LA, Manduchi, E, Stoeckert, CJ, Grapin-Botton, A, Magnuson, MA. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells, 30(10), 2297-308, 2012

Kopinke, D, Brailsford, M, Pan, FC, Magnuson, MA, Wright, CV, Murtaugh, LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol, 362(1), 57-64, 2012 PMCID:3254730

McKenna, NJ, Howard, CL, Aufiero, M, Easton-Marks, J, Steffen, DL, Becnel, LB, Magnuson, MA, McIndoe, RA, Cartailler, JP. Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia. Mol Endocrinol, 26(10), 1675-81, 2012

Chen, SX, Osipovich, AB, Ustione, A, Potter, LA, Hipkens, S, Gangula, R, Yuan, W, Piston, DW, Magnuson, MA. Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Dis Model Mech, 4(4), 537-47, 2011 PMCID:3124063

Gu, Y, Lindner, J, Kumar, A, Yuan, W, Magnuson, MA. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes, 60(3), 827-37, 2011 PMCID:3124063

Papizan, JB, Singer, RA, Tschen, SI, Dhawan, S, Friel, JM, Hipkens, SB, Magnuson, MA, Bhushan, A, Sussel, L. Nkx2.2 repressor complex regulates islet I?-cell specification and prevents I?-to-I?-cell reprogramming. Genes Dev, 25(21), 2291-305, 2011 PMCID:3219233

Petersen, DR, Gustavsen, C, Lindskog, SR, Magnuson, MA, Zaret, KS, Serup, P. Engineering Artificial Signaling Centers to Polarize Embryoid Body Differentiation. Stem Cells Dev, 2011 PMCID:3219233

Plank, JL, Frist, AY, Legrone, AW, Magnuson, MA, Labosky, PA. Loss of Foxd3 Results in Decreased I?-Cell Proliferation and Glucose Intolerance During Pregnancy. Endocrinology, 152(12), 4589-600, 2011

Porat, S, Weinberg-Corem, N, Tornovsky-Babaey, S, Schyr-Ben-Haroush, R, Hija, A, Stolovich-Rain, M, Dadon, D, Granot, Z, Ben-Hur, V, White, P, Girard, CA, Karni, R, Kaestner, KH, Ashcroft, FM, Magnuson, MA, Saada, A, Grimsby, J, Glaser, B, Dor, Y. Control of pancreatic I? cell regeneration by glucose metabolism. Cell Metab, 13(4), 440-9, 2011 PMCID:3115606

Potter, LA, Choi, E, Hipkens, SB, Wright, CV, Magnuson, MA. An RMCE-derived cyan fluorescent protein reporter allele for Pdx1. Genesis, 2011

Salpeter, SJ, Klochendler, A, Weinberg-Corem, N, Porat, S, Granot, Z, Shapiro, AM, Magnuson, MA, Eden, A, Grimsby, J, Glaser, B, Dor, Y. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic I?-cells through glycolysis and calcium channels. Endocrinology, 152(7), 2589-98, 2011 PMCID:3115606

Watanabe, H, Yang, T, Stroud, DM, Lowe, JS, Harris, L, Atack, TC, Wang, DW, Hipkens, SB, Leake, B, Hall, L, Kupershmidt, S, Chopra, N, Magnuson, MA, Tanabe, N, Knollmann, BC, George, AL, Roden, DM. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation, 124(9), 1001-11, 2011

Artner, I, Hang, Y, Mazur, M, Yamamoto, T, Guo, M, Lindner, J, Magnuson, MA, Stein, R. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes, 59(10), 2530-9, 2010 PMCID:3124063

Boulbes, D, Chen, CH, Shaikenov, T, Agarwal, NK, Peterson, TR, Addona, TA, Keshishian, H, Carr, SA, Magnuson, MA, Sabatini, DM, Sarbassov, dos D. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res, 8(6), 896-906, 2010 PMCID:2896829

Jiang, M, Fernandez, S, Jerome, WG, He, Y, Yu, X, Cai, H, Boone, B, Yi, Y, Magnuson, MA, Roy-Burman, P, Matusik, RJ, Shappell, SB, Hayward, SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ, 17(3), 469-81, 2010 PMCID:2882427

Kumar, A, Lawrence, JC, Jung, DY, Ko, HJ, Keller, SR, Kim, JK, Magnuson, MA, Harris, TE. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes, 59(6), 1397-406, 2010 PMCID:2874700

Lee, K, Gudapati, P, Dragovic, S, Spencer, C, Joyce, S, Killeen, N, Magnuson, MA, Boothby, M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity, 32(6), 743-53, 2010

Masui, T, Swift, GH, Deering, T, Shen, C, Coats, WS, Long, Q, Els??sser, HP, Magnuson, MA, MacDonald, RJ. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology, 139(1), 270-80, 2010 PMCID:2902682

