Biomedical Research Education & Training
Faculty Member

Ware, Lorraine B., M.D.
Professor of Medicine
Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 322 8614

Email Address: lorraine.ware@vanderbilt.edu

Ware, Lorraine's picture
Academic history
B.A., Claremont McKenna College
M.D., Johns Hopkins

Office Address   Mailing Address

B1321 MCN

T-1218 MCN 1161 21st Avenue S 37232-2650


Research Keywords
acute lung injury, coagulation , fibrinolysis, biomarkers, ARDS, sepsis, alveolar epithelium, alveolar epithelial fluid transport, respiratory failure, lung transplantation, free hemoglobin

Clinical Research Keywords
acute lung injury, ARDS, pulmonary edema, acute respiratory failure, sepsis, coagulation, fibrinolysis, biomarker, proteomics, lung transplantation

Patient Care Specialty
pulmonary and critical care medicine

Research Specialty
Translational research in acute lung injury and lung transplantation

Research Description
Our lab does basic, translational and clinical research on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury and the acute respiratory distress syndrome. Current projects include studies of the role of cell-free hemoglobin in the pathogenesis of lung epithelial injury in acute lung injury, investigation of the role of alveolar epithelium in modulating intra-alveolar fibrin deposition in the injured lung, translational studies of biomarkers for diagnosis and prognosis in acute lung injury, and studies of donor management for lung transplantation.

Clinical Research Description
Our lab does basic, translational and clinical research on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury and the acute respiratory distress syndrome. Current projects include studies of the role of cell-free hemoglobin in the pathogenesis of lung epithelial injury in acute lung injury, investigation of the role of alveolar epithelium in modulating intra-alveolar fibrin deposition in the injured lung, translational studies of biomarkers for diagnosis and prognosis in acute lung injury, and studies of donor management for lung transplantation.

Clinical Interests
Acute lung injury, ARDS, sepsis, acute respiratory failure, critical illness, acute kidney injury

Publications
Barnett, N, Zhao, Z, Koyama, T, Janz, DR, Wang, CY, May, AK, Bernard, GR, Ware, LB. Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study. Ann Intensive Care, 4(1), 5, 2014

Bastarache, JA, Koyama, T, Wickersham, NE, Ware, LB. Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples. J Immunol Methods, 408, 13-23, 2014

Bastarache, JA, Roberts, LJ, Ware, LB. Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury. Am J Physiol Lung Cell Mol Physiol, 306(3), L231-2, 2014

Brittain, EL, Janz, DR, Austin, ED, Bastarache, JA, Wheeler, LA, Ware, LB, Hemnes, AR. Elevation of Plasma Cell Free Hemoglobin in Pulmonary Arterial Hypertension. Chest, 2014

Calfee, CS, Delucchi, K, Parsons, PE, Thompson, BT, Ware, LB, Matthay, MA, , . Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med, 2(8), 611-20, 2014

Chen, Q, Wu, H, Ware, LB, Koyama, T. A Bayesian Approach for the Cox Proportional Hazards Model with Covariates Subject to Detection Limit. Int J Stat Med Res, 3(1), 32-43, 2014

Diamond, JM, Akimova, T, Kazi, A, Shah, RJ, Cantu, E, Feng, R, Levine, MH, Kawut, SM, Meyer, NJ, Lee, JC, Hancock, WW, Aplenc, R, Ware, LB, Palmer, SM, Bhorade, S, Lama, VN, Weinacker, A, Orens, J, Wille, K, Crespo, M, Lederer, DJ, Arcasoy, S, Demissie, E, Christie, JD, , . Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction. Am J Respir Crit Care Med, 189(5), 567-75, 2014

Janz, DR, Ware, LB. Plasma biomarkers in acute respiratory distress syndrome: a work in progress*. Crit Care Med, 42(3), 755-6, 2014

Kangelaris, KN, Calfee, CS, May, AK, Zhuo, H, Matthay, MA, Ware, LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS. Ann Intensive Care, 4(1), 4, 2014

Reilly, JP, Bellamy, S, Shashaty, MG, Gallop, R, Meyer, NJ, Lanken, PN, Kaplan, S, Holena, DN, May, AK, Ware, LB, Christie, JD. Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma. Ann Am Thorac Soc, 11(5), 728-36, 2014

