Biomedical Research Education & Training
Faculty Member

Reynolds, Albert B., Ph.D.
Professor of Cancer Biology
Ingram Professor of Cancer Research

Lab Url: N/A

Phone Number: 615-343-9532

Email Address: al.reynolds@vanderbilt.edu

Reynolds, Albert's picture
Academic history
B.A., Kenyon College, Gambier, OH
Ph.D., University of Virginia, Charlottesville, VA
Postdoc, University of Virginia Cancer Ctr., Charlottesville

Office Address   Mailing Address

440 PRB

771 PRB 37232-6840


Research Keywords
cadherins, catenins, p120 catenin, Kaiso, cell-cell adhesion, metastasis, tumor suppressor, cancer, signaling, phosphorylation, mouse modeling, colon cancer, breast cancer

Research Specialty
p120-catenin and Kaiso function in cell-cell adhesion and cancer

Research Description
My laboratory combines molecular and biochemical approaches with 3D culture and mouse models of colon and breast cancer to study the roles of p120-catenin (p120) in cell-cell adhesion, tumorigenesis and metastasis. Most proteins linked physically or functionally to p120 are, in fact, tumor suppressors or oncogenes (eg, Src, Receptor Tyrosine kinases, Rho GTPases, E-cadherin, B-catenin, Adenomatous Polyposis Coli), implying a role for p120 in cancer. Previously, we showed that p120 interaction is essential for cadherin stability at the cell surface. For example, p120 knockdown in many epithelial cell lines (eg, MCF10A, A431) causes rapid degradation of the entire E-cadherin complex and partial or complete loss of cell-cell adhesion. These observations have led to the notion that p120 itself is a tumor and/or metastasis suppressor - on its own, or in collaboration with E-cadherin. Indeed, E-cadherin is broadly established as a tumor and metastasis suppressor and p120 is frequently downregulated and/or mislocalized in most major human cancers (e.g. colon, breast, lung, pancreas, prostate).

We are heavily invested in mouse models of colon cancer. Using conditional p120 KO in APC mutant mice, we recently found that p120 is, in fact, a haploinsufficient tumor suppressor in the colon (and probably other tissues). Interestingly, loss of one p120 allele increases tumor number by 10 fold. Although biallic loss is well tolerated in wild type intestinal epithelium, it is not permitted in the context of the tumor. Based on data from Sleeping Beauty insertional mutagenesis screens (in collaboration with Neal Copeland) we have extended these findings to a-catenin and E-cadherin, and to several different oncogenic backgrounds (e.g., K-Ras, Smad4, p53). Thus, it appears that loss of E-cadherin complex components is not restricted to late stage tumors. Instead, very early loss of any single allele for p120, a-catenin or E-cadherin likely comprises a major bottleneck to tumor progression, exceeded only by the mandatory initiating mutation in APC.

In the mammary gland, we are using a well-characterized MMTV-mT breast cancer model to examine the role of p120 in metastasis. Interestingly, in contrast to the intestine, the mammary gland does not form at all in the absence of p120. Transformation by mT, on the other hand, rescues the epithelium and gives rise to p120 null primary tumors. However, tumor cells lacking p120 cannot metastasize to the lung. Thus, we have arrived at a unique and powerful system for examining not only the role of p120 (and p120 isoforms) in metastasis, but also recently postulated roles for EMT and ???stemness??? as they pertain to the metastatic process. The system is complemented by mechanistic studies based on ex-vivo manipulation of cells follow by reconstitution in vivo or in in vitro 3D cell cultures.

Finally, A third line of research focuses on the transcription factor Kaiso, discovered some time ago in our lab as a direct p120 binding partner. The interaction is reminiscent of Wnt-pathway mediated B-catenin ??? TCF4 interactions and may connect p120 to the nucleus. The Kaiso landscape is evolving rapidly in the wake of whole genome sequencing technologies such as ChipSEQ. We are examining different aspects of Kaiso activity in intestinal and mammary systems and moving into exciting new areas including epigenetics, transcription and genome maintenance. Kaiso is going to be an exciting place to be over the next decade.