Siuta, MA, Robertson, SD, Kocalis, H, Saunders, C, Gresch, PJ, Khatri, V, Shiota, C, Kennedy, JP, Lindsley, CW, Daws, LC, Polley, DB, Veenstra-Vanderweele, J, Stanwood, GD, Magnuson, MA, Niswender, KD, Galli, A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol, 8(6), e1000393, 2010 PMCID:2882427

Treins, C, Warne, PH, Magnuson, MA, Pende, M, Downward, J. Rictor is a novel target of p70 S6 kinase-1. Oncogene, 29(7), 1003-16, 2010 PMCID:2874700

Berglund, ED, Lee-Young, RS, Lustig, DG, Lynes, SE, Donahue, EP, Camacho, RC, Meredith, ME, Magnuson, MA, Charron, MJ, Wasserman, DH. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest, 119(8), 2412-22, 2009 PMCID:2719934

Huppert, SS, Magnuson, MA. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Sci Signal, 2(83), pe50, 2009 PMCID:2882427

Wang, S, Jensen, JN, Seymour, PA, Hsu, W, Dor, Y, Sander, M, Magnuson, MA, Serup, P, Gu, G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A, 106(24), 9715-20, 2009 PMCID:2701002

Zhang, H, Ables, ET, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev, 126(11-12), 958-73, 2009 PMCID:2882427

Burlison, JS, Long, Q, Fujitani, Y, Wright, CV, Magnuson, MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol, 316(1), 74-86, 2008 PMCID:2425677

Elrod, JW, Harrell, M, Flagg, TP, Gundewar, S, Magnuson, MA, Nichols, CG, Coetzee, WA, Lefer, DJ. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury. Circulation, 117(11), 1405-13, 2008

Gannon, M, Ables, ET, Crawford, L, Lowe, D, Offield, MF, Magnuson, MA, Wright, CV. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol, 314(2), 406-17, 2008 PMCID:2269701

Hagan, GN, Lin, Y, Magnuson, MA, Avruch, J, Czech, MP. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol, 28(13), 4215-26, 2008 PMCID:2447144

Hori, K, Cholewa-Waclaw, J, Nakada, Y, Glasgow, SM, Masui, T, Henke, RM, Wildner, H, Martarelli, B, Beres, TM, Epstein, JA, Magnuson, MA, Macdonald, RJ, Birchmeier, C, Johnson, JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev, 22(2), 166-78, 2008 PMCID:2192752

Kumar, A, Harris, TE, Keller, SR, Choi, KM, Magnuson, MA, Lawrence, JC. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol, 28(1), 61-70, 2008 PMCID:2223287

Shiota, M, Magnuson, MA. Hepatic glucose sensing: does flux matter. J Clin Invest, 118(3), 841-4, 2008 PMCID:2248806

Zelent, B, Odili, S, Buettger, C, Shiota, C, Grimsby, J, Taub, R, Magnuson, MA, Vanderkooi, JM, Matschinsky, FM. Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence. Biochem J, 413(2), 269-80, 2008

Burgess, SC, He, T, Yan, Z, Lindner, J, Sherry, AD, Malloy, CR, Browning, JD, Magnuson, MA. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab, 5(4), 313-20, 2007 PMCID:2680089

Magnuson, MA, Burlison, JS. Caveats and considerations for performing pancreas-specific gene manipulations in the mouse. Diabetes Obes Metab, 9 Suppl 2, 5-13, 2007

Masui, T, Long, Q, Beres, TM, Magnuson, MA, MacDonald, RJ. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev, 21(20), 2629-43, 2007 PMCID:2000326

Niswender, KD, Magnuson, MA. Obesity and the beta cell: lessons from leptin. J Clin Invest, 117(10), 2753-6, 2007 PMCID:1994637

Pearce, LR, Huang, X, Boudeau, J, Paw??owski, R, Wullschleger, S, Deak, M, Ibrahim, AF, Gourlay, R, Magnuson, MA, Alessi, DR. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J, 405(3), 513-22, 2007 PMCID:2267312

Pino, MF, Kim, KA, Shelton, KD, Lindner, J, Odili, S, Li, C, Collins, HW, Shiota, M, Matschinsky, FM, Magnuson, MA. Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations. J Biol Chem, 2007

Wang, S, Zhang, J, Zhao, A, Hipkens, S, Magnuson, MA, Gu, G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev, 124(11-12), 898-910, 2007 PMCID:2141686

Yoshida, K, Murao, K, Imachi, H, Cao, WM, Yu, X, Li, J, Ahmed, RA, Kitanaka, N, Wong, NC, Unterman, TG, Magnuson, MA, Ishida, T. Pancreatic Glucokinase is Activated by Insulin-like Growth Factor-I. Endocrinology, 2007