Shah, RJ, Emtiazjoo, AM, Diamond, JM, Smith, PA, Roe, DW, Wille, KM, Orens, JB, Ware, LB, Weinacker, A, Lama, VN, Bhorade, SM, Palmer, SM, Crespo, M, Lederer, DJ, Cantu, E, Eckert, GJ, Christie, JD, Wilkes, DS. Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation. Am J Respir Crit Care Med, 189(12), 1564-7, 2014

Shah, RJ, Wickersham, N, Lederer, DJ, Palmer, SM, Cantu, E, Diamond, JM, Kawut, SM, Lama, VN, Bhorade, S, Crespo, M, Demissie, E, Sonett, J, Wille, K, Orens, J, Weinacker, A, Shah, P, Arcasoy, S, Wilkes, DS, Christie, JD, Ware, LB, , . Preoperative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation. Am J Transplant, 14(2), 446-52, 2014

Walter, JM, Wilson, J, Ware, LB. Biomarkers in acute respiratory distress syndrome: from pathobiology to improving patient care. Expert Rev Respir Med, 1-14, 2014

Wang, CY, Calfee, CS, Paul, DW, Janz, DR, May, AK, Zhuo, H, Bernard, GR, Matthay, MA, Ware, LB, Kangelaris, KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med, 40(3), 388-96, 2014

Ware, LB, Landeck, M, Koyama, T, Zhao, Z, Singer, J, Kern, R, Neidlinger, N, Nguyen, J, Johnson, E, Janz, DR, Bernard, GR, Lee, JW, Matthay, MA, , . A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am J Transplant, 14(3), 621-8, 2014

West, JD, Austin, ED, Gaskill, C, Marriott, S, Baskir, R, Bilousova, G, Jean, JC, Hemnes, AR, Menon, S, Bloodworth, NC, Fessel, JP, Kropski, JA, Irwin, DC, Ware, LB, Wheeler, LA, Hong, CC, Meyrick, BO, Loyd, JE, Bowman, AB, Ess, KC, Klemm, DJ, Young, PP, Merryman, WD, Kotton, D, Majka, SM. Identification of a Common Wnt Associated Genetic Signature Across Multiple Cell Types in Pulmonary Arterial Hypertension. Am J Physiol Cell Physiol, 2014

Janz, DR, Bastarache, JA, Peterson, JF, Sills, G, Wickersham, N, May, AK, Roberts, LJ, Ware, LB. Association Between Cell-Free Hemoglobin, Acetaminophen, and Mortality in Patients With Sepsis: An Observational Study. Crit Care Med, 41(3), 784-790, 2013

Janz, DR, Bastarache, JA, Sills, G, Wickersham, N, May, AK, Bernard, GR, Ware, LB. Association between haptoglobin, hemopexin and mortality in adults with sepsis. Crit Care, 17(6), R272, 2013

Sebag, SC, Bastarache, JA, Ware, LB. Mechanical stretch inhibits lipopolysaccharide (LPS)-induced KC and tissue factor (TF) expression while increasing procoagulant activity in murine lung epithelial cells. J Biol Chem, 2013

Ware, LB. Autopsy in ARDS: insights into natural history. Lancet Respir Med, 1(5), 352-4, 2013

Ware, LB. Acute respiratory distress syndrome: from TRALI to trials. Lancet Respir Med, 1(1), e1-2, 2013

Ware, LB, Koyama, T, Zhao, Z, Janz, DR, Wickersham, N, Bernard, GR, May, AK, Calfee, CS, Matthay, MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care, 17(5), R253, 2013

Bastarache, JA, Diamond, JM, Kawut, SM, Lederer, DJ, Ware, LB, Christie, JD. Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients. Gend Med, 9(3), 154-65, 2012

Bastarache, JA, Sebag, SC, Clune, JK, Grove, BS, Lawson, WE, Janz, DR, Roberts, LJ, Dworski, R, Mackman, N, Ware, LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax, 67(12), 1032-9, 2012

Bastarache, JA, Ware, LB, Girard, TD, Wheeler, AP, Rice, TW. Markers of Inflammation and Coagulation May Be Modulated by Enteral Feeding Strategy. JPEN J Parenter Enteral Nutr, 2012