Publications
Bryce, NS, Reynolds, AB, Koleske, AJ, Weaver, AM. WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. PLoS One, 8(5), e64533, 2013

Reynolds, AB, Kanner, SB, Bouton, AH, Schaller, MD, Weed, SA, Flynn, DC, Parsons, JT. SRChing for the substrates of Src. Oncogene, 2013

Barrett, CW, Smith, JJ, Lu, LC, Markham, N, Stengel, KR, Short, SP, Zhang, B, Hunt, AA, Fingleton, BM, Carnahan, RH, Engel, ME, Chen, X, Beauchamp, RD, Wilson, KT, Hiebert, SW, Reynolds, AB, Williams, CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS One, 7(12), e51205, 2012

Kurley, SJ, Bierie, B, Carnahan, RH, Lobdell, NA, Davis, MA, Hofmann, I, Moses, HL, Muller, WJ, Reynolds, AB. p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development, 139(10), 1754-64, 2012

Markham, NO, Cooper, T, Goff, M, Gribben, EM, Carnahan, RH, Reynolds, AB. Monoclonal antibodies to DIPA: a novel binding partner of p120-catenin isoform 1. Hybridoma (Larchmt), 31(4), 246-54, 2012

Smith, AL, Dohn, MR, Brown, MV, Reynolds, AB. Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell, 23(1), 99-110, 2012

Reynolds, AB. Epithelial organization: new perspective on a-catenin from an ancient source. Curr Biol, 21(11), R430-2, 2011

Smalley-Freed, WG, Efimov, A, Short, SP, Jia, P, Zhao, Z, Washington, MK, Robine, S, Coffey, RJ, Reynolds, AB. Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS One, 6(5), e19880, 2011

Smith, AL, Friedman, DB, Yu, H, Carnahan, RH, Reynolds, AB. ReCLIP (reversible cross-link immuno-precipitation): an efficient method for interrogation of labile protein complexes. PLoS One, 6(1), e16206, 2011

Carnahan, RH, Rokas, A, Gaucher, EA, Reynolds, AB. The molecular evolution of the p120-catenin subfamily and its functional associations. PLoS One, 5(12), e15747, 2010

Donowitz, M, Singh, S, Singh, P, Salahuddin, FF, Chen, Y, Chakraborty, M, Murtazina, R, Gucek, M, Cole, RN, Zachos, NC, Kovbasnjuk, O, Broere, N, Smalley-Freed, WG, Reynolds, AB, Hubbard, AL, Seidler, UE, Weinman, EJ, de Jonge, HR, Hogema, BM, Li, X. Alterations in the Proteome of the NHERF1 Knockout Mouse Jejunal Brush Border Membrane Vesicles. Physiol Genomics, 2010

Oas, RG, Xiao, K, Summers, S, Wittich, KB, Chiasson, CM, Martin, WD, Grossniklaus, HE, Vincent, PA, Reynolds, AB, Kowalczyk, AP. p120-Catenin is required for mouse vascular development. Circ Res, 106(5), 941-51, 2010 PMCID:2877948

Reynolds, AB. Exposing p120 catenin''s most intimate affair. Cell, 141(1), 20-2, 2010 PMCID:2877948

Smalley-Freed, WG, Efimov, A, Burnett, PE, Short, SP, Davis, MA, Gumucio, DL, Washington, MK, Coffey, RJ, Reynolds, AB. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest, 120(6), 1824-35, 2010 PMCID:2877948

Wong, LE, Reynolds, AB, Dissanayaka, NT, Minden, A. p120-catenin is a binding partner and substrate for Group B Pak kinases. J Cell Biochem, 110(5), 1244-54, 2010

Anderson, AR, Hassanein, M, Branch, KM, Lu, J, Lobdell, NA, Maier, J, Basanta, D, Weidow, B, Narasanna, A, Arteaga, CL, Reynolds, AB, Quaranta, V, Estrada, L, Weaver, AM. Microenvironmental independence associated with tumor progression. Cancer Res, 69(22), 8797-806, 2009 PMCID:2877948

