Biomedical Research Education & Training
Faculty Member

Aune, Thomas M., Ph.D.
Professor of Medicine
Associate Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 615-343-7353

Email Address: thomas.m.aune@vanderbilt.edu

Aune, Thomas's picture
Academic history
B.S., Rhodes College, Memphis, TN
Ph.D., University of Tennessee, Memphis, TN

Office Address   Mailing Address

A-3327A Medical Center North

T-3219 MCN 2681


Research Keywords
Immunology, epigenetics, gene regulation, human autoimmune disease,Gene regulation,Immunology

Research Specialty
Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation.

Research Description
Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation. Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, a critical cytokine required to induce cell-mediated inflammation to the use of these approaches to gain new insights into human disease, including diseases of the endocrine system. These include recent studies evaluating relationships among gene expression signatures in atherosclerosis, type 2 diabetes and metabolic syndrome and study of copy number polymorphisms in type 1 diabetes, type 2 diabetes, and multiple sclerosis.

Publications
Collier, SP, Collins, PL, Williams, CL, Boothby, MR, Aune, TM. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol, 189(5), 2084-8, 2012

Collins, PL, Henderson, MA, Aune, TM. Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element. Genes Immun, 13(6), 481-8, 2012

Collins, PL, Henderson, MA, Aune, TM. Diverse functions of distal regulatory elements at the IFNG locus. J Immunol, 188(4), 1726-33, 2012

Reed, NP, Henderson, MA, Oltz, EM, Aune, TM. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Genes Immun, 2012

Spurlock, CF, Tossberg, JT, Fuchs, HA, Olsen, NJ, Aune, TM. Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum, 64(6), 1780-9, 2012

Grayson, BL, Aune, TM. A comparison of genomic copy number calls by Partek Genomics Suite, Genotyping Console and Birdsuite algorithms to quantitative PCR. BioData Min, 4, 8, 2011 PMCID:3084167

Grayson, BL, Wang, L, Aune, TM. Peripheral blood gene expression profiles in metabolic syndrome, coronary artery disease and type 2 diabetes. Genes Immun, 12(5), 341-51, 2011 PMCID:3084167

Spurlock, CF, Aune, ZT, Tossberg, JT, Collins, PL, Aune, JP, Huston, JW, Crooke, PS, Olsen, NJ, Aune, TM. Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK. Arthritis Rheum, 63(9), 2606-16, 2011

Wang, L, Jia, P, Wolfinger, RD, Chen, X, Grayson, BL, Aune, TM, Zhao, Z. An efficient hierarchical generalized linear mixed model for pathway analysis of genome-wide association studies. Bioinformatics, 27(5), 686-92, 2011 PMCID:3084167

Collins, PL, Aune, TM. Keeping one''s option open. Immunity, 32(5), 581-3, 2010

Collins, PL, Chang, S, Henderson, M, Soutto, M, Davis, GM, McLoed, AG, Townsend, MJ, Glimcher, LH, Mortlock, DP, Aune, TM. Distal regions of the human IFNG locus direct cell type-specific expression. J Immunol, 185(3), 1492-501, 2010

Grayson, BL, Smith, ME, Thomas, JW, Wang, L, Dexheimer, P, Jeffrey, J, Fain, PR, Nanduri, P, Eisenbarth, GS, Aune, TM. Genome-wide analysis of copy number variation in type 1 diabetes. PLoS One, 5(11), e15393, 2010 PMCID:2981564

Hoek, KL, Gordy, LE, Collins, PL, Parekh, VV, Aune, TM, Joyce, S, Thomas, JW, Van Kaer, L, Sebzda, E. Follicular B Cell Trafficking within the Spleen Actively Restricts Humoral Immune Responses. Immunity, 2010

Aune, TM, Collins, PL, Chang, S. Epigenetics and T helper 1 differentiation. Immunology, 126(3), 299-305, 2009 PMCID:2669810

Liu, Z, Sokka, T, Maas, K, Olsen, NJ, Aune, TM. Prediction of disease severity in patients with early rheumatoid arthritis by gene expression profiling. Hum Genomics Proteomics, 2009, 2009 PMCID:2950309

Chang, S, Collins, PL, Aune, TM. T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J Immunol, 181(12), 8372-81, 2008

Chang, S, Aune, TM. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol, 8(7), 723-31, 2007