Girard, TD, Ware, LB, Bernard, GR, Pandharipande, PP, Thompson, JL, Shintani, AK, Jackson, JC, Dittus, RS, Ely, EW. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med, 38(12), 1965-73, 2012

Polosukhin, VV, Degryse, AL, Newcomb, DC, Jones, BR, Ware, LB, Lee, JW, Loyd, JE, Blackwell, TS, Lawson, WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res, 38(3), 135-46, 2012

Ware, LB, Neyrinck, A, O''Neal, HR, Lee, JW, Landeck, M, Johnson, E, Calfee, CS, Matthay, MA, , . Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant, 2012

Wu, H, Chen, Q, Ware, LB, Koyama, T. A Bayesian Approach for Generalized Linear Models with Explanatory Biomarker Measurement Variables Subject to Detection Limit - an Application to Acute Lung Injury. J Appl Stat, 39(8), 1733-1747, 2012

Zeyed, YF, Bastarache, JA, Matthay, MA, Ware, LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol, 303(6), L550-5, 2012

Barnett, N, Ware, LB. Biomarkers in acute lung injury--marking forward progress. Crit Care Clin, 27(3), 661-83, 2011 PMCID:3134784

Bastarache, JA, Koyama, T, Wickersham, NE, Mitchell, DB, Mernaugh, RL, Ware, LB. Accuracy and reproducibility of a multiplex immunoassay platform: a validation study. J Immunol Methods, 367(1-2), 33-9, 2011 PMCID:3108329

Bastarache, JA, Ong, T, Matthay, MA, Ware, LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care, 26(3), 249-56, 2011 PMCID:2982881

Bastarache, JA, Sebag, SC, Grove, BS, Ware, LB. Interferon-I? and tumor necrosis factor-I? act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp Lung Res, 37(8), 509-17, 2011

Polosukhin, VV, Cates, JM, Lawson, WE, Zaynagetdinov, R, Milstone, AP, Massion, PP, Ocak, S, Ware, LB, Lee, JW, Bowler, RP, Kononov, AV, Randell, SH, Blackwell, TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 184(3), 317-27, 2011 PMCID:3265275

Rice, TW, Ware, LB, Haponik, EF, Chiles, C, Wheeler, AP, Bernard, GR, Steingrub, JS, Hite, RD, Matthay, MA, Wright, P, Ely, EW, , . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care, 15(2), R86, 2011 PMCID:3219344

Sebag, SC, Bastarache, JA, Ware, LB. Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol, 12(9), 1481-96, 2011 PMCID:3265275

Siew, ED, Ware, LB, Ikizler, TA. Biological markers of acute kidney injury. J Am Soc Nephrol, 22(5), 810-20, 2011 PMCID:3265275

Ware, LB, Fessel, JP, May, AK, Roberts, LJ. Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis. Shock, 36(1), 12-7, 2011 PMCID:3117035

Ware, LB, Johnson, AC, Zager, RA. Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury. Am J Physiol Renal Physiol, 300(3), F628-38, 2011 PMCID:3064135

Ware, LB, Koyama, T, Billheimer, D, Landeck, M, Johnson, E, Brady, S, Bernard, GR, Matthay, MA, , . Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care, 1(1), 20, 2011 PMCID:3224478

Fremont, RD, Koyama, T, Calfee, CS, Wu, W, Dossett, LA, Bossert, FR, Mitchell, D, Wickersham, N, Bernard, GR, Matthay, MA, May, AK, Ware, LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma, 68(5), 1121-7, 2010 PMCID:3347639

Lee, HJ, Joo, M, Abdolrasulnia, R, Young, DG, Choi, I, Ware, LB, Blackwell, TS, Christman, BW. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Biol Chem, 285(51), 39655-62, 2010 PMCID:3000946

Siew, ED, Ikizler, TA, Gebretsadik, T, Shintani, A, Wickersham, N, Bossert, F, Peterson, JF, Parikh, CR, May, AK, Ware, LB. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol, 5(8), 1497-505, 2010 PMCID:2924408

Ware, LB, Koyama, T, Billheimer, DD, Wu, W, Bernard, GR, Thompson, BT, Brower, RG, Standiford, TJ, Martin, TR, Matthay, MA, , . Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest, 137(2), 288-96, 2010 PMCID:2816641