Doliba, NM, Qin, W, Vatamaniuk, MZ, Buettger, CW, Collins, HW, Magnuson, MA, Kaestner, KH, Wilson, DF, Carr, RD, Matschinsky, FM. Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. Am J Physiol Endocrinol Metab, 291(3), E525-35, 2006

Fujitani, Y, Fujitani, S, Boyer, DF, Gannon, M, Kawaguchi, Y, Ray, M, Shiota, M, Stein, RW, Magnuson, MA, Wright, CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev, 20(2), 253-66, 2006 PMCID:1356115

Fujitani, Y, Fujitani, S, Luo, H, Qiu, F, Burlison, J, Long, Q, Kawaguchi, Y, Edlund, H, MacDonald, RJ, Furukawa, T, Fujikado, T, Magnuson, MA, Xiang, M, Wright, CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development, 133(22), 4439-50, 2006

Liu, K, Hipkens, S, Yang, T, Abraham, R, Zhang, W, Chopra, N, Knollmann, B, Magnuson, MA, Roden, DM. Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis, 44(11), 556-64, 2006

Matschinsky, FM, Magnuson, MA, Zelent, D, Jetton, TL, Doliba, N, Han, Y, Taub, R, Grimsby, J. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes, 55(1), 1-12, 2006

Shiota, C, Woo, JT, Lindner, J, Shelton, KD, Magnuson, MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell, 11(4), 583-9, 2006

Stiles, BL, Kuralwalla-Martinez, C, Guo, W, Gregorian, C, Wang, Y, Tian, J, Magnuson, MA, Wu, H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol, 26(7), 2772-81, 2006 PMCID:1430339

Babaev, Vladimir R, Yancey, Patricia G, Ryzhov, Sergey V, Kon, Valentina, Breyer, Matthew D, Magnuson, Mark A, Fazio, Sergio, Linton, Macrae F. Conditional Knockout of Macrophage PPAR{gamma} Increases Atherosclerosis in C57BL/6 and Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol, 2005

Gloyn, AL, Odili, S, Zelent, D, Buettger, C, Castleden, HA, Steele, AM, Stride, A, Shiota, C, Magnuson, MA, Lorini, R, d''Annunzio, G, Stanley, CA, Kwagh, J, van Schaftingen, E, Veiga-da-Cunha, M, Barbetti, F, Dunten, P, Han, Y, Grimsby, J, Taub, R, Ellard, S, Hattersley, AT, Matschinsky, FM. Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young. J Biol Chem, 280(14), 14105-13, 2005

Guan, Youfei, Hao, Chuanming, Cha, Dae Ryong, Rao, Reena, Lu, Wendell, Kohan, Donald E, Magnuson, Mark A, Redha, Reyadh, Zhang, Yahua, Breyer, Matthew D. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med, 2005

Gunawardana, Subhadra C, Hara, Manami, Bell, Graeme I, Head, W Steven, Magnuson, Mark A, Piston, David W. Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells. In Vitro Cell Dev Biol Anim, 41(1-2), 7-11, 2005

Jones, JR, Shelton, KD, Magnuson, MA. Strategies for the use of site-specific recombinases in genome engineering. Methods Mol Med, 103, 245-57, 2005

Jones, Julie R, Barrick, Cordelia, Kim, Kyoung-Ah, Lindner, Jill, Blondeau, Bertrand, Fujimoto, Yuka, Shiota, Masakazu, Kesterson, Robert A, Kahn, Barbara B, Magnuson, Mark A. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A, 102(17), 6207-12, 2005 PMCID:556131

Lee, JY, Ristow, M, Lin, X, White, MF, Magnuson, MA, Hennighausen, L. RIP-Cre revisited: Evidence for impairments of pancreatic beta-cell function. J Biol Chem, 2005

Miura, A, Yamagata, K, Kakei, M, Hatakeyama, H, Takahashi, N, Fukui, K, Nammo, T, Yoneda, K, Inoue, Y, Sladek, FM, Magnuson, MA, Kasai, H, Miyagawa, J, Gonzalez, FJ, Shimomura, I. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem, 2005

Park, SY, Wang, X, Chen, Z, Powers, AC, Magnuson, MA, Head, WS, Piston, DW, Bell, GI. Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis, 43(2), 80-6, 2005

Roccisana, J, Reddy, V, Vasavada, RC, Gonzalez-Pertusa, JA, Magnuson, MA, Garcia-Oca??a, A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes, 54(7), 2090-102, 2005

Romero-Gallo, J, Sozmen, EG, Chytil, A, Russell, WE, Whitehead, R, Parks, WT, Holdren, MS, Her, MF, Gautam, S, Magnuson, M, Moses, HL, Grady, WM. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene, 24(18), 3028-41, 2005

Schonhoff, S, Baggio, L, Ratineau, C, Ray, SK, Lindner, J, Magnuson, MA, Drucker, DJ, Leiter, AB. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol Cell Biol, 25(10), 4189-99, 2005 PMCID:1087718