Brown, MV, Burnett, PE, Denning, MF, Reynolds, AB. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp Cell Res, 315(1), 39-49, 2009

Dohn, MR, Brown, MV, Reynolds, AB. An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth. J Cell Biol, 184(3), 437-50, 2009 PMCID:2646551

Fukumoto, Y, Shintani, Y, Reynolds, AB, Johnson, KR, Wheelock, MJ. The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane. Exp Cell Res, 314(1), 52-67, 2008 PMCID:2211447

Ogden, SR, Wroblewski, LE, Weydig, C, Romero-Gallo, J, O''Brien, DP, Israel, DA, Krishna, US, Fingleton, B, Reynolds, AB, Wessler, S, Peek, RM. p120 and Kaiso Regulate Helicobacter pylori-induced Expression of Matrix Metalloproteinase-7. Mol Biol Cell, 2008 PMCID:2555941

Ezaki, T, Guo, RJ, Li, H, Reynolds, AB, Lynch, JP. The Homeodomain Transcription Factors Cdx1 and Cdx2 Induce E-cadherin Adhesion Activity by Reducing {beta}- and p120-catenin Tyrosine Phosphorylation. Am J Physiol Gastrointest Liver Physiol, 2007

Reynolds, AB. p120-catenin: Past and present. Biochim Biophys Acta, 1773(1), 2-7, 2007

Vaughan, MH, Xia, X, Wang, X, Chronopoulou, E, Gao, GJ, Campos-Gonzalez, R, Reynolds, AB. Generation and characterization of a novel phospho-specific monoclonal antibody to p120-catenin serine 879. Hybridoma (Larchmt), 26(6), 407-15, 2007

Davis, MA, Reynolds, AB. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev Cell, 10(1), 21-31, 2006

Madhavan, R, Zhao, XT, Reynolds, AB, Peng, HB. Involvement of p120 catenin in myopodial assembly and nerve-muscle synapse formation. J Neurobiol, 66(13), 1511-27, 2006

Perez-Moreno, M, Davis, MA, Wong, E, Pasolli, HA, Reynolds, AB, Fuchs, E. p120-catenin mediates inflammatory responses in the skin. Cell, 124(3), 631-44, 2006 PMCID:2443688

Wildenberg, GA, Dohn, MR, Carnahan, RH, Davis, MA, Lobdell, NA, Settleman, J, Reynolds, AB. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell, 127(5), 1027-39, 2006

Xia, X, Carnahan, RH, Vaughan, MH, Wildenberg, GA, Reynolds, AB. p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation. Exp Cell Res, 312(17), 3336-48, 2006

Soubry, A, van Hengel, J, Parthoens, E, Colpaert, C, Van Marck, E, Waltregny, D, Reynolds, AB, van Roy, F. Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. Cancer Res, 65(6), 2224-33, 2005

Gu, Jinming, Xia, Xiaobo, Yan, Peijun, Liu, Hanjian, Podust, Vladimir N, Reynolds, Albert B, Fanning, Ellen. Cell Cycle-dependent Regulation of a Human DNA Helicase That Localizes in DNA Damage Foci. Mol Biol Cell, 15(7), 3320-32, 2004 PMCID:452586

Kowalczyk, AP, Reynolds, AB. Protecting your tail: regulation of cadherin degradation by p120-catenin. Curr Opin Cell Biol, 16(5), 522-7, 2004

Mariner, Deborah J, Davis, Michael A, Reynolds, Albert B. EGFR signaling to p120-catenin through phosphorylation at Y228. J Cell Sci, 117(Pt 8), 1339-50, 2004

Reynolds, AB, Carnahan, RH. Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin Cell Dev Biol, 15(6), 657-63, 2004

Reynolds, AB, Roczniak-Ferguson, A. Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene, 23(48), 7947-56, 2004

Xia, X, Brooks, J, Campos-Gonz?!lez, R, Reynolds, AB. Serine and threonine phospho-specific antibodies to p120-catenin. Hybrid Hybridomics, 23(6), 343-51, 2004