Ware, LB, Eisner, MD, Flaherty, KR. Clinical year in review II: Sepsis, mechanical ventilation, occupational and environmental lung disease, and sleep. Proc Am Thorac Soc, 6(6), 494-9, 2009 PMCID:2816641

Ware, LB, Matthay, MA. Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol, 296(1), L12-3, 2009 PMCID:2636947

Bastarache, JA, Wang, L, Wang, Z, Albertine, KH, Matthay, MA, Ware, LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol, 294(5), L874-81, 2008

Calfee, CS, Eisner, MD, Parsons, PE, Thompson, BT, Conner, ER, Matthay, MA, Ware, LB, , . Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med, 2008

Calfee, CS, Ware, LB, Eisner, MD, Parsons, PE, Thompson, BT, Wickersham, N, Matthay, MA, , . Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax, 63(12), 1083-9, 2008

Gerszten, RE, Accurso, F, Bernard, GR, Caprioli, RM, Klee, EW, Klee, GG, Kullo, I, Laguna, TA, Roth, FP, Sabatine, M, Srinivas, P, Wang, TJ, Ware, LB. Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs. Am J Physiol Lung Cell Mol Physiol, 295(1), L16-22, 2008 PMCID:2494793

Hoffman, SA, Wang, L, Shah, CV, Ahya, VN, Pochettino, A, Olthoff, K, Shaked, A, Wille, K, Lama, VN, Milstone, A, Ware, LB, Orens, J, Weinacker, A, Demissie, E, Bellamy, S, Kawut, SM, Hancock, WW, Christie, JD, , . Plasma Cytokines and Chemokines in Primary Graft Dysfunction Post-Lung Transplantation. Am J Transplant, 2008

Iles, KE, Wright, MM, Cole, MP, Welty, NE, Ware, LB, Matthay, MA, Schopfer, FJ, Baker, PR, Agarwal, A, Freeman, BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med, 2008

Lawson, WE, Crossno, PF, Polosukhin, VV, Roldan, J, Cheng, DS, Lane, KB, Blackwell, TR, Xu, C, Markin, C, Ware, LB, Miller, GG, Loyd, JE, Blackwell, TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol, 294(6), L1119-26, 2008

McClintock, D, Zhuo, H, Wickersham, N, Matthay, MA, Ware, LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care, 12(2), R41, 2008 PMCID:2447583

Moss, M, Wilkes, D, Ware, LB. Clinical year in review II: Pulmonary infections in the immunocompetent host, issues in the training of fellows and residents, asthma, and chronic obstructive pulmonary disease. Proc Am Thorac Soc, 5(7), 745-50, 2008

Wang, L, Bastarache, JA, Ware, LB. The coagulation cascade in sepsis. Curr Pharm Des, 14(19), 1860-9, 2008

Ware, LB. Modeling human lung disease in animals. Am J Physiol Lung Cell Mol Physiol, 294(2), L149-50, 2008

White, KE, Ding, Q, Moore, BB, Peters-Golden, M, Ware, LB, Matthay, MA, Olman, MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol, 180(1), 637-46, 2008

Bastarache, JA, Wang, L, Geiser, T, Wang, Z, Albertine, KH, Matthay, MA, Ware, LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax, 62(7), 608-16, 2007

Calfee, CS, Eisner, MD, Ware, LB, Thompson, BT, Parsons, PE, Wheeler, AP, Korpak, A, Matthay, MA, , . Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med, 35(10), 2243-50, 2007

Calfee, CS, Eisner, MD, Ware, LB, Thompson, BT, Parsons, PE, Wheeler, AP, Korpak, A, Matthay, MA, , . Trauma-associated lung injury differs clinically and biologically from acute lung injury owing to other clinical disorders. Crit Care Med, Publish Ahead of Print, 2007

Christie, JD, Robinson, N, Ware, LB, Plotnick, M, De Andrade, J, Lama, V, Milstone, A, Orens, J, Weinacker, A, Demissie, E, Bellamy, S, Kawut, SM. Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction. Am J Respir Crit Care Med, 175(1), 69-74, 2007 PMCID:1899260

