Biomedical Research Education & Training
Faculty Member

Sanders Bush, Elaine, Ph.D.
Professor of Pharmacology, Emerita

Lab Url: http://pharmacology.mc.vanderbilt.edu/Faculty/Sanders_Bush_Lab/index.htm

Phone Number: (615) 936-1685

Email Address: elaine.bush@vanderbilt.edu

Sanders Bush, Elaine's picture
Academic history
B.S., Western Kentucky University
Ph.D., Vanderbilt University
Postdoc, Vanderbilt Unviersity

Office Address   Mailing Address

8158 MRB III. Lab Office: 8160B MRB III, 465 21st Ave. South (8548)

Chair, Vanderbilt Brain Institute Neuroscience Council Director, Vanderbilt Brain Institute 37232-8548


Research Keywords
serotonin, G protein-coupled receptors, hallucingenic drugs, psychopharmacology, Signal transduction

Research Specialty
Function and regulation of specific serotonin receptor subtypes in the brain

Research Description
Two members of the 5-HT2 family of serotonin receptors (5-HT2A and 5-HT2C receptors) are implicated in the control of physiological processes such as cognition, appetite and mood and in the action of antipsychotic and hallucinogenic drugs. Our studies combine multidisciplinary approaches ranging from molecular biology to animal behavior to define the mechanisms of normal and abnormal regulation of the structure and function of these G protein-coupled receptors.

Publications
Benneyworth, MA, Xiang, Z, Smith, RL, Garcia, EE, Conn, PJ, Sanders-Bush, E. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol Pharmacol, 72(2), 477-84, 2007

Garcia, EE, Smith, RL, Sanders-Bush, E. Role of G(q) protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane. Neuropharmacology, 52(8), 1671-7, 2007 PMCID:1987710

Gresch, PJ, Barrett, RJ, Sanders-Bush, E, Smith, RL. 5-Hydroxytryptamine (serotonin)2A receptors in rat anterior cingulate cortex mediate the discriminative stimulus properties of d-lysergic acid diethylamide. J Pharmacol Exp Ther, 320(2), 662-9, 2007

Hackler, EA, Turner, GH, Gresch, PJ, Sengupta, S, Deutch, AY, Avison, MJ, Gore, JC, Sanders-Bush, E. 5-Hydroxytryptamine2C Receptor Contribution to m-Chlorophenylpiperazine and N-Methyl-beta-carboline-3-carboxamide-Induced Anxiety-Like Behavior and Limbic Brain Activation. J Pharmacol Exp Ther, 320(3), 1023-9, 2007

Muldowney, JA, Painter, CA, Sanders-Bush, E, Brown, NJ, Vaughan, DE. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of Galpha(q), PLC-beta, IP(3) and 5,6-epoxyeicosatrienoic acid. Thromb Haemost, 97(2), 263-71, 2007

Myers, RL, Airey, DC, Manier, DH, Shelton, RC, Sanders-Bush, E. Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biol Psychiatry, 61(2), 167-73, 2007

Hackler, EA, Airey, DC, Shannon, CC, Sodhi, MS, Sanders-Bush, E. 5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice. Neurosci Res, 55(1), 96-104, 2006

Tomlinson, ID, Gies, AP, Gresch, PJ, Dillard, J, Orndorff, RL, Sanders-Bush, E, Hercules, DM, Rosenthal, SJ. Universal polyethylene glycol linkers for attaching receptor ligands to quantum dots. Bioorg Med Chem Lett, 16(24), 6262-6, 2006

Akin, Demet, Hal Manier, D, Sanders-Bush, Elaine, Shelton, Richard C. Signal transduction abnormalities in melancholic depression. Int J Neuropsychopharmacol, 8(1), 5-16, 2005

Benneyworth, Michael, Smith, Randy, Barrett, Robert, Sanders-Bush, Elaine. Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice. Psychopharmacology (Berl), 2005

Bentzen, EL, Tomlinson, ID, Mason, J, Gresch, P, Warnement, MR, Wright, D, Sanders-Bush, E, Blakely, R, Rosenthal, SJ. Surface modification to reduce nonspecific binding of quantum dots in live cell assays. Bioconjug Chem, 16(6), 1488-94, 2005

Fentress, HM, Grinde, E, Mazurkiewicz, JE, Backstrom, JR, Herrick-Davis, K, Sanders-Bush, E. Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms. Pharmacogenomics J, 5(4), 244-54, 2005