Yanagisawa, Masahiro, Kaverina, Irina N, Wang, Aixia, Fujita, Yasuyuki, Reynolds, Albert B, Anastasiadis, Panos Z. A novel interaction between kinesin and p120 modulates p120 localization and function. J Biol Chem, 279(10), 9512-21, 2004

Davis, Michael A, Ireton, Renee C, Reynolds, Albert B. A core function for p120-catenin in cadherin turnover. J Cell Biol, 163(3), 525-34, 2003 PMCID:2173649

Goodwin, M, Kovacs, EM, Thoreson, MA, Reynolds, AB, Yap, AS. Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation. J Biol Chem, 278(23), 20533-9, 2003

Roczniak-Ferguson, Agnes, Reynolds, Albert B. Regulation of p120-catenin nucleocytoplasmic shuttling activity. J Cell Sci, 116(Pt 20), 4201-12, 2003

Xia, Xiaobo, Mariner, Debbie J, Reynolds, Albert B. Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin. Biochemistry, 42(30), 9195-204, 2003

Yoon, Ho-Geun, Chan, Doug W, Reynolds, Albert B, Qin, Jun, Wong, Jiemin. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell, 12(3), 723-34, 2003

Daniel, Juliet M, Spring, Christopher M, Crawford, Howard C, Reynolds, Albert B, Baig, Akeel. The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res, 30(13), 2911-9, 2002 PMCID:117053

Ireton, Renee C, Davis, Michael A, van Hengel, Jolanda, Mariner, Deborah J, Barnes, Kirk, Thoreson, Molly A, Anastasiadis, Panos Z, Matrisian, Linsey, Bundy, Linda M, Sealy, Linda, Gilbert, Barbara, van Roy, Frans, Reynolds, Albert B. A novel role for p120 catenin in E-cadherin function. J Cell Biol, 159(3), 465-76, 2002 PMCID:2173073

Thoreson, Molly A, Reynolds, Albert B. Altered expression of the catenin p120 in human cancer: implications for tumor progression. Differentiation, 70(9-10), 583-9, 2002

Anastasiadis, P Z, Reynolds, A B. Regulation of Rho GTPases by p120-catenin. Curr Opin Cell Biol, 13(5), 604-10, 2001

Daniel, JM, Ireton, RC, Reynolds, AB. Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein. Hybridoma, 20(3), 159-66, 2001

Mariner, D J, Anastasiadis, P, Keilhack, H, B??hmer, F D, Wang, J, Reynolds, A B. Identification of Src phosphorylation sites in the catenin p120ctn. J Biol Chem, 276(30), 28006-13, 2001

Anastasiadis, P Z, Moon, S Y, Thoreson, M A, Mariner, D J, Crawford, H C, Zheng, Y, Reynolds, A B. Inhibition of RhoA by p120 catenin. Nat Cell Biol, 2(9), 637-44, 2000

Anastasiadis, P Z, Reynolds, A B. The p120 catenin family: complex roles in adhesion, signaling and cancer. J Cell Sci, 113 ( Pt 8), 1319-34, 2000

Mariner, D J, Wang, J, Reynolds, A B. ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes. J Cell Sci, 113 ( Pt 8), 1481-90, 2000

Thoreson, M A, Anastasiadis, P Z, Daniel, J M, Ireton, R C, Wheelock, M J, Johnson, K R, Hummingbird, D K, Reynolds, A B. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J Cell Biol, 148(1), 189-202, 2000 PMCID:2156209

Zondag, GC, Reynolds, AB, Moolenaar, WH. Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn). J Biol Chem, 275(15), 11264-9, 2000

Aono, S, Nakagawa, S, Reynolds, AB, Takeichi, M. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J Cell Biol, 145(3), 551-62, 1999 PMCID:2185070

Daniel, J M, Reynolds, A B. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol, 19(5), 3614-23, 1999 PMCID:84161

Jin, F, Reynolds, AB, Hines, MD, Jensen, PJ, Johnson, KR, Wheelock, MJ. Src induces morphological changes in A431 cells that resemble epidermal differentiation through an SH3- and Ras-independent pathway. J Cell Sci, 112 ( Pt 17), 2913-24, 1999