Covarrubias, M, Ware, LB, Kawut, SM, De Andrade, J, Milstone, A, Weinacker, A, Orens, J, Lama, V, Wille, K, Bellamy, S, Shah, C, Demissie, E, Christie, JD, , . Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. Am J Transplant, 7(11), 2573-8, 2007

Flori, HR, Ware, LB, Milet, M, Matthay, MA. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med, 8(2), 96-101, 2007

Fremont, RD, Kallet, RH, Matthay, MA, Ware, LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest, 131(6), 1742-6, 2007

Girard, TD, Ware, LB. Biomarkers of cardiac injury in acute respiratory distress syndrome: getting to the heart of the matter. Crit Care Med, 35(11), 2638-9, 2007

Lee, JW, Fang, X, Dolganov, G, Fremont, RD, Bastarache, JA, Ware, LB, Matthay, MA. Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J Biol Chem, 282(33), 24109-19, 2007

Liu, KD, Glidden, DV, Eisner, MD, Parsons, PE, Ware, LB, Wheeler, A, Korpak, A, Thompson, BT, Chertow, GM, Matthay, MA, , . Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med, 2007

Liu, KD, Glidden, DV, Eisner, MD, Parsons, PE, Ware, LB, Wheeler, A, Korpak, A, Thompson, BT, Chertow, GM, Matthay, MA, , . Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med, 35(12), 2755-61, 2007

McClintock, DE, Ware, LB, Eisner, MD, Wickersham, N, Thompson, BT, Matthay, MA, , . Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med, 175(3), 256-62, 2007 PMCID:1899263

Raj, JU, Aliferis, C, Caprioli, RM, Cowley, AW, Davies, PF, Duncan, MW, Erle, DJ, Erzurum, SC, Finn, PW, Ischiropoulos, H, Kaminski, N, Kleeberger, SR, Leikauf, GD, Loyd, JE, Martin, TR, Matalon, S, Moore, JH, Quackenbush, J, Sabo-Attwood, T, Shapiro, SD, Schnitzer, JE, Schwartz, DA, Schwiebert, LM, Sheppard, D, Ware, LB, Weiss, ST, Whitsett, JA, Wurfel, MM, Matthay, MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol, 293(1), L45-51, 2007

Rice, TW, Wheeler, AP, Bernard, GR, Hayden, DL, Schoenfeld, DA, Ware, LB, , . Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest, 132(2), 410-7, 2007

Wang, L, Bastarache, JA, Wickersham, N, Fang, X, Matthay, MA, Ware, LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol, 36(4), 497-503, 2007 PMCID:1899324

Ware, LB, Matthay, MA, Parsons, PE, Thompson, BT, Januzzi, JL, Eisner, MD, , . Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med, 35(8), 1821-8, 2007

Ware, LB, Matthay, MA, Parsons, PE, Thompson, BT, Januzzi, JL, Eisner, MD, , . Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med, 2007

Bastarache, JA, Ware, LB, Bernard, GR. The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med, 27(4), 365-76, 2006

Bhandari, V, Choo-Wing, R, Lee, CG, Zhu, Z, Nedrelow, JH, Chupp, GL, Zhang, X, Matthay, MA, Ware, LB, Homer, RJ, Lee, PJ, Geick, A, de Fougerolles, AR, Elias, JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med, 12(11), 1286-93, 2006

Ganter, MT, Ware, LB, Howard, M, Roux, J, Gartland, B, Matthay, MA, Fleshner, M, Pittet, JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol, 291(3), L354-61, 2006

Matthay, MA, Christman, JW, Pitt, BR, Schwiebert, LM, Stevens, T, Ware, LB. Perspectives, translational research, and letters to the editor. Am J Physiol Lung Cell Mol Physiol, 290(4), L621, 2006

Sakuma, T, Gu, X, Wang, Z, Maeda, S, Sugita, M, Sagawa, M, Osanai, K, Toga, H, Ware, LB, Folkesson, G, Matthay, MA. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med, 34(3), 676-81, 2006

Sapru, A, Wiemels, JL, Witte, JS, Ware, LB, Matthay, MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med, 32(9), 1293-303, 2006

Uchida, T, Shirasawa, M, Ware, LB, Kojima, K, Hata, Y, Makita, K, Mednick, G, Matthay, ZA, Matthay, MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med, 173(9), 1008-15, 2006 PMCID:2662912