Gresch, PJ, Smith, RL, Barrett, RJ, Sanders-Bush, E. Behavioral tolerance to lysergic acid diethylamide is associated with reduced serotonin-2A receptor signaling in rat cortex. Neuropsychopharmacology, 30(9), 1693-702, 2005

Sodhi, MS, Airey, DC, Lambert, W, Burnet, PW, Harrison, PJ, Sanders-Bush, E. A rapid new assay to detect RNA editing reveals antipsychotic-induced changes in serotonin-2C transcripts. Mol Pharmacol, 68(3), 711-9, 2005

Akin, Demet, Manier, D Hal, Sanders-Bush, Elaine, Shelton, Richard C. Decreased serotonin 5-HT2A receptor-stimulated phosphoinositide signaling in fibroblasts from melancholic depressed patients. Neuropsychopharmacology, 29(11), 2081-7, 2004

Hazelwood, Lisa A, Sanders-Bush, Elaine. His452Tyr polymorphism in the human 5-HT2A receptor destabilizes the signaling conformation. Mol Pharmacol, 66(5), 1293-300, 2004

McGrew, Lori, Price, Raymond D, Hackler, Elizabeth, Chang, Mike S S, Sanders-Bush, Elaine. RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA. Mol Pharmacol, 65(1), 252-6, 2004

Nichols, Charles D, Sanders-Bush, Elaine. Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins. J Neurochem, 90(3), 576-84, 2004

Sodhi, Monsheel S K, Sanders-Bush, Elaine. Serotonin and brain development. Int Rev Neurobiol, 59, 111-74, 2004

Miner, L A H, Backstrom, J R, Sanders-Bush, E, Sesack, S R. Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Neuroscience, 116(1), 107-17, 2003

Nichols, Charles D, Garcia, Efrain E, Sanders-Bush, Elaine. Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration. Brain Res Mol Brain Res, 111(1-2), 182-8, 2003

Parker, Lisan L, Backstrom, Jon R, Sanders-Bush, Elaine, Shieh, Bih-Hwa. Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1. J Biol Chem, 278(24), 21576-83, 2003

Sanders-Bush, Elaine, Fentress, Hugh, Hazelwood, Lisa. Serotonin 5-ht2 receptors: molecular and genomic diversity. Mol Intervent, 3(6), 319-30, 2003

Smith, Randy L, Barrett, Robert J, Sanders-Bush, Elaine. Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6J mice. Psychopharmacology (Berl), 166(1), 61-8, 2003

Gresch, P J, Strickland, L V, Sanders-Bush, E. Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors. Neuroscience, 114(3), 707-13, 2002

McGrew, L, Chang, M S S, Sanders-Bush, E. Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. Mol Pharmacol, 62(6), 1339-43, 2002

Nichols, C D, Ronesi, J, Pratt, W, Sanders-Bush, E. Hallucinogens and Drosophila: linking serotonin receptor activation to behavior. Neuroscience, 115(3), 979-84, 2002

Nichols, Charles D, Sanders-Bush, Elaine. A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain. Neuropsychopharmacology, 26(5), 634-42, 2002

Smith, Randy L, Gresch, Paul J, Barrett, Robert J, Sanders-Bush, Elaine. Stimulus generalization by fenfluramine in a quipazine-ketanserin drug discrimination is not dependent on indirect serotonin release. Pharmacol Biochem Behav, 72(1-2), 77-85, 2002

Berg, K A, Cropper, J D, Niswender, C M, Sanders-Bush, E, Emeson, R B, Clarke, W P. RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity. Br J Pharmacol, 134(2), 386-92, 2001 PMCID:1572953

Bubser, M, Backstrom, J R, Sanders-Bush, E, Roth, B L, Deutch, A Y. Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Synapse, 39(4), 297-304, 2001

Niswender, C M, Herrick-Davis, K, Dilley, G E, Meltzer, H Y, Overholser, J C, Stockmeier, C A, Emeson, R B, Sanders-Bush, E. RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology, 24(5), 478-91, 2001

Peavy, R D, Chang, M S, Sanders-Bush, E, Conn, P J. Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. J Neurosci, 21(24), 9619-28, 2001

Price, R D, Weiner, D M, Chang, M S, Sanders-Bush, E. RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein. J Biol Chem, 276(48), 44663-8, 2001

Backstrom, J R, Price, R D, Reasoner, D T, Sanders-Bush, E. Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses. J Biol Chem, 275(31), 23620-6, 2000