Eivazova, ER, Vassetzky, YS, Aune, TM. Selective matrix attachment regions in T helper cell subsets support loop conformation in the Ifng gene. Genes Immun, 8(1), 35-43, 2007

Fossey, SC, Vnencak-Jones, CL, Olsen, NJ, Sriram, S, Garrison, G, Deng, X, Crooke, PS, Aune, TM. Identification of molecular biomarkers for multiple sclerosis. J Mol Diagn, 9(2), 197-204, 2007 PMCID:1867435

Liu, Z, Aune, TM. Deregulated stress system in non-obese diabetic lymphocyte. Genes Immun, 7(5), 352-8, 2006

Liu, Z, Maas, K, Aune, TM. Identification of gene expression signatures in autoimmune disease without the influence of familial resemblance. Hum Mol Genet, 15(3), 501-9, 2006

Zhang, F, Thomas, LR, Oltz, EM, Aune, TM. Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608. Nat Immunol, 7(12), 1309-16, 2006

Chang, S, Aune, TM. Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells. Proc Natl Acad Sci U S A, 102(47), 17095-100, 2005 PMCID:1283154

Liu, Z, Yelverton, RW, Kraft, B, Tanner, SB, Olsen, NJ, Aune, TM. Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. Clin Exp Allergy, 35(12), 1581-90, 2005

Maas, K, Chen, H, Shyr, Y, Olsen, NJ, Aune, T. Shared gene expression profiles in individuals with autoimmune disease and unaffected first-degree relatives of individuals with autoimmune disease. Hum Mol Genet, 14(10), 1305-14, 2005

Maas, K, Westfall, M, Pietenpol, J, Olsen, NJ, Aune, T. Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis. Arthritis Rheum, 52(4), 1047-57, 2005

Tong, Y, Aune, T, Boothby, M. T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A, 102(6), 2034-9, 2005 PMCID:548570

Aune, TM, Maas, K, Parker, J, Moore, JH, Olsen, NJ. Profiles of gene expression in human autoimmune disease. Cell Biochem Biophys, 40(2), 81-96, 2004

Aune, TM, Parker, JS, Maas, K, Liu, Z, Olsen, NJ, Moore, JH. Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity. Genet Epidemiol, 27(2), 162-72, 2004

Eivazova, ER, Aune, TM. Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation. Proc Natl Acad Sci U S A, 101(1), 251-6, 2004 PMCID:314171

Liu, Z, Maas, K, Aune, TM. Comparison of differentially expressed genes in T lymphocytes between human autoimmune disease and murine models of autoimmune disease. Clin Immunol, 112(3), 225-30, 2004

Olsen, N, Sokka, T, Seehorn, CL, Kraft, B, Maas, K, Moore, J, Aune, TM. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis, 63(11), 1387-92, 2004 PMCID:1754808

Olsen, NJ, Moore, JH, Aune, TM. Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells. Arthritis Res Ther, 6(3), 120-8, 2004 PMCID:416456

Zhou, W, Chang, S, Aune, TM. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc Natl Acad Sci U S A, 101(8), 2440-5, 2004 PMCID:356969

Aune, TM, Maas, K, Moore, JH, Olsen, NJ. Gene expression profiles in human autoimmune disease. Curr Pharm Des, 9(23), 1905-17, 2003

Zhang, F, Liang, Z, Matsuki, N, Van Kaer, L, Joyce, S, Wakeland, EK, Aune, TM. A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. J Immunol, 171(9), 4613-20, 2003

Zhou, W, Zhang, F, Aune, TM. Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells. J Immunol, 170(2), 735-40, 2003

Zhou, W., and Aune, T.M. IL-2 and IL-12 are equivalent Th1 differentiation factors for NOD T cells. J. Immunol., 170, 735-740, 2003

Maas, Chan, S., Parker J., Slater, A., Moore, J., Olsen, N and Aune, T. Cutting Edge: Molecular Portrait of Human Autoimmune Disease. J. Immunol., 169, 5-9, 2002

Maas, K, Chan, S, Parker, J, Slater, A, Moore, J, Olsen, N, Aune, TM. Cutting edge: molecular portrait of human autoimmune disease. J Immunol, 169(1), 5-9, 2002