Wardwell, NR, Miller, R, Ware, LB. Pulmonary alveolar proteinosis associated with a disease-modifying antirheumatoid arthritis drug. Respirology, 11(5), 663-5, 2006

Ware, LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med, 27(4), 337-49, 2006

Ware, LB, Camerer, E, Welty-Wolf, K, Schultz, MJ, Matthay, MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol, 291(3), L307-11, 2006

Arcasoy, SM, Fisher, A, Hachem, RR, Scavuzzo, M, Ware, LB, , . Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V: predictors and outcomes. J Heart Lung Transplant, 24(10), 1483-8, 2005

Cheng, IW, Eisner, MD, Thompson, BT, Ware, LB, Matthay, MA, , . Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit Care Med, 33(1), 63-70, 2005

Fussell, KM, Awad, JA, Ware, LB. Case of fulminant hepatic failure due to unrecognized peripartum cardiomyopathy. Crit Care Med, 33(4), 891-3, 2005

Parsons, PE, Matthay, MA, Ware, LB, Eisner, MD, , . Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol, 288(3), L426-31, 2005

Ware, LB. Prognostic determinants of acute respiratory distress syndrome in adults: impact on clinical trial design. Crit Care Med, 33(3 Suppl), S217-22, 2005

Ware, LB, Bastarache, JA, Wang, L. Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets. Keio J Med, 54(3), 142-9, 2005

Ware, LB, Fang, X, Wang, Y, Babcock, WD, Jones, K, Matthay, MA. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant, 24(10), 1650-6, 2005

Ware, LB, Kaner, RJ, Crystal, RG, Schane, R, Trivedi, NN, McAuley, D, Matthay, MA. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur Respir J, 26(1), 101-5, 2005 PMCID:2757043

Ware, LB, Matthay, MA. Clinical practice. Acute pulmonary edema. N Engl J Med, 353(26), 2788-96, 2005

Bowler, RP, Duda, B, Chan, ED, Enghild, JJ, Ware, LB, Matthay, MA, Duncan, MW. Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol, 286(6), L1095-104, 2004

Matthay, MA, Ware, LB. Can nicotine treat sepsis. Nat Med, 10(11), 1161-2, 2004

Matthay, MA, Ware, LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit Care Med, 32(5 Suppl), S229-32, 2004

Nathens, AB, Curtis, JR, Beale, RJ, Cook, DJ, Moreno, RP, Romand, JA, Skerrett, SJ, Stapleton, RD, Ware, LB, Waldmann, CS. Management of the critically ill patient with severe acute pancreatitis. Crit Care Med, 32(12), 2524-36, 2004

Nathens, AB, Curtis, JR, Beale, RJ, Cook, DJ, Moreno, RP, Romand, JA, Skerrett, SJ, Stapleton, RD, Ware, LB, Waldmann, CS. Executive summary: management of the critically ill patient with severe acute pancreatitis. Proc Am Thorac Soc, 1(4), 289-90, 2004

Olman, MA, White, KE, Ware, LB, Simmons, WL, Benveniste, EN, Zhu, S, Pugin, J, Matthay, MA. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol, 172(4), 2668-77, 2004

Sue, RD, Matthay, MA, Ware, LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med, 30(10), 1921-6, 2004

Wang, L, Zhu, du M, Su, X, Bai, CX, Ware, LB, Matthay, MA. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp Lung Res, 30(1), 31-42, 2004

Ware, LB. Keratinocyte growth factor as an epithelial protective agent: where do we stand. Int J Radiat Oncol Biol Phys, 60(5), 1345-6, 2004

Ware, LB. Modulation of alveolar fluid clearance by acute inflammation: the plot thickens. Am J Respir Crit Care Med, 169(3), 332-3, 2004

Ware, LB, Eisner, MD, Thompson, BT, Parsons, PE, Matthay, MA. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med, 170(7), 766-72, 2004

Bowler, RP, Velsor, LW, Duda, B, Chan, ED, Abraham, E, Ware, LB, Matthay, MA, Day, BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med, 31(9), 2309-15, 2003

Cheng, IW, Ware, LB, Greene, KE, Nuckton, TJ, Eisner, MD, Matthay, MA. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit Care Med, 31(1), 20-7, 2003