Chang, M S, Tam, J P, Sanders-Bush, E. Dissecting intracellular signaling pathways with membrane-permeable peptides. Sci STKE, 2000(47), PL1, 2000

Chang, M, Zhang, L, Tam, J P, Sanders-Bush, E. Dissecting G protein-coupled receptor signaling pathways with membrane-permeable blocking peptides. Endogenous 5-HT(2C) receptors in choroid plexus epithelial cells. J Biol Chem, 275(10), 7021-9, 2000

Price, R D, Sanders-Bush, E. RNA editing of the human serotonin 5-HT(2C) receptor delays agonist-stimulated calcium release. Mol Pharmacol, 58(4), 859-62, 2000

Backstrom, J R, Chang, M S, Chu, H, Niswender, C M, Sanders-Bush, E. Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD). Neuropsychopharmacology, 21(2 Suppl), 77S-81S, 1999

Backstrom, J R, Chang, M S, Chu, H, Niswender, C M, Sanders-Bush, E. Agonist-Directed Signaling of Serotonin 5-HT(2C) Receptors: Differences Between Serotonin and Lysergic Acid Diethylamide (LSD). Neuropsychopharmacology, 21 Suppl 1, S77-81, 1999

Bancila, M, Verg??, D, Rampin, O, Backstrom, J R, Sanders-Bush, E, McKenna, K E, Marson, L, Calas, A, Giuliano, F. 5-Hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience, 92(4), 1523-37, 1999

Grotewiel, M S, Sanders-Bush, E. Differences in agonist-independent activity of 5-Ht2A and 5-HT2c receptors revealed by heterologous expression. Naunyn Schmiedebergs Arch Pharmacol, 359(1), 21-7, 1999

Niswender, C M, Copeland, S C, Herrick-Davis, K, Emeson, R B, Sanders-Bush, E. RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem, 274(14), 9472-8, 1999

Smith, R L, Barrett, R J, Sanders-Bush, E. Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor. Psychopharmacology (Berl), 144(3), 248-54, 1999

Willins, D L, Berry, S A, Alsayegh, L, Backstrom, J R, Sanders-Bush, E, Friedman, L, Roth, B L. Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo. Neuroscience, 91(2), 599-606, 1999

Niswender, C M, Sanders-Bush, E, Emeson, R B. Identification and characterization of RNA editing events within the 5-HT2C receptor. Ann N Y Acad Sci, 861, 38-48, 1998

Seifert, R, Wenzel-Seifert, K, Lee, T W, Gether, U, Sanders-Bush, E, Kobilka, B K. Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. J Biol Chem, 273(9), 5109-16, 1998

Seifert, R, Wenzel-Seifert, K, Lee, T W, Gether, U, Sanders-Bush, E, Kobilka, B K. Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. J Biol Chem, 273(18), 5109-16, 1998

Smith, R L, Canton, H, Barrett, R J, Sanders-Bush, E. Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors. Pharmacol Biochem Behav, 61(3), 323-30, 1998

Willins, D L, Alsayegh, L, Berry, S A, Backstrom, J R, Sanders-Bush, E, Friedman, L, Khan, N, Roth, B L. Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo. Ann N Y Acad Sci, 861, 121-7, 1998

Backstrom, J R, Sanders-Bush, E. Generation of anti-peptide antibodies against serotonin 5-HT2A and 5-HT2C receptors. J Neurosci Methods, 77(1), 109-17, 1997

Burns, C M, Chu, H, Rueter, S M, Hutchinson, L K, Canton, H, Sanders-Bush, E, Emeson, R B. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature, 387(6630), 303-8, 1997

Gether, U, Ballesteros, J A, Seifert, R, Sanders-Bush, E, Weinstein, H, Kobilka, B K. Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility. J Biol Chem, 272(5), 2587-90, 1997

Monte, A P, Waldman, S R, Marona-Lewicka, D, Wainscott, D B, Nelson, D L, Sanders-Bush, E, Nichols, D E. Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives. J Med Chem, 40(19), 2997-3008, 1997

Canton, H, Emeson, R B, Barker, E L, Backstrom, J R, Lu, J T, Chang, M S, Sanders-Bush, E. Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. Mol Pharmacol, 50(4), 799-807, 1996

Westphal, R S, Sanders-Bush, E. Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division. Mol Pharmacol, 49(3), 474-80, 1996