Mariner, D J, Sirotkin, H, Daniel, J M, Lindman, B R, Mernaugh, R L, Patten, A K, Thoreson, M A, Reynolds, A B. Production and characterization of monoclonal antibodies to ARVCF. Hybridoma, 18(4), 343-9, 1999

Paulson, AF, Fang, X, Ji, H, Reynolds, AB, McCrea, PD. Misexpression of the catenin p120(ctn)1A perturbs Xenopus gastrulation but does not elicit Wnt-directed axis specification. Dev Biol, 207(2), 350-63, 1999

Dillon, DA, D''Aquila, T, Reynolds, AB, Fearon, ER, Rimm, DL. The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin. Am J Pathol, 152(1), 75-82, 1998 PMCID:1858125

Gold, JS, Reynolds, AB, Rimm, DL. Loss of p120ctn in human colorectal cancer predicts metastasis and poor survival. Cancer Lett, 132(1-2), 193-201, 1998

Keirsebilck A, van Hengel J, Staes K, Bonne S, Nollet F, Reynolds AB, van Roy F. Molecular cloning of the human p120ctn catenin gene: expression of multiple alternatively spliced isoforms. Genomics, 50, 129-146, 1998

Sheng, H, Shao, J, Williams, C S, Pereira, M A, Taketo, M M, Oshima, M, Reynolds, A B, Washington, M K, DuBois, R N, Beauchamp, R D. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis, 19(4), 543-9, 1998

Wu, J, Mariner, DJ, Thoreson, MA, Reynolds, AB. Production and characterization of monoclonal antibodies to the catenin p120ctn. Hybridoma, 17(2), 175-83, 1998

Daniel, J M, Reynolds, A B. Tyrosine phosphorylation and cadherin/catenin function. Bioessays, 19(10), 883-91, 1997

Fornerod, M., van Deursen, J., van Baal, S., Reynolds, A., Davis, D., Murti, G.K., Fransen, J., Grosveld, G. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup2l4 and a novel nuclear pore component Nup88. EMBO J, 16, 807-816, 1997

Reynolds, A; Daniel, J.. P120ctn: a Src-substrate turned catenin.. In Cytoskeletal-Membrane Interactions and Signals Transduction, (eds. P. Cowin and M. Klymiowsky, Landes Bioscience, USA. Chapt. 3), 1997

Mo, YY, Reynolds, AB. Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res, 56(11), 2633-40, 1996

Reynolds, AB, Daniel, JM, Mo, YY, Wu, J, Zhang, Z. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp Cell Res, 225(2), 328-37, 1996

Reynolds, AB, Jenkins, NA, Gilbert, DJ, Copeland, NG, Shapiro, DN, Wu, J, Daniel, JM. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). Genomics, 31(1), 127-9, 1996

Daniel, JM, Reynolds, AB. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol, 15(9), 4819-24, 1995 PMCID:230726

Parham, DM, Reynolds, AB, Webber, BL. Use of monoclonal antibody 1H1, anticortactin, to distinguish normal and neoplastic smooth muscle cells: comparison with anti-alpha-smooth muscle actin and antimuscle-specific actin. Hum Pathol, 26(7), 776-83, 1995

Peifer, M, Berg, S, Reynolds, AB. A repeating amino acid motif shared by proteins with diverse cellular roles. Cell, 76(5), 789-91, 1994

Reynolds, AB, Daniel, J, McCrea, PD, Wheelock, MJ, Wu, J, Zhang, Z. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol, 14(12), 8333-42, 1994 PMCID:359372

Flynn, DC, Leu, TH, Reynolds, AB, Parsons, JT. Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Mol Cell Biol, 13(12), 7892-900, 1993 PMCID:364861

Reynolds, AB, Herbert, L, Cleveland, JL, Berg, ST, Gaut, JR. p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene, 7(12), 2439-45, 1992

Schaller, MD, Borgman, CA, Cobb, BS, Vines, RR, Reynolds, AB, Parsons, JT. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A, 89(11), 5192-6, 1992 PMCID:49256