Shiota, C, Rocheleau, JV, Shiota, M, Piston, DW, Magnuson, MA. Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. Am J Physiol Endocrinol Metab, 289(4), E570-7, 2005

Thierbach, R, Schulz, TJ, Isken, F, Voigt, A, Mietzner, B, Drewes, G, von Kleist-Retzow, JC, Wiesner, RJ, Magnuson, MA, Puccio, H, Pfeiffer, AF, Steinberg, P, Ristow, M. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet, 14(24), 3857-64, 2005

Wang, CZ, Wang, Y, Di, A, Magnuson, MA, Ye, H, Roe, MW, Nelson, DJ, Bell, GI, Philipson, LH. 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochem Biophys Res Commun, 330(4), 1073-9, 2005

Biondi, Christine A, Gartside, Michael G, Waring, Paul, Loffler, Kelly A, Stark, Mitchell S, Magnuson, Mark A, Kay, Graham F, Hayward, Nicholas K. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol, 24(8), 3125-31, 2004 PMCID:381682

Burgess, SC, Hausler, N, Merritt, M, Jeffrey, FM, Storey, C, Milde, A, Koshy, S, Lindner, J, Magnuson, MA, Malloy, CR, Sherry, AD. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem, 279(47), 48941-9, 2004

Chu, Chang An, Fujimoto, Yuka, Igawa, Kayano, Grimsby, Joseph, Grippo, Joseph F, Magnuson, Mark A, Cherrington, Alan D, Shiota, Masakazu. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am J Physiol Gastrointest Liver Physiol, 286(4), G627-34, 2004

Dentin, R, P??gorier, JP, Benhamed, F, Foufelle, F, Ferr??, P, Fauveau, V, Magnuson, MA, Girard, J, Postic, C. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem, 279(19), 20314-26, 2004

Doliba, NM, Qin, W, Vatamaniuk, MZ, Li, C, Zelent, D, Najafi, H, Buettger, CW, Collins, HW, Carr, RD, Magnuson, MA, Matschinsky, FM. Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine. Am J Physiol Endocrinol Metab, 286(5), E834-43, 2004

Gorogawa, S, Fujitani, Y, Kaneto, H, Hazama, Y, Watada, H, Miyamoto, Y, Takeda, K, Akira, S, Magnuson, MA, Yamasaki, Y, Kajimoto, Y, Hori, M. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun, 319(4), 1159-70, 2004

Long, Q, Shelton, KD, Lindner, J, Jones, JR, Magnuson, MA. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection. Genesis, 39(4), 256-62, 2004

Moates, JM, Magnuson, MA. The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised. Diabetologia, 47(9), 1632-40, 2004

Schneider, A, Guan, Y, Zhang, Y, Magnuson, MA, Pettepher, C, Loftin, CD, Langenbach, R, Breyer, RM, Breyer, MD. Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis, 40(1), 7-14, 2004

Stiles, B, Wang, Y, Stahl, A, Bassilian, S, Lee, WP, Kim, YJ, Sherwin, R, Devaskar, S, Lesche, R, Magnuson, MA, Wu, H. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A, 101(7), 2082-7, 2004 PMCID:357055

Crabtree, JS, Scacheri, PC, Ward, JM, McNally, SR, Swain, GP, Montagna, C, Hager, JH, Hanahan, D, Edlund, H, Magnuson, MA, Garrett-Beal, L, Burns, AL, Ried, T, Chandrasekharappa, SC, Marx, SJ, Spiegel, AM, Collins, FS. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol, 23(17), 6075-85, 2003 PMCID:180910

Gloyn, AL, Noordam, K, Willemsen, MA, Ellard, S, Lam, WW, Campbell, IW, Midgley, P, Shiota, C, Buettger, C, Magnuson, MA, Matschinsky, FM, Hattersley, AT. Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes, 52(9), 2433-40, 2003

Grimsby, J, Sarabu, R, Corbett, WL, Haynes, NE, Bizzarro, FT, Coffey, JW, Guertin, KR, Hilliard, DW, Kester, RF, Mahaney, PE, Marcus, L, Qi, L, Spence, CL, Tengi, J, Magnuson, MA, Chu, CA, Dvorozniak, MT, Matschinsky, FM, Grippo, JF. Allosteric activators of glucokinase: potential role in diabetes therapy. Science, 301(5631), 370-3, 2003

Hara, M, Wang, X, Kawamura, T, Bindokas, VP, Dizon, RF, Alcoser, SY, Magnuson, MA, Bell, GI. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab, 284(1), E177-83, 2003

Henderson, CJ, Otto, DM, Carrie, D, Magnuson, MA, McLaren, AW, Rosewell, I, Wolf, CR. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem, 278(15), 13480-6, 2003

Lee, YH, Magnuson, MA, Muppala, V, Chen, SS. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol, 23(3), 923-32, 2003 PMCID:140695