Eisner, MD, Parsons, P, Matthay, MA, Ware, L, Greene, K, , . Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax, 58(11), 983-8, 2003 PMCID:1746524

Flori, HR, Ware, LB, Glidden, D, Matthay, MA. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med, 4(3), 315-21, 2003

Galiacy, S, Planus, E, Lepetit, H, F??r??ol, S, Laurent, V, Ware, L, Isabey, D, Matthay, M, Harf, A, d'Ortho, MP. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res, 283(2), 215-29, 2003

Prabhakaran, P, Ware, LB, White, KE, Cross, MT, Matthay, MA, Olman, MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol, 285(1), L20-8, 2003

Ware, LB, Fang, X, Matthay, MA. Protein C and thrombomodulin in human acute lung injury. Am J Physiol Lung Cell Mol Physiol, 285(3), L514-21, 2003

Albertine, KH, Soulier, MF, Wang, Z, Ishizaka, A, Hashimoto, S, Zimmerman, GA, Matthay, MA, Ware, LB. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol, 161(5), 1783-96, 2002 PMCID:1850801

Atabai, K, Ishigaki, M, Geiser, T, Ueki, I, Matthay, MA, Ware, LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol, 283(1), L163-9, 2002

Atabai, K, Ware, LB, Snider, ME, Koch, P, Daniel, B, Nuckton, TJ, Matthay, MA. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med, 28(6), 705-11, 2002

Matthay, MA, Bhattacharya, S, Gaver, D, Ware, LB, Lim, LH, Syrkina, O, Eyal, F, Hubmayr, R. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am J Physiol Lung Cell Mol Physiol, 283(4), L678-82, 2002

Olman, MA, White, KE, Ware, LB, Cross, MT, Zhu, S, Matthay, MA. Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest, 121(3 Suppl), 69S-70S, 2002

Pham, I, Uchida, T, Planes, C, Ware, LB, Kaner, R, Matthay, MA, Clerici, C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol, 283(5), L1133-42, 2002

Ware, LB, Fang, X, Wang, Y, Sakuma, T, Hall, TS, Matthay, MA. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J Appl Physiol, 93(5), 1869-74, 2002

Ware, LB, Matthay, MA. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet, 360(9341), 1187-8, 2002

Ware, LB, Matthay, MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol, 282(5), L924-40, 2002

Ware, LB, Wang, Y, Fang, X, Warnock, M, Sakuma, T, Hall, TS, Matthay, M. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet, 360(9333), 619-20, 2002

Brower, RG, Ware, LB, Berthiaume, Y, Matthay, MA. Treatment of ARDS. Chest, 120(4), 1347-67, 2001

Geiser, T, Atabai, K, Jarreau, PH, Ware, LB, Pugin, J, Matthay, MA. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Am J Respir Crit Care Med, 163(6), 1384-8, 2001

Ware, LB, Conner, ER, Matthay, MA. von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med, 29(12), 2325-31, 2001

Ware, LB, Matthay, MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med, 163(6), 1376-83, 2001

Zhu, S, Ware, LB, Geiser, T, Matthay, MA, Matalon, S. Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Am J Respir Crit Care Med, 163(1), 166-72, 2001

Ware, LB, Matthay, MA. The acute respiratory distress syndrome. N Engl J Med, 342(18), 1334-49, 2000

Verghese, GM, Ware, LB, Matthay, BA, Matthay, MA. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. J Appl Physiol, 87(4), 1301-12, 1999

Wang, Y, Folkesson, HG, Jayr, C, Ware, LB, Matthay, MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. J Appl Physiol, 87(5), 1852-60, 1999

Ware, LB, Golden, JA, Finkbeiner, WE, Matthay, MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med, 159(3), 980-8, 1999

Matthay, MA, Flori, HR, Conner, ER, Ware, LB. Alveolar epithelial fluid transport: basic mechanisms and clinical relevance. Proc Assoc Am Physicians, 110(6), 496-505, 1998

Ware, LB, Keith, FM, Gordon, RL, Ries, CA, Seitz, RF, Gold, WM, Golden, JA. Lung transplantation for pulmonary amyloidosis: a case report. J Heart Lung Transplant, 17(11), 1129-32, 1998


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
08/21/2014