Biomedical Research Education & Training
Faculty Member

McIntyre, J. Oliver, Ph.D.
Research Professor of Radiology and Radiological Sciences
Research Professor of Cancer Biology

Lab Url: http://www.mc.vanderbilt.edu/vicc/biology/index.html

Phone Number: (615) 936-2913

Email Address: oliver.mcintyre@vanderbilt.edu

McIntyre, J.'s picture
Academic history
B.A., Cambridge Univ
M.A., Cambridge Univ
Ph.D., Vanderbilt
Post-doc, Vanderbilt

Office Address   Mailing Address

734 PRB

771 PRB 37232-6840


Research Keywords
Molecular Imaging, Enzymology,Biochemistry,Cancer,Membrane,Mouse,NMR,Spectroscopy

Research Specialty
In vivo molecular imaging of tumor-associated proteinases.

Publications
Harrell, Permila C, McCawley, Lisa J, Fingleton, Barbara, McIntyre, J Oliver, Matrisian, Lynn M. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp Cell Res, 303(2), 308-20, 2005

Fingleton, Barbara, Menon, Ramkumar, Carter, Kathy J, Overstreet, P Dawn, Hachey, David L, Matrisian, Lynn M, McIntyre, J Oliver. Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Clin Cancer Res, 10(23), 7865-74, 2004

McIntyre, J Oliver, Fingleton, Barbara, Wells, K Sam, Piston, David W, Lynch, Conor C, Gautam, Shiva, Matrisian, Lynn M. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J, 377(Pt 3), 617-28, 2004 PMCID:1223892

McIntyre, J Oliver, Matrisian, Lynn M. Molecular imaging of proteolytic activity in cancer. J Cell Biochem, 90(6), 1087-97, 2003

Jeyakumar, L H, Ballester, L, Cheng, D S, McIntyre, J O, Chang, P, Olivey, H E, Rollins-Smith, L, Barnett, J V, Murray, K, Xin, H B, Fleischer, S. FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem Biophys Res Commun, 281(4), 979-86, 2001

Chelius, D., Loeb-Hennard, C., Fleischer, S., McIntyre, J.O., Marks, A.R., Moeller, J., Hahn, S., De, S., Philipp, R., Wise, J.G., and Trommer, W.E . (2000) Phosphatidylcholine Activation of Human heart (R)-3-Hydroxybutyrate Dehydrogenase Mutants Lacking Active Center Sulfhydryls: Site-Directed Mutagenesis of a Novel Recombinant Fusion Protein. Biochemistry, 39:9687-9697

Loeb-Hennard, C, McIntyre, J O. (R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain. Biochemistry, 39(39), 11928-38, 2000

Picklo, M J, Amarnath, V, McIntyre, J O, Graham, D G, Montine, T J. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. J Neurochem, 72(4), 1617-24, 1999

Green, D., Marks, A.R., Fleischer, S., and McIntyre, J.O. Wild Type and Mutant Human Heart (R)-3- Hydroxybutyrate Dehydrogenase Expressed in Insect Cells. Biochemistry, 35, 8158-8165 , 1996

Klein, K., Rudy, B., McIntyre, J.O., Fleischer, S., and Trommer, W.E. Specific Interaction of (R)-3-Hydroxybutyrate Dehydrogenase with Membrane Phosphatidylcholine as Studied by ESR Specroscopy in Oriented Phospholipid Multibilayers: Coenzyme Binding Enhances the Interaction with Phosphatidylcholine. Biochemistry, 35, 3044-3049 , 1996

Adami, P, Duncan, T M, McIntyre, J O, Carter, C E, Fu, C, Melin, M, Latruffe, N, Fleischer, S. Monoclonal antibodies for structure-function studies of (R)-3-hydroxybutyrate dehydrogenase, a lipid-dependent membrane-bound enzyme. Biochem J, 292 ( Pt 3), 863-72, 1993 PMCID:1134194

Dalton, L A, McIntyre, J O, Fleischer, S. Effect of selective thiol-group derivatization on enzyme kinetics of (R)-3-hydroxybutyrate dehydrogenase. Biochem J, 296 ( Pt 3), 563-9, 1993 PMCID:1137735

Fleischer, B, McIntyre, J O, Kempner, E S. Target sizes of galactosyltransferase, sialyltransferase, and uridine diphosphatase in Golgi apparatus of rat liver. Biochemistry, 32(8), 2076-81, 1993

Cortese, J D, McIntyre, J O, Duncan, T M, Fleischer, S. Cooperativity in lipid activation of 3-hydroxybutyrate dehydrogenase: role of lecithin as an essential allosteric activator. Biochemistry, 28(7), 3000-8, 1989

McIntyre, J O, Latruffe, N, Brenner, S C, Fleischer, S. Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondria. Arch Biochem Biophys, 262(1), 85-98, 1988


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
02/02/2005