Magnuson, MA, She, P, Shiota, M. Gene-altered mice and metabolic flux control. J Biol Chem, 278(35), 32485-8, 2003

Mart?-n, J, Hunt, SL, Dubus, P, Sotillo, R, N??hm??-P??lluard, F, Magnuson, MA, Parlow, AF, Malumbres, M, Ortega, S, Barbacid, M. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene, 22(34), 5261-9, 2003

Miyatsuka, T, Kaneto, H, Kajimoto, Y, Hirota, S, Arakawa, Y, Fujitani, Y, Umayahara, Y, Watada, H, Yamasaki, Y, Magnuson, MA, Miyazaki, J, Hori, M. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun, 310(3), 1017-25, 2003

Ristow, M, Mulder, H, Pomplun, D, Schulz, TJ, M??ller-Schmehl, K, Krause, A, Fex, M, Puccio, H, M??ller, J, Isken, F, Spranger, J, M??ller-Wieland, D, Magnuson, MA, M??hlig, M, Koenig, M, Pfeiffer, AF. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J Clin Invest, 112(4), 527-34, 2003 PMCID:171391

Rosen, ED, Kulkarni, RN, Sarraf, P, Ozcan, U, Okada, T, Hsu, CH, Eisenman, D, Magnuson, MA, Gonzalez, FJ, Kahn, CR, Spiegelman, BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol, 23(20), 7222-9, 2003 PMCID:230305

Schulla, V, Renstr??m, E, Feil, R, Feil, S, Franklin, I, Gjinovci, A, Jing, XJ, Laux, D, Lundquist, I, Magnuson, MA, Oberm??ller, S, Olofsson, CS, Salehi, A, Wendt, A, Klugbauer, N, Wollheim, CB, Rorsman, P, Hofmann, F. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J, 22(15), 3844-54, 2003 PMCID:169062

She, P, Burgess, SC, Shiota, M, Flakoll, P, Donahue, EP, Malloy, CR, Sherry, AD, Magnuson, MA. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes, 52(7), 1649-54, 2003

Christesen, HB, Jacobsen, BB, Odili, S, Buettger, C, Cuesta-Munoz, A, Hansen, T, Brusgaard, K, Massa, O, Magnuson, MA, Shiota, C, Matschinsky, FM, Barbetti, F. The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. Diabetes, 51(4), 1240-6, 2002

Chytil, A, Magnuson, MA, Wright, CV, Moses, HL. Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis, 32(2), 73-5, 2002

Jones, JR, Shelton, KD, Guan, Y, Breyer, MD, Magnuson, MA. Generation and functional confirmation of a conditional null PPARgamma allele in mice. Genesis, 32(2), 134-7, 2002

Kulkarni, RN, Holzenberger, M, Shih, DQ, Ozcan, U, Stoffel, M, Magnuson, MA, Kahn, CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet, 31(1), 111-5, 2002

Rizzo, MA, Magnuson, MA, Drain, PF, Piston, DW. A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin. J Biol Chem, 277(37), 34168-75, 2002

Shiota, C, Larsson, O, Shelton, KD, Shiota, M, Efanov, AM, Hoy, M, Lindner, J, Kooptiwut, S, Juntti-Berggren, L, Gromada, J, Berggren, PO, Magnuson, MA. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem, 277(40), 37176-83, 2002

Xin, HB, Senbonmatsu, T, Cheng, DS, Wang, YX, Copello, JA, Ji, GJ, Collier, ML, Deng, KY, Jeyakumar, LH, Magnuson, MA, Inagami, T, Kotlikoff, MI, Fleischer, S. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature, 416(6878), 334-8, 2002

Efanov, AM, H??y, M, Br??nstr??m, R, Zaitsev, SV, Magnuson, MA, Efendic, S, Gromada, J, Berggren, PO. The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function. Biochem Biophys Res Commun, 284(4), 918-22, 2001

Holla, VR, Adas, F, Imig, JD, Zhao, X, Price, E, Olsen, N, Kovacs, WJ, Magnuson, MA, Keeney, DS, Breyer, MD, Falck, JR, Waterman, MR, Capdevila, JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A, 98(9), 5211-6, 2001 PMCID:33189

Jetton, TL, Shiota, M, Knobel, SM, Piston, DW, Cherrington, AD, Magnuson, MA. Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int J Exp Diabetes Res, 2(3), 173-86, 2001 PMCID:2478546

Nj??lstad, PR, S??vik, O, Cuesta-Mu??oz, A, Bj??rkhaug, L, Massa, O, Barbetti, F, Undlien, DE, Shiota, C, Magnuson, MA, Molven, A, Matschinsky, FM, Bell, GI. Neonatal diabetes mellitus due to complete glucokinase deficiency. N Engl J Med, 344(21), 1588-92, 2001

Postic, C, Shiota, M, Magnuson, MA. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog Horm Res, 56, 195-217, 2001