Backstrom, J R, Westphal, R S, Canton, H, Sanders-Bush, E. Identification of rat serotonin 5-HT2C receptors as glycoproteins containing N-linked oligosaccharides. Brain Res Mol Brain Res, 33(2), 311-8, 1995

Ike, J, Canton, H, Sanders-Bush, E. Developmental switch in the hippocampal serotonin receptor linked to phosphoinositide hydrolysis. Brain Res, 678(1-2), 49-54, 1995

Monte, A P, Marona-Lewicka, D, Kanthasamy, A, Sanders-Bush, E, Nichols, D E. Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. J Med Chem, 38(6), 958-66, 1995

Onaivi, E S, Bishop-Robinson, C, Darmani, N A, Sanders-Bush, E. Behavioral effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI) in the elevated plus-maze test. Life Sci, 57(26), 2455-66, 1995

Sanders-Bush E, Canton H. Serotonin receptors: Signal transduction pathways. Psychopharmacology: Fourth Generation of Progress, 1995

Smith, R L, Barrett, R J, Sanders-Bush, E. Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor. J Pharmacol Exp Ther, 275(2), 1050-7, 1995

Westphal, R S, Backstrom, J R, Sanders-Bush, E. Increased basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization. Mol Pharmacol, 48(2), 200-5, 1995

Barker, E L, Westphal, R S, Schmidt, D, Sanders-Bush, E. Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem, 269(16), 11687-90, 1994

Grotewiel, M S, Chu, H, Sanders-Bush, E. m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine are partial agonists at cloned 5-HT2A receptors expressed in fibroblasts. J Pharmacol Exp Ther, 271(2), 1122-6, 1994

Grotewiel, M S, Sanders-Bush, E. Regulation of serotonin2A receptors in heterologous expression systems. J Neurochem, 63(4), 1255-60, 1994

Mayer, S E, Sanders-Bush, E. 5-Hydroxytryptamine type 2A and 2C receptors linked to Na+/K+/Cl- cotransport. Mol Pharmacol, 45(5), 991-6, 1994

Sanders-Bush, E. Neurochemical evidence that hallucinogenic drugs are 5-HT1c receptor agonists: what next. NIDA Res Monogr, 146, 203-13, 1994

Westphal, R S, Sanders-Bush, E. Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists. Mol Pharmacol, 46(5), 937-42, 1994

Barker, E L, Sanders-Bush, E. 5-hydroxytryptamine1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and (-)-1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. Mol Pharmacol, 44(4), 725-30, 1993

Mayer, S E, Sanders-Bush, E. Sodium-dependent antiporters in choroid plexus epithelial cultures from rabbit. J Neurochem, 60(4), 1308-16, 1993

Burris, K D, Sanders-Bush, E. Unsurmountable antagonism of brain 5-hydroxytryptamine2 receptors by (+)-lysergic acid diethylamide and bromo-lysergic acid diethylamide. Mol Pharmacol, 42(5), 826-30, 1992

Esterle, T M, Sanders-Bush, E. Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium. J Neurosci, 12(12), 4775-82, 1992

Glennon, R A, Teitler, M, Sanders-Bush, E. Hallucinogens and serotonergic mechanisms. NIDA Res Monogr, 119, 131-5, 1992

Barker, E L, Burris, K D, Sanders-Bush, E. Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus. Brain Res, 552(2), 330-2, 1991

Burris, K D, Breeding, M, Sanders-Bush, E. (+)Lysergic acid diethylamide, but not its nonhallucinogenic congeners, is a potent serotonin 5HT1C receptor agonist. J Pharmacol Exp Ther, 258(3), 891-6, 1991

Esterle, T M, Sanders-Bush, E. From neurotransmitter to gene: identifying the missing links. Trends Pharmacol Sci, 12(10), 375-9, 1991

Sanders-Bush, E, Breeding, M. Choroid plexus epithelial cells in primary culture: a model of 5HT1C receptor activation by hallucinogenic drugs. Psychopharmacology (Berl), 105(3), 340-6, 1991

Sanders-Bush, E. Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis. Neuropsychopharmacology, 3(5-6), 411-6, 1990

Sanders-Bush, E, Breeding, M. Serotonin1c receptor reserve in choroid plexus masks receptor subsensitivity. J Pharmacol Exp Ther, 252(3), 984-8, 1990