Moore, J.H., Parker, J.S., Olsen, N., and Aune, T.M. Symbolic Discriminant Analysis of Microarray Data in Autoimmune Disease. Genetic Epidemiology, 23, 57-69, 2002

Moore, JH, Parker, JS, Olsen, NJ, Aune, TM. Symbolic discriminant analysis of microarray data in autoimmune disease. Genet Epidemiol, 23(1), 57-69, 2002

Soutto, M, Zhang, F, Enerson, B, Tong, Y, Boothby, M, Aune, TM. A minimal IFN-gamma promoter confers Th1 selective expression. J Immunol, 169(8), 4205-12, 2002

Soutto, M, Zhou, W, Aune, TM. Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells. J Immunol, 169(12), 6664-7, 2002

Soutto, M., Zhang, F., Emerson, B., Tong, Y., Boothby, M., and Aune, T.M. A minimal IFN-gamma promoter confers Th1 selective expression. J. Immunol., 169, 4205-4212, 2002

Soutto, M., Zhou, W., and Aune, T.M. Cutting Edge: Distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells. J. Immunol., 169, 6664-6667, 2002

Aune, TM. Transcriptional reprogramming during T helper cell differentiation. Immunol Res, 23(2-3), 193-204, 2001

Zhang, F, Rincon, M, Flavell, RA, Aune, TM. Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2. J Immunol, 165(4), 1762-70, 2000

Zhang, F., Rincon, M., Flavell, R.A., and Aune, T.M. Defective Th function induced by a dominant negative cAMP response element binding protein mutation is reversed by Bcl 2. J. Immunol., 165, 1762 1770, 2000

Aune, T.M., A.L. Mora, S. Kim, M. Boothby, and A.H. Lichtman. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkBa degradation. J. Immunol., 162, 5805-5811, 1999

Aune, TM, Mora, AL, Kim, S, Boothby, M, Lichtman, AH. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation. J Immunol, 162(10), 5805-12, 1999

Zhang, F, Nakamura, T, Aune, TM. TCR and IL-12 receptor signals cooperate to activate an individual response element in the IFN-gamma promoter in effector Th cells. J Immunol, 163(2), 728-35, 1999

Zhang, F., Nakamura, T., and Aune, T.M. . T cell receptor and IL-12 receptor signals cooperate to activate an individual response element in the IFNγ promoter in effector T helper cells. . J. Immunol, 163, 728-735, 1999

Zhang, F., T. Nakamura, and T.M. Aune. TCR and IL-12 receptor signals cooperate to activate an individual response element in the IFN-gamma promoter in effector Th cells. J. Immunol, 163, 728-735, 1999

Zhang, F, Wang, DZ, Boothby, M, Penix, L, Flavell, RA, Aune, TM. Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. J Immunol, 161(11), 6105-12, 1998

Zhang, F., D.Z Wang, M.Boothby, L.Penix, R.A. Flavell, and T.M. Aune. Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. J. Immuno., 161, 6105-6112, 1998

Aune, T.M., L. A. Penix, M.R. Rincon, and R. A. Flavell. Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells. Mol. Cel. Biol., 17, 199-208, 1997

Aune, T.M., and R. A. Flavell. Differential expression of transcription directed by a discrete NF-AT binding element from the IL-4 promoter in naive and effector CD4 T cells. J. Immunol., 159, 36-43, 1997

Aune, T.M., Golden, H.W., and McGrath, K.M. Inhibition of serotonin synthesis or inhibition of serotonin 1A receptors inhibits T cell function in vitro and in vivo. J. Immunol., 153, 489-498, 1994

Aune, T.M., McGrath, K.M., Sarr, T., Bombara, M.P., and Kelley, K.A. Expression of 5HT1a receptors on activated human T lymphocytes: Regulation of cAMP levels and T cell proliferation by 5HT. J. Immunol., 151, 1175-1183, 1993

Bombara, M.P., Webb, D.L., Conrad, P., Marlor, C.W., Sarr, T., Ranges, G.E., Aune, T.M., and Blue, M-L. Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines. J. Leuk. Biol, 54, 399-406, 1993

Rothman, B.L., Kennure, N., Kelley, K.A., Katz, M., and Aune, T.M. Elevation of intracellular cAMP in human T lymphocytes by an anti-CD44 mAb. J. Immunol., 151, 6036-6042, 1993