Sakai, T, Johnson, KJ, Murozono, M, Sakai, K, Magnuson, MA, Wieloch, T, Cronberg, T, Isshiki, A, Erickson, HP, F??ssler, R. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med, 7(3), 324-30, 2001

Shiota, M, Postic, C, Fujimoto, Y, Jetton, TL, Dixon, K, Pan, D, Grimsby, J, Grippo, JF, Magnuson, MA, Cherrington, AD. Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes, 50(3), 622-9, 2001

Sund, NJ, Vatamaniuk, MZ, Casey, M, Ang, SL, Magnuson, MA, Stoffers, DA, Matschinsky, FM, Kaestner, KH. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev, 15(13), 1706-15, 2001 PMCID:312732

Gannon, M, Shiota, C, Postic, C, Wright, CV, Magnuson, M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis, 26(2), 139-42, 2000

Grimsby, J, Coffey, JW, Dvorozniak, MT, Magram, J, Li, G, Matschinsky, FM, Shiota, C, Kaur, S, Magnuson, MA, Grippo, JF. Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem, 275(11), 7826-31, 2000

Michael, MD, Kulkarni, RN, Postic, C, Previs, SF, Shulman, GI, Magnuson, MA, Kahn, CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell, 6(1), 87-97, 2000

Postic, C, Magnuson, MA. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis, 26(2), 149-50, 2000

She, P, Shiota, M, Shelton, KD, Chalkley, R, Postic, C, Magnuson, MA. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol, 20(17), 6508-17, 2000 PMCID:86125

Silva, JP, K??hler, M, Graff, C, Oldfors, A, Magnuson, MA, Berggren, PO, Larsson, NG. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet, 26(3), 336-40, 2000

Sund, NJ, Ang, SL, Sackett, SD, Shen, W, Daigle, N, Magnuson, MA, Kaestner, KH. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol, 20(14), 5175-83, 2000 PMCID:85966

Wan, YJ, An, D, Cai, Y, Repa, JJ, Hung-Po Chen, T, Flores, M, Postic, C, Magnuson, MA, Chen, J, Chien, KR, French, S, Mangelsdorf, DJ, Sucov, HM. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol, 20(12), 4436-44, 2000 PMCID:85811

Davis, EA, Cuesta-Mu??oz, A, Raoul, M, Buettger, C, Sweet, I, Moates, M, Magnuson, MA, Matschinsky, FM. Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Diabetologia, 42(10), 1175-86, 1999

Kennedy, CR, Zhang, Y, Brandon, S, Guan, Y, Coffee, K, Funk, CD, Magnuson, MA, Oates, JA, Breyer, MD, Breyer, RM. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med, 5(2), 217-20, 1999

Kulkarni, RN, Br??ning, JC, Winnay, JN, Postic, C, Magnuson, MA, Kahn, CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell, 96(3), 329-39, 1999

Kupershmidt, S, Yang, T, Anderson, ME, Wessels, A, Niswender, KD, Magnuson, MA, Roden, DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res, 84(2), 146-52, 1999

Lu, JT, Son, YJ, Lee, J, Jetton, TL, Shiota, M, Moscoso, L, Niswender, KD, Loewy, AD, Magnuson, MA, Sanes, JR, Emeson, RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci, 14(2), 99-120, 1999

Piston, DW, Knobel, SM, Postic, C, Shelton, KD, Magnuson, MA. Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J Biol Chem, 274(2), 1000-4, 1999

Postic, C, Magnuson, MA. [Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique. Journ Annu Diabetol Hotel Dieu, 115-24, 1999

Postic, C, Shiota, M, Niswender, KD, Jetton, TL, Chen, Y, Moates, JM, Shelton, KD, Lindner, J, Cherrington, AD, Magnuson, MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274(1), 305-15, 1999

Shiota, C, Coffey, J, Grimsby, J, Grippo, JF, Magnuson, MA. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J Biol Chem, 274(52), 37125-30, 1999

Williams, CP, Postic, C, Robin, D, Robin, P, Parrinello, J, Shelton, K, Printz, RL, Magnuson, MA, Granner, DK, Forest, C, Chalkley, R. Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Mol Cell Endocrinol, 148(1-2), 67-77, 1999

Castillo, SO, Baffi, JS, Palkovits, M, Goldstein, DS, Kopin, IJ, Witta, J, Magnuson, MA, Nikodem, VM. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol Cell Neurosci, 11(1-2), 36-46, 1998

Jetton, TL, Moates, JM, Lindner, J, Wright, CV, Magnuson, MA. Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Proc Natl Acad Sci U S A, 95(15), 8654-9, 1998 PMCID:21131

Matschinsky, FM, Glaser, B, Magnuson, MA. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes, 47(3), 307-15, 1998

Weaver, CD, Partridge, JG, Yao, TL, Moates, JM, Magnuson, MA, Verdoorn, TA. Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas. Mol Pharmacol, 54(4), 639-46, 1998

Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997 PMCID:20311

Kesavan, P, Wang, L, Davis, E, Cuesta, A, Sweet, I, Niswender, K, Magnuson, MA, Matschinsky, FM. Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). Biochem J, 322 ( Pt 1), 57-63, 1997 PMCID:1218158

Moates, JM, Postic, C, Decaux, JF, Girard, J, Magnuson, MA. Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene. Genomics, 45(1), 185-93, 1997

Niswender, KD, Postic, C, Jetton, TL, Bennett, BD, Piston, DW, Efrat, S, Magnuson, MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem, 272(36), 22564-9, 1997

Niswender, KD, Postic, C, Shiota, M, Jetton, TL, Magnuson, MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochem Soc Trans, 25(1), 113-7, 1997

Niswender, KD, Shiota, M, Postic, C, Cherrington, AD, Magnuson, MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem, 272(36), 22570-5, 1997

Qu, S, Niswender, KD, Ji, Q, van der Meer, R, Keeney, D, Magnuson, MA, Wisdom, R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development, 124(20), 3999-4008, 1997

Bennett, BD, Jetton, TL, Ying, G, Magnuson, MA, Piston, DW. Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. J Biol Chem, 271(7), 3647-51, 1996

Moates, JM, Shelton, KD, Magnuson, MA. Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation. Mol Endocrinol, 10(6), 723-31, 1996

Offield, MF, Jetton, TL, Labosky, PA, Ray, M, Stein, RW, Magnuson, MA, Hogan, BL, Wright, CV. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development, 122(3), 983-95, 1996

Parsa, R, Decaux, JF, Bossard, P, Robey, BR, Magnuson, MA, Granner, DK, Girard, J. Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element. Eur J Biochem, 236(1), 214-21, 1996

Wang, R, Macmillan, LB, Fremeau, RT, Magnuson, MA, Lindner, J, Limbird, LE. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5'' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience, 74(1), 199-218, 1996

Liang, Y, Kesavan, P, Wang, LQ, Niswender, K, Tanizawa, Y, Permutt, MA, Magnuson, MA, Matschinsky, FM. Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. Biochem J, 309 ( Pt 1), 167-73, 1995 PMCID:1135815

Niswender, KD, Blackman, SM, Rohde, L, Magnuson, MA, Piston, DW. Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc, 180 ( Pt 2), 109-16, 1995

Postic, C, Niswender, KD, Decaux, JF, Parsa, R, Shelton, KD, Gouhot, B, Pettepher, CC, Granner, DK, Girard, J, Magnuson, MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics, 29(3), 740-50, 1995

Williams, CP, Granner, DK, Magnuson, MA, Chalkley, R. Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene. Biochem Biophys Res Commun, 215(1), 272-9, 1995

Efrat, S, Leiser, M, Wu, YJ, Fusco-DeMane, D, Emran, OA, Surana, M, Jetton, TL, Magnuson, MA, Weir, G, Fleischer, N. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Natl Acad Sci U S A, 91(6), 2051-5, 1994 PMCID:43307

Franklin, AJ, Jetton, TL, Shelton, KD, Magnuson, MA. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol Cell Biol, 14(10), 6773-88, 1994 PMCID:359208

Jetton, TL, Liang, Y, Pettepher, CC, Zimmerman, EC, Cox, FG, Horvath, K, Matschinsky, FM, Magnuson, MA. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem, 269(5), 3641-54, 1994

Lazar, J, Desvergne, B, Zimmerman, EC, Zimmer, DB, Magnuson, MA, Nikodem, VM. A role for intronic sequences on expression of thyroid hormone receptor alpha gene. J Biol Chem, 269(32), 20352-9, 1994

Liang, Y, Jetton, TL, Zimmerman, EC, Najafi, H, Berner, DK, Matschinsky, FM, Magnuson, MA. Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene. Diabetes, 43(9), 1138-45, 1994

Meyrick, B, Magnuson, MA. Identification and functional characterization of the bovine manganous superoxide dismutase promoter. Am J Respir Cell Mol Biol, 10(1), 113-21, 1994

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest, 94(4), 1373-82, 1994 PMCID:295259

Brigham, KL, Meyrick, B, Christman, B, Conary, JT, King, G, Berry, LC, Magnuson, MA. Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice. Am J Respir Cell Mol Biol, 8(2), 209-13, 1993

Kijima, Y, Saito, A, Jetton, TL, Magnuson, MA, Fleischer, S. Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes. J Biol Chem, 268(5), 3499-506, 1993

Magnuson, MA, Jetton, TL. Evolutionary conservation of elements in the upstream glucokinase promoter. Biochem Soc Trans, 21(1), 160-3, 1993

Printz, RL, Magnuson, MA, Granner, DK. Mammalian glucokinase. Annu Rev Nutr, 13, 463-96, 1993