Sanders-Bush, E, Tsutsumi, M, Burris, K D. Serotonin receptors and phosphatidylinositol turnover. Ann N Y Acad Sci, 600, 224-35; discussion 235-6, 1990

Smith, R L, Barrett, R J, Sanders-Bush, E. Adaptation of brain 5HT2 receptors after mianserin treatment: receptor sensitivity, not receptor binding, more accurately correlates with behavior. J Pharmacol Exp Ther, 254(2), 484-8, 1990

Tsutsumi, M, Sanders-Bush, E. 5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1c receptor. J Pharmacol Exp Ther, 254(1), 253-7, 1990

Sanders-Bush, E, Breeding, M, Knoth, K, Tsutsumi, M. Sertraline-induced desensitization of the serotonin 5HT-2 receptor transmembrane signaling system. Psychopharmacology (Berl), 99(1), 64-9, 1989

Tsutsumi, M, Skinner, M K, Sanders-Bush, E. Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells. Regulation by serotonin and cyclic adenosine 3',5'-monophosphate. J Biol Chem, 264(16), 9626-31, 1989

Gillespie, D D, Manier, D H, Sanders-Bush, E, Sulser, F. The serotonin/norepinephrine-link in brain. II. Role of serotonin in the regulation of beta adrenoceptors in the low agonist affinity conformation. J Pharmacol Exp Ther, 244(1), 154-9, 1988

Sanders-Bush, E, Breeding, M. Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus. J Pharmacol Exp Ther, 247(1), 169-73, 1988

Sanders-Bush, E, Burris, K D, Knoth, K. Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. J Pharmacol Exp Ther, 246(3), 924-8, 1988

Conn, P J, Janowsky, A, Sanders-Bush, E. Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus. Brain Res, 400(2), 396-8, 1987

Conn, P J, Sanders-Bush, E. Central serotonin receptors: effector systems, physiological roles and regulation. Psychopharmacology (Berl), 92(3), 267-77, 1987

Conn, P J, Sanders-Bush, E. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther, 242(2), 552-7, 1987

Manier, D H, Gillespie, D D, Sanders-Bush, E, Sulser, F. The serotonin/noradrenaline-link in brain. I. The role of noradrenaline and serotonin in the regulation of density and function of beta adrenoceptors and its alteration by desipramine. Naunyn Schmiedebergs Arch Pharmacol, 335(2), 109-14, 1987

Sanders-Bush, E, Breeding, M, Roznoski, M. 5HT2 binding sites after mianserin: comparison of loss of sites and brain levels of drug. Eur J Pharmacol, 133(2), 199-204, 1987

Sulser, F, Sanders-Bush, E. The serotonin-norepinephrine link hypothesis of affective disorders: receptor-receptor interactions in brain. Adv Exp Med Biol, 221, 489-502, 1987

Blackshear, M A, Martin, L L, Sanders-Bush, E. Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists. Neuropharmacology, 25(11), 1267-71, 1986

Conn, P J, Sanders-Bush, E. Biochemical characterization of serotonin stimulated phosphoinositide turnover. Life Sci, 38(7), 663-9, 1986

Conn, P J, Sanders-Bush, E. Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site. J Neurosci, 6(12), 3669-75, 1986

Conn, P J, Sanders-Bush, E. Agonist-induced phosphoinositide hydrolysis in choroid plexus. J Neurochem, 47(6), 1754-60, 1986

Conn, P J, Sanders-Bush, E, Hoffman, B J, Hartig, P R. A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc Natl Acad Sci U S A, 83(11), 4086-8, 1986 PMCID:323671

Sanders-Bush, E, Conn, P J. Effector systems coupled to serotonin receptors in brain: serotonin stimulated phosphoinositide hydrolysis. Psychopharmacol Bull, 22(3), 829-36, 1986

Conn, P J, Sanders-Bush, E. Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions. J Pharmacol Exp Ther, 234(1), 195-203, 1985

Sanders-Bush, E, Conn, J, Sulser, F. The serotonin/norepinephrine-linked beta-adrenoceptor system and the mode of action of antidepressants. Psychopharmacol Bull, 21(3), 373-8, 1985

Conn, P J, Sanders-Bush, E. Selective 5HT-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex. Neuropharmacology, 23(8), 993-6, 1984

Friedman, R L, Barrett, R J, Sanders-Bush, E. Discriminative stimulus properties of quipazine: mediation by serotonin2 binding sites. J Pharmacol Exp Ther, 228(3), 628-35, 1984