Piela-Smith, T.H., Aune, T.M., Aneiro, L., Nuveen, E., and Korn, J.H. Impairment of lymphocyte adhesion to cultured fibroblasts and endothelial cells by gamma-irradiation. J. Immunol., 148, 41-46, 1992

Rothman, B.L., Blue, M-L, Kelley, K.A., Wunderlich, D., Mierz, D.V., and Aune, T.M. Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44. J. Immunol., 147, 2493-2499, 1991

Aune, T.M., Kelley, K.A., Ranges, G.E., and Bombara, M.P. Serotonin activated signal transduction in human T cells.. J. Immunol., 145, 1826-1831, 1990

Webb, D.R., Mensi, N., Freire-Moar, J., Schnaper, H.W., Lewis R.V., Semenuk, G., Devens, B.H., Koontz, A., Danho, W., Pan, Y-C, Wesselschmidt, R., Aune, T.M. and Pierce, C.W. Putative amino terminal sequence of murine soluble immune response suppressor (SIRS): Significant homology with short neurotoxin 1.. Inter. Immunol., 2, 765-774, 1990

Aune, T.M., and Pogue, S.L. Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: Induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide.. J. Clin. Invest., 84, 863-875, 1989

Aune, T.M., and Pogue, S.L. Generation and initial characterization of a human CD8+ suppressor T cell line. J. Immunol., 142, 3731-3739, 1989

Schnaper, H.W., and Aune, T.M. Steroid sensitive mechanism of soluble immune response suppressor production in steroid responsive nephrotic syndrome. J.Clin.Invest. , 79, 254-264, 1987

Schnaper, H.W., and Aune, T.M. Suppression of immune responses to sheep erythrocytes by the lymphokine soluble immune response suppressor (SIRS) in vivo. J.Immunol., 137, 863-867, 1986

Aune, T.M. Inhibition of soluble immune response suppressor activity by growth factors. Proc. Nat'l Acad. Sci. U.S.A., 82, 6260-6264, 1985

Aune, T.M. ELISA for the detection of the lymphokine soluble immune response suppressor.. J. Immunol. Methods, 84, 33-44, 1985

Aune, T.M., Freeman, G.L., and Colley,. D.G. Production of the lymphokine, SIRS, during chronic experimental schistosomiasis mansoni.. J.Immunol. , 135, 2768-2771, 1985

Schnaper, H.W., and Aune, T.M. Identification of the lymphokine, soluble immune response suppressor, in urine of patients with nephrotic syndrome. J.Clin. Invest., 76, 341-349, 1985

Webb, D.R., Mason, K., Semenuk, G., Aune, T.M. and Pierce, C. W. Purification and isolation of isoforms of soluble immune response suppressor (SIRS). . J.Immunol., 135, 3238-3242, 1985

Webb, D.R., Mason, K., Semenuk, G., Aune, T.M. and Pierce, C. W. Purification and isolation of isoforms of soluble immune response suppressor (SIRS). J.Immunol. , 135, 3238-3242, 1985

Aune, T.M., Webb, D.R., and Pierce, C.W. Purification of radiolabeled soluble immune responses suppressor. Interleukins, Lymphokines and Cytokines, J.J. Oppenheim and Cohen, eds. Academic Press, New York, 383-389, 1983

Aune, T.M., Webb, D.R., and Pierce, C.W. Purification and initial characterization of the lymphokine, soluble immune response suppressor. J. Immunol., 131, 2848-2852, 1983

Aune, T.M., and Pierce, C.W. Inhibition of interferon or soluble immune response suppressor mediated suppression by levamisole. Int. J. Immunopharm., 5, 91-98, 1983

Schnaper, H.W., Aune, T.M., and Pierce, C.W. Suppressor T cell Activation by human lymphocyte interferon. J. Immunol., 131, 2301-2306, 1983

Aune, T.M. and Pierce, C.W. Activation of A Suppressor T Cell Pathway by Interferon. Proc. Nat'l Acad. Sci., 79, 3808-3812, 1982

Aune, T.M., Pierce, C.W. Conversion of Soluble Immune Response Suppressor to Macrophage-derived Suppressor Factor by Peroxide. Proc. Nat'l Acad. Sci., 78, 5099-5103, 1981


Postdoctoral Position Available
No

Postdoctoral Position Details
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Updated Date
12/12/2012