Jetton, TL, Magnuson, MA. Heterogeneous expression of glucokinase among pancreatic beta cells. Proc Natl Acad Sci U S A, 89(7), 2619-23, 1992 PMCID:48713

Liang, Y, Najafi, H, Smith, RM, Zimmerman, EC, Magnuson, MA, Tal, M, Matschinsky, FM. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes, 41(7), 792-806, 1992

Magnuson, MA. Tissue-specific regulation of glucokinase gene expression. J Cell Biochem, 48(2), 115-21, 1992

Shelton, KD, Franklin, AJ, Khoor, A, Beechem, J, Magnuson, MA. Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol, 12(10), 4578-89, 1992 PMCID:360385

Short, MK, Clouthier, DE, Schaefer, IM, Hammer, RE, Magnuson, MA, Beale, EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol, 12(3), 1007-20, 1992 PMCID:369533

Liang, Y, Jetton, TL, Zimmerman, EC, Najafi, H, Matschinsky, FM, Magnuson, MA. Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary. J Biol Chem, 266(11), 6999-7007, 1991

Zimmerman, EC, Jones, CM, Fet, V, Hogan, BL, Magnuson, MA. Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor. Nucleic Acids Res, 19(4), 956, 1991 PMCID:333739

Forest, CD, O''Brien, RM, Lucas, PC, Magnuson, MA, Granner, DK. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol Endocrinol, 4(9), 1302-10, 1990

Magnuson, MA. Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes, 39(5), 523-7, 1990

O''Brien, RM, Lucas, PC, Forest, CD, Magnuson, MA, Granner, DK. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science, 249(4968), 533-7, 1990

Zimmer, DB, Magnuson, MA. Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. J Histochem Cytochem, 38(2), 171-8, 1990

Andreone, TL, Printz, RL, Pilkis, SJ, Magnuson, MA, Granner, DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem, 264(1), 363-9, 1989

Brigham, KL, Meyrick, B, Christman, B, Magnuson, M, King, G, Berry, LC. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. Am J Med Sci, 298(4), 278-81, 1989

Magnuson, MA, Andreone, TL, Printz, RL, Koch, S, Granner, DK. Rat glucokinase gene: structure and regulation by insulin. Proc Natl Acad Sci U S A, 86(13), 4838-42, 1989 PMCID:297510

Magnuson, MA, Shelton, KD. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J Biol Chem, 264(27), 15936-42, 1989

Morioka, H, Magnuson, MA, Mitsuhashi, T, Song, MK, Rall, JE, Nikodem, VM. Structural characterization of the rat malic enzyme gene. Proc Natl Acad Sci U S A, 86(13), 4912-6, 1989 PMCID:297525

Nikodem, VM, Magnuson, MA, Dozin, B, Morioka, H. Coding nucleotide sequence of rat malic enzyme mRNA and tissue specific regulation by thyroid hormone. Endocr Res, 15(4), 547-64, 1989

Petersen, DD, Magnuson, MA, Granner, DK. Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol, 8(1), 96-104, 1988 PMCID:363086

Quinn, PG, Wong, TW, Magnuson, MA, Shabb, JB, Granner, DK. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol, 8(8), 3467-75, 1988 PMCID:363584

Magnuson, MA, Quinn, PG, Granner, DK. Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin''s effects oppose those of cAMP and dexamethasone. J Biol Chem, 262(31), 14917-20, 1987

Dozin, B, Magnuson, MA, Nikodem, VM. Thyroid hormone regulation of malic enzyme synthesis. Dual tissue-specific control. J Biol Chem, 261(22), 10290-2, 1986

Magnuson, MA, Morioka, H, Tecce, MF, Nikodem, VM. Coding nucleotide sequence of rat liver malic enzyme mRNA. J Biol Chem, 261(3), 1183-6, 1986

Tecce, MF, Dozin, B, Magnuson, MA, Nikodem, VM. Transcriptional regulation by thyroid hormone of an mRNA homologous to a protease inhibitor. Biochemistry, 25(19), 5831-4, 1986

Dozin, B, Magnuson, MA, Nikodem, VM. Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Biochemistry, 24(20), 5581-6, 1985

Magnuson, MA, Dozin, B, Nikodem, VM. Regulation of specific rat liver messenger ribonucleic acids by triiodothyronine. J Biol Chem, 260(10), 5906-12, 1985

Magnuson, MA, Nikodem, VM. Molecular cloning of a cDNA sequence for rat malic enzyme. Direct evidence for induction in vivo of rat liver malic enzyme mRNA by thyroid hormone. J Biol Chem, 258(20), 12712-7, 1983

Olson, JD, Brockway, WJ, Fass, DN, Magnuson, MA, Bowie, EJ. Evaluation of ristocetin-Willebrand factor assay and ristocetin-induced platelet aggregation. Am J Clin Pathol, 63(2), 210-8, 1975

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