Wong, S, Reynolds, AB, Papkoff, J. Platelet activation leads to increased c-src kinase activity and association of c-src with an 85-kDa tyrosine phosphoprotein. Oncogene, 7(12), 2407-15, 1992

Cobb, BS, Payne, DM, Reynolds, AB, Parsons, JT. Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527). Mol Cell Biol, 11(12), 5832-8, 1991 PMCID:361728

Downing, JR, Reynolds, AB. PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate. Oncogene, 6(4), 607-13, 1991

Kanner, SB, Reynolds, AB, Parsons, JT. Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Mol Cell Biol, 11(2), 713-20, 1991 PMCID:359722

Kanner, SB, Reynolds, AB, Wang, HC, Vines, RR, Parsons, JT. The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. EMBO J, 10(7), 1689-98, 1991 PMCID:452840

Wu, H, Reynolds, AB, Kanner, SB, Vines, RR, Parsons, JT. Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol, 11(10), 5113-24, 1991 PMCID:361526

Kanner, SB, Reynolds, AB, Vines, RR, Parsons, JT. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U S A, 87(9), 3328-32, 1990 PMCID:53893

Kozma, LM, Reynolds, AB, Weber, MJ. Glycoprotein tyrosine phosphorylation in Rous sarcoma virus-transformed chicken embryo fibroblasts. Mol Cell Biol, 10(2), 837-41, 1990 PMCID:360886

Kanner, SB, Gilmer, TM, Reynolds, AB, Parsons, JT. Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis. Oncogene, 4(3), 295-300, 1989

Kanner, SB, Reynolds, AB, Parsons, JT. Immunoaffinity purification of tyrosine-phosphorylated cellular proteins. J Immunol Methods, 120(1), 115-24, 1989

Reynolds, AB, Kanner, SB, Wang, HC, Parsons, JT. Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins. Mol Cell Biol, 9(9), 3951-8, 1989 PMCID:362457

Reynolds, AB, Roesel, DJ, Kanner, SB, Parsons, JT. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol, 9(2), 629-38, 1989 PMCID:362640

Reynolds, AB, Thomas, TS, Wilson, WL, Oliphant, G. Concentration of acrosome stabilizing factor (ASF) in rabbit epididymal fluid and species specificity of anti-ASF antibodies. Biol Reprod, 40(3), 673-80, 1989

Potts, WM, Reynolds, AB, Lansing, TJ, Parsons, JT. Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95. Oncogene Res, 3(4), 343-55, 1988

Reynolds, AB, Vila, J, Lansing, TJ, Potts, WM, Weber, MJ, Parsons, JT. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J, 6(8), 2359-64, 1987 PMCID:553640

Wilson, WL, Reynolds, AB, Marta, J, Oliphant, G. Correlation of conformational changes in the acrosome stabilizing factor (ASF) with its biological activity. Biol Reprod, 36(4), 1069-77, 1987

Reynolds, AB, Oliphant, G. Quantitation of the rabbit sperm acrosome stabilizing factor utilizing a sensitive immunoradiometric assay. Biol Reprod, 35(3), 705-15, 1986

Thomas, TS, Wilson, WL, Reynolds, AB, Oliphant, G. Chemical and physical characterization of rabbit sperm acrosome stabilizing factor. Biol Reprod, 35(3), 691-703, 1986

Oliphant, G, Reynolds, AB, Thomas, TS. Sperm surface components involved in the control of the acrosome reaction. Am J Anat, 174(3), 269-83, 1985

Reynolds, AB, Oliphant, G. Production and characterization of monoclonal antibodies to the sperm acrosome stabilizing factor (ASF): utilization for purification and molecular analysis of ASF. Biol Reprod, 30(3), 775-86, 1984

Thomas, TS, Reynolds, AB, Oliphant, G. Evaluation of the site of synthesis of rabbit sperm acrosome stabilizing factor using immunocytochemical and metabolic labeling techniques. Biol Reprod, 30(3), 693-705, 1984


Postdoctoral Position Available
No

Postdoctoral Position Details
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Updated Date
03/13/2014