Friedman, R L, Sanders-Bush, E, Barrett, R L. Clozapine blocks disruptive and discriminative stimulus effects of quipazine. Eur J Pharmacol, 106(1), 191-3, 1984

Blackshear, M A, Friedman, R L, Sanders-Bush, E. Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites. Naunyn Schmiedebergs Arch Pharmacol, 324(2), 125-9, 1983

Friedman, R, Barrett, R J, Sanders-Bush, E. Additional evidence that L-5-hydroxytryptophan discrimination models a unique serotonin receptor. Psychopharmacology (Berl), 80(3), 209-13, 1983

Barrett, R J, Blackshear, M A, Sanders-Bush, E. Discriminative stimulus properties of L-5-hydroxytryptophan: behavioral evidence for multiple serotonin receptors. Psychopharmacology (Berl), 76(1), 29-35, 1982

Blackshear, M A, Sanders-Bush, E. Serotonin receptor sensitivity after acute and chronic treatment with mianserin. J Pharmacol Exp Ther, 221(2), 303-8, 1982

Martin, L L, Sanders-Bush, E. Comparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release. Naunyn Schmiedebergs Arch Pharmacol, 321(3), 165-70, 1982

Martin, L L, Sanders-Bush, E. The serotonin autoreceptor: antagonism by quipazine. Neuropharmacology, 21(5), 445-50, 1982

Sanders-Bush, E. Regulation of serotonin storage and release. Adv Biochem Psychopharmacol, 34, 17-34, 1982

Blackshear, M A, Steranka, L R, Sanders-Bush, E. Multiple serotonin receptors: regional distribution and effect of Raphe lesions. Eur J Pharmacol, 76(4), 325-34, 1981

Bush, M T, Sanders-Bush, E. Diazomethane: improved analytical and distillation techniques for small quantities and some synthetic applications. Anal Biochem, 106(2), 351-62, 1980

Steranka, L R, Sanders-Bush, E. Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice. Eur J Pharmacol, 65(4), 439-43, 1980

Mobley, P L, Sanders-Bush, E, Smith, H E, Sulser, F. Modification of the noradrenergic cyclic AMP generating system in the rat limbic forebrain by amphetamine: role of its hydroxylated metabolites. Naunyn Schmiedebergs Arch Pharmacol, 306(3), 267-73, 1979

Steranka, L R, Sanders-Bush, E. Species differences in the rate of disappearance of fenfluramine and its effects on brain serotonin neurons. Biochem Pharmacol, 28(20), 3103-7, 1979

Steranka, L R, Sanders-Bush, E. Long-term effects of fenfluramine on central serotonergic mechanisms. Neuropharmacology, 18(11), 895-903, 1979

Massari, V J, Tizabi, Y, Sanders-Bush, E. Evaluation of the neurotoxic effects of p-chloroamphetamine: a histological and biochemical study. Neuropharmacology, 17(7), 541-8, 1978

Sanders-Bush, E, Steranka, L R. Immediate and long-term effects of p-chloroamphetamine on brain amines. Ann N Y Acad Sci, 305, 208-21, 1978

Steranka, L R, Sanders-Bush, E. Long-term effects of continuous exposure to p-chloroamphetamine on central serotonergic mechanisms in mice. Biochem Pharmacol, 27(16), 2033-7, 1978

Steranka, L R, Sanders-Bush, E. Long-term reduction of brain serotonin by p-chloroamphetamine: effects of inducers and inhibitors of drug metabolism. J Pharmacol Exp Ther, 206(2), 460-7, 1978

El-Yousef, M K, Steranka, L, Sanders-Bush, E. Rapid tolerance to the motor effects of p-chloroamphetamine in rats. Psychopharmacology (Berl), 55(2), 109-14, 1977

Sanders-Bush, E, Massari, V J. Actions of drugs that deplete serotonin. Fed Proc, 36(8), 2149-53, 1977

Steranka, L R, Barrett, R J, Sanders-Bush, E. Facilitation of Sidman avoidance performance by p-chloroamphetamine: role of biogenic amines. Neuropharmacology, 16(11), 751-9, 1977

Steranka, L R, Sanders-Bush, E, Barrett, R J. Tolerance to p-chloroamphetamines effects on Sidman avoidance performance and catecholamine metabolism. Neuropharmacology, 16(11), 761-9, 1977

Steranka, L, Bessent, R, Sanders-Bush, E. Reversible and irreversible effects of p-chloroamphetamine on brain serotonin in mice. Commun Psychopharmacol, 1(5), 447-54, 1977

Steranka, L, Sanders-Bush, E. Temporal effects of p-chloroamphetamine on catecholamine synthesis. Eur J Pharmacol, 45(1), 83-6, 1977

Sanders-Bush, E. Long-term effects of para-chloroamphetamine on central serotonergic mechanisms. Psychopharmacol Bull, 12(3), 57-9, 1976

Sanders-Bush, E, Oates, J A, Bush, M T. Metabolism of bufotenine-2'-14C in human volunteers. Life Sci, 19(9), 1407-11, 1976

Gallager, D W, Sanders-Bush, E, Aghajanian, G K, Sulser, F. An evaluation of the use of intraventricularly administered [3H]5-hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine. Brain Res, 93(1), 111-22, 1975

Massari, V J, Sanders-Bush, E. Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions. Eur J Pharmacol, 33(2), 419-22, 1975

Sanders-Bush, E, Bushing, J A, Sulser, F. Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms. J Pharmacol Exp Ther, 192(1), 33-41, 1975

Sekerke, H J, Smith, H E, Bushing, J A, Sanders-Bush, E. Correlation between brain levels and biochemical effects of the optical isomers of p-chloroamphetamine. J Pharmacol Exp Ther, 193(3), 835-44, 1975

Sanders-Bush, E, Gallager, D A, Sulser, F. On the mechanism of brain 5-hydroxytryptamine depletion by p-chloroamphetamine and related drugs and the specificity of their action. Adv Biochem Psychopharmacol, 10, 185-94, 1974

Schaefer, G J, Barrett, R J, Sanders-Bush, E, Vorhees, C V. p-Chloroamphetamine: evidence against a serotonin mediated learning deficit in PKU. Pharmacol Biochem Behav, 2(6), 783-9, 1974

Smith, H E, Burrows, E P, Miano, J D, Mount, C D, Sanders-Bush, E, Sulser, F. Action of (S)-and(R)-para-substituted amphetamine hydrochlorides and (alphaS)-and (alphaR)-p-chloronorephedrine and (alphaS)-and (alphaR)-p-chloronorpseudoephedrine hydrochlorides on the level of 5-hydroxytryptamine and the activity of tryptophan hydroxylase in rat brain. J Med Chem, 17(4), 416-21, 1974

Yarbrough, G G, Buxbaum, D M, Sanders-Bush, E. Biogenic amines and narcotic effects. II. Serotonin turnover in the rat after acute and chronic morphine administration. J Pharmacol Exp Ther, 185(2), 328-35, 1973

Gallager, D W, Sanders-Bush, E, Sulser, F. Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following 9 -tetrahydrocannabinol. Psychopharmacologia, 26(4), 337-45, 1972

Sanders-Bush, E, Bushing, J A, Sulser, F. Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in brain. Eur J Pharmacol, 20(3), 385-8, 1972

Sanders-Bush, E, Bushing, J A, Sulser, F. p-Chloroamphetamine--inhibition of cerebral tryptophan hydroxylase. Biochem Pharmacol, 21(10), 1501-10, 1972

Miller, K W, Sanders-Bush, E, Dingell, J V. p-Chloramphetamine--species differences in the rate of disappearance and the lowering of cerebral serotonin. Biochem Pharmacol, 20(2), 500-3, 1971

Schmidt, M J, Sanders-Bush, E. Tryptophan hydroxylase activity in developing rat brain. J Neurochem, 18(12), 2549-51, 1971

Sulser, F, Sanders-Bush, E. Effect of drugs on amines in the CNS. Annu Rev Pharmacol, 11, 209-30, 1971

Yarbrough, G G, Buxbaum, D M, Sanders-Bush, E. Increased serotonin turnover in the acutely morphine treated rat. Life Sci I, 10(17), 977-83, 1971

Sanders-Bush, E, Sulser, F. P-chloroamphetamine: in vivo investigations on the mechanism of action of the selective depletion of cerebral serotonin. J Pharmacol Exp Ther, 175(2), 419-26, 1970

Strada, S J, Sanders-Bush, E, Sulser, F. p-Chloroamphetamine. Temporal relationship between psychomotor stimulation and metabolism of brain norepinephrine. Biochem Pharmacol, 19(9), 2621-9, 1970


Postdoctoral Position Available
No

Postdoctoral Position Details
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Updated Date
12/